journal
https://read.qxmd.com/read/36951968/clinical-significance-of-high-dose-chemotherapy-with-autologous-stem-cell-transplantation-in-the-era-of-novel-agents-in-patients-older-than-65%C3%A2-years-with-multiple-myeloma
#1
JOURNAL ARTICLE
Shuku Sato, Shun Tsunoda, Teiko Kawahigashi, Wataru Kamata, Yotaro Tamai
High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is the standard treatment for symptomatic multiple myeloma (MM) in patients under 65 years of age. However, the performing of ASCT in older patients > 65 years without comorbidities or complications is controversial. Introduction of novel drugs, such as daratumumab, has improved the long-term survival of patients with MM who are ineligible for ASCT. This retrospective study aimed to evaluate the clinical significance of ASCT in older patients, even in the era of novel drugs...
March 23, 2023: Annals of Hematology
https://read.qxmd.com/read/36951967/ferroptosis-a-new-target-for-iron-overload-induced-hemophilic-arthropathy-synovitis
#2
JOURNAL ARTICLE
Zhiwei Han, Liujie Zheng, Dasheng Luo, Nanyu Pang, Yunfeng Yao
Iron deposition is closely related to developing haemophilic arthropathy (HA). Studying the relationship between ferroptosis signal expression and iron overload in HA synovium facilitates understanding the pathogenesis of joint synovial hyperplasia in bloodborne arthritis and the development of new protective methods. The knee synovium was collected from HA and osteoarthritis (OA) patients, and pathological changes were analysed by HE and Prussian blue staining. Ferroptosis phenotypes were examined by immunohistochemistry and western blotting...
March 23, 2023: Annals of Hematology
https://read.qxmd.com/read/36951966/prognostic-value-of-metabolic-tumor-volume-of-extranodal-involvement-in-diffuse-large-b-cell-lymphoma
#3
JOURNAL ARTICLE
Kana Oiwa, Kei Fujita, Shin Lee, Tetsuji Morishita, Tetsuya Tsujikawa, Eiju Negoro, Takeshi Hara, Hisashi Tsurumi, Takanori Ueda, Takahiro Yamauchi
Extranodal involvement predicts poor outcomes of diffuse large B cell lymphoma (DLBCL), but the impact of the metabolic tumor burden (MTV) of extranodal sites using positron emission tomography has not been clarified. This study aimed to assess the impact of extranodal MTV on overall survival (OS). We retrospectively analyzed 145 newly diagnosed DLBCL patients and verified the prognostic impact of each extranodal and nodal MTV. Multivariate Cox hazards modelling using both extranodal and nodal MTV as covariables identified extranodal MTV as a significant factor for OS (hazard ratio [HR] 1...
March 23, 2023: Annals of Hematology
https://read.qxmd.com/read/36949293/stem-cell-mobilization-in-multiple-myeloma-challenges-strategies-and-current-developments
#4
REVIEW
Xiaolei Wei, Yongqiang Wei
Among hematological malignancies, multiple myeloma (MM) represents the leading indication of autologous hematopoietic stem cell transplantation (auto-HCT). Auto-HCT is predominantly performed with peripheral blood stem cells (PBSCs), and the mobilization and collection of PBSCs are essential steps for auto-HCT. Despite the improved success of conventional methods with the incorporation of novel agents for PBSC mobilization in MM, mobilization failure is still a concern. The current review comprehensively summarizes various mobilization strategies for mobilizing PBSCs in MM patients and the evolution of these strategies over time...
