journal
Journals Journal of Psychiatry & Neuros...

Journal of Psychiatry & Neuroscience : JPN

https://read.qxmd.com/read/38816030/emotions-related-to-threatening-events-are-mainly-linked-to-the-right-hemisphere
#1
JOURNAL ARTICLE
Guido Gainotti
A recent meta-analysis of functional neuroimaging contrasts between emotional and neutral face processing has shown that the processing of facial emotions can be better classified according to threat detection than emotional valence, with the authors suggesting that their data are inconsistent with both the right-hemisphere and valence models of emotional laterality. I report empirical and theoretical data indicating that facial expressions are better classified according to threat detection than to the distinction between positive and negative emotions...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38816029/oxytocin-neurons-in-the-paraventricular-nucleus-and-fear-empathy-among-male-mice
#2
JOURNAL ARTICLE
Lu Zhang, Hai-Chao Chen, Bing Li, Jia-Xin Cao, Xiao-Mei Su, Yi-Ting Kang, Li-Ping Gao, Yu-Hong Jing
BACKGROUND: Recent studies have identified empathy deficit as a core impairment and diagnostic criterion for people with autism spectrum disorders; however, the improvement of empathy focuses primarily on behavioural interventions without the target regulation. We sought to compare brain regions associated with empathy-like behaviours of fear and pain, and to explore the role of the oxytocin-oxytocin receptor system in fear empathy. METHODS: We used C57BL mice to establish 2 models of fear empathy and pain empathy...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38816028/widespread-reductions-in-cortical-thickness-following-ketamine-abuse
#3
JOURNAL ARTICLE
Jinsong Tang, Qiuxia Wu, Chang Qi, An Xie, Jianbin Liu, Yunkai Sun, Tifei Yuan, Wei Chen, Tieqiao Liu, Wei Hao, Xu Shao, Yanhui Liao
BACKGROUND: Esketamine is a version of ketamine that has been approved for treatment-resistant depression, but our previous studies showed a link between non-medical use of ketamine and brain structural and functional alterations, including dorsal prefrontal grey matter reduction among chronic ketamine users. In this study, we sought to determine cortical thickness abnormalities following long-term, non-medical use of ketamine. METHODS: We acquired structural brain images for patients with ketamine use disorder and drug-free healthy controls...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38729664/effects-of-repetitive-transcranial-magnetic-stimulation-on-individual-variability-of-resting-state-functional-connectivity-in-major-depressive-disorder
#4
JOURNAL ARTICLE
Vinh Tan, Jonathan Downar, Sean Nestor, Fidel Vila-Rodriguez, Zafiris J Daskalakis, Daniel M Blumberger, Colin Hawco
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for major depressive disorder (MDD), but substantial heterogeneity in outcomes remains. We examined a potential mechanism of action of rTMS to normalize individual variability in resting-state functional connectivity (rs-fc) before and after a course of treatment. METHODS: Variability in rs-fc was examined in healthy controls (baseline) and individuals with MDD (baseline and after 4-6 weeks of rTMS)...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38692693/disproportionate-neuroanatomical-effects-of-dcc-haploinsufficiency-in-adolescence-compared-with-adulthood-links-to-dopamine-connectivity-covariance-and-gene-expression-brain-maps-in-mice
#5
JOURNAL ARTICLE
Daniel Hoops, Yohan Yee, Christopher Hammill, Sammi Wong, Colleen Manitt, Barry J Bedell, Lindsay Cahill, Jason P Lerch, Cecilia Flores, John G Sled
BACKGROUND: Critical adolescent neural refinement is controlled by the DCC (deleted in colorectal cancer) protein, a receptor for the netrin-1 guidance cue. We sought to describe the effects of reduced DCC on neuroanatomy in the adolescent and adult mouse brain. METHODS: We examined neuronal connectivity, structural covariance, and molecular processes in a DCC -haploinsufficient mouse model, compared with wild-type mice, using new, custom analytical tools designed to leverage publicly available databases from the Allen Institute...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38692692/altered-effective-connectivity-among-face-processing-systems-in-major-depressive-disorder
#6
JOURNAL ARTICLE
Fangrui Sheng, Yun Wang, Ruinan Li, Xiaoya Li, Xiongying Chen, Zhifang Zhang, Rui Liu, Ling Zhang, Yuan Zhou, Gang Wang
