journal
MENU ▼
Read by QxMD icon Read
search

Thyroid: Official Journal of the American Thyroid Association

journal
https://read.qxmd.com/read/30973094/hmgb1-is-associated-with-the-inflammatory-pathogenesis-of-graves-orbitopathy
#1
So Young Han, Soo Hyun Choi, Jeon-Soo Shin, Eun Jig Lee, Seung-Han Han, Jin Sook Yoon
BACKGROUND: High-mobility group box 1 (HMGB1) has been implicated in the pathogenesis of inflammatory autoimmune diseases. We investigated the influence and mechanisms of HMGB1 in Graves' orbitopathy (GO). METHODS: HMGB1 and its receptors (receptor for advanced glycation end products (RAGE), Toll-like receptor (TLR) 2, and TLR4 mRNA levels were evaluated by real-time polymerase chain reaction (qPCR) in GO and non-GO orbital tissues. The mRNA expressions of HMGB1 and its receptors were evaluated in primary cultured orbital fibroblasts from six GO patients and five healthy control subjects under IL-1β or TNF-α stimulation using qPCR...
April 11, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30973063/three-consecutive-pregnancies-in-a-patient-with-chronic-autoimmune-thyroid-disease-associated-with-hypothyroidism-and-extremely-high-levels-of-anti-tsh-receptor-antibodies
#2
Hervé Grulet, Sara Barraud, Karim Chikh, Pierre François Souchon, Olivier Claris, Raymonde Bouvier, Jacqueline Trouillas, René Gabriel, Jean Paul Bory, Claire Schvartz, Jacques J Orgiazzi, Brigitte Delemer
BACKGROUND: Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications. PATIENT FINDINGS: We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). At the 22-week point of her first gestation, sonography detected fetal growth retardation and cardiac abnormalities (extreme tachycardia, right ventricular dilatation, pericardial effusion)...
April 11, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30963820/empathy-a-new-tool-for-identifying-the-most-suitable-thyroxine-formulation-in-hypothyroid-patients
#3
Giuseppe Bellastella, Mariangela Caputo, Maria Ida Maiorino, Miriam Longo, Lorenzo Scappaticcio, Dario Giugliano, Katherine Esposito
Therapy of hypothyroidism is based on the administration of appropriate doses of L-thyroxine (L-T4). A failure to achieve the TSH target may be due to poor compliance with the L-T4 therapy in about 60% of cases or to malabsorption in about 40% of cases. No tools are available for detecting malabsorption disorders before the choice of the most appropriate therapy. The aim of this study is to validate the EMPATHY questionnaire and to demonstrate its usefulness in indicating the most appropriate therapy. PATIENTS AND METHODS: EMPATHY (Evaluation of Malabsorption in PATients with HYpothyroidism) is a questionnaire consisting of seven questions that allow the evaluation of several intolerances and allergies...
April 9, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30963819/sphk1-s1p-s1pr1-signaling-is-involved-in-the-development-of-autoimmune-thyroiditis-in-patients-and-nod-h-2h4-mice
#4
Cheng Han, Xue He, Xinghai Xia, Jiahui Guo, Aihua Liu, Xin Liu, Xinyi Wang, Chenyan Li, Shiqiao Peng, Wei Zhao, Mi Zhou, Xiaoguang Shi, Yushu Li, Yongze Li, Zhongyan Shan, Weiping Teng
BACKGROUND: There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite synthesized intracellularly by two closely related sphingosine kinases (SphK), SphK1 and SphK2, is involved in inflammation. However, the role of SphKs/S1P/S1P receptors (S1PRs) in autoimmune thyroiditis (AIT) has not been studied to date. METHOD: This study examined whether SphK1/S1P/S1PR1 signaling is aberrantly altered in thyroid tissues and serum of both AIT patients and a spontaneously autoimmune thyroiditis (SAT) mouse model...
