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Journal of Veterinary Medical Science

Aiko Iguchi, Junichi Ooshida, Ikki Mitsui, Naohiro Uchida, Saori Kobayashi, Masahiro Yamasaki, Reeko Satou
A 12-year-old, male miniature dachshund has an ulcer on the footpad of the right hind limb. Despite treatment for longer than 6 months, the ulcer did not heal. Biopsy of the lesion was done to make a definitive diagnosis. Histologically, there were lumens containing weakly eosinophilic fluid surrounded by tumor cells with a similar circular pale nucleus and distinct nucleoli that showed some variation in size. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3) and vimentin, were negative for S100 and p63...
April 18, 2019: Journal of Veterinary Medical Science
Kasumi Sudo, Cuong VAN Dao, Atsushi Miyamoto, Mitsuya Shiraishi
Mercury (Hg) and cadmium (Cd) are the major toxic heavy metals and are known to induce neurotoxicity. Although many studies have shown that several heavy metals have neurotoxic effects, the cellular and molecular mechanisms thereof are still not clear. Oxidative stress is reported to be a common and important mechanism in cytotoxicity induced by heavy metals. However, the assays for identifying toxic mechanisms were not performed under the same experimental conditions, making it difficult to compare toxic properties of the heavy metals...
April 18, 2019: Journal of Veterinary Medical Science
Sooa Yoon, Sang-Kwon Lee, Juhwan Lee, Yeong-Bin Baek, Kyoung-Oh Cho, Jihye Choi
In an 8-year-old Labrador Retriever with progressive anorexia, constipation, and depression, CT revealed intussusception of the cecum into the ascending colon and a small cecal mass showing strong enhancement on arterial phase. The ileocecocolic junction was surgically resected and histologically diagnosed as cecocolic intussusception with carcinoid tumor. The carcinoid tumor worked as a lead point of intussusception in this case. Dual phasic CT is useful to assess the presence of gastrointestinal tumors as lead points in old dogs with intussusception...
April 17, 2019: Journal of Veterinary Medical Science
Shotaro Nakagun, Kenichi Watanabe, Takashi Matsuishi, Mari Kobayashi, Yoshiyasu Kobayashi
Systemic amyloidosis is rarely reported among cetaceans, and a surveillance dedicated for its occurrence across a certain geographic location has not been reported. Between 2013 and 2018, comprehensive gross and histopathologic examinations were conducted on 54 animals comprising 11 species of stranded and bycaught cetaceans in Hokkaido, Japan. Systemic amyloidosis was diagnosed in 2 out of 3 Stejneger's beaked whales (Mesoplodon stejnegeri), through Congo red staining and immunohistochemistry for amyloid A...
April 17, 2019: Journal of Veterinary Medical Science
Hellen Fialho Hartmann, Marília Teresa DE Oliveira, João Pedro Scussel Feranti, Gabriela Pesamosca Coradini, Stephanie Lanzarini Abati, Bibiana Zoppas Pierezan, Vanessa Zanchi Sarturi, Marcella Teixeira Linhares, Álvaro José Chávez Silva, Francisco Miguel Sanchez Margallo, Anne Santos DO Amaral, Maurício Veloso Brun
Mesothelioma is a very aggressive malignant tumor with low survival rates that is often diagnosed belatedly. Pericardial effusion is a common consequence in cases of mesothelioma, with pericardiocentesis and pericardiectomy indicated; therefor thoracocentesis is necessary to drain the contents no longer retained in the pericardium. The present report describes a mesothelioma - carrying dog with a history of cardiac tamponade that underwent thoracoscopic pericardiectomy and, later, thoracoscopic implantation of a fully implantable catheter to function as a thoracic drain...
April 17, 2019: Journal of Veterinary Medical Science
Mizuki Hamada, Tsubasa Ihara, Mitsuhiro Furuse
Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. At the neonatal stage, free amino acids in milk are important nutrients because they act as immediate nutrients for offspring and may affect later health and behavior of the offspring. Therefore, the present study aimed to investigate free amino acid concentrations in milk and the relationships between free amino acid concentrations in milk and plasma in WIS and WKY rats...
April 15, 2019: Journal of Veterinary Medical Science
Kazuhei Sawada, Akio Suzuki, Takeshi Yamasaki, Yoshifumi Iwamaru, Yuichi Matsuura, Kohtaro Miyazawa, Kentaro Masujin, Ryuichiro Atarashi, Motohiro Horiuchi
Atypical bovine spongiform encephalopathy (BSE), first identified in 2004, poses a threat due to the potential to spread the disease to cattle and other animals, including humans. Here, we estimated prion titers in various tissues of cattle infected with atypical BSE using a real-time quaking-induced conversion assay that detects amyloid seeding activity of a disease-specific prion protein, PrPSc , a major component of prions. PrPSc was detected both in and outside of nerve tissues, and some of the peripheral nerve tissues contained relatively high prion titers...