March 22, 2023: Annals of Hematology
https://read.qxmd.com/read/36947214/superiority-of-polatuzumab-vedotin-over-other-novel-agents-in-previously-untreated-abc-type-diffuse-large-b-cell-lymphoma-a-network-meta-analysis-of-20-rcts
#5
REVIEW
Zhixin Sheng, Dianfang Li, Bing Chen, Chunwu Zhao, Wenxing Zhang, Baolong Ding, Lida Wang
Because of lacking of head-to-head comparison among polatuzumab (Pola) vedotin and other novel agents for untreated diffuse large B-cell lymphoma (DLBCL), the optimal option remains undefined. We searched twelve relevant published reports, covering 8376 subjects. Interestingly, the PFS benefit with Pola-R-CHP over other regimens was found prominently in those B-cell-like type (ABC-type) patients. For those ABC-type patients, the PFS advantage with Pola-R-CHP was statistically significant, when compared to R-CHOP+Bort (HR: 0...
March 22, 2023: Annals of Hematology
https://read.qxmd.com/read/36947213/jak2-v617f-mutated-polycythemia-vera-developing-in-a-patient-with-a-20-year-long-chronic-myeloid-leukemia-at-the-time-of-first-molecular-response
#6
LETTER
Luca Tosoni, Dora Fabbro, Umberto Pizzano, Rikard Mullai, Gianluca Morelli, Alessandra Franzoni, Giuseppe Damante, Eleonora Toffoletti, Daniela Damiani, Renato Fanin, Mario Tiribelli
No abstract text is available yet for this article.
March 22, 2023: Annals of Hematology
https://read.qxmd.com/read/36947212/pediatric-chemotherapy-versus-allo-hsct-for-adolescent-and-adult-philadelphia-chromosome-negative-all-in-first-complete-remission-a-meta-analysis
#7
JOURNAL ARTICLE
Zengkai Pan, Luxiang Wang, Weijia Fu, Chuanhe Jiang, Zilu Zhang, Qi Chen, Libing Wang, Xiaoxia Hu
Pediatric-inspired chemotherapy significantly improves survival for adolescent and adult patients with acute lymphoblastic leukemia (ALL). However, the benefits over allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain unclear. To compare clinical outcomes between pediatric-inspired chemotherapy and allo-HSCT in consolidation therapy of adolescent and adult Philadelphia chromosome-negative (Ph-neg) ALL in first complete remission (CR1), related studies from MEDLINE, Embase, and Cochrane Controlled Register of Trials updated to July 2022 were searched...
March 22, 2023: Annals of Hematology
https://read.qxmd.com/read/36947211/diagnostic-yield-indications-and-outcomes-of-cranial-imaging-in-aml-patients-admitted-for-intensive-induction-or-consolidation-chemotherapy-a-single-center-experience
#8
JOURNAL ARTICLE
Sebastian E Koschade, Jan A Stratmann, Pia S Zeiner, Fabian Finkelmeier, Jörg Chromik, Björn Steffen, Hubert Serve, Christian H Brandts, Olivier Ballo
Cranial imaging (CI) is a widely used diagnostic procedure, especially in acute myeloid leukemia (AML) patients with suspected bleeding or infection. However, common clinical decision rules to guide CI do not apply to AML patients and the diagnostic yield and outcomes of CI for AML patients are largely unknown. We retrospectively evaluated all CI from newly diagnosed non-promyelocytic AML patients receiving intensive induction or consolidation chemotherapy between 2007 and 2019 for imaging indications, diagnostic yield, and consequences...
March 22, 2023: Annals of Hematology
https://read.qxmd.com/read/36944847/treatment-of-hydroxyurea-resistant-intolerant-polycythemia-vera-a-discussion-of-best-practices
#9
REVIEW
Andrew T Kuykendall
Polycythemia vera (PV) is a burdensome, chronic myeloproliferative neoplasm characterized by activating mutations in Janus kinase 2, erythrocytosis, and bone marrow hypercellularity. The goals of treatment are to achieve hematocrit and blood count control to ultimately reduce the risk of thrombohemorrhagic events and improve PV-related symptoms. Treatment is risk-stratified and typically includes cytoreduction with hydroxyurea or interferon formulations in first line for high-risk disease. However, inadequate response, resistance, or intolerance to first-line cytoreductive therapies may warrant introduction of second-line treatments, such as ruxolitinib...
