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Thyroid : Official Journal of ...
Thyroid : Official Journal of the American Thyroid Association
#1
JOURNAL ARTICLE
Makoto Tahara, Hiroshi Takami, Yasuhiro Ito, Takahiro Okamoto, Iwao Sugitani, Kiminori Sugino, Shunji Takahashi, Hiroshi Takeyama, Hidemitsu Tsutsui, Hisato Hara, Ayako Mitsuma, Hiroyuki Yamashita, Yasuo Ohashi, Tsuneo Imai
Background: Although lenvatinib is the preferred treatment for unresectable radioactive iodine-refractory differentiated thyroid cancer (RR-DTC), this agent exerts considerable toxicities, which can lead to frequent dose interruptions and modifications. The adoption of planned drug holidays has been recently suggested as one means of minimizing or avoiding these severe adverse events. Our retrospective study demonstrated that planned drug holidays appear to be a promising strategy for continuing of lenvatinib...
April 17, 2024: Thyroid: Official Journal of the American Thyroid Association
#2
(no author information available yet)
No abstract text is available yet for this article.
April 16, 2024: Thyroid: Official Journal of the American Thyroid Association
#3
JOURNAL ARTICLE
Kyubo Shin, Hokyung Choung, Min Joung Lee, Jongchan Kim, Gyeong Min Lee, Seongmi Kim, Jae Hyuk Kim, Richul Oh, Jisun Park, Sang Muk Lee, Jaemin Park, Namju Kim, Jae Hoon Moon
BACKGROUND: We previously developed a machine learning (ML)-assisted system for predicting the clinical activity score (CAS) in thyroid-associated orbitopathy (TAO) using digital facial images taken by a DSLR camera in a studio setting. In this study, we aimed to apply this system to smartphones and detect active TAO (CAS ≥ 3) using facial images captured by smartphone cameras. We evaluated the performance of our system on various smartphone models and compared it with the performance of ophthalmologists with varying clinical experience...
April 16, 2024: Thyroid: Official Journal of the American Thyroid Association
#4
JOURNAL ARTICLE
Ning Huang, Lixue Chen, Zhiqiang Yan, Lin Zeng, Haining Wang, Hongbin Chi, Jie Qiao
BACKGROUND: It has been reported that intracytoplasmic sperm injection (ICSI) may be the preferred fertilization method for women with thyroid autoimmunity (TAI) seeking assisted reproduction. We compared the reproductive outcomes of women with TAI who were treated with ICSI compared to in vitro fertilization (IVF). METHODS: In this retrospective cohort study, we included women with infertility who were referred to the Reproductive Centre of Peking University Third Hospital for their first IVF/ICSI and embryo transfer treatment cycle from January, 2019 to February, 2021...
April 16, 2024: Thyroid: Official Journal of the American Thyroid Association
#5
JOURNAL ARTICLE
Vera Schempp, Ayse Nurcan Cebeci, Christina Reinauer, Joachim Woelfle, Helmuth-Günther Dörr, Marie-Thérèse Roosen, Jonas Gohlke, Bettina Gohlke
Background Agranulocytosis is a rare antithyroid drug treatment (ATD) side effect seen in children suffering from Graves' disease (GD). Neutropenia is a recognized adverse event associated with ATD but has also been reported as pre-treatment neutropenia in GD. Methods We performed a retrospective cohort study to analyze the longitudinal clinical and biochemical data of 161 pediatric patients with GD who received either methimazole (MMI) or carbimazole (CBZ) as ATD. The inclusion criteria were elevated free thyroxine (fT4 >25 pmol/L), suppressed thyroid stimulation hormone (TSH <0...
April 13, 2024: Thyroid: Official Journal of the American Thyroid Association
#6
JOURNAL ARTICLE
Balázs Szécsi, Richárd Sinkó, Alexandra Vereb, Dmitry Khochanskiy, Kálmán Benke, Tamás Radovits, Bálint Lakatos, Andrea Kőszegi, Eszter Losoncz, Szilvia Kugler, Márk Szabó, Béla Merkely, Andrea Székely, Balázs Gereben
BACKGROUND: Orthotopic heart transplantation (HTx) is a long-term surgical therapeutic approach for patients with end-stage heart failure. The objective of the current study was to uncover associations between altered thyroid hormone (TH) status and adverse outcomes after HTx. METHODS: In this prospective, single-center cohort study, 283 patients were subjected to HTx between 2013 and 2020 at the Heart and Vascular Center of Semmelweis University. Beside routinely measured parameters, TH economy was assessed in patients pre- and postoperatively by measuring serum free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH)...
