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Thyroid: Official Journal of the American Thyroid Association | Page 2

Bjarke Borregaard Medici, Birte Nygaard, Jeppe Lerche La Cour, Mia Klinten Grand, Volkert Siersma, Dagny Ros Nicolaisdottir, Bent Lind, Niels De Fine Olivarius, Christen Lykkegaard Andersen
Background Increased public attention towards health and quality of life issues has led to more intensified screening for various medical conditions including hypothyroidism. A falling serum thyroid stimulating hormone (s-TSH) at initiation of levothyroxine (L-T4) treatment has been reported in the UK between 2001- 2009 indicating a falling TSH threshold which may lead to less benefit from therapy and possibly overtreatment. Objective To investigate changes in s-TSH threshold used by the general practitioners to initiate L-T4 therapy between 2001-2015 in Copenhagen...
April 24, 2019: Thyroid: Official Journal of the American Thyroid Association
Fereidoun Azizi, Miralireza Takyar, Elham Madreseh, Atieh Amouzegar
Background: This study aimed to compare the effectiveness and safety of long-term methimazole (MMI) and radioiodine (RAI) in the treatment of toxic multinodular goiter (TMNG). Methods: In this randomized, parallel-group trial, 130 consecutive and untreated patients with TMNG, aged <60 years, were enrolled and randomized to either long-term MMI or RAI treatment. Both groups of patients were followed for 60-100 months, with median durations of 72 and 84 months in the MMI and RAI groups, respectively. Results: In the MMI and RAI groups, 12 and 11 patients, respectively, were excluded because of side effects, choosing other modes of treatment and not returning for follow-up; 53 and 54 patients, respectively, completed the study for 60-100 months...
April 23, 2019: Thyroid: Official Journal of the American Thyroid Association
Aurélie Strickaert, Cyril Corbet, Sélim-Alex Spinette, Ligia Craciun, Geneviève Dom, Guy Andry, Denis Larsimont, Ruddy Wattiez, Jacques E Dumont, Olivier Feron, Carine Maenhaut
BACKGROUND: Energetic metabolism is described to be deregulated in cancer and the Warburg effect is presented as a major hallmark. Recently, cellular heterogeneity in tumors and tumor microenvironment have been recognized to play an important role in several metabolic pathways in cancer. However, their contribution to papillary thyroid cancer (PTC) development and metabolism is still poorly described. METHODS: We performed a proteomic analysis of 5 PTC and investigated the cellular distribution of several upregulated metabolic proteins in the cancer and in the stromal cells of PTC...
April 16, 2019: Thyroid: Official Journal of the American Thyroid Association
Giuseppe Bellastella, Mariangela Caputo, Maria Ida Maiorino, Miriam Longo, Lorenzo Scappaticcio, Dario Giugliano, Katherine Esposito
Therapy of hypothyroidism is based on the administration of appropriate doses of L-thyroxine (L-T4). A failure to achieve the TSH target may be due to poor compliance with the L-T4 therapy in about 60% of cases or to malabsorption in about 40% of cases. No tools are available for detecting malabsorption disorders before the choice of the most appropriate therapy. The aim of this study is to validate the EMPATHY questionnaire and to demonstrate its usefulness in indicating the most appropriate therapy. PATIENTS AND METHODS: EMPATHY (Evaluation of Malabsorption in PATients with HYpothyroidism) is a questionnaire consisting of seven questions that allow the evaluation of several intolerances and allergies...
April 9, 2019: Thyroid: Official Journal of the American Thyroid Association
Cheng Han, Xue He, Xinghai Xia, Jiahui Guo, Aihua Liu, Xin Liu, Xinyi Wang, Chenyan Li, Shiqiao Peng, Wei Zhao, Mi Zhou, Xiaoguang Shi, Yushu Li, Yongze Li, Zhongyan Shan, Weiping Teng
BACKGROUND: There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite synthesized intracellularly by two closely related sphingosine kinases (SphK), SphK1 and SphK2, is involved in inflammation. However, the role of SphKs/S1P/S1P receptors (S1PRs) in autoimmune thyroiditis (AIT) has not been studied to date. METHOD: This study examined whether SphK1/S1P/S1PR1 signaling is aberrantly altered in thyroid tissues and serum of both AIT patients and a spontaneously autoimmune thyroiditis (SAT) mouse model...
April 9, 2019: Thyroid: Official Journal of the American Thyroid Association
Yanqiang Wang, Sandya Liyanarachchi, Katherine E Miller, Taina T Nieminen, Daniel F Comiskey, Wei Li, Pamela Brock, David E Symer, Keiko Akagi, Katherine E DeLap, Huiling He, Daniel C Koboldt, Albert de la Chapelle
BACKGROUND: Familial non-medullary thyroid cancer (FNMTC) accounts for a relatively small proportion of thyroid cancer cases, but it displays strong genetic predisposition. So far, only a few of NMTC susceptible genes and low-penetrance variants contributing to NMTC have been described. In this study, we aim to identify rare germline variants that may predispose individuals to non-medullary thyroid carcinoma (NMTC) by sequencing a cohort of 17 NMTC families. METHODS: We performed whole genome sequencing (WGS) and genome-wide linkage analysis in 17 NMTC families...
