journal
https://read.qxmd.com/read/38484734/a-humoral-stress-response-protects-drosophila-tissues-from-antimicrobial-peptides
#21
JOURNAL ARTICLE
Samuel Rommelaere, Alexia Carboni, Juan F Bada Juarez, Jean-Philippe Boquete, Luciano A Abriata, Fernando Teixeira Pinto Meireles, Verena Rukes, Crystal Vincent, Shu Kondo, Marc S Dionne, Matteo Dal Peraro, Chan Cao, Bruno Lemaitre
7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress...
March 5, 2024: Current Biology: CB
https://read.qxmd.com/read/38479387/dynamic-antennal-positioning-allows-honeybee-followers-to-decode-the-dance
#22
JOURNAL ARTICLE
Anna Hadjitofi, Barbara Webb
The honeybee waggle dance has been widely studied as a communication system, yet we know little about how nestmates assimilate the information needed to navigate toward the signaled resource. They are required to detect the dancer's orientation relative to gravity and duration of the waggle phase and translate this into a flight vector with a direction relative to the sun1 and distance from the hive.2 , 3 Moreover, they appear capable of doing so from varied, dynamically changing positions around the dancer...
March 5, 2024: Current Biology: CB
https://read.qxmd.com/read/38460514/trade-offs-trade-ups-and-high-mutational-parallelism-underlie-microbial-adaptation-during-extreme-cycles-of-feast-and-famine
#23
JOURNAL ARTICLE
Megan G Behringer, Wei-Chin Ho, Samuel F Miller, Sarah B Worthan, Zeer Cen, Ryan Stikeleather, Michael Lynch
Microbes are evolutionarily robust organisms capable of rapid adaptation to complex stress, which enables them to colonize harsh environments. In nature, microbes are regularly challenged by starvation, which is a particularly complex stress because resource limitation often co-occurs with changes in pH, osmolarity, and toxin accumulation created by metabolic waste. Often overlooked are the additional complications introduced by eventual resource replenishment, as successful microbes must withstand rapid environmental shifts before swiftly capitalizing on replenished resources to avoid invasion by competing species...
March 5, 2024: Current Biology: CB
https://read.qxmd.com/read/38460513/parallel-gene-size-and-isoform-expansion-of-ancient-neuronal-genes
#24
JOURNAL ARTICLE
Matthew J McCoy, Andrew Z Fire
How nervous systems evolved is a central question in biology. A diversity of synaptic proteins is thought to play a central role in the formation of specific synapses leading to nervous system complexity. The largest animal genes, often spanning hundreds of thousands of base pairs, are known to be enriched for expression in neurons at synapses and are frequently mutated or misregulated in neurological disorders and diseases. Although many of these genes have been studied independently in the context of nervous system evolution and disease, general principles underlying their parallel evolution remain unknown...
March 5, 2024: Current Biology: CB
https://read.qxmd.com/read/38460512/spatial-heterogeneity-of-neo-and-paleo-endemism-for-plants-in-madagascar
#25
JOURNAL ARTICLE
Wyckliffe Omondi Omollo, Romer Narindra Rabarijaona, Rindra Manasoa Ranaivoson, Mijoro Rakotoarinivo, Russell L Barrett, Qiang Zhang, Yang-Jun Lai, Jian-Fei Ye, Chi Toan Le, Alexandre Antonelli, Zhi-Duan Chen, Bing Liu, Li-Min Lu
Madagascar is a biogeographically unique island with a remarkably high level of endemism. However, endemic taxa in Madagascar are massively threatened due to unprecedented pressures from anthropogenic habitat modification and climate change. A comprehensive phylogeny-based biodiversity evaluation of the island remains lacking. Here, we identify hotspots of taxonomic and phylogenetic plant diversity and neo- and paleo-endemism by generating a novel dated tree of life for the island. The tree is based on unprecedented sampling of 3,950 species (33% of the total known species) and 1,621 genera (93% of the total known genera and 69% of endemic genera) of Malagasy vascular plants...
