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Thyroid: Official Journal of the American Thyroid Association

Alessio Basolo, Brittany Begaye, Tim Hollstein, Karyne Vinales, Mary Walter, Ferruccio Santini, Jonathan Krakoff, Paolo Piaggi
Background Greater decrease in 24-h energy expenditure (EE) during fasting and smaller increase in 24-h EE during low-protein overfeeding (metabolic "thrifty" phenotype) predict weight gain. As thyroid hormones (TH) are implicated in energy intake and metabolism, we assessed whether: 1) TH concentrations are altered by 24-h fasting or overfeeding diets with varying protein content; 2) diet-related changes in TH correlate with concomitant changes in EE. Methods Fifty-eight euthyroid, healthy subjects with normal glucose regulation underwent 24-h dietary interventions including fasting, eucaloric feeding, and five overfeeding diets in a crossover design within a whole-room indirect calorimeter to measure 24-h EE...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Houda Boumaza, Suzy Markossian, Baptiste Busi, Gilles Rautureau, Karine Gauthier, Bénédicte Elena-Herrmann, Frederic Flamant
BACKGROUND: Resistance to thyroid hormone (RTHα) is a rare genetic disease due to mutations in the THRA gene, which encodes thyroid hormone receptor alpha (TRα1). Since its first description in 2012, 46 cases of RTHα have been reported worldwide, corresponding to 26 different mutations of TRα1. The high variability of clinical features and the absence of reliable biochemical markers make the diagnosis of this disease difficult. In addition, identified RTHα patients present some common features with hypothyroid patients, which may delay the diagnosis in some cases...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Xu Wang, Cong Liu, Mingzhi Zhang, Yingying Han, Heidi Aase, Gro Dehli Villanger, Oddvar Myhre, Aaron van Donkelaar, Randall V Martin, Erica Anne Baines, Renjie Chen, Haidong Kan, Yankai Xia
BACKGROUND: Particulate matter (PM) air pollution is an environmental risk to public health. The prevalence of thyroid disease during pregnancy has increased rapidly in recent decades, but the available data on the relationships among air pollution, thyroid function and birth outcomes in pregnant women, particularly in China, are scarce. We aimed to evaluate the association between maternal exposure to PM2.5 and its components and maternal and neonatal thyroid function and to investigate whether thyroid function acts as a mediator between air pollution and birth weight...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Yuri E Nikiforov, Alyaksandr V Nikitski, Susan L Rominski, Vincenzo Condello, Cihan Kaya, Mamta Wankhede, Federica Panebianco, Hong Yang, Daniel Altschuler
BACKGROUND: Thyroid tumor progression from well-differentiated cancer to poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) involves step-wise dedifferentiation associated with loss of iodine avidity and poor outcome. <i>ALK</i> fusions, typically <i>STRN-ALK</i>, are found with higher incidence in human PDTC compared to well-differentiated cancer and, as we previously have shown, can drive the development of murine PDTC. The aim of this study was to evaluate thyroid cancer initiation and progression in mice with concomitant expression of <i>STRN-ALK</i> and inactivation of the tumor suppressor <i>p53 (Trp53)</i> in thyroid follicular cells...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Christine E Cherella, Trevor E Angell, Danielle M Richman, Mary C Frates, Carol B Benson, Francis D Moore, Justine A Barletta, Monica Hollowell, Jessica R Smith, Erik K Alexander, Edmund S Cibas, Ari J Wassner
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) is used to interpret fine-needle aspiration (FNA) cytology of thyroid nodules in children and adults. Nodule management is guided by the implied malignancy risk of each cytological category, which has been derived from adult populations. Whether these implied risks are applicable to pediatric thyroid nodules remains uncertain. We compared malignancy rates between pediatric and adult thyroid nodules within each cytological category...
July 12, 2019: Thyroid: Official Journal of the American Thyroid Association
Aya Tanaka, Michiko Matsuse, Vladimir A Saenko, Tomoe Nakao, Kosho Yamanouchi, Chika Sakimura, Hiroshi Yano, Eijun Nishihara, Mitsuyoshi Hirokawa, Keiji Suzuki, Akira Miyauchi, Susumu Eguchi, Koh-Ichiro Yoshiura, Shunichi Yamashita, Takeshi Nagayasu, Norisato Mitsutake
BACKGROUND: TERT promoter mutations have been found in a subset of papillary thyroid carcinomas (PTCs) and are associated with tumor aggressiveness and worse prognosis. However, little is known about the status of TERT mRNA expression and its relation to TERT promoter mutations and clinicopathological features. METHODS: We analyzed 159 PTC samples for TERT promoter mutations using direct DNA sequencing. TERT expression was measured using quantitative RT-PCR. To examine low allelic frequency of TERT promoter mutations with high sensitivity, we used droplet digital PCR (ddPCR)...