April 8, 2019: Thyroid: Official Journal of the American Thyroid Association
Christian M Schürch, Matthias A Roelli, Stefan Forster, Marie-Hélène Wasmer, Frido Brühl, Renaud Maire, Sergio Di Pancrazio, Marc-David Ruepp, Roland Giger, Aurel Perren, Anja Schmitt, Philippe Krebs, Roch-Philippe Charles, Matthias S Dettmer
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers with a median survival of only 3-6 months. Standard treatment options and even targeted therapies have so far failed to improve long-term overall survival. Thus, novel treatment modalities for ATC, such as immunotherapy, are urgently needed. CD47 is a "don't eat me" signal which prevents cancer cells from phagocytosis by binding to signal regulatory protein α (SIRPα) on macrophages. So far, the role of macrophages and the CD47-SIRPα signaling axis in ATC is not well understood...
April 2, 2019: Thyroid: Official Journal of the American Thyroid Association
Joao Dts Anselmo, Neal Scherberg, Alexandra M Dumitrescu, Samuel Refetoff
BACKGROUND: Evidence for transgenerational epigenetic inheritance in humans is still controversial given the requirement to demonstrate persistence of the phenotype across three generations. In a previous study we showed that exposure of human and mouse embryos to high maternal thyroid hormone (TH) concentrations not only affects the newborns but also subsequently reduces thyrotroph sensitivity to TH during adult life. In the current investigation we setout to determine if this epigenetic effect is transmitted by humans not exposed in utero to high TH levels to their offspring...
April 2, 2019: Thyroid: Official Journal of the American Thyroid Association
Antonela Matana, Marijana Popović, Thibaud Boutin, Vesela Torlak Lovrić, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Igor Rudan, Ozren Polašek, Maja Barbalić, Caroline Hayward, Tatijana Zemunik
BACKGROUND: Thyroglobulin (Tg) is a 660 kDa iodoglycoprotein that serves as a scaffold for thyroid hormone synthesis. Although a twin study showed that variability of serum Tg levels has a substantial genetic basis, no genome-wide association study (GWAS) of serum/plasma Tg levels has been performed to date. The aim of this study was to identify genetic variants associated with plasma Tg levels among healthy individuals. METHODS: We conducted a GWAS on two Croatian cohorts and performed a combined analysis...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
Lauren Jin Suk Joo, Jocelyn Weiss, Anthony J Gill, Roderick J Clifton-Bligh, Himanshu Brahmbhatt, Jennifer A MacDiarmid, Matti L Gild, Bruce Robinson, Jing Ting Zhao, Stan Sidhu
BACKGROUND: Medullary thyroid carcinoma (MTC) presents a disproportionate number of thyroid cancer deaths due to the lack of an adjuvant treatment beyond surgery. Gain-of-function mutations of the human Rearranged during Transfection (RET) proto-oncogene have been well-established as the key driver of MTC tumorigenesis. RET has been targeted by tyrosine kinase inhibitors (TKIs), such as cabozantinib and vandetanib, however clinical results have been disappointing with regular dose reductions and inevitable progression...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
Ryota Otsubo, Katsuya Matsuda, Zhanna Mussazhanova, Ayako Sato, Megumi Matsumoto, Hiroshi Yano, Masahiro Oikawa, Hisayoshi Kondo, Masahiro Ito, Akira Miyauchi, Mitsuyoshi Hirokawa, Takeshi Nagayasu, Masahiro Nakashima
BACKGROUND: The preoperative diagnosis of thyroid follicular carcinomas by fine-needle aspiration cytology (FNAC) is almost impossible. We previously demonstrated that p53-binding protein 1 (53BP1) expression, based on immunofluorescence (IF), can serve as a valuable biomarker to estimate the malignant potential of various cancers. 53BP1 belongs to a class of DNA damage response molecules that rapidly localize to the site of DNA double-strand breaks (DSBs), forming nuclear foci (NF). This study aimed to elucidate the utility of 53BP1 NF expression as a biomarker to differentiate follicular tumors (FTs)...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
Andrew Turk, Sylvia L Asa, Zubair W Baloch, William C Faquin, Giovanni Fellegara, Ronald Ghossein, Thomas J Giordano, Virginia Livolsi, Ricardo V Lloyd, Ozgur Mete, Juan Rosai, Saul Suster, Lester D R Thompson, Bruce M Wenig
BACKGROUND: Extrathyroidal extension (ETE) by papillary and follicular thyroid carcinoma (PTC / FTC) can be associated with increased risk of tumor recurrence and mortality. In the 7th edition of its Cancer Staging Manual, the American Joint Committee on Cancer (AJCC) defined minimal ETE as involvement of skeletal muscle (i.e. strap muscles) or perithyroidal soft tissue. The AJCC 8th edition has changed the criteria so that only grossly evident (macroscopic) ETE involving strap muscles (not microscopic ETE involving perithyroidal soft tissue) affects tumor staging...
