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Annals of Hematology

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https://read.qxmd.com/read/30761408/tocilizumab-for-focal-segmental-glomerulosclerosis-secondary-to-multicentric-castleman-s-disease
#1
LETTER
Kazutoshi Ebisawa, Yosuke Masamoto, Junji Tokushige, Hiroshi Nishi, Kenjiro Honda, Munetoshi Hinata, Kazuhiro Toyama, Masaomi Nangaku, Mineo Kurokawa
No abstract text is available yet for this article.
February 13, 2019: Annals of Hematology
https://read.qxmd.com/read/30759270/acute-myeloid-leukemia-with-t-8-16-p11-2-p13-3-kat6a-crebbp-in-adults
#2
Wei Xie, Shimin Hu, Jie Xu, Zhining Chen, L Jeffrey Medeiros, Guilin Tang
t(8;16)(p11.2;p13.3)/KAT6A-CREBBP is a rare recurrent cytogenetic abnormality associated with acute myeloid leukemia (AML). We report 15 cases with t(8;16)(p11.2;p13.3). All patients were adult and had AML: 13 women and 2 men, with a median age of 50 years. Ten patients had a history of malignancy and received cytotoxic therapies before therapy-related AML (t-AML), and five patients had de novo AML. All cases of AML showed monoblastic (n = 12) or myelomonocytic (n = 3) differentiation. Hemophagocytosis was observed in seven patients...
February 13, 2019: Annals of Hematology
https://read.qxmd.com/read/30758645/different-prognostic-effects-of-core-binding-factor-positive-aml-with-korean-aml-registry-data
#3
Ho-Jin Shin, Woo-Sung Min, Yoo Hong Min, June-Won Cheong, Je-Hwan Lee, In-Ho Kim, Dae Sik Hong, Jae-Sook Ahn, Hyeoung-Joon Kim, Won-Sik Lee, Chul Won Jung, Jun-Ho Jang, Young Park, Hee-Je Kim
Core-binding factor acute myeloid leukemia (CBF-AML) data in Asian countries has been rarely reported. We analyzed 392 patients with CBF-AML [281 with t(8;21), 111 with inv.(16)/t(16;16)] among data from 3041 patients with AML from the Korean AML Registry. Interestingly, del(9q) was less frequently detected in Korean than in German patients with t(8;21) (7.5% vs. 17%), and del(7q) was more frequently detected in Korean patients with inv(16). Overall survival (OS) was similar between patients in the first complete remission (CR) who received allogeneic (alloSCT) and autologous stem cell transplantation (ASCT) for CBF-AML...
February 13, 2019: Annals of Hematology
https://read.qxmd.com/read/30747249/comparison-of-the-safety-and-efficacy-of-prophylactic-donor-lymphocyte-infusion-after-haploidentical-versus-matched-sibling-pbsct-in-very-high-risk-acute-myeloid-leukemia
#4
Xiao-Ning Gao, Ji Lin, Li-Jun Wang, Fei Li, Hong-Hua Li, Shu-Hong Wang, Wen-Rong Huang, Chun-Ji Gao, Li Yu, Dai-Hong Liu
Donor lymphocyte infusion (DLI) might be used prophylactically to reduce relapse after allogeneic hematopoietic stem cell transplantation for very high-risk leukemia/lymphoma without effective targeted therapy. To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective analysis in a cohort of 21 HID-SCT and 13 MSD-SCT recipients, displaying similar baseline characteristics except for donor's gender distribution...
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30747248/a-novel-nucleotide-substitution-in-the-5-untranslated-region-of-ankrd26-gene-is-associated-with-inherited-thrombocytopenia-a-report-of-two-new-families
#5
LETTER
Robert T Diep, Kristin Corey, Murat O Arcasoy
No abstract text is available yet for this article.
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30747247/acquired-factor-v-inhibitor-after-antibiotic-treatment-in-a-patient-with-pneumonia-a-case-report
#6
LETTER
Masaya Taniwaki, Shinya Katsutani, Masahiro Yamasaki, Kazuma Kawamoto, Kunihiko Funaishi, Yu Matsumoto, Naoko Matsumoto, Nobuyuki Ohashi, Noboru Hattori
No abstract text is available yet for this article.
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30747246/a-case-report-of-congenital-erythropoietic-anemia-ii-in-china-with-a-novel-mutation
#7
LETTER
Hong Zhang, Wuqing Wan, Xiaoyan Liu, Chuan Wen, Ying Liu, Senlin Luo, Xiao Sun, Shizhe Liu
No abstract text is available yet for this article.
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30746560/acute-leukemias-xvii-biology-and-treatment-strategies
#8
(no author information available yet)
No abstract text is available yet for this article.
