Cristian González-Guerrero, Marco Borsò, Pouya Alikhani, Yago Alcaina, Federico Salas Lucia, Xiao-Hui Liao, Jorge García-Giménez, Andrea Bertolini, Diana Martin, Adrian Moratilla, Roberto Mora, Antonio Buño-Soto, Ali R Mani, Juan Bernal, Alessandro Saba, María P de Miguel, Samuel Refetoff, Riccardo Zucchi, Jose Carlos Moreno
BACKGROUND: Iodine is required for the synthesis of thyroid hormone (TH), but its natural availability is limited. Dehalogenase1 (Dehal1) recycles iodine from mono- and di-iodotyrosines (MIT, DIT) to sustain TH synthesis when iodine supplies are scarce, but its role in the dynamics of storage and conservation of iodine is unknown. METHODS: Dehal1 knockout mice (Dehal1KO) were generated by gene-trapping and the timing of expression and distribution was investigated by X-Gal staining and immunofluorescence using recombinant Dehal1-Betagalactosidase protein produced in fetuses and adult mice...
March 6, 2023: Thyroid: Official Journal of the American Thyroid Association