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Thyroid: Official Journal of the American Thyroid Association | Page 2

Jennifer Rui Wang, Mark Zafereo, Ramona Dadu, Renata Ferrarotto, Naifa Busaidy, Charles Lu, Salmaan Ahmed, Maria Gule-Monroe, Michelle D Williams, Erich Sturgis, Ryan P Goepfert, Neil D Gross, Stephen Y Lai, Brandon Gunn, Jack Phan, David I Rosenthal, Clifton Fuller, William H Morrison, Priyanka C Iyer, Maria Cabanillas
BACKGROUND: When achieved, complete surgical resection improves outcomes in anaplastic thyroid carcinoma (ATC). However, most ATC patients present with advanced inoperable disease, often with impending airway obstruction, increased hemorrhage risk, and significant dysphagia. Novel treatment strategies are critically needed to improve disease control and decrease locoregional morbidity. The objective of the present study was to determine the feasibility and effectiveness of a neoadjuvant regimen using dabrafenib with trametinib followed by surgical resection in patients with initially unresectable BRAFV600E-mutated ATC...
July 18, 2019: Thyroid: Official Journal of the American Thyroid Association
Leila Shobab, Cristiane Jeyce Gomes-Lima, Alexander Zeymo, Rebecca Feldman, Jacqueline Jonklaas, Leonard Wartofsky, Kenneth D Burman
Background Six to 20% of thyroid cancer (TC) patients develop distant metastases, and one third become radioiodine refractory (RAIR). Available targeted therapies increase progression free survival but are associated with toxicities. This study aims to characterize clinical, pathological and molecular profiles of patients with RAIR TC. METHODS: Data of TC patients seen 2013-2017 at two tertiary care centers were retrospectively analyzed. Patients were considered RAIR according to ATA guidelines (5)...
July 18, 2019: Thyroid: Official Journal of the American Thyroid Association
Yasuhiro Ito, Hideki Ishikawa, Minoru Kihara, Mitsuyoshi Hirokawa, Naomi Kiyota, Toshihiko Kasahara, Akira Miyauchi
BACKGROUND: The cribriform-morular variant (CMV) is a rare subtype of papillary thyroid carcinoma (PTC), and is often associated with familial adenomatous polyposis (FAP). This variant is generally indolent, but some aggressive cases have been reported. PATIENT FINDINGS: We present the case of a 24-year-old woman who underwent total thyroidectomy with prophylactic central lymph node dissection and modified radical neck dissection for CMV-PTC. No distant metastases were identified preoperatively...
July 18, 2019: Thyroid: Official Journal of the American Thyroid Association
Fereidoun Azizi, Atieh Amouzegar, Maryam Tohidi, Mehdi Hedayati, Davood Khalili, Leila Cheraghi, Yadollah Mehrabi, Miralireza Takyar
BACKGROUND Studies differ regarding whether, compared to courses of conventional duration, longer-term antithyroid drug treatment increases frequency of remission in patients with Graves' hyperthyroidism. We prospectively conducted a randomized, parallel-group study comparing relapse rates in patients receiving longer-term vs. conventional-length methimazole courses. We also sought variables associated with relapse following the latter. METHODS We enrolled 302 consecutive patients with untreated first episodes of Graves' hyperthyroidism...
July 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Rebecca J Thompson, Alice Fletcher, Katie Brookes, Hannah Nieto, Mohammed M Alshahrani, Jonathan W Mueller, Nicholas Hf Fine, David J Hodson, Kristien Boelaert, Martin L Read, Vicki Emma Smith, Christopher J McCabe
Background The ability of thyroid follicular epithelial cells to accumulate iodide via the sodium/iodide symporter (NIS) is exploited to successfully treat most thyroid cancers, although a subset of patients lose functional NIS activity and become unresponsive to radioiodide therapy, with poor clinical outcome. Our knowledge of NIS regulation remains limited, however. Whilst numerous membrane proteins are functionally regulated via dimerization, there is little definitive evidence of NIS dimerization, and whether this might impact upon radioiodide uptake and treatment success is entirely unknown...
July 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Emmely Marije de Vries, Olga Surovtseva, Winnie Vos, Roni Kunst, Mieke van Beeren, Joan Kwakkel, Olivier Chassande, Mariette T Ackermans, Eric Fliers, Anita Boelen
BACKGROUND: Inflammation is associated with marked changes in cellular thyroid hormone metabolism in triiodothyronine (T3) target organs. In the hypothalamus, type 2 deiodinase (D2), the main T3 producing enzyme, increases upon inflammation, leading to an increase in local T3 availability which in turn decreases TRH expression in the paraventricular nucleus (PVN). Type 3 deiodinase (D3), the T3 inactivating enzyme, decreases during inflammation, which might also contribute to the increased T3 availability in the hypothalamus...
