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Journals
Thyroid : Official Journal of ...
Thyroid : Official Journal of the American Thyroid Association
#1
JOURNAL ARTICLE
Paul Stewardson, Markus Eszlinger, Jiahui Wu, Moosa Khalil, Adrian Box, Marco Perizzolo, Zoya Punjwani, Bjoern Ziehr, Ratna Sanyal, Douglas J Demetrick, Ralf Paschke
Background Molecular testing for cytologically indeterminate thyroid nodules (ITNs) is often reported with incomplete data on clinical assessment and ultrasound malignancy risk (USMR) stratification. This study aimed to clinically validate the diagnostic accuracy of a novel molecular test, assess the incremental preoperative malignancy risk of other clinical factors, and measure the impacts of introducing molecular testing at the population level. Methods Comprehensive clinical data were collected prospectively for the first 615 consecutive patients with ITNs in a centralized healthcare system following implementation of a reflexive molecular test...
September 24, 2023: Thyroid: Official Journal of the American Thyroid Association
#2
JOURNAL ARTICLE
Xi Xiao, Mengke Chen, Ye Sang, Junyu Xue, Ke Jiang, Yulu Chen, Luyao Zhang, Shuang Yu, Weiming Lv, Yanbing Li, Rengyun Liu, Haipeng Xiao
BACKGROUND: Aberrant expression of oncogenes and/or tumor suppressor genes (TSGs) drives the tumorigenesis and development of thyroid cancer. We investigated the expression and function of a member of the activating transcription factor (ATF)/CREB transcription factor (TF) family, ATF3, in thyroid cancer. METHODS: Data from eighty patients with papillary thyroid cancer (PTC) in the First Affiliated Hospital of Sun Yat-sen University and 510 PTC samples in The Cancer Genome Atlas thyroid cancer database were utilized for gene expression and prognosis analyses...
September 24, 2023: Thyroid: Official Journal of the American Thyroid Association
#3
JOURNAL ARTICLE
Michael Gupta, Ana-Maria Misariu, Nadim Saydy, Anthony Nichols, Francisco Laxague, Antoine Eskander, Huaqi Li, Natalie Weisbrod, Jesse D Pasternak, Bahar Golbon, Elaine Jin, Stan Hm Van Uum, Maryse Brassard, Florence Levesque, Nader Sadeghi, Thavakumar Subramaniam, Aleksander M Mlynarek, Gregoire Bernard Morand, Pierre Fortier, Laurent Fradet, Sana Ghaznavi, Shamir P Chandarana, Eitan Prisman, Tareck Ayad, Apostolos Christopoulos, Joel Davies, Murali Rajaraman, Martin Corsten, Kye Rajaraman, Anastasios Maniakas
N/A.
September 19, 2023: Thyroid: Official Journal of the American Thyroid Association
#4
JOURNAL ARTICLE
Selwan Khamisi, Ruzan Udumyan, Gabriel Sjölin, Jan Calissendorff, Helena Filipsson Nyström, Mats Holmberg, Bengt Hallengren, Mikael Lantz, Tereza Planck, Göran Wallin, Östen Ljunggren
Background Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The aim of this study was to investigate fracture risk in patients with GD. Methods A total of 2134 patients with incident GD and 21261 age, sex- and county-matched controls were included 16-18 years after diagnosis in a retrospective cohort study...
September 19, 2023: Thyroid: Official Journal of the American Thyroid Association
#5
JOURNAL ARTICLE
Bernadette Biondi, Martina Pucci, Gilda Pontieri, Pietro Formisano, Roberta Esposito
BACKGROUND: Evidence is needed on the risks and benefits of combination therapy with Levothyroxine (LT4) + Liothyronine (LT3) for treatment of hypothyroidism. OBJECTIVE AND METHODS: We performed a randomized double-blind placebo-controlled study to assess the effects of LT4 + LT3 therapy vs LT4 + placebo in a homogenous group of athyreotic patients, without cardiovascular risk factors during long-term replacement monotherapy with LT4. The primary objective of the study was to assess the effects of combination LT4 + LT3 therapy on heart rate, cardiac rhythm and sensitive cardiovascular parameters of cardiac morphology and function by means of electrocardiography and Doppler echocardiography...
September 19, 2023: Thyroid: Official Journal of the American Thyroid Association
#6
JOURNAL ARTICLE
Perrine Shu Ting Huisman, Jesper Krogh, Claus Henrik Nielsen, Henriette Svarre Nielsen, Ulla Feldt-Rasmussen, Sofie Bliddal
Background: Thyroid autoimmunity is the most prevalent autoimmune disorder among women of reproductive age and has been suggested as a risk factor in recurrent pregnancy loss (RPL) - a condition in which couples suffer several consecutive pregnancy losses, but where a cause can be identified in less than half of the cases. Most studies have focused on thyroid peroxidase antibodies (TPOAbs), not considering the presence of thyroglobulin antibodies (TgAbs). The aim of this study was to systematically assess the prevalence of TgAb-positivity in women with RPL, and whether TgAb-positivity was associated with the outcome of the next pregnancy...