April 13, 2024: Thyroid: Official Journal of the American Thyroid Association
#7
JOURNAL ARTICLE
Riccardo Dore, Sarah Christine Sentis, Kornelia Johann, Nuria Lopez-Alcantara, Julia Resch, Akila Chandrasekar, Helge Müller-Fielitz, Lars Christian Moeller, Dagmar Fuehrer, Markus Schwaninger, Benedikt Obermayer, Robert Opitz, Jens Mittag
Background: Thyroid hormones regulate cardiac functions mainly through direct actions in the heart and by binding to the thyroid hormone receptor (TR) isoforms α1 and β. While the role of the most abundantly expressed isoform, TRα1, is widely studied and well characterized, the role of TRβ in regulating heart functions is still poorly understood, primarily due to the accompanying elevation of circulating thyroid hormone in TRβ knockout mice (TRβ-KO). However, their hyperthyroidism is ameliorated at thermoneutrality, which allows studying the role of TRβ without this confounding factor...
April 8, 2024: Thyroid: Official Journal of the American Thyroid Association
#8
JOURNAL ARTICLE
Peter Lauffer, Charlotte A Heinen, Annika W M Goorsenberg, Arjan Malekzadeh, Peter Henneman, Annemieke C Heijboer, Nitash Zwaveling-Soonawala, Anita Boelen, A S Paul van Trotsenburg
Background: Initial evaluation of the hypothalamus-pituitary-thyroid axis is done by measuring serum free thyroxine (fT4) and thyrotropin concentrations. For correct interpretation of these measurements, reliable age-specific reference intervals (RIs) are fundamental. Since neonatal fT4 RIs conforming to the Clinical and Laboratory Standards Institute guidelines are not available for all assays, we set out to create literature-based uniform age-specific neonatal fT4 RIs that may be used for every assay. Methods: For meta-analysis of individual participant fT4 concentrations, we systematically searched MEDLINE and Embase (search date December 6, 2023; PROSPERO registration CRD42016041871)...
April 2, 2024: Thyroid: Official Journal of the American Thyroid Association
#9
JOURNAL ARTICLE
Joris A J Osinga, Yindi Liu, Tuija Männistö, Marina Vafeiadi, Fang-Biao Tao, Bijay Vaidya, Tanja G M Vrijkotte, Lorena Mosso, Judit Bassols, Abel López-Bermejo, Laura Boucai, Ashraf Aminorroaya, Ulla Feldt-Rasmussen, Aya Hisada, Jun Yoshinaga, Maarten A C Broeren, Sachiko Itoh, Reiko Kishi, Ghalia Ashoor, Liangmiao Chen, Flora Veltri, Xuemian Lu, Peter N Taylor, Suzanne J Brown, Leda Chatzi, Polina V Popova, Elena N Grineva, Farkhanda Ghafoor, Amna Pirzada, Maryam Kianpour, Emily Oken, Eila Suvanto, Andrew Hattersley, Marisa Rebagliato, Isolina Riaño-Galán, Amaia Irizar, Martine Vrijheid, Juana Maria Delgado-Saborit, Ana Fernández-Somoano, Loreto Santa-Marina, Kristien Boelaert, Gabriela Brenta, Rima Dhillon-Smith, Chrysoula Dosiou, Jennifer L Eaton, Haixia Guan, Sun Y Lee, Spyridoula Maraka, Lilah F Morris-Wiseman, Caroline T Nguyen, Zhongyan Shan, Mònica Guxens, Victor J M Pop, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, W Edward Visser, David M Carty, Christian Delles, Scott M Nelson, Erik K Alexander, Layal Chaker, Glenn E Palomaki, Robin P Peeters, Sofie Bliddal, Kun Huang, Kris G Poppe, Elizabeth N Pearce, Arash Derakhshan, Tim I M Korevaar
Background: International guidelines recommend targeted screening to identify gestational thyroid dysfunction. However, currently used risk factors have questionable discriminative ability. We quantified the risk for thyroid function test abnormalities for a subset of risk factors currently used in international guidelines. Methods: We included prospective cohort studies with data on gestational maternal thyroid function and potential risk factors (maternal age, body mass index [BMI], parity, smoking status, pregnancy through in vitro fertilization, twin pregnancy, gestational age, maternal education, and thyroid peroxidase antibody [TPOAb] or thyroglobulin antibody [TgAb] positivity)...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