BACKGROUND: Neuroimaging studies have revealed abnormal functional interaction during the processing of emotional faces in patients with major depressive disorder (MDD), thereby enhancing our comprehension of the pathophysiology of MDD. However, it is unclear whether there is abnormal directional interaction among face-processing systems in patients with MDD. METHODS: A group of patients with MDD and a healthy control group underwent a face-matching task during functional magnetic resonance imaging...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38653528/correction-to-improving-causality-perception-judgments-in-schizophrenia-spectrum-disorder-via-transcranial-direct-current-stimulation
#7
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38653527/correction-to-navigated-and-individual-%C3%AE-peak-frequency-guided-transcranial-magnetic-stimulation-in-male-patients-with-treatment-refractory-schizophrenia
#8
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38569725/neuroimaging-alterations-and-relapse-in-early-stage-psychosis
#9
JOURNAL ARTICLE
Marina Mihaljevic, Anisha Nagpal, Semra Etyemez, Zui Narita, Anna Ross, Rebecca Schaub, Nicola G Cascella, Jennifer M Coughlin, Gerald Nestadt, Frederik C Nucifora, Thomas W Sedlak, Vince D Calhoun, Andreia V Faria, Kun Yang, Akira Sawa
BACKGROUND: Recent reports have indicated that symptom exacerbation after a period of improvement, referred to as relapse, in early-stage psychosis could result in brain changes and poor disease outcomes. We hypothesized that substantial neuroimaging alterations may exist among patients who experience relapse in early-stage psychosis. METHODS: We studied patients with psychosis within 2 years after the first psychotic event and healthy controls. We divided patients into 2 groups, namely those who did not experience relapse between disease onset and the magnetic resonance imaging (MRI) scan (no-relapse group) and those who did experience relapse between these 2 timings (relapse group)...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38569724/making-use-of-n-of-1-trials-to-treat-adhd-in-people-with-psychosis-a-hypothetical-case
#10
JOURNAL ARTICLE
Kathryn Dalton, Ridha Joober, Sherif Karama, Lena Palaniyappan
No abstract text is available yet for this article.
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38569723/dr-francis-wayne-quan-memorial-prize-2023
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38569722/public-discourse-on-mental-health-a-critical-view
#12
EDITORIAL
Ashok Malla, Ian Gold
No abstract text is available yet for this article.
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38490647/advances-in-the-understanding-of-the-pathophysiology-of-schizophrenia-and-bipolar-disorder-through-induced-pluripotent-stem-cell-models
#13
REVIEW
Andrea Perrottelli, Francesco Flavio Marzocchi, Edoardo Caporusso, Giulia Maria Giordano, Luigi Giuliani, Antonio Melillo, Pasquale Pezzella, Paola Bucci, Armida Mucci, Silvana Galderisi
The pathophysiology of schizophrenia and bipolar disorder involves a complex interaction between genetic and environmental factors that begins in the early stages of neurodevelopment. Recent advancements in the field of induced pluripotent stem cells (iPSCs) offer a promising tool for understanding the neurobiological alterations involved in these disorders and, potentially, for developing new treatment options. In this review, we summarize the results of iPSC-based research on schizophrenia and bipolar disorder, showing disturbances in neurodevelopmental processes, imbalance in glutamatergic-GABAergic transmission and neuromorphological alterations...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38490646/intracranial-self-stimulation-reverses-impaired-spatial-learning-and-regulates-serum-microrna-levels-in-a-streptozotocin-induced-rat-model-of-alzheimer-disease
#14
JOURNAL ARTICLE
Andrea Riberas-Sánchez, Irene Puig-Parnau, Laia Vila-Solés, Soleil Garcia-Brito, Laura Aldavert-Vera, Pilar Segura-Torres, Gemma Huguet, Elisabet Kádár
BACKGROUND: The assessment of deep brain stimulation (DBS) as a therapeutic alternative for treating Alzheimer disease (AD) is ongoing. We aimed to determine the effects of intracranial self-stimulation at the medial forebrain bundle (MFB-ICSS) on spatial memory, neurodegeneration, and serum expression of microRNAs (miRNAs) in a rat model of sporadic AD created by injection of streptozotocin. We hypothesized that MFB-ICSS would reverse the behavioural effects of streptozotocin and modulate hippocampal neuronal density and serum levels of the miRNAs...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38428970/navigated-and-individual-%C3%AE-peak-frequency-guided-transcranial-magnetic-stimulation-in-male-patients-with-treatment-refractory-schizophrenia