July 15, 2019: Thyroid: Official Journal of the American Thyroid Association
Alessio Basolo, Brittany Begaye, Tim Hollstein, Karyne Vinales, Mary Walter, Ferruccio Santini, Jonathan Krakoff, Paolo Piaggi
Background Greater decrease in 24-h energy expenditure (EE) during fasting and smaller increase in 24-h EE during low-protein overfeeding (metabolic "thrifty" phenotype) predict weight gain. As thyroid hormones (TH) are implicated in energy intake and metabolism, we assessed whether: 1) TH concentrations are altered by 24-h fasting or overfeeding diets with varying protein content; 2) diet-related changes in TH correlate with concomitant changes in EE. Methods Fifty-eight euthyroid, healthy subjects with normal glucose regulation underwent 24-h dietary interventions including fasting, eucaloric feeding, and five overfeeding diets in a crossover design within a whole-room indirect calorimeter to measure 24-h EE...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Houda Boumaza, Suzy Markossian, Baptiste Busi, Gilles Rautureau, Karine Gauthier, Bénédicte Elena-Herrmann, Frederic Flamant
BACKGROUND: Resistance to thyroid hormone (RTHα) is a rare genetic disease due to mutations in the THRA gene, which encodes thyroid hormone receptor alpha (TRα1). Since its first description in 2012, 46 cases of RTHα have been reported worldwide, corresponding to 26 different mutations of TRα1. The high variability of clinical features and the absence of reliable biochemical markers make the diagnosis of this disease difficult. In addition, identified RTHα patients present some common features with hypothyroid patients, which may delay the diagnosis in some cases...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Xu Wang, Cong Liu, Mingzhi Zhang, Yingying Han, Heidi Aase, Gro Dehli Villanger, Oddvar Myhre, Aaron van Donkelaar, Randall V Martin, Erica Anne Baines, Renjie Chen, Haidong Kan, Yankai Xia
BACKGROUND: Particulate matter (PM) air pollution is an environmental risk to public health. The prevalence of thyroid disease during pregnancy has increased rapidly in recent decades, but the available data on the relationships among air pollution, thyroid function and birth outcomes in pregnant women, particularly in China, are scarce. We aimed to evaluate the association between maternal exposure to PM2.5 and its components and maternal and neonatal thyroid function and to investigate whether thyroid function acts as a mediator between air pollution and birth weight...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Yuri E Nikiforov, Alyaksandr V Nikitski, Susan L Rominski, Vincenzo Condello, Cihan Kaya, Mamta Wankhede, Federica Panebianco, Hong Yang, Daniel Altschuler
BACKGROUND: Thyroid tumor progression from well-differentiated cancer to poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) involves step-wise dedifferentiation associated with loss of iodine avidity and poor outcome. <i>ALK</i> fusions, typically <i>STRN-ALK</i>, are found with higher incidence in human PDTC compared to well-differentiated cancer and, as we previously have shown, can drive the development of murine PDTC. The aim of this study was to evaluate thyroid cancer initiation and progression in mice with concomitant expression of <i>STRN-ALK</i> and inactivation of the tumor suppressor <i>p53 (Trp53)</i> in thyroid follicular cells...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Christine E Cherella, Trevor E Angell, Danielle M Richman, Mary C Frates, Carol B Benson, Francis D Moore, Justine A Barletta, Monica Hollowell, Jessica R Smith, Erik K Alexander, Edmund S Cibas, Ari J Wassner
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) is used to interpret fine-needle aspiration (FNA) cytology of thyroid nodules in children and adults. Nodule management is guided by the implied malignancy risk of each cytological category, which has been derived from adult populations. Whether these implied risks are applicable to pediatric thyroid nodules remains uncertain. We compared malignancy rates between pediatric and adult thyroid nodules within each cytological category...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Aya Tanaka, Michiko Matsuse, Vladimir A Saenko, Tomoe Nakao, Kosho Yamanouchi, Chika Sakimura, Hiroshi Yano, Eijun Nishihara, Mitsuyoshi Hirokawa, Keiji Suzuki, Akira Miyauchi, Susumu Eguchi, Koh-Ichiro Yoshiura, Shunichi Yamashita, Takeshi Nagayasu, Norisato Mitsutake
BACKGROUND: TERT promoter mutations have been found in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor aggressiveness and worse prognosis. However, little is known about the status of TERT mRNA expression and its relation to TERT promoter mutations and clinicopathological features. METHODS: We analyzed 159 PTC samples for TERT promoter mutations using direct DNA sequencing. TERT expression was measured using quantitative RT-PCR. To examine low allelic frequency of TERT promoter mutations with high sensitivity, we used droplet digital PCR (ddPCR)...