#10
JOURNAL ARTICLE
Hannah J Sfreddo, Elizabeth S Koh, Karena Zhao, Christina E Swartzwelder, Brian R Untch, Jennifer L Marti, Benjamin R Roman, Jared Dublin, Ronald S Wang, Rong Xia, Jean-Marc Cohen, Bin Xu, Ronald Ghossein, Babak Givi, Jay O Boyle, R Michael Tuttle, James A Fagin, Richard J Wong, Luc G T Morris
Background: Genomic profiling is now available for risk stratification of cytologically indeterminate thyroid nodules (ITNs). Mutations in RAS genes ( HRAS , NRAS , KRAS ) are found in both benign and malignant thyroid nodules, although isolated RAS mutations are rarely associated with aggressive tumors. Because the long-term behavior of RAS -mutant ITNs is not well understood, most undergo immediate surgery. In this multicenter retrospective cohort study, we characterize tumor growth kinetics of RAS -mutant ITNs followed with active surveillance (AS) using serial ultrasound (US) scans and examine the histopathologic diagnoses of those surgically resected...
March 28, 2024: Thyroid: Official Journal of the American Thyroid Association
#11
JOURNAL ARTICLE
Siying Liu, Cihang Lu, Liang He, Zhongyan Shan, Weiping Teng, Yongze Li, Liu Tingting
BACKGROUND: Thyroid disorders are associated with various dietary factors and nutritional elements. The aim of this study was to investigate the relationships between dietary vitamin E intake and the prevalence of thyroid dysfunction and thyroid antibody positivity using data from the National Health and Nutrition Examination Survey (NHANES) database. METHODS: Data from the NHANES database collected between 2007 and 2012 were analyzed. A total of 7,773 nonpregnant adults without preexisting thyroid diseases and possessing complete thyroid and vitamin E data were included in the study...
March 27, 2024: Thyroid: Official Journal of the American Thyroid Association
#12
JOURNAL ARTICLE
Kamilla Ryom Riis, Camilla Bøgelund Larsen, Steen Joop Bonnema
BACKGROUND: Desiccated thyroid extract (DTE) is no longer recommended for treatment of hypothyroidism but is still in use. This review aimed to summarize the available literature on treatment with DTE in adult hypothyroid patients. METHODS: The search was conducted up until the 6th of January 2024 in six electronic databases. Two reviewers independently screened all search results. The retrieved studies compared DTE treatment with levothyroxine or combination therapy with liothyronine and levothyroxine...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
#13
JOURNAL ARTICLE
Julia Winter, Erland Axelsson, Linda Björkhem-Bergman, Catharina Ihre Lundgren, Christel Hedman
Background Despite a good prognosis, survivors of differentiated thyroid cancer (DTC) may have reduced health-related quality of life (HRQOL) many years after treatment, and it is unclear how suppression of thyroid stimulating hormone (TSH) may contribute to HRQOL. This study investigated changes in HRQOL in the five years following DTC treatment, the association between HRQOL and TSH suppression, and how HRQOL compares to the general population. Methods In this nationwide prospective cohort study, 487 DTC patients were identified between 2012 and 2017 from all Swedish hospitals treating DTC patients...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
#14
JOURNAL ARTICLE
Yu-Jia Jiang, Yun Xia, Yi-Xuan Hu, Zhuo-Jun Han, An-Yuan Guo, Tao Huang
Background: Familial non-medullary thyroid carcinoma (FNMTC) is a genetically predisposed disease with unclear genetic mechanisms. This makes research on susceptibility genes important for the diagnosis and treatment options. Methods: This study included a five-member family affected by papillary thyroid carcinoma. The candidate genes were identified through whole-exome sequencing and Sanger sequencing in family members, other FNMTC patients, and sporadic non-medullary thyroid carcinoma patients. The pathogenicity of the mutation was predicted using in silico tools...