#15
JOURNAL ARTICLE
Heli Tuppurainen, Sara Määttä, Mervi Könönen, Petro Julkunen, Hannu Kautiainen, Soile Hyvärinen, Olli Vaurio, Mikko Joensuu, Matti Vanhanen, Kati Aho-Mustonen, Esa Mervaala, Jari Tiihonen
BACKGROUND: Previous electroencephalography (EEG) studies have indicated altered brain oscillatory α-band activity in schizophrenia, and treatment with repetitive transcranial magnetic stimulation (rTMS) using individualized α-frequency has shown therapeutic effects. Magnetic resonance imaging-based neuronavigation methods allow stimulation of a specific cortical region and improve targeting of rTMS; therefore, we sought to study the efficacy of navigated, individual α-peak-frequency-guided rTMS (αTMS) on treatment-refractory schizophrenia...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38428969/lessons-from-studies-of-medication-reduction-in-psychosis-giving-participants-accurate-information-about-risk-in-psychiatric-research-trials
#16
JOURNAL ARTICLE
David Foreman
All research needs ethical regulation, which is institutionalized in research ethics committees. The patient information sheet, approved by a research ethics committee, sets out what patients need to know to make an informed choice about research participation. However, guidance from research ethics committees is much less explicit about risk communication. In this commentary, the balance of risk in the patient information sheets from protocols of 2 randomized controlled trials (RCTs) of medication reduction in psychosis was compared with numbers needed to treat and harm from the literature...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38383036/ending-the-overdose-epidemic-by-ending-the-war-on-drug-users-can-this-work
#17
EDITORIAL
Marco Leyton, R Michael Krausz
No abstract text is available yet for this article.
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38359933/pharmacological-adjuncts-and-transcranial-magnetic-stimulation-induced-synaptic-plasticity-a-systematic-review
#18
JOURNAL ARTICLE
Myren N Sohn, Joshua C Brown, Prayushi Sharma, Ulf Ziemann, Alexander McGirr
BACKGROUND: Transcranial magnetic stimulation (TMS) is a noninvasive neurostimulation modality that has been used to study human synaptic plasticity. Leveraging work in ex vivo preparations, mechanistically informed pharmacological adjuncts to TMS have been used to improve our fundamental understanding of TMS-induced synaptic plasticity. METHODS: We systematically reviewed the literature pairing pharmacological adjuncts with TMS plasticity-induction protocols in humans...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38359932/epigenetic-profile-of-the-immune-system-associated-with-symptom-severity-and-treatment-response-in-schizophrenia
#19
JOURNAL ARTICLE
Yuanhao Tang, Yunlong Tan, Lena Palaniyappan, Yin Yao, Qiang Luo, Yanli Li
BACKGROUND: Environmental modification of genetic information (epigenetics) is often invoked to explain interindividual differences in the phenotype of schizophrenia. In clinical practice, such variability is most prominent in the symptom profile and the treatment response. Epigenetic regulation of immune function is of particular interest, given the therapeutic relevance of this mechanism in schizophrenia. METHODS: We analyzed the DNA methylation data of immune-relevant genes in patients with schizophrenia whose disease duration was less than 3 years, with previous lifetime antipsychotic treatment of no more than 2 weeks total...
2024: Journal of Psychiatry & Neuroscience: JPN
https://read.qxmd.com/read/38302137/permissive-epigenetic-regulatory-mechanisms-at-the-histone-level-are-enhanced-in-postmortem-dorsolateral-prefrontal-cortex-of-individuals-with-schizophrenia
#20
JOURNAL ARTICLE
Oihane Martínez-Peula, Benito Morentin, Luis F Callado, J Javier Meana, Guadalupe Rivero, Alfredo Ramos-Miguel
BACKGROUND: Susceptibility to schizophrenia is determined by interactions between genes and environment, possibly via epigenetic mechanisms. Schizophrenia has been associated with a restrictive epigenome, and histone deacetylase (HDAC) inhibitors have been postulated as coadjuvant agents to potentiate the efficacy of current antipsychotic drugs. We aimed to evaluate global histone posttranslational modifications (HPTMs) and HDAC expression and activity in the dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia...
2024: Journal of Psychiatry & Neuroscience: JPN
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