April 15, 2019: Journal of Veterinary Medical Science
Seri Seki, Kenji Teshima, Daisuke Ito, Masato Kitagawa, Yoshiki Yamaya
The present study used data from anesthetic records to analyze variables of intracranial pressure (ICP) during brain tumor surgery or in the early postoperative period as prognostic indicators in dogs. Data from 17 dogs which were scheduled to undergo elective craniotomy for brain tumor surgery from 2009 to 2012 were included. Of these, five (29.4%) died during 14 days after the surgery because of respiratory failure following pneumonia (n=2), euthanasia due to difficulty in treatment of status epilepticus (n=1), tumor-bed hematoma (n=1), and unknown reason (n=1)...
April 12, 2019: Journal of Veterinary Medical Science
Taisuke Senoh, Shin Oikawa, Ken Nakada, Takayoshi Tagami, Tomohito Iwasaki
The purpose of this study is to compare the assessment of pre- and postpartum oxidative stress-related causal indicators and other metabolites in cows with postpartum subclinical ketosis (SCK). The prepartum serum malondialdehyde concentration and body condition score (BCS) were elevated in the SCK cows (n=17) compared to healthy controls (n=12), while the insulin sensitivity check index was lower in the SCK cows than in the controls. Oxidative stress is enhanced in cows with prepartum higher BCS, causing insulin resistance, and may be associated with onset of postpartum SCK...
April 11, 2019: Journal of Veterinary Medical Science
Yasunori Shinozuka, Kazuhiro Kawai, Akira Takeda, Michiaki Yamada, Fumi Kayasaki, Nao Kondo, Yoshiko Sasaki, Nahoko Kanai, Takuma Mukai, Masaki Sawaguchi, Masaya Higuchi, Haruka Kondo, Kouki Sugimoto, Shinogu Kumagai, Isao Murayama, Yasushi Sakai, Kumiko Baba, Kazuki Maemichi, Takeshi Ohishi, Toshio Mizunuma, Akiko Kawana, Akane Yasuda, Aiko Watanabe
The purpose of this study was to clarify the therapeutic effects of oxytetracycline (OTC) as a first-line antibiotic in cattle with acute Escherichia coli mastitis and systemic signs.Drug susceptibility was determined by the minimum inhibitory concentration (MIC) of E. coli isolated from cows with acute E. coli mastitis (n=38). Cattle were divided into OTC-susceptible (S, n=30) and OTC-resistant (R, n= 8) groups. They were further subdivided according to susceptibility to the antibiotic used as a second treatment, into susceptible-susceptible (SS, n=30), resistant-susceptible (RS, n=5), and resistant-resistant (RR, n=3) groups...
April 10, 2019: Journal of Veterinary Medical Science
Kaoru Hatate, Nao Tsuzuki, Ayako Kajihara, Bhuminand Devkota, Kazuya Takehana, Reiichiro Sato, Kimie Iino, Takahiro Aoki, Eiji Takahashi, Norio Yamagishi
The aim of this study was to examine the treatment outcomes of tibial fracture using different configurations of transfixation pinning and casting (TPC) in eight cattle. After pins were inserted to stabilize the fracture site, cast material was placed from the level of the stifle to the hoof (full TPC) in six cases and from the stifle to the proximal metatarsus (partial TPC) in two cases. Five cattle (three full TPC and two partial TPC cases) underwent TPC removal 36-86 days after surgery and resumed productivity...
April 10, 2019: Journal of Veterinary Medical Science
Yusuke Sakai, Masato Hiyama, Saya Kagimoto, Yuki Mitsui, Miko Imaiumi, Takeshi Okayama, Kaori Haradono, Masashi Sakurai, Masahiro Morimoto
An 11-month-old female Japanese Black calf had showed chronic intestinal symptoms. A large mass surrounding the colon wall that was continuous with the colon submucosa was surgically removed. After recurrence and euthanasia, a large mass in the colon region and metastatic masses in the omentum, liver, and lung were revealed at necropsy. Pleomorphic small cells proliferated in the mass and muscular layer of the colon. The cells were positively stained with anti-doublecortin (DCX), PGP9.5, nestin, and neuron specific enolase (NSE)...
April 9, 2019: Journal of Veterinary Medical Science
Woongchul Shin, Yuko Okamatsu-Ogura, Shinya Matsuoka, Ayumi Tsubota, Kazuhiro Kimura
Brown adipocytes, which exist in brown adipose tissue (BAT), are activated by adrenergic stimulation, depending on the activity of uncoupling protein 1 (UCP1). Beige adipocytes emerge from white adipose tissue (WAT) in response to chronic adrenergic stimulation. We investigated obesity-related changes in responses of both types of adipocytes to adrenergic stimulation in mice. Feeding of mice with high-fat diets (HFD: 45%-kcal fat) for 14 weeks resulted in significantly higher body and WAT weight compared to feeding with normal diets (ND: 10%-kcal fat)...