February 12, 2019: Annals of Hematology
https://read.qxmd.com/read/30729289/clinicopathological-features-of-hcv-positive-splenic-diffuse-large-b-cell-lymphoma
#9
Joji Shimono, Hiroaki Miyoshi, Fumiko Arakawa, Kyohei Yamada, Takeshi Sugio, Kohta Miyawaki, Tetsuya Eto, Takuto Miyagishima, Koji Kato, Koji Nagafuji, Koichi Akashi, Takanori Teshima, Koichi Ohshima
The hepatitis C virus (HCV) is a single-stranded RNA virus which is thought to be involved in the onset of B cell lymphoma. HCV-positive diffuse large B cell lymphoma (DLBCL) has been reported to clinically manifest in extranodal lesions (e.g., in the liver, spleen, and stomach). Here, we investigated HCV-positive and -negative primary splenic DLBCL (p-spDLBCL) and non-primary splenic DLBCL (ordinary DLBCL). Furthermore, to examine HCV lymphomagenesis, RNA in situ hybridization (ISH), RT-PCR (reverse-transcription polymerase chain reaction), and NS3 immunostaining of HCV viral nonstructural proteins were performed...
February 7, 2019: Annals of Hematology
https://read.qxmd.com/read/30729283/cardiac-complications-and-iron-overload-in-beta-thalassemia-major-patients-a-systematic-review-and-meta-analysis
#10
F Koohi, T Kazemi, E Miri-Moghaddam
Despite the major improvement in therapeutic management of thalassemia major, iron overload is considered a challenging conundrum in these patients and heart disease still remains a major cause of morbidity and mortality in these patients. Therefore, this study aimed to investigate the prevalence of cardiac iron overload and cardiovascular complications in transfusion-dependent thalassemia patients in the worldwide. The following databases were searched: ISI/Web of Science, Embase, PubMed, Scopus, up to February 30, 2018...
February 7, 2019: Annals of Hematology
https://read.qxmd.com/read/30729282/the-role-of-abcb1-polymorphism-as-a-prognostic-marker-for-primary-central-nervous-system-lymphoma
#11
Ting Wu, Hui Kang, Dongxiao Zhuang, Yan Ma, Zhiguang Lin, Dina Suolitiken, Bobin Chen, Xiaoping Xu
To investigate the possible role of functional single nucleotide polymorphism (SNP) in circadian genes as prognostic markers of primary central nervous system lymphoma (PCNSL). We conducted a prospective study using data from Huashan Hospital 2006-2015 and followed up 91 PCNSL patients until June 30, 2016. The survival of patients with different prognostic factors was compared by log-rank test. Univariate and multivariate analyses were performed by Cox regression. During a long-term follow-up (6-110 months), overall survival (OS) was 32 months (95% CI, 13...
February 6, 2019: Annals of Hematology
https://read.qxmd.com/read/30729281/survival-differences-in-multiple-myeloma-in-latin-america-and-asia-a-comparison-involving-3664-patients-from-regional-registries
#12
Vania T M Hungria, Jae Hoon Lee, Angelo Maiolino, Edvan de Queiroz Crusoe, Gracia Martinez, Rosane Bittencourt, Gislaine Oliveira Duarte, Dorotea Beatriz Fantl, Juan Ramon Navarro, Guillermo Conte, David Gomez-Almaguer, Guillermo J Ruiz-Argüelles, Kihyun Kim, Kazuyuki Shimizu, Wenming Chen, Shang-Yi Huang, Wee-Joo Chng, Chor Sang Chim, Weerasak Nawarawong, Brian Durie
In previous observational studies, we have separately characterized patients with multiple myeloma (MM) both from Latin America (LA) and from Asia. Here, we analyze these two datasets jointly, in order to assess the overall survival (OS) in these two world regions. Data were available from 3664 patients (1968 from LA and 1696 from Asia); all of whom diagnosed between 1998 and 2007. Approximately, 26% of patients in both world regions underwent transplantation. OS (from diagnosis of MM) was explored with Kaplan-Meier analyses and Cox proportional hazards models...
February 6, 2019: Annals of Hematology
https://read.qxmd.com/read/30721337/hyperuricemia-urine-uric-excretion-and-associated-complications-in-thalassemia-patients
#13
Juthatip Chaloemwong, Adisak Tantiworawit, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, Lalita Norasetthada, Pimlak Charoenkwan, Worawit Louthrenoo
Thalassemia patients have a high cell turnover rate due to chronic hemolysis and ineffective erythropoiesis; therefore, hyperuricemia is anticipated. This study aimed to identify the prevalence of hyperuricemia, gout and nephrolithiasis, conditions associated with serum uric acid (SUA), and urine uric acid excretion (UUA) in thalassemia patients. This was a cross-sectional study in patients aged 15 years or older at Chiang Mai University Hospital. All patients had blood and 24-h urine collection test. We enrolled 112 thalassemia patients in which 67...