July 9, 2019: Thyroid: Official Journal of the American Thyroid Association
Sarantis Livadas, Christina Bothou, Ioannis Androulakis, Anastasios Boniakos, Nicholas Angelopoulos, Leonidas H Duntas
July 2, 2019: Thyroid: Official Journal of the American Thyroid Association
Bianca Neofiti-Papi, Ruda Prestes Albuquerque, Manuela Miranda-Rodrigues, Nathalia Juliana Nardelli Gonçalves, Vanda Jorgetti, Patricia Chacur Brum, Julio Cesar Batista Ferreira, Cecilia H Gouveia
BACKGROUND: Thyrotoxicosis increases bone turnover with net bone loss. Sympathetic nervous system (SNS) activation, via β2-adrenoceptor (β2-AR) signaling, also has osteopenic effects. Because thyroid hormones (TH) interact with the SNS to regulate several physiological processes, we hypothesize that this interaction also occurs to regulate bone mass. Previous studies support this hypothesis, as α2-AR knockout mice are less susceptible to the thyrotoxicosis-induced osteopenia. Here, we evaluated whether TH-SNS interactions in bone involve β2-AR signaling...
July 2, 2019: Thyroid: Official Journal of the American Thyroid Association
Munir Abu-Helalah, Hussam Ahmad Alshraideh, Sameeh Abdulkareem Al-Sarayreh, Ahmad Hassan Khalaf Al Shawabkeh, Adel Nesheiwat, Nidal Younes, AbdelFattah Al-Hader
Background: Insufficient production of thyroid hormones results in hypothyroidism, while overproduction results in hyperthyroidism. These are common adult disorders, with hypothyroidism more common in the elderly. Jordan has had past problems with dietary iodine deficiency but there are no published studies assessing the population prevalence of these disorders in the Arab Middle East. Methods: A cross-sectional study was conducted in three representative areas of Jordan. There were 7085 participants with a mean age of 40...
July 1, 2019: Thyroid: Official Journal of the American Thyroid Association
Svenja Plöhn, Matthias Hose, Anke Schlüter, Lars Michel, Salvador J Diaz-Cano, Ulrike Hendgen-Cotta, J Paul Banga, Nikolaos Bechrakis, Wiebke Hansen, Anja Eckstein, Utta Berchner-Pfannschmidt
Graves' disease and Graves´ orbitopathy are associated with stimulating thyrotropin receptor (TSHR) autoantibodies and autoreactive T cells. Recent in vitro studies suggested sphingosine-1-phosphate (S1P) signaling is involved in orbitopathy. In the current study we explored the immune modulatory potential of S1P receptor antagonist fingolimod in a murine model for Graves' disease. Fingolimod was orally administered preventively during disease onset or therapeutically after disease onset. Administration of fingolimod during disease onset completely prevented the formation of TSHR-stimulating autoantibodies...
June 25, 2019: Thyroid: Official Journal of the American Thyroid Association
Gilbert A Sigal, Thauany Tavoni, Bruna Silva, Roberto Kalil Filho, Lenine Garcia Brandão, Raul C Maranhão
June 25, 2019: Thyroid: Official Journal of the American Thyroid Association
Maria Papaleontiou, David Reyes-Gastelum, Brittany L Gay, Kevin C Ward, Ann S Hamilton, Sarah T Hawley, Megan R Haymart
BACKGROUND: Little is known about cancer-related worry in thyroid cancer survivors with favorable prognosis. METHODS: A diverse cohort of patients diagnosed with differentiated thyroid cancer in 2014-2015 from the Surveillance, Epidemiology and End Results Program (SEER) registries of Georgia and Los Angeles County were surveyed two to four years after diagnosis. Main outcomes were any versus no worry about harms from treatments, quality of life, family at risk for thyroid cancer, recurrence and death...
June 22, 2019: Thyroid: Official Journal of the American Thyroid Association
Simon H S Pearce, Colin Dayan, David C Wraith, Kevin Barrell, Natalie Olive, Lotta Jansson, Terrie Walker-Smith, Christina Carnegie, Keith F Martin, Kristien Boelaert, Jackie Gilbert, Claire E Higham, Ilaria Muller, Robert D Murray, Petros Perros, Salman Razvi, Bijay Vaidya, Florian Wernig, George J Kahaly
Background: Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in Graves' hyperthyroidism. Methods: Twelve participants (11 female) with previously untreated mild to moderate Graves' hyperthyroidism were enrolled in a Phase I open label trial to receive 10 doses of ATX-GD-59 administered intradermally over an 18-week period...
June 13, 2019: Thyroid: Official Journal of the American Thyroid Association
Sandra M McLachlan, Holly Aliesky, Basil Rapoport
BACKGROUND: Graves' disease, caused by autoantibodies that activate the TSH receptor (TSHR), has only been reported in humans. Thyroiditis-prone NOD.H2h4 mice develop autoantibodies to thyroglobulin and thyroid peroxidase but not to the TSHR. Evidence supports the importance of the shed TSHR A-subunit in the initiation and/or amplification of the autoimmune response to the holoreceptor. Cells expressing the gene for the isolated A-subunit secrete A-subunit protein, a surrogate for holoreceptor A-subunit shedding...
June 11, 2019: Thyroid: Official Journal of the American Thyroid Association
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