September 19, 2023: Thyroid: Official Journal of the American Thyroid Association
#7
JOURNAL ARTICLE
Simone De Leo, Silvia D'Elia, Giorgio Grani, Francesco Dondi, Francesco Bertagna, Efisio Puxeddu, Silvia Morelli, Alessandro Piovesan, Alice Nervo, Maria Chiara Zatelli, Irene Gagliardi, Maria Teresa Samà, Gianluca Aimaretti, Umberto Crocetti, Michela Massa, Maurilio Deandrea, Francesca Retta, Loredana Pagano, Mattia Rossi, Erica Solaroli, Luciano Pezzullo, Maria Grazia Chiofalo, Alfredo Pontecorvi, Celestino Pio Lombardi, Alessandro Antonelli, Armando Patrizio, Ilaria Messuti, Flavia Magri, Giovanna Spiazzi, Graziano Ceresini, Rocco Bruno, Clotilde Sparano, Marco Centanni, Anna Crescenzi, Giovanni Tallini, Vincenzo Marotta, Bruno Madeo, Caterina Mian, Sebastiano Filetti, Cosimo Durante, Laura Fugazzola
Background There is some controversy on the potential relationship between autoimmune processes and clinicopathological features as well as prognosis of differentiated thyroid cancer (DTC), and the evidence is limited by its largely retrospective nature. We examined the relationship between the presence of autoimmune thyroiditis and 1-year thyroid cancer treatment outcomes in a large, multi-center study, using prospectively collected data. Methods We included data from consecutive DTC patients enrolled in the Italian Thyroid Cancer observatory (ITCO) database (NCT04031339)...
September 19, 2023: Thyroid: Official Journal of the American Thyroid Association
#8
JOURNAL ARTICLE
David Balakirouchenane, Romain Seban, Lionel Groussin, Alicja Puszkiel, Anne Segolene Cottereau, Jerome Clerc, Michel Vidal, Francois Goldwasser, Jennifer Arrondeau, Benoit Blanchet, Olivier Huillard
BACKGROUND: BRAF and MEK inhibitors are cornerstones of the redifferentiation strategy in metastatic radioactive iodine (RAI) resistant mutant thyroid cancers. We explored exposure-toxicity relationship for dose-limiting toxicity (DLT) onset in patients treated with dabrafenib and/or trametinib and investigated whether plasma exposure was associated with RAI reuptake. METHODS: We conducted a retrospective monocentric study in which we reviewed the electronic medical records of patients treated in our institution with a tumor redifferentiation strategy, for whom plasma concentration of dabrafenib, its active metabolite hydroxy-dabrafenib, and trametinib was measured...
September 19, 2023: Thyroid: Official Journal of the American Thyroid Association
#9
JOURNAL ARTICLE
Mary Waterhouse, Hai Pham, Sabbir Rahman, Catherine Baxter, Briony Duarte Romero, Bruce Armstrong, Peter R Ebeling, Dallas English, Gunter Hartel, Jolieke van der Pols, Alison Venn, Penelope M Webb, David C Whiteman, Donald S A McLeod, Rachel Neale
BACKGROUND: Hypothyroidism is common, and in iodine-sufficient areas is primarily caused by autoimmune destruction of the thyroid gland. Observational studies have consistently shown an inverse association between serum 25-hydroxyvitamin D concentration and autoimmune diseases; however, there is a lack of evidence from randomized controlled trials to support a benefit of vitamin D supplementation, particularly for autoimmune thyroid diseases. We therefore aimed to assess the effect of vitamin D supplementation on the incidence of hypothyroidism...
September 12, 2023: Thyroid: Official Journal of the American Thyroid Association
#10
JOURNAL ARTICLE
Sophie Moog, Livia Lamartina, Mohamed-Amine Bani, Abir Al Ghuzlan, Luc Friboulet, Antoine Italiano, Ludovic Lacroix, Sophie Postel-Vinay, Lambros Tselikas, Frédéric Deschamps, Baptiste Bonnet, Fabiana Pani, Eric Baudin, Julien Hadoux
BACKGROUND: Patients with metastatic medullary thyroid cancer (MTC) who progressed under tyrosine kinase inhibitors can benefit from alkylating agent such as Dacarbazine or Temozolomide. PATIENT FINDINGS: We describe two patients with metastatic MTC who developed a hypermutant phenotype after alkylating agent treatment. This phenotype was characterized by a high tumor mutational burden (TMB) and a mutational signature indicative of alkylating agent mutagenesis (Single Base Substitution 11)...
September 12, 2023: Thyroid: Official Journal of the American Thyroid Association
#11
JOURNAL ARTICLE
Amanda Silver Karcioglu, Amr H Abdelhamid Ahmed, Zipei Feng, Marika Russell, David C Shonka, Ayaka Iwata, Maria Cabanillas, Jennifer J Shin, Natalia Kyriazidis, Jong Chul Park, Lori J Wirth, Mark E Zafereo, Gregory W Randolph
NA.