March 5, 2024: Current Biology: CB
https://read.qxmd.com/read/38479389/basolateral-amygdala-parvalbumin-interneurons-coordinate-oscillations-to-drive-reward-behaviors
#26
JOURNAL ARTICLE
Kenneth A Amaya, Eric Teboul, Grant L Weiss, Pantelis Antonoudiou, Jamie L Maguire
The basolateral amygdala (BLA) mediates both fear and reward learning.1 , 2 Previous work has shown that parvalbumin (PV) interneurons in the BLA contribute to BLA oscillatory states integral to fear expression.3 , 4 , 5 , 6 , 7 However, despite it being critical to our understanding of reward behaviors, it is unknown whether BLA oscillatory states and PV interneurons similarly contribute to reward processing. Local field potentials in the BLA were collected as male and female mice consumed sucrose reward, where prominent changes in the beta band (15-30 Hz) emerged with reward experience...
March 4, 2024: Current Biology: CB
https://read.qxmd.com/read/38479388/pheromone-mediated-command-from-the-female-to-male-clock-induces-and-synchronizes-circadian-rhythms-of-the-moth-spodoptera-littoralis
#27
JOURNAL ARTICLE
Sagnik Ghosh, Caroline Suray, Françoise Bozzolan, Antonio Palazzo, Christelle Monsempès, François Lecouvreur, Abhishek Chatterjee
To extract any adaptive benefit, the circadian clock needs to be synchronized to the 24-h day-night cycles. We have investigated if it is a general property of the brain's circadian clock to recognize social interactions as external time givers. Sociosexual interactions with the opposite sex are universal, prevalent even in the lives of solitary animals. The solitary adult life of the Spodoptera littoralis moth is singularly dedicated to sex, offering an ideal context for exploring the impact of sociosexual cues on circadian timekeeping...
March 4, 2024: Current Biology: CB
https://read.qxmd.com/read/38458192/dissociable-encoding-of-motivated-behavior-by-parallel-thalamo-striatal-projections
#28
JOURNAL ARTICLE
Sofia Beas, Isbah Khan, Claire Gao, Gabriel Loewinger, Emma Macdonald, Alison Bashford, Shakira Rodriguez-Gonzalez, Francisco Pereira, Mario A Penzo
The successful pursuit of goals requires the coordinated execution and termination of actions that lead to positive outcomes. This process relies on motivational states that are guided by internal drivers, such as hunger or fear. However, the mechanisms by which the brain tracks motivational states to shape instrumental actions are not fully understood. The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that shapes motivated behaviors via its projections to the nucleus accumbens (NAc)1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 and monitors internal state via interoceptive inputs from the hypothalamus and brainstem...
March 2, 2024: Current Biology: CB
https://read.qxmd.com/read/38447572/the-hierarchical-radiation-of-phyllostomid-bats-as-revealed-by-adaptive-molar-morphology
#29
JOURNAL ARTICLE
David M Grossnickle, Alexa Sadier, Edward Patterson, Nashaly N Cortés-Viruet, Stephanie M Jiménez-Rivera, Karen E Sears, Sharlene E Santana
Adaptive radiations are bursts in biodiversity that generate new evolutionary lineages and phenotypes. However, because they typically occur over millions of years, it is unclear how their macroevolutionary dynamics vary through time and among groups of organisms. Phyllostomid bats radiated extensively for diverse diets-from insects to vertebrates, fruit, nectar, and blood-and we use their molars as a model system to examine the dynamics of adaptive radiations. Three-dimensional shape analyses of lower molars of Noctilionoidea (Phyllostomidae and close relatives) indicate that different diet groups exhibit distinct morphotypes...
February 29, 2024: Current Biology: CB
https://read.qxmd.com/read/38452759/securin-acetylation-prevents-precocious-separase-activation-and-premature-sister-chromatid-separation
#30
JOURNAL ARTICLE
Tianning Wang, Yuhong Zou, Hui Meng, Pengli Zheng, Junlin Teng, Ning Huang, Jianguo Chen
Lysine acetylation of non-histone proteins plays crucial roles in many cellular processes. In this study, we examine the role of lysine acetylation during sister chromatid separation in mitosis. We investigate the acetylation of securin at K21 by cell-cycle-dependent acetylome analysis and uncover its role in separase-triggered chromosome segregation during mitosis. Prior to the onset of anaphase, the acetylated securin via TIP60 prevents its degradation by the APC/CCDC20 -mediated ubiquitin-proteasome system...