March 27, 2019: Thyroid: Official Journal of the American Thyroid Association
Whitney Cowell, Andreas Sjodin, Richard L Jones, Ya Wang, Shuang Wang, Robin Whyatt, Pam Factor-Litvak, Gary Bradwin, Abeer Hassoun, Sharon Oberfield, Julie Herbstman
BACKGROUND: Penta brominated diphenyl ethers (PentaBDEs) are endocrine disrupting chemicals that structurally resemble thyroid hormones and were widely used as flame retardants in household consumer products from 1975-2004. Polybrominated diphenyl ethers (PBDEs) cross the placenta and evidence suggests that for many children, body burdens may peak during toddler years. We aimed to understand the impact of exposure timing by examining both pre and postnatal exposure to BDE-47, the predominant PentaBDE congener detected in humans, in relation to thyroid hormone parameters measured during early childhood...
March 23, 2019: Thyroid: Official Journal of the American Thyroid Association
R Michael Tuttle, Sukhjeet Ahuja, Anca M Avram, Victor Bernet, Patrick Bourguet, Gilbert H Daniels, Gary Dillehay, Ciprian Draganescu, Luca Giovanella, Glenn Flux, Dagmar Fuehrer, Bennett Greenspan, Markus Luster, Kristoff Muylle, Jan Smit, Douglas Van Nostrand, Frederik Verburg, Laszlo Hegedus
BACKGROUND: Publication of the 2015 American Thyroid Association (ATA) management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer was met with disagreement by the extended nuclear medicine community with regard to some of the recommendations related to the diagnostic and therapeutic use of radioiodine. Because of these concerns, the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) declined to endorse the ATA guidelines...
March 22, 2019: Thyroid: Official Journal of the American Thyroid Association
Trevor E Angell, Howard T Heller, Edmund S Cibas, Justine A Barletta, Matthew I Kim, Jeffrey F Krane, Ellen Marqusee
BACKGROUND: For thyroid nodules with indeterminate cytology, the Afirma Gene Expression Classifier (GEC) identified benign nodules to reduce diagnostic surgery, though many nodules classified as suspicious still proved histopathologically benign. The current Afirma Genomic Sequencing Classifier (GSC) demonstrates improved specificity, suggesting more nodules will have a benign result (benign call rate [BCR]), but independent data are needed to confirm this in clinical practice. METHODS: Retrospective analysis was performed of all Bethesda III or IV cytology thyroid nodules ≥1 cm tested with GEC (between January 1, 2011, and July 19, 2017) or GSC (between July 20, 2017, and August 27, 2018) at the authors' institution...
March 22, 2019: Thyroid: Official Journal of the American Thyroid Association
Alfredo Campenni, Pierpaolo Trimboli, Luca Giovanella
99mTc-MIBI scan in patients with thyroid nodules: not for everyone but….
March 20, 2019: Thyroid: Official Journal of the American Thyroid Association
Luis-Mauricio Hurtado-López, Carlos M Duncker
March 20, 2019: Thyroid: Official Journal of the American Thyroid Association
Robin P F Dullaart
no abstract required for response letter.
March 19, 2019: Thyroid: Official Journal of the American Thyroid Association
Sofie Malmstroem, Diana Grove-Laugesen, Anne Lene Riis, Bjarke Johannessen Bruun, Eva Ebbehoj, Klavs Würgler Hansen, Torquil Watt, Lars Rejnmark
BACKGROUND: Reduced muscle strength is an acknowledged symptom of Graves' disease, but our knowledge on severity is sparse. We aimed to investigate muscle strength, balance, and muscle function in patients with Graves' disease compared to age- and gender-matched healthy controls. METHOD: Using a cross sectional design, we compared 55 patients newly diagnosed with Graves' disease with 55 euthyroid controls, matched on sex, age, and menopausal status. We measured isometric muscle strength (Newton) and maximum force production (Newton/second) across different muscles groups using a dynamometer chair and postural stability (balance) in different positions using a stadiometer...
March 18, 2019: Thyroid: Official Journal of the American Thyroid Association
Sophie Leboulleux, Corinne Dupuy, Ludovic Lacroix, Marie Attard, Serena Grimaldi, Raphaël Corre, Marcel Ricard, Sarah Nasr, Amandine Berdelou, Julien Hadoux, Dana Hartl, Marie Terroir, Eric Baudin, Martin Schlumberger, Abir Al Ghuzlan
A 59 years old woman with locally invasive poorly differentiated thyroid cancer with synchronous lung, mediastinal and bone metastases and a BRAF-K601E somatic mutation with contra-indication for antiangiogneic drugs was treated with dabrafenib and trametinib. During treatment, serum levels of thyroglobulin increased as soon as day 7 up to 10 folds over baseline at week 4. Concurrently, clinical hyperthyroidism occurred, with free T3 and free T4 levels increasing to 6.6 and 4.4 times its upper normal limit...
March 18, 2019: Thyroid: Official Journal of the American Thyroid Association
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