February 5, 2019: Annals of Hematology
https://read.qxmd.com/read/30721336/achieving-minimal-residual-disease-negative-by-multiparameter-flow-cytometry-may-ameliorate-a-poor-prognosis-in-mm-patients-with-high-risk-cytogenetics-a-retrospective-single-center-analysis
#14
Hanqing Li, Feng Li, Xiaogang Zhou, Jiangang Mei, Ping Song, Zhiming An, Qian Zhao, Xing Guo, Xuli Wang, Yongping Zhai
The aim of our study was to evaluate the prognostic impact of minimal residual disease (MRD) and high-risk cytogenetics (HRCs) on outcomes in multiple myeloma (MM) patients. We applied multiparameter flow cytometry (MFC) to detect MRD in 123 consecutive patients diagnosed with MM for the first time who achieved very good partial remission (VGPR) or better after bortezomib or thalidomide-based induction therapy. Moreover, we examined the cytogenetic features of MM patients using magnetic-activated cell sorting and interphase fluorescence in situ hybridization (MACS-iFISH) at diagnosis...
February 5, 2019: Annals of Hematology
https://read.qxmd.com/read/30721335/using-pu-1-and-jun-dimerization-protein-2-transcription-factor-expression-in-myelodysplastic-syndromes-to-predict-treatment-response-and-leukaemia-transformation
#15
LETTER
Kristian Boasman, Matthew James Simmonds, Ciaren Graham, Yogen Saunthararajah, Ciro Roberto Rinaldi
No abstract text is available yet for this article.
February 5, 2019: Annals of Hematology
https://read.qxmd.com/read/30715567/incidence-risk-factors-and-clinical-significance-of-epstein-barr-virus-reactivation-in-myelodysplastic-syndrome-after-allogeneic-haematopoietic-stem-cell-transplantation
#16
Hong Wang, Tong-Tong Zhang, Jia-Qian Qi, Tian-Tian Chu, Miao Miao, Hui-Ying Qiu, Cheng-Cheng Fu, Xiao-Wen Tang, Chang-Geng Ruan, De-Pei Wu, Yue Han
Epstein-Barr virus (EBV) reactivation is a life-threatening complication after allogeneic haematopoietic stem cell transplantation (allo-HSCT). In this study, we investigated the characteristics of EBV reactivation in 186 consecutive myelodysplastic (MDS) patients who underwent allo-HSCT in our centre. In 35 patients (18.8%) who experienced EBV reactivation after allo-HSCT, the median onset was 53 days (range 4-381 days). The cumulative incidence of EBV reactivation at the first, sixth, and twelfth month after allo-HSCT was 10...
February 4, 2019: Annals of Hematology
https://read.qxmd.com/read/30715566/high-dose-etoposide-could-discriminate-the-benefit-from-autologous-peripheral-blood-stem-cell-transplantation-in-the-patients-with-refractory-diffuse-large-b-cell-lymphoma
#17
REVIEW
Yu Cai, Liping Wan, Juan Yang, Jun Zhu, Jieling Jiang, Su Li, Xianmin Song, Chun Wang
To evaluate the strategy of using high-dose etoposide mobilization followed by autologous peripheral blood stem cell transplantation (APBSCT) in patients with diffuse large B cell lymphoma (DLBCL) refractory to rituximab-based chemotherapy. Forty patients with refractory DLBCL were treated with high-dose etoposide for stem cell mobilization. All patients were in progressive disease (PD) prior to mobilization and underwent high-dose chemotherapy followed by APBSCT. Successful PBSC mobilization was achieved in all patients...
February 4, 2019: Annals of Hematology
https://read.qxmd.com/read/30706086/inhibitor-eradication-in-refractory-acquired-hemophilia-with-lenalidomide
#18
LETTER
C Pfrepper, W Poenisch, M Pierer, M Metze, T Kaiser, S Petros
No abstract text is available yet for this article.
February 1, 2019: Annals of Hematology
https://read.qxmd.com/read/30697642/treatment-patterns-and-comparative-analysis-of-non-intensive-regimens-in-elderly-acute-myeloid-leukemia-patients-a-real-world-experience-from-india
#19
Govind B Kanakasetty, Chethan R, Lakshmaiah K C, Lokanatha Dasappa, Linu Abraham Jacob, Suresh Babu M C, Lokesh K N, Rudresha Antapura Haleshappa, Rajeev L K, Smitha Carol Saldanha, Koppaka Deepak, Patidar Rajesh, Vikas Asati
Elderly patients with acute myeloid leukemia have a poor prognosis. Data from developing countries is sparse in the literature. In this retrospective study, 402 patients aged ≥ 60 years, diagnosed between Jan 2013 and Dec 2017, were analyzed for treatment patterns and survival. Median age of the whole cohort was 68 years (range 61-84). A total of 213 patients (53.3%) refused care; 188 patients (46.7%) received either BSC, LDAC, or HMA. Survival (in months) was 3.9, 6.4, and 1.2 with LDAC, HMA, and BSC, respectively...
January 29, 2019: Annals of Hematology
https://read.qxmd.com/read/30694364/clinical-efficacy-of-bortezomib-and-lenalidomide-in-blastic-plasmacytoid-dendritic-cell-neoplasm
#20
LETTER
Chunli Yang, Chunxi Fu, You Feng, Sha Zhao, Huawei Weng, Li Zhang, Hongyan Du, Liqun Zou
No abstract text is available yet for this article.
January 29, 2019: Annals of Hematology
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