July 9, 2019: Thyroid: Official Journal of the American Thyroid Association
Sarantis Livadas, Christina Bothou, Ioannis Androulakis, Anastasios Boniakos, Nicholas Angelopoulos, Leonidas H Duntas
July 2, 2019: Thyroid: Official Journal of the American Thyroid Association
Bianca Neofiti-Papi, Ruda Prestes Albuquerque, Manuela Miranda-Rodrigues, Nathalia Juliana Nardelli Gonçalves, Vanda Jorgetti, Patricia Chacur Brum, Julio Cesar Batista Ferreira, Cecilia H Gouveia
BACKGROUND: Thyrotoxicosis increases bone turnover with net bone loss. Sympathetic nervous system (SNS) activation, via β2-adrenoceptor (β2-AR) signaling, also has osteopenic effects. Because thyroid hormones (TH) interact with the SNS to regulate several physiological processes, we hypothesize that this interaction also occurs to regulate bone mass. Previous studies support this hypothesis, as α2-AR knockout mice are less susceptible to the thyrotoxicosis-induced osteopenia. Here, we evaluated whether TH-SNS interactions in bone involve β2-AR signaling...
July 2, 2019: Thyroid: Official Journal of the American Thyroid Association
Svenja Plöhn, Matthias Hose, Anke Schlüter, Lars Michel, Salvador J Diaz-Cano, Ulrike Hendgen-Cotta, J Paul Banga, Nikolaos Bechrakis, Wiebke Hansen, Anja Eckstein, Utta Berchner-Pfannschmidt
Graves' disease and Graves´ orbitopathy are associated with stimulating thyrotropin receptor (TSHR) autoantibodies and autoreactive T cells. Recent in vitro studies suggested sphingosine-1-phosphate (S1P) signaling is involved in orbitopathy. In the current study we explored the immune modulatory potential of S1P receptor antagonist fingolimod in a murine model for Graves' disease. Fingolimod was orally administered preventively during disease onset or therapeutically after disease onset. Administration of fingolimod during disease onset completely prevented the formation of TSHR-stimulating autoantibodies...
June 25, 2019: Thyroid: Official Journal of the American Thyroid Association
Gilbert A Sigal, Thauany Tavoni, Bruna Silva, Roberto Kalil Filho, Lenine Garcia Brandão, Raul C Maranhão
June 25, 2019: Thyroid: Official Journal of the American Thyroid Association
Maria Papaleontiou, David Reyes-Gastelum, Brittany L Gay, Kevin C Ward, Ann S Hamilton, Sarah T Hawley, Megan R Haymart
BACKGROUND: Little is known about cancer-related worry in thyroid cancer survivors with favorable prognosis. METHODS: A diverse cohort of patients diagnosed with differentiated thyroid cancer in 2014-2015 from the Surveillance, Epidemiology and End Results Program (SEER) registries of Georgia and Los Angeles County were surveyed two to four years after diagnosis. Main outcomes were any versus no worry about harms from treatments, quality of life, family at risk for thyroid cancer, recurrence and death...
June 22, 2019: Thyroid: Official Journal of the American Thyroid Association
Simon H S Pearce, Colin Dayan, David C Wraith, Kevin Barrell, Natalie Olive, Lotta Jansson, Terrie Walker-Smith, Christina Carnegie, Keith F Martin, Kristien Boelaert, Jackie Gilbert, Claire E Higham, Ilaria Muller, Robert D Murray, Petros Perros, Salman Razvi, Bijay Vaidya, Florian Wernig, George J Kahaly
Background: Graves' disease is one of the most common autoimmune conditions, but treatment remains imperfect. This study explores the first-in-human use of antigen-specific immunotherapy with a combination of two thyrotropin receptor (TSHR) peptides (termed ATX-GD-59) in Graves' hyperthyroidism. Methods: Twelve participants (11 female) with previously untreated mild to moderate Graves' hyperthyroidism were enrolled in a Phase I open label trial to receive 10 doses of ATX-GD-59 administered intradermally over an 18-week period...
June 13, 2019: Thyroid: Official Journal of the American Thyroid Association
Sandra M McLachlan, Holly Aliesky, Basil Rapoport
BACKGROUND: Graves' disease, caused by autoantibodies that activate the TSH receptor (TSHR), has only been reported in humans. Thyroiditis-prone NOD.H2h4 mice develop autoantibodies to thyroglobulin and thyroid peroxidase but not to the TSHR. Evidence supports the importance of the shed TSHR A-subunit in the initiation and/or amplification of the autoimmune response to the holoreceptor. Cells expressing the gene for the isolated A-subunit secrete A-subunit protein, a surrogate for holoreceptor A-subunit shedding...
June 11, 2019: Thyroid: Official Journal of the American Thyroid Association
Douglas Van Nostrand
BACKGROUND: Radioiodine scanning may help risk stratify patents with differentiated thyroid carcinoma (DTC) during initial and subsequent re-staging. To maximize the information obtained from radioiodine scanning, image quality and interpretation should be optimized. However, not all radioiodine scans are performed equally. This illustrated article reviews seven techniques that may significantly improve the information obtained from a radioiodine scan in patients with DTC, which in turn may alter management such as showing regional or distant metastases that were otherwise unknown and/or help classify whether or not a metastases is radioiodine avid...