April 9, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30957677/identification-of-rare-variants-predisposing-to-thyroid-cancer
#5
Yanqiang Wang, Sandya Liyanarachchi, Katherine E Miller, Taina T Nieminen, Daniel F Comiskey, Wei Li, Pamela Brock, David E Symer, Keiko Akagi, Katherine E DeLap, Huiling He, Daniel C Koboldt, Albert de la Chapelle
BACKGROUND: Familial non-medullary thyroid cancer (FNMTC) accounts for a relatively small proportion of thyroid cancer cases, but it displays strong genetic predisposition. So far, only a few of NMTC susceptible genes and low-penetrance variants contributing to NMTC have been described. In this study, we aim to identify rare germline variants that may predispose individuals to non-medullary thyroid carcinoma (NMTC) by sequencing a cohort of 17 NMTC families. METHODS: We performed whole genome sequencing (WGS) and genome-wide linkage analysis in 17 NMTC families...
April 8, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30957663/the-risk-of-adverse-obstetric-outcomes-and-the-abnormal-growth-of-offspring-in-women-with-a-history-of-thyroid-cancer
#6
Geum Joon Cho, So-Youn Kim, Hoi Chang Lee, Kyu-Min Lee, Sung Won Han, Min-Jeong Oh, Teresa Woodruff
BACKGROUND: It is unclear whether a history of thyroid cancer is associated with an increased risk of adverse pregnancy outcomes in subsequent pregnancies. This study aimed to evaluate the risk of adverse obstetric outcomes and the abnormal growth of offspring in women with a history of thyroid cancer. METHODS: In this retrospective observational study, we used nationwide data between 2006 and 2014 to compare pregnancy outcomes between women with a history of thyroid cancer and those with no such history...
April 8, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30938231/targeting-cd47-in-anaplastic-thyroid-carcinoma-enhances-tumor-phagocytosis-by-macrophages-and-is-a-promising-therapeutic-strategy
#7
Christian M Schürch, Matthias A Roelli, Stefan Forster, Marie-Hélène Wasmer, Frido Brühl, Renaud Maire, Sergio Di Pancrazio, Marc-David Ruepp, Roland Giger, Aurel Perren, Anja Schmitt, Philippe Krebs, Roch-Philippe Charles, Matthias S Dettmer
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human cancers with a median survival of only 3-6 months. Standard treatment options and even targeted therapies have so far failed to improve long-term overall survival. Thus, novel treatment modalities for ATC, such as immunotherapy, are urgently needed. CD47 is a "don't eat me" signal which prevents cancer cells from phagocytosis by binding to signal regulatory protein α (SIRPα) on macrophages. So far, the role of macrophages and the CD47-SIRPα signaling axis in ATC is not well understood...
April 2, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30938226/reduced-sensitivity-to-thyroid-hormone-as-a-transgenerational-epigenetic-marker-transmitted-along-human-male-line
#8
Joao Dts Anselmo, Neal Scherberg, Alexandra M Dumitrescu, Samuel Refetoff
BACKGROUND: Evidence for transgenerational epigenetic inheritance in humans is still controversial given the requirement to demonstrate persistence of the phenotype across three generations. In a previous study we showed that exposure of human and mouse embryos to high maternal thyroid hormone (TH) concentrations not only affects the newborns but also subsequently reduces thyrotroph sensitivity to TH during adult life. In the current investigation we setout to determine if this epigenetic effect is transmitted by humans not exposed in utero to high TH levels to their offspring...
