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Bio-medical Materials and Engineering

Lijia Cheng, Zhiping Liu, Shuo Yan, Zusheng Chen, Liang Zou, Zheng Shi
OBJECTIVE: Bone remodeling is mediated by the interaction between osteoblasts and osteoclasts, so does osteoinduction triggered by calcium phosphate (CaP) biomaterials. This study aims to investigate the role and function of osteoclasts in ectopic bone formation induced by CaP biomaterials. METHODS: Four kinds of mice, two outbred mouse strains (KM and ICR) and two inbred mouse strains (C57BL/6 and BALB/c), were chosen for the experiments. The hydroxyapatite/ RESULTS: The number of multinucleated cells, the number of new blood vessels, and the area percentage of new bone tissues were more in outbred mouse strains than that in inbred mouse strains; and there were more TRAP-positive cells in the outbred mouse strains group...
April 11, 2019: Bio-medical Materials and Engineering
Evren Sariyilmaz, Özlem Sivas Yilmaz, Cangül Keskin, Ali Keleş
The objective of this study was to evaluate the effect of sodium hypochlorite and chlorhexidine solutions and their inactivating agents on the push-out bond strength of mineral trioxide aggregate (MTA). One hundred fifty root slices were prepared and their root canal spaces were enlarged using diamond burs. MTA was prepared and compacted to root canal spaces. The samples were randomly separated to 4 groups that would be immersed into the selected solutions (5.25% sodium hypochlorite (NaOCl), 5.25% NaOCl and sodium thiosulfate, 2% chlorhexidine (CHX), 2% CHX and a mixture of Tween 80 and 0...
April 11, 2019: Bio-medical Materials and Engineering
Shahrokh Rahmani, Amin Jarrahi, Behdad Saed, Mahdi Navidbakhsh, Hekmat Farjpour, Mansour Alizadeh
BACKGROUND: Marfan Syndrome (MFS) is a genetic disorder of the connective tissue. It most prominently influences the skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected as well. OBJECTIVE: This study aims to investigate a realistic three-dimensional model of an aorta of a specific patient suffering from MFS by considering elastic and hyperelastic materials for the tissue using fluid-structure interaction (FSI)...
April 10, 2019: Bio-medical Materials and Engineering
Ekaterina Karteva, Neshka Manchorova, Nadia Petrova, Zhelyazko Damyanov, Stoyan Vladimirov
BACKGROUND: Human dentin is a highly calcified tissue of mesenchymal origin with a heterogeneous structure. Its morphology is constantly remodelled throughout the life span of the tooth, as well as under the influence of external stimuli. OBJECTIVE: The aim of the present study was to obtain information about the thermal changes in the crown and root dentin specimens of vital and devitalized teeth. METHODS: The investigated samples were divided into 6 groups, depending on the patients' age and dentin location (crown, root)...
February 7, 2019: Bio-medical Materials and Engineering
A Toshimitsu Yokobori, Koyu Watanabe, Yoshikatsu Saiki, Yu Nishikawa, Kazuki Kudo, Toshihito Ohmi, Yukihiro Hayatsu, Marina Suzuki, Konosuke Sasaki
In this research, using our proposed method, clinical measurements on the pulsatile velocity of blood vessel wall were conducted for cases with aneurysm. Furthermore, detailed analyses of frequency and attracter of trajectories of velocity of blood vessel wall were conducted. On the basis of these analyses, we tried to conduct unified clarification of the change and disturbance of frequency and wave form of pulsatile velocity of blood vessel wall caused by blood vessel diseases such as aneurysm. The following results were obtained...
February 6, 2019: Bio-medical Materials and Engineering
Yukihiro Hayatsu, Koyu Watanabe, Konosuke Sasaki, Naoki Masaki, Shintaro Katahira, Kiichiro Kumagai, Shunsuke Kawamoto, Toshihito Ohmi, A Toshimitsu Yokobori, Yoshikatsu Saiki
OBJECTIVES: We aimed to develop a novel ultrasound system and examine its feasibility for noninvasively detecting thoracic aortic aneurysm (TAA) in clinical settings. METHODS: We developed a novel ultrasound system consisting of a modified console and data analysis algorithm. The exploratory study included 100 patients hospitalized for elective cardiovascular surgery. After admission, the arterial pulse waveform at the left carotid artery was acquired using the novel system...
February 6, 2019: Bio-medical Materials and Engineering
Surangika Wadugodapitiya, Makoto Sakamoto, Kaito Sugita, Yusuke Morise, Masaei Tanaka, Koichi Kobayashi
BACKGROUND: In vivo evaluation of the elastic properties of the knee joint capsule has not been adequately performed. OBJECTIVES: To establish a methodology to assess the stiffness of the normal knee joint capsule over a range of knee flexion angles using ultrasound elastography. METHODS: Ultrasound elastography with an acoustic coupler was used to assess the stiffness of the anteromedial capsule of the knee joints of 10 male (mean age 22...
