Melisande E Konadu, Murray B Reed, Ulrike Kaufmann, Patricia A Handschuh, Benjamin Spurny-Dworak, Manfred Klöbl, Clemens Schmidt, Godber, M Godbersen, Elisa Briem, René Seiger, Pia Baldinger-Melich, Georg S Kranz, Rupert Lanzenberger, Marie Spies
BACKGROUND: Among its pleiotropic properties, gender-affirming hormone therapy (GHT) affects regional brain volumes. The hypothalamus, which regulates neuroendocrine function and associated emotional and cognitive processes, is an intuitive target for probing GHT effects. We sought to assess changes to hypothalamus and hypothalamic subunit volumes after GHT, thereby honouring the region's anatomical and functional heterogeneity. METHODS: Individuals with gender dysphoria and cisgender controls underwent 2 MRI measurements, with a median interval of 145 days (interquartile range [IQR] 128...
2023: Journal of Psychiatry & Neuroscience: JPN