April 2, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30931815/time-varying-pattern-of-mortality-and-recurrence-from-papillary-thyroid-cancer-lessons-from-a-long-term-follow-up
#9
Wenwu Dong, Kiyomi Horiuchi, Hiroki Tokumitsu, Akiko Sakamoto, Eiichiro Noguchi, Yoshinori Ueda, Takahiro Okamoto
BACKGROUND: Little is known about annual hazard rates of cancer mortality and recurrence for papillary thyroid cancer (PTC). In this study we investigated the time-varying pattern of cancer death and recurrence from PTC and independent prognostic factors for cause specific mortality (CSM) and recurrence of PTC. METHODS: This retrospective chart review enrolled 466 patients diagnosed with PTC who underwent curative initial surgery between April 1981 and December 1991 with a median follow-up of 18...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30929638/genetic-variants-in-the-st6gal1-gene-are-associated-with-thyroglobulin-plasma-level-in-healthy-individuals
#10
Antonela Matana, Marijana Popović, Thibaud Boutin, Vesela Torlak Lovrić, Dubravka Brdar, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Igor Rudan, Ozren Polašek, Maja Barbalić, Caroline Hayward, Tatijana Zemunik
BACKGROUND: Thyroglobulin (Tg) is a 660 kDa iodoglycoprotein that serves as a scaffold for thyroid hormone synthesis. Although a twin study showed that variability of serum Tg levels has a substantial genetic basis, no genome-wide association study (GWAS) of serum/plasma Tg levels has been performed to date. The aim of this study was to identify genetic variants associated with plasma Tg levels among healthy individuals. METHODS: We conducted a GWAS on two Croatian cohorts and performed a combined analysis...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30929637/machine-learning-assisted-system-for-thyroid-nodule-diagnosis
#11
Bin Zhang, Jie Tian, Shufang Pei, Yubin Chen, Xin He, Yuhao Dong, Lu Zhang, Xiaokai Mo, Wenhui Huang, Shuzhen Cong, Shuixing Zhang
BACKGROUND: Ultrasound (US) examination is helpful in differential diagnosis of thyroid nodules (malignant vs. benign), but its accuracy relies heavily on examiner experience. Therefore, we aimed to develop a less subjective diagnostic model aided by machine learning. METHODS: Institutional review board approval was obtained, and informed consent was waived in this retrospective study. A total of 2064 thyroid nodules (2032 patients; 695 men and 1337 women; 45.25 ± 13...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30929576/ret-kinase-regulated-microrna-153-3p-improves-therapeutic-efficacy-in-medullary-thyroid-carcinoma
#12
Lauren Jin Suk Joo, Jocelyn Weiss, Anthony J Gill, Roderick J Clifton-Bligh, Himanshu Brahmbhatt, Jennifer A MacDiarmid, Matti L Gild, Bruce Robinson, Jing Ting Zhao, Stan Sidhu
BACKGROUND: Medullary thyroid carcinoma (MTC) presents a disproportionate number of thyroid cancer deaths due to the lack of an adjuvant treatment beyond surgery. Gain-of-function mutations of the human Rearranged during Transfection (RET) proto-oncogene have been well-established as the key driver of MTC tumorigenesis. RET has been targeted by tyrosine kinase inhibitors (TKIs), such as cabozantinib and vandetanib, however clinical results have been disappointing with regular dose reductions and inevitable progression...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30929573/a-novel-diagnostic-method-for-thyroid-follicular-tumors-based-on-immunofluorescence-analysis-of-p53-binding-protein-1-expression-detection-of-genomic-instability
#13
Ryota Otsubo, Katsuya Matsuda, Zhanna Mussazhanova, Ayako Sato, Megumi Matsumoto, Hiroshi Yano, Masahiro Oikawa, Hisayoshi Kondo, Masahiro Ito, Akira Miyauchi, Mitsuyoshi Hirokawa, Takeshi Nagayasu, Masahiro Nakashima
BACKGROUND: The preoperative diagnosis of thyroid follicular carcinomas by fine-needle aspiration cytology (FNAC) is almost impossible. We previously demonstrated that p53-binding protein 1 (53BP1) expression, based on immunofluorescence (IF), can serve as a valuable biomarker to estimate the malignant potential of various cancers. 53BP1 belongs to a class of DNA damage response molecules that rapidly localize to the site of DNA double-strand breaks (DSBs), forming nuclear foci (NF). This study aimed to elucidate the utility of 53BP1 NF expression as a biomarker to differentiate follicular tumors (FTs)...
March 30, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30924726/targeting-super-enhancer-driven-oncogenic-transcription-by-cdk7-inhibition-in-anaplastic-thyroid-cancer
#14
Xinyi Cao, Lin Dang, Xiangqian Zheng, Yi Lu, Yumei Lu, Rongjie Ji, Xianhui Ruan, Jingtai Zhi, Xiukun Hou, Xianfu Yi, Mulin Jun Li, Ming Gao, Lirong Zhang, Yupeng Chen
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive malignancies with no effective treatment currently available. The molecular mechanisms of ATC carcinogenesis remain poorly understood. The objective of this study was to investigate the mechanisms and functions of super-enhancer-driven oncogenic transcriptional addiction in the progression of ATC and identify new drug targets for ATC treatments. METHODS: High-throughput chemical screening was performed to identify new drugs inhibiting ATC cell growth...
