Xinming Liang, Wenli Fu, YuHui Peng, Juanjuan Duan, Ting Zhang, Daogui Fan, Wei Hong, Xiaolan Qi, ChangXue Wu, Yan He, Wenfeng Yu, Jing Zhou, Pengxiang Guo, Hua Bai, Qifang Zhang
Acute myeloid leukemia (AML) is the most common hematopoietic malignancy with abnormal lipid metabolism. However, currently available information on the involvement of the alterations in lipid metabolism in AML development is limited. In this study, we demonstrate that FABP5 expression facilitates AML cell viability, protects AML cells from apoptosis, and maintains triglyceride production. Our bioinformatics analysis revealed that FABP5 expression was upregulated and correlated with unfavorable overall survival of AML patients...
March 21, 2023: Annals of Hematology