June 11, 2019: Thyroid: Official Journal of the American Thyroid Association
Sung Hye Kong, Junsun Ryu, Min Joo Kim, Sun Wook Cho, Young Shin Song, Ka Hee Yi, Do Joon Park, Yul Hwangbo, You Jin Lee, Kyu Eun Lee, Su-Jin Kim, Woo-Jin Jeong, Eun Jae Chung, Jeong Hun Hah, June Young Choi, Chang Hwan Ryu, Yuh-S Jung, Jae Hoon Moon, Eun Kyung Lee, Young Joo Park
BACKGROUND: In this ongoing multicenter prospective cohort study on active surveillance in low risk papillary thyroid microcarcinoma, we aimed to compare the quality of life (QoL) of participants based on their choice of treatment, i.e., active surveillance (AS) or immediate surgery (OP). METHODS: QoL of 203 participants who chose AS and 192 who underwent OP was evaluated using a thyroid-specific QoL questionnaire at diagnosis and during follow-up (median 8 months)...
June 4, 2019: Thyroid: Official Journal of the American Thyroid Association
Mayumi Endo, Fadi Nabhan, Kyle Porter, Katie Roll, Lawrence Shirley, Irina Azaryan, Dena Tonkovich, Jean Perlick, Laura E Ryan, Shumei Meng, John E Phay, Raheela Khawaja, Matthew D Ringel, Jennifer A Sipos
BACKGROUND: The Afirma Gene Expression Classifier (GEC) has been used to further elucidate cytologically indeterminate (cyto-I) thyroid nodules into either benign or suspicious categories. However, its relatively low positive predictive value (PPV) limited its use as a classifier for patients with suspicious results. The Afirma Gene Sequencing Classifier (GSC) was developed to improve PPV while maintaining a high NPV, yet real-world assessment of its performance is lacking. METHODS: We analyzed all patients who had cyto-I nodules and molecular testing with either GEC or GSC between 2011 and 2018 at a single academic medical center...
June 1, 2019: Thyroid: Official Journal of the American Thyroid Association
Munir Abu-Helalah, Hussam Ahmad Alshraideh, Sameeh Abdulkareem Al-Sarayreh, Ahmad Hassan Al Shawabkeh, Adel Nesheiwat, Nidal Younes, AbdelFattah Al-Hader
BACKGROUND: Insufficient production of thyroid hormones results in hypothyroidism, while overproduction results in hyperthyroidism. These are common adult disorders, with hypothyroidism more common in the elderly. Jordan has had past problems with dietary iodine deficiency but there are no published studies assessing the population prevalence of these disorders in the Arab Middle East. METHODS: A cross-sectional study was conducted in three representative areas of Jordan...
May 31, 2019: Thyroid: Official Journal of the American Thyroid Association
Gabrielle Dufort, Stéphanie Larrivée-Vanier, Dardye Eugène, Xavier De Deken, Britta Seebauer, Karl Heinimann, Sébastien Lévesque, Serge Gravel, Gabor Szinnai, Guy Van Vliet, Johnny Deladoëy
Six patients are described with bi-allelic DUOX2 variants and widely variable phenotypes. Patient 1 is an infant with a compressive hypothyroid goiter causing respiratory distress, which was promptly alleviated by levothyroxine (LT4). He was a compound heterozygote for DUOX2 variants, including a novel deletion of 540 base pairs. Patients 2 and 3 are siblings with the same compound heterozygous mutations of DUOX2 , yet one had overt hypothyroidism at 14 months and the other lifelong euthyroidism. Patient 4 is a compound heterozygote individual and has mild persistent congenital hypothyroidism; his sister (patient 5) only had a borderline thyrotropin elevation at newborn screening, consistent with homozygous DUOX2 variants with a mild impact on enzyme activity...
May 31, 2019: Thyroid: Official Journal of the American Thyroid Association
Evert F S van Velsen, Merel Stegenga, Folkert J van Kemenade, Boen Kam, Tessa Malaika van Ginhoven, W Edward Visser, Robin Peeters
Background The 2015 American Thyroid Association (ATA) Risk Stratification System for differentiated thyroid cancer (DTC) is designed to predict recurring/persisting disease but not survival. Earlier studies evaluating this System either evaluated the 2009 edition, comprised low number of patients with ATA High Risk, had low number of patients with follicular thyroid cancer (FTC), or did not distinguish between papillary and follicular thyroid cancer. Therefore, we evaluated the prognostic value of the 2015 ATA Risk Stratification System in a large population of High Risk thyroid cancer patients which included a substantial proportion of FTC patients...
May 29, 2019: Thyroid: Official Journal of the American Thyroid Association
Ulla Feldt-Rasmussen, Charles H Emerson, Douglas S Ross, Peter A Kopp, Elizabeth N Pearce
May 29, 2019: Thyroid: Official Journal of the American Thyroid Association
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