March 25, 2024: Thyroid: Official Journal of the American Thyroid Association
#15
JOURNAL ARTICLE
Li-An Huang, Shih-Chang Lo, Yi-Sun Yang, Chien-Ning Huang, Chi-Chih Wang, Yu-Hsun Wang, Edy Kornelius
Background: The COVID-19 pandemic's impact on thyroid function is a growing concern. Previous studies have produced inconclusive results, and there is a lack of comprehensive research into the long-term risks of thyroid dysfunction following COVID-19 infection. Methods: In this retrospective cohort study, we used data from the TriNetX international database, which includes electronic health records from a broad, diverse patient population. We compared patients with COVID-19 (cases) to those without (controls), matching for age, sex, race, and comorbidities using propensity score matching...
March 20, 2024: Thyroid: Official Journal of the American Thyroid Association
#16
JOURNAL ARTICLE
Pablo Fernández Velasco, Paloma Pérez López, Beatriz Torres Torres, Esther Delgado, Daniel de Luis, Gonzalo Díaz Soto
Background: This study aimed to evaluate the clinical impact of an artificial intelligence (AI)-based decision support system (DSS), Koios DS, on the analysis of ultrasound imaging and suspicious characteristics for thyroid nodule risk stratification. Methods: A retrospective ultrasound study was conducted on all thyroid nodules with histological findings from June 2021 to December 2022 in a thyroid nodule clinic. The diagnostic performance of ultrasound imaging was evaluated by six readers on the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) before and after the use of the AI-based DSS and by AI itself...
March 19, 2024: Thyroid: Official Journal of the American Thyroid Association
#17
JOURNAL ARTICLE
Hajime Iwasaki, Hirotsugu Suwanai, Fumiyoshi Yakou, Hiroyuki Sakai, Keitaro Ishii, Natsuko Hara, Ashley M Buckle, Kohsuke Kanekura, Tamami Miyagi, Satoshi Narumi, Ryo Suzuki
BACKGROUND: Congenital hypothyroidism (CH) is caused by mutations in cysteine residues, including Cys655 and Cys825 that form disulfide bonds in thyroid peroxidase (TPO). It is highly likely that these disulfide bonds could play an important role in TPO activity. However, to date, no study has comprehensively analyzed cysteine mutations that form disulfide bonds in TPO. In this study, we induced mutations in cysteine residues involved in disulfide bonds formation and analyzed their effect on subcellular localization, degradation, and enzyme activities to evaluate the importance of disulfide bonds in TPO activity...
March 14, 2024: Thyroid: Official Journal of the American Thyroid Association
#18
JOURNAL ARTICLE
Anna M Sawka, Sangeet Ghai, Lorne Rotstein, Jonathan C Irish, Jesse D Pasternak, Eric Monteiro, Janet Chung, Afshan Zahedi, Jie Su, Wei Xu, Jennifer Jones, Amiram Gafni, Nancy Baxter, David P Goldstein
BACKGROUND: It is important to understand cancer survivors' perceptions about their treatment decisions and quality of life. METHODS: We performed a prospective observational cohort study of Canadian patients with small (< 2cm) low risk papillary thyroid cancer who were offered the choice of active surveillance (AS) or surgery (Clinicaltrials.gov NCT03271892). Participants completed a questionnaire one year after their treatment decision. The primary intention-to-treat analysis compared the mean decision regret scale total score between patients who chose AS or surgery...
March 13, 2024: Thyroid: Official Journal of the American Thyroid Association
#19
JOURNAL ARTICLE
M Regina Castro
No abstract text is available yet for this article.
February 21, 2024: Thyroid: Official Journal of the American Thyroid Association
#20
JOURNAL ARTICLE
Leonidas H Duntas
NA.
February 18, 2024: Thyroid: Official Journal of the American Thyroid Association
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