February 27, 2024: Current Biology: CB
https://read.qxmd.com/read/38442709/tactile-localization-promotes-infant-self-recognition-in-the-mirror-mark-test
#31
JOURNAL ARTICLE
Lisa K Chinn, Claire F Noonan, Katarina S Patton, Jeffrey J Lockman
Mirror self-recognition has been hailed by many as a milestone in the acquisition of self-awareness with respect to phylogenesis and human ontogenesis.1 , 2 , 3 , 4 , 5 , 6 Yet there has been considerable controversy over the extent to which species other than humans and their closest primate relatives are capable of mirror self-recognition, and to the mechanisms that give rise to this ability.1 , 7 One influential view is that mirror self-recognition in humans and their closest primate relatives is a cognitive advance that is a product of primate evolution, stemming from more recently evolved neural structures and networks that develop through experience-independent mechanisms during ontogenesis...
February 27, 2024: Current Biology: CB
https://read.qxmd.com/read/38428416/collective-cell-migration-relies-on-ppp1r15-mediated-regulation-of-the-endoplasmic-reticulum-stress-response
#32
JOURNAL ARTICLE
Yujun Chen, Jocelyn A McDonald
Collective cell migration is integral to many developmental and disease processes. Previously, we discovered that protein phosphatase 1 (Pp1) promotes border cell collective migration in the Drosophila ovary. We now report that the Pp1 phosphatase regulatory subunit dPPP1R15 is a critical regulator of border cell migration. dPPP1R15 is an ortholog of mammalian PPP1R15 proteins that attenuate the endoplasmic reticulum (ER) stress response. We show that, in collectively migrating border cells, dPPP1R15 phosphatase restrains an active physiological protein kinase R-like ER kinase- (PERK)-eIF2α-activating transcription factor 4 (ATF4) stress pathway...
February 27, 2024: Current Biology: CB
https://read.qxmd.com/read/38490200/a-vertebrate-family-without-a-functional-hypocretin-orexin-arousal-system
#33
JOURNAL ARTICLE
Vassilis Bitsikas, Fabien Cubizolles, Alexander F Schier
The Hypocretin/Orexin signaling pathway suppresses sleep and promotes arousal, whereas the loss of Hypocretin/Orexin results in narcolepsy, including the involuntary loss of muscle tone (cataplexy).1 Here, we show that the South Asian fish species Chromobotia macracanthus exhibits a sleep-like state during which individuals stop swimming and rest on their side. Strikingly, we discovered that the Hypocretin/Orexin system is pseudogenized in C. macracanthus, but in contrast to Hypocretin-deficient mammals, C...
February 23, 2024: Current Biology: CB
https://read.qxmd.com/read/38452760/local-people-enhance-our-understanding-of-afrotropical-frugivory-networks
#34
JOURNAL ARTICLE
Clémentine Durand-Bessart, Etienne François Akomo-Okoue, Ghislain Wilfried Ebang Ella, Vincent Porcher, Paul Yannick Bitome Essono, François Bretagnolle, Colin Fontaine
Afrotropical forests are undergoing massive change caused by defaunation, i.e., the human-induced decline of animal species,1 most of which are frugivorous species.1 , 2 , 3 Frugivores' depletion and their functional disappearance are expected to cascade on tree dispersal and forest structure via interaction networks,4 , 5 , 6 , 7 as the majority of tree species depend on frugivores for their dispersal.8 However, frugivory networks remain largely unknown, especially in Afrotropical areas,9 , 10 , 11 which considerably limits our ability to predict changes in forest dynamics and structures using network analysis...
February 23, 2024: Current Biology: CB
https://read.qxmd.com/read/38430909/incomplete-immunity-in-a-natural-animal-microbiota-interaction-selects-for-higher-pathogen-virulence
#35
JOURNAL ARTICLE
Kim L Hoang, Timothy D Read, Kayla C King
Incomplete immunity in recovered hosts is predicted to favor more virulent pathogens upon re-infection in the population.1 The microbiota colonizing animals can generate a similarly long-lasting, partial immune response, allowing for infection but dampened disease severity.2 We tracked the evolutionary trajectories of a widespread pathogen (Pseudomonas aeruginosa), experimentally passaged through populations of nematodes immune-primed by a natural microbiota member (P. berkeleyensis). This bacterium can induce genes regulated by a mitogen-activated protein kinase (MAPK) signaling pathway effective at conferring protection against pathogen-induced death despite infection...