September 11, 2023: Thyroid: Official Journal of the American Thyroid Association
#12
JOURNAL ARTICLE
Viswanath Gunda, Chandrayee Ghosh, Jiangnan Hu, Lisa Zhang, Ya-Qin Zhang, Min Shen, Electron Kebebew
BACKGROUND: Anaplastic thyroid cancer (ATC) is uniformly lethal. BRAFV600E mutation is present in up to 45% of patients with ATC. Targeted therapy with combined BRAF and MEK inhibition in BRAFV600E-mutant ATC can be effective, but acquired resistance is common because this combination targets the same pathway. Drug matrix screening, in BRAFV600E ATC cells, of highly active compounds in combination with BRAF inhibition showed multitargeting tyrosine kinase inhibitors (MTKIs) had the highest synergistic/additive activity...
September 7, 2023: Thyroid: Official Journal of the American Thyroid Association
#13
JOURNAL ARTICLE
James A Fagin, Yuri E Nikiforov
Background: Very little was known about the molecular pathogenesis of thyroid cancer until the late 1980s. As part of the Centennial celebration of the American Thyroid Association, we review the historical discoveries that contributed to our current understanding of the genetic underpinnings of thyroid cancer. Summary: The pace of discovery was heavily dependent on scientific breakthroughs in nucleic acid sequencing technology, cancer biology, thyroid development, thyroid cell signaling, and growth regulation...
September 4, 2023: Thyroid: Official Journal of the American Thyroid Association
#14
JOURNAL ARTICLE
Katleen Van Uytfanghe, Joel Ehrenkranz, David Halsall, Kelly Hoff, Tze Ping Loh, Carole A Spencer, Josef Köhrle
Background: Despite being the most performed laboratory endocrine investigation, the optimum use of thyroid tests (thyrotropin [TSH] and thyroid hormone [TH] measurement) is open to question and the interpretation of the results from these tests can be ambiguous. The American Thyroid Association (ATA) with its expertise support the endeavor of the U.S. Centers for Disease Control (CDC) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) to improve and maintain standardization and harmonization of thyroid testing...
September 1, 2023: Thyroid: Official Journal of the American Thyroid Association
#15
JOURNAL ARTICLE
Catherine F Sinclair, Jung Hwan Baek, Kathleen E Hands, Steven P Hodak, Timothy C Huber, Iram Hussain, Brian Hung Hin Lang, Julia Noel, Maria Papaleontiou, Kepal N Patel, Gilles Russ, Jonathon Russell, Stefano Spiezia, Jennifer H Kuo
BACKGROUND: The primary goal of this interdisciplinary consensus statement is to provide a framework for the safe adoption and implementation of ablation technologies for benign thyroid nodules. SUMMARY: This consensus statement is organized around three key themes: i. safety of ablation techniques and their implementation, ii. optimal skillset criteria for proceduralists performing ablative procedures, and iii. defining expectations of success for this treatment option given its unique risks and benefits...
August 29, 2023: Thyroid: Official Journal of the American Thyroid Association
#16
(no author information available yet)
No abstract text is available yet for this article.
August 28, 2023: Thyroid: Official Journal of the American Thyroid Association
#17
JOURNAL ARTICLE
Yaru Bao, Daham Kim, Yoon Hee Cho, Cheol Ryong Ku, Jin Sook Yoon, Eun Jig Lee
BACKGROUND: Graves' disease (GD), one of the most common forms of autoimmune thyroid disorder, is characterized by hyperthyroidism caused by antibodies (Ab) against the extracellular A-subunit of the thyrotropin receptor (TSHR). Various approaches have been used to create mouse models of GD, including transfected fibroblasts and immunization with plasmids or adenoviruses expressing human TSHR A-subunit (hTSHR A-subunit). These models, however, require repeated immunizations and produce inconsistent results...
August 25, 2023: Thyroid: Official Journal of the American Thyroid Association
#18
JOURNAL ARTICLE
Douglas S Ross
n/a.
August 25, 2023: Thyroid: Official Journal of the American Thyroid Association
#19
JOURNAL ARTICLE
Shin Jeong Pak, Douk Kwon, Byung-Chang Kim, Jae Won Cho, Won Woong Kim, Yu-Mi Lee, Tae-Yon Sung, Jung Hwan Baek, Won Gu Kim, Won Bae Kim, Ki-Wook Chung
Background The optimal extent of surgery for unilateral papillary thyroid carcinoma (PTC) with contralateral nodules remains unclear. This study evaluated the long-term outcomes in a large cohort of patients with unilateral PTC and contralateral low-to-intermediate suspicious nodules who underwent lobectomy. Methods This retrospective cohort study included patients with unilateral PTC who underwent lobectomy between January 2016 and December 2017 at Asan Medical Center in Korea. Patients were divided into two groups, those with and without contralateral nodules at the time of lobectomy: the Present group and the Absent group...
August 25, 2023: Thyroid: Official Journal of the American Thyroid Association
#20
JOURNAL ARTICLE
David S Cooper, Peter A Kopp
No abstract text is available yet for this article.
August 25, 2023: Thyroid: Official Journal of the American Thyroid Association
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