March 21, 2023: Annals of Hematology
https://read.qxmd.com/read/36943465/lycorine-induces-apoptosis-of-acute-myeloid-leukemia-cells-and-inhibits-triglyceride-production-via-binding-and-targeting-fabp5
#10
JOURNAL ARTICLE
Xinming Liang, Wenli Fu, YuHui Peng, Juanjuan Duan, Ting Zhang, Daogui Fan, Wei Hong, Xiaolan Qi, ChangXue Wu, Yan He, Wenfeng Yu, Jing Zhou, Pengxiang Guo, Hua Bai, Qifang Zhang
Acute myeloid leukemia (AML) is the most common hematopoietic malignancy with abnormal lipid metabolism. However, currently available information on the involvement of the alterations in lipid metabolism in AML development is limited. In this study, we demonstrate that FABP5 expression facilitates AML cell viability, protects AML cells from apoptosis, and maintains triglyceride production. Our bioinformatics analysis revealed that FABP5 expression was upregulated and correlated with unfavorable overall survival of AML patients...
March 21, 2023: Annals of Hematology
https://read.qxmd.com/read/36939867/myomatous-erythrocytosis-syndrome-an-uncommon-cause-of-secondary-polycythemia
#11
LETTER
Mariana de Oliveira Marques, Natalia Campos Gomes, Pedro de Andrade Young, Otávio de Oliveira Marques, Fábio Rodrigues Kerbauy, Alex Freire Sandes
No abstract text is available yet for this article.
March 20, 2023: Annals of Hematology
https://read.qxmd.com/read/36933041/high-tox-expression-on-cd8-t-cells-in-pure-red-cell-aplasia
#12
JOURNAL ARTICLE
Haiyue Niu, Li Yan, Liping Yang, Mengying Zhang, Mengyuan Liu, Jie Ren, Zonghong Shao, Rong Fu, Limin Xing, Huaquan Wang
Thymocyte selection-associated high-mobility group box protein (TOX) is an important molecule regulating the development and exhaustion of T lymphocytes. Our aim is to investigate the role of TOX in the immune pathogenesis of pure red cell aplasia (PRCA). TOX expression of CD8+ lymphocytes from the peripheral blood of patients with PRCA was detected by flow cytometry. Additionally, the expression of immune checkpoint molecules PD1 and LAG3 and cytotoxic molecules perforin and granzyme B of CD8+ lymphocytes was measured...
March 18, 2023: Annals of Hematology
https://read.qxmd.com/read/36930260/sustained-spontaneous-remission-in-kmt2a-mllt3-mutated-myeloid-sarcoma
#13
LETTER
Chris Armstrong, Wing-Yan Au, Edmond S K Ma, Simon Ho Man Wong, Nina Orfali
No abstract text is available yet for this article.
March 17, 2023: Annals of Hematology
https://read.qxmd.com/read/36930259/safe-and-successful-car-t-cell-therapy-targeting-bcma-in-a-multiple-myeloma-patient-requiring-hemodialysis
#14
LETTER
Ralph Wäsch, Tim Strüssmann, Claudia Wehr, Reinhard Marks, Phillip T Meyer, Gerd Walz, Monika Engelhardt
No abstract text is available yet for this article.
March 17, 2023: Annals of Hematology
https://read.qxmd.com/read/36928308/evidence-of-bendamustine-plus-rituximab-for-old-and-frail-patients-with-aggressive-b-cell-lymphoma
#15
LETTER
Enrico Schalk, Kathleen Jentsch-Ullrich
No abstract text is available yet for this article.