February 23, 2024: Current Biology: CB
https://read.qxmd.com/read/38428417/host-adaptive-radiation-is-associated-with-rapid-virus-diversification-and-cross-species-transmission-in-african-cichlid-fishes
#36
JOURNAL ARTICLE
Vincenzo A Costa, Fabrizia Ronco, Jonathon C O Mifsud, Erin Harvey, Walter Salzburger, Edward C Holmes
Adaptive radiations are generated through a complex interplay of biotic and abiotic factors. Although adaptive radiations have been widely studied in the context of animal and plant evolution, little is known about how they impact the evolution of the viruses that infect these hosts, which in turn may provide insights into the drivers of cross-species transmission and hence disease emergence. We examined how the rapid adaptive radiation of the cichlid fishes of African Lake Tanganyika over the last 10 million years has shaped the diversity and evolution of the viruses they carry...
February 22, 2024: Current Biology: CB
https://read.qxmd.com/read/38428415/post-invasion-selection-acts-on-standing-genetic-variation-despite-a-severe-founding-bottleneck
#37
JOURNAL ARTICLE
Kathleen A Dogantzis, Rika Raffiudin, Ramadhani Eka Putra, Ismail Shaleh, Ida M Conflitti, Mateus Pepinelli, John Roberts, Michael Holmes, Benjamin P Oldroyd, Amro Zayed, Rosalyn Gloag
Invasive populations often have lower genetic diversity relative to the native-range populations from which they derive.1 , 2 Despite this, many biological invaders succeed in their new environments, in part due to rapid adaptation.3 , 4 , 5 , 6 Therefore, the role of genetic bottlenecks in constraining the adaptation of invaders is debated.7 , 8 , 9 , 10 Here, we use whole-genome resequencing of samples from a 10-year time-series dataset, representing the natural invasion of the Asian honey bee (Apis cerana) in Australia, to investigate natural selection occurring in the aftermath of a founding event...
February 21, 2024: Current Biology: CB
https://read.qxmd.com/read/38423017/identification-of-olfactory-alarm-substances-in-zebrafish
#38
JOURNAL ARTICLE
Miwa Masuda, Sayoko Ihara, Naoki Mori, Tetsuya Koide, Nobuhiko Miyasaka, Noriko Wakisaka, Keiichi Yoshikawa, Hidenori Watanabe, Kazushige Touhara, Yoshihiro Yoshihara
Escaping from danger is one of the most ndamental survival behaviors for animals. Most freshwater fishes display olfactory alarm reactions in which an injured fish releases putative alarm substances from the skin to notify its shoaling company about the presence of danger. Here, we identified two small compounds in zebrafish skin extract, designated as ostariopterin and daniol sulfate. Ostariopterin is a pterin derivative commonly produced in many freshwater fishes belonging to the Ostariophysi superorder. Daniol sulfate is a novel sulfated bile alcohol specifically present in the Danio species, including zebrafish...
February 21, 2024: Current Biology: CB
https://read.qxmd.com/read/38417446/retinal-origin-of-orientation-but-not-direction-selective-maps-in-the-superior-colliculus
#39
JOURNAL ARTICLE
Daniel de Malmazet, Norma K Kühn, Chen Li, Karl Farrow
Neurons in the mouse superior colliculus ("colliculus") are arranged in ordered spatial maps. While orientation-selective (OS) neurons form a concentric map aligned to the center of vision, direction-selective (DS) neurons are arranged in patches with changing preferences across the visual field. It remains unclear whether these maps are a consequence of feedforward input from the retina or local computations in the colliculus. To determine whether these maps originate in the retina, we mapped the local and global distribution of OS and DS retinal ganglion cell axon boutons using in vivo two-photon calcium imaging...
February 21, 2024: Current Biology: CB
https://read.qxmd.com/read/38417445/differences-in-the-expression-of-cortex-wide-neural-dynamics-are-related-to-behavioral-phenotype
#40
JOURNAL ARTICLE
Camden J MacDowell, Brandy A Briones, Michael J Lenzi, Morgan L Gustison, Timothy J Buschman
Behavior differs across individuals, ranging from typical to atypical phenotypes.1 Understanding how differences in behavior relate to differences in neural activity is critical for developing treatments of neuropsychiatric and neurodevelopmental disorders. One hypothesis is that differences in behavior reflect individual differences in the dynamics of how information flows through the brain. In support of this, the correlation of neural activity between brain areas, termed "functional connectivity," varies across individuals2 and is disrupted in autism,3 schizophrenia,4 and depression...
February 21, 2024: Current Biology: CB
journal
journal
30739
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.