March 29, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30913992/interobserver-variability-in-the-histopathologic-assessment-of-extrathyroidal-extension-of-well-differentiated-thyroid-carcinoma-supports-the-new-ajcc-8th-edition-criteria-for-tumor-staging
#15
Andrew Turk, Sylvia L Asa, Zubair W Baloch, William C Faquin, Giovanni Fellegara, Ronald Ghossein, Thomas J Giordano, Virginia Livolsi, Ricardo V Lloyd, Ozgur Mete, Juan Rosai, Saul Suster, Lester D R Thompson, Bruce M Wenig
BACKGROUND: Extrathyroidal extension (ETE) by papillary and follicular thyroid carcinoma (PTC / FTC) can be associated with increased risk of tumor recurrence and mortality. In the 7th edition of its Cancer Staging Manual, the American Joint Committee on Cancer (AJCC) defined minimal ETE as involvement of skeletal muscle (i.e. strap muscles) or perithyroidal soft tissue. The AJCC 8th edition has changed the criteria so that only grossly evident (macroscopic) ETE involving strap muscles (not microscopic ETE involving perithyroidal soft tissue) affects tumor staging...
March 27, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30909818/thiamazole-associated-neuropathy
#16
Milou den Besten, Marc Engelen, Theo Sas, A S Paul van Trotsenburg, Nitash Zwaveling-Soonawala
Only very few cases of thiamazole associated neuropathy have been reported dating back to the 1950's-1980's. We report three cases of neuropathy during thiamazole treatment and suggest that this side effect may be more common than previously reported.
March 26, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30907253/pre-and-postnatal-polybrominated-diphenyl-ether-concentrations-in-relation-to-thyroid-parameters-measured-during-early-childhood
#17
Whitney Cowell, Andreas Sjodin, Richard L Jones, Ya Wang, Shuang Wang, Robin Whyatt, Pam Factor-Litvak, Gary Bradwin, Abeer Hassoun, Sharon Oberfield, Julie Herbstman
BACKGROUND: Penta brominated diphenyl ethers (PentaBDEs) are endocrine disrupting chemicals that structurally resemble thyroid hormones and were widely used as flame retardants in household consumer products from 1975-2004. Polybrominated diphenyl ethers (PBDEs) cross the placenta and evidence suggests that for many children, body burdens may peak during toddler years. We aimed to understand the impact of exposure timing by examining both pre and postnatal exposure to BDE-47, the predominant PentaBDE congener detected in humans, in relation to thyroid hormone parameters measured during early childhood...
March 23, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30900516/controversies-consensus-and-collaboration-in-the-use-of-i-131-therapy-in-differentiated-thyroid-cancer
#18
R Michael Tuttle, Sukhjeet Ahuja, Anca M Avram, Victor Bernet, Patrick Bourguet, Gilbert H Daniels, Gary Dillehay, Ciprian Draganescu, Luca Giovanella, Glenn Flux, Dagmar Fuehrer, Bennett Greenspan, Markus Luster, Kristoff Muylle, Jan Smit, Douglas Van Nostrand, Frederik Verburg, Laszlo Hegedus
BACKGROUND: Publication of the 2015 American Thyroid Association (ATA) management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer was met with disagreement by the extended nuclear medicine community with regard to some of the recommendations related to the diagnostic and therapeutic use of radioiodine. Because of these concerns, the European Association of Nuclear Medicine (EANM) and the Society of Nuclear Medicine and Molecular Imaging (SNMMI) declined to endorse the ATA guidelines...
March 22, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30892146/99mtc-mibi-scan-in-patients-with-thyroid-nodules-not-for-everyone-but%C3%A2
#19
Alfredo Campenni, Pierpaolo Trimboli, Luca Giovanella
99mTc-MIBI scan in patients with thyroid nodules: not for everyone but….
March 20, 2019: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/30892138/the-use-of-tc-99m-methoxy-isobutyl-isonitrile-mibi-for-differentiation-of-malignant-thyroid-nodules
#20
Luis-Mauricio Hurtado-López, Carlos M Duncker
NA.
March 20, 2019: Thyroid: Official Journal of the American Thyroid Association
journal
journal
30691
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"