April 8, 2019: Journal of Veterinary Medical Science
Takae Kawaguchi, Rina Hashimoto, Youko Yasukawa, Shusaku Yamada, Aritada Yoshimura, Daiki Hirao, Takahiro Omori, Ryuji Fukushima
Maintaining a good ventricular systolic function is important in the long-term therapy of dogs with supraventricular tachyarrhythmia (SVTA). The objective of this study was to evaluate the inhibitory effect of telmisartan on myocardial injury and the resulting ventricular systolic dysfunction in a canine model of SVTA. A total of 14 dogs were randomly assigned to a Telmisartan (oral telmisartan, 1.0 mg/kg daily, n=7) or a Control (no drug administration, n=7) group; the duration of rapid atrial pacing (RAP) was 3 weeks for both groups...
April 8, 2019: Journal of Veterinary Medical Science
Rommaneeya Leela-Arporn, Hiroshi Ohta, Masahiro Tamura, Noriyuki Nagata, Kazuyoshi Sasaoka, Angkhana Dermlim, Khoirun Nisa, Keitaro Morishita, Noboru Sasaki, Kensuke Nakamura, Satoshi Takagi, Kenji Hosoya, Mitsuyoshi Takiguchi
A definitive diagnosis of focal liver lesions (FLLs) requires invasive procedures for histopathologic examination. Thus, a simpler noninvasive diagnostic method, such as conventional ultrasonography combined with clinical data, is needed for the prediction of liver malignancy. The objective of this study was to examine the diagnostic accuracy of clinical data and ultrasonographic (US) features to differentiate benign and malignant liver lesions. Medical records and US images from dogs with FLLs that underwent abdominal US and histopathologic examinations following surgery or liver biopsy were retrospectively reviewed...
April 8, 2019: Journal of Veterinary Medical Science
Marianthi Ioannidis, Miyuu Tanaka, Sayaka Yasui, Chiho Kezuka, Maremichi Oyamada, Tetsuya Hasegawa, Takeshi Izawa, Jyoji Yamate, Mitsuru Kuwamura
An 8-year-old female Magellanic penguin (Spheniscus magellanicus) started to show epilepsy-like seizures. Subsequent Magnetic Resonance Imaging (MRI) examinations did not reveal any responsible lesions. The neurological symptoms worsened at the age of 10. This penguin became recumbent and died 6 months later after the apparition of the recumbency. At necropsy, only multiple yellowish necrotic lesions in the air sacs and lungs were found. Histopathological evaluation of the brain showed a marked loss of Purkinje cells and many hypertrophied parvalbumin-positive basket/stellate cells were seen in the cerebellar cortex...
April 5, 2019: Journal of Veterinary Medical Science
Reiichiro Sato, Nao Kamimura, Kazuyuki Kaneko
We describe the successful surgical repair of third-degree perineal lacerations with rectovestibular fistulae in four cases using the single-stage modified Aanes method with purse-string suture of the vaginal vestibule and rectum. Fistulae formation and dehiscence of the repair were not observed after surgery. Two cows had five calves and one cow had four calves after surgery. The pregnant cows delivered normally. Additionally, there was no dehiscence of the suture line during the subsequent parturition. The breeding and fertility results obtained after the surgery are presented...
April 2, 2019: Journal of Veterinary Medical Science
Yohei Mochizuki, Ryohei Suzuki, Yuyo Yasumura, Takahiro Saito, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
Beta-blockers are used to treat cats with hypertrophic obstructive cardiomyopathy (HOCM). However, there are various hemodynamic responses to beta-blockers. This retrospective study aimed to explore the relationship between the response to carvedilol and the presence of geometric abnormalities. Medical records were reviewed for 16 cats diagnosed with HOCM. Cats were divided into two groups based on the velocity of the left-ventricular outflow-tract after carvedilol treatment (responder: eight cats, non-responder: eight cats)...
April 2, 2019: Journal of Veterinary Medical Science
Seong Hun Seok, Sun Young Kang, Young Bin Im, Han Sang Yoo, Seong-Chan Yeon
In this study, we used multiplex polymerase chain reaction (PCR) to determine the sex of leopard cats (Prionailurus bengalensis euptilurus) in Korea. When we applied PCR using primers based on the intronic region between ZFX and ZFY, only one DNA band of 143 bp was detected in females, compared with two specific bands of 143 and 310 bp in males, indicating that the band patterns were clearly different between females and males. Since the set of primers also proved compatible with tissue and fecal samples, the results of the present study demonstrate that the present PCR could be a convenient tool for identifying the sex of leopard cats...
April 2, 2019: Journal of Veterinary Medical Science
Hiro Horikirizono, Kumiko Ishigaki, Takao Amaha, Keigo Iizuka, Takahiro Nagumo, Kei Tamura, Mamiko Seki, Kazuya Edamura, Kazushi Asano
This study investigated the direct effects of non-steroidal anti-inflammatory drugs (NSAIDs) and atrial natriuretic peptide (ANP) on canine-derived vascular endothelial cells (VECs). VECs were isolated and cultured from canine arteries and veins. The mRNA expressions of vascular endothelial growth factor receptor 2, cyclooxygenase-2, and natriuretic peptide receptor 1 were detected in the cultured VECs. The viability of the cultured VECs was reduced in a dose-dependent manner by meloxicam, carprofen, and robenacoxib...
March 29, 2019: Journal of Veterinary Medical Science
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