March 16, 2023: Annals of Hematology
https://read.qxmd.com/read/36922432/long-term-outcomes-in-older-patients-with-primary-central-nervous-system-lymphoma-an-analysis-of-the-texas-cancer-registry
#16
JOURNAL ARTICLE
Ethan A Burns, Cesar Gentille Sanchez, Sunil Mathur, Carlo Guerrero, Ibrahim N Muhsen, Humaira Sarfraz, Chih-Chi Andrew Hu, Chih-Hang Anthony Tang, Shilpan S Shah, Ivo W Tremont, Bin Teh, Siddhartha Ganguly, Sai Ravi Kiran Pingali
Primary central nervous system lymphoma (PCNSL) is an aggressive subtype of non-Hodgkin lymphoma that carries a poor prognosis in the elderly. The aim of this study is to investigate treatment patterns and survival trends in patients ≥ 65 years with PCNSL through data provided by the Texas Cancer Registry. Adults ≥ 65 years diagnosed with PCNSL and followed between 1995-2017 were identified and separated into three eras: 1995-2003, 2004-2012, and 2013-2017...
March 16, 2023: Annals of Hematology
https://read.qxmd.com/read/36918415/allogeneic-transplantation-of-bone-marrow-versus-peripheral-blood-stem-cells-from-hla-identical-relatives-in-patients-with-myelodysplastic-syndromes-and-oligoblastic-acute-myeloid-leukemia-a-propensity-score-analysis-of-a-nationwide-database
#17
JOURNAL ARTICLE
Hidehiro Itonaga, Yasushi Miyazaki, Kazunari Aoki, Naoki Shingai, Yukiyasu Ozawa, Takahiro Fukuda, Keisuke Kataoka, Toshiro Kawakita, Yasunori Ueda, Takahide Ara, Masatsugu Tanaka, Yuta Katayama, Masashi Sawa, Tetsuya Eto, Junya Kanda, Yoshiko Atsuta, Ken Ishiyama
Bone marrow (BM) and granulocyte colony-stimulating factor-mobilized peripheral blood stem cells (PBSC) are used as grafts from HLA-identical-related donors for adults with myelodysplastic syndrome (MDS). To assess the impact of graft sources on post-transplant outcomes in MDS patients, we conducted a retrospective analysis of a nationwide database. A total of 247 and 280 patients underwent transplantation with BM and PBSC, respectively. The inverse probability of treatment weighting (IPTW) methods revealed that overall survival (OS) was comparable between BM and PBSC (P = ...
March 15, 2023: Annals of Hematology
https://read.qxmd.com/read/36918414/epidemiology-and-early-mortality-patterns-of-acute-promyelocytic-leukemia-in-the-united-states
#18
JOURNAL ARTICLE
Aditi Sharma, Jay Yang, Vijendra Singh
There is a lack of contemporary population-based data on the epidemiology of acute promyelocytic leukemia (APL) in the United States. In this study, we aim to elucidate the demographics and early mortality patterns of APL hospitalizations utilizing the National Inpatient Sample database from 2016-2019. APL's annual age-adjusted incidence rate was 0.28/100,000, and the incidence increased with age, with the peak incidence in the 75-79 age group at 0.62/100,000. Whites constituted the majority of admissions at 67...
March 14, 2023: Annals of Hematology
https://read.qxmd.com/read/36914888/effectiveness-and-management-of-ponatinib-as-second-line-treatment-in-chronic-myeloid-leukemia-an-analysis-from-the-monitoring-registries-of-the-italian-medicines-agency-aifa
#19
LETTER
Massimo Breccia, Pier Paolo Olimpieri, Simone Celant, Odoardo Maria Olimpieri, Fabrizio Pane, Alessandra Iurlo, Valentina Summa, Paolo Corradini, Pierluigi Russo
No abstract text is available yet for this article.
March 13, 2023: Annals of Hematology
https://read.qxmd.com/read/36907912/use-of-roxadustat-fg-4592-in-ruxolitinib-treatment-related-anemia-of-two-myelofibrosis-patients
#20
LETTER
Kai Ding, Zhaoyun Liu, Yue Ren, Hui Liu, Rong Fu
No abstract text is available yet for this article.
March 13, 2023: Annals of Hematology
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