February 6, 2019: Bio-medical Materials and Engineering
Tzu-Rong Su, Ying-Hung Chu, Hui-Wen Yang, Yu-Feng Huang, Shinn-Jyh Ding
BACKGROUND: Surface modification of metallic implants is critical for improving the clinical performance of the dental and orthopedic devices. Bioactive glasses exhibit different levels of cellular function and physicochemical behavior; however, there have been few previous studies on the effect of constituents of the bioactive glasses on the in vitro osteogenic activity and corrosion resistance of apatite-based coatings. OBJECTIVE: The objective of this work was thus to investigate the effect of SiO2, CaO, Na2O, and P2O5 on plasma-sprayed apatite coatings on Ti alloy substrates for tailoring the properties of implants making them suitable for clinical applications...
February 6, 2019: Bio-medical Materials and Engineering
Jin Cheng, Cong Wang, Yongquan Gu
BACKGROUND: A tissue engineering technique based on use of the extracellular matrix (ECM) as a scaffold shows great potential for preparing small-caliber vascular grafts. Decellularization protocols are still not standardized for the bioengineering. The effects of freeze-thaw cycles used for decellularization has been unclear. OBJECTIVE: To evaluate the effects of freeze-thaw cycles on porcine carotid arteries during decellularization and to develop a promising protocol for preparing ECM scaffolds...
February 6, 2019: Bio-medical Materials and Engineering
Marcin Zaczyk
INTRODUCTION: We present a description of an experiment in which the parameters describing the quality of the mandrel embedding an implant into a bone were determined. A method was developed that allows, from outside a living organism, the strength of the mandrel of the implant in the bone tissue to be determined. Using the proposed technique, we investigated how the mechanical properties of the bone affect the quality of the implant mandrel embedding in the bone tissue. MATERIALS AND METHODS: As part of the research work, we conducted 15 compression tests on previously prepared samples that reflected an uncemented endoprosthesis embedding in the proximal base of a femur bone...
February 6, 2019: Bio-medical Materials and Engineering
Kyoung-Tak Kang, Joon-Hee Park, Yong-Gon Koh, Jaewon Shin, Kwan Kyu Park
BACKGROUND: The effects of the posterior slope of the tibial prosthesis on unicompartmental knee arthroplasty have not been fully evaluated and controversies still exist. OBJECTIVE: This study evaluates the effects of the posterior slope of the tibia on contact stresses in polyethylene inserts and articular cartilage using finite element analysis. METHODS: We generated a computational model followed by the development of a posterior tibial slope (PTS) from -1° to 15° cases with increments of 2° PTS models...
February 6, 2019: Bio-medical Materials and Engineering
Zhang Yu, Jiang Lili, Zheng Tiezheng, Sha Li, Wang Jianzhuang, Dong Haichao, Song Kedong, Liu Tianqing
BACKGROUND: The meniscus tissue engineering has provided a great potential treatment for meniscal injuries. However, few scaffolds in meniscus tissue engineering have matched the mechanical properties of native meniscus. OBJECTIVE: In this study,we developed a composite scaffold using decellularized meniscus extracellular matrix (DMECM) and gelatin/chitosan (G/C), to explore apreferable ratio to enhance the elastic modulus and cytotoxicity properties of scaffolds...
February 6, 2019: Bio-medical Materials and Engineering
Kwan Kyu Park, Yong-Gon Koh, Kyoung-Mi Park, Joon-Hee Park, Kyoung-Tak Kang
BACKGROUND: Component malalignment in unicompartmental knee arthroplasty (UKA) has been related to the concentration in tibiofemoral joint of contact stress and to poor post-operative outcomes. Few studies investigated a biomechanical effect of femur component position in sagittal plane. The purpose of this study was to evaluate the biomechanical effect of the femoral components on the sagittal alignment under flexion and extension conditions using computational simulations. METHODS: The flexion and extension conditions of the femoral component were analyzed from 10° extension to 10° flexion in 1° increments...
February 5, 2019: Bio-medical Materials and Engineering
Kyoung-Tak Kang, Yong-Gon Koh, Kyoung-Mi Park, Jun-Sang Lee, Sae Kwang Kwon
BACKGROUND: The conservation of the joint anatomy is an important factor in total knee arthroplasty (TKA). The restoration of the femoral posterior condylar offset (PCO) has been well known to influence the clinical outcome after TKA. OBJECTIVE: The purpose of this study was to determine the mechanism of PCO in finite element models with conservation of subject anatomy and different PCO of ±1, ±2, ±3 mm in posterior direction using posterior cruciate ligament-retaining TKA...
February 5, 2019: Bio-medical Materials and Engineering
Xiangdong Bi, Panita Maturavongsadit, Yu Tan, Morgan Watts, Evelyn Bi, Zachary Kegley, Steve Morton, Lin Lu, Qian Wang, Aiye Liang
BACKGROUND: Biocompatible hydrogel systems with tunable mechanical properties have been reported to influence the behavior and differentiation of mesenchymal stem cells (MSCs). OBJECTIVE: To develop a functionalized hydrogel system with well-defined chemical structures and tunable mechanical property for regulation of stem cell differentiation. METHODS: An in-situ forming hydrogel system is developed by crosslinking vinyl sulfone functionalized polyamidoamine (PAMAM) dendrimer and multi-armed thiolated polyethylene glycol (PEG) through a thiol-ene Michael addition in aqueous conditions...
December 12, 2018: Bio-medical Materials and Engineering
R J Limón-Martínez, I Olivas-Armendáriz, E Sosa-Rodarte, C I Rodríguez-Rodríguez, J F Hernández-Paz, L S Acosta-Torres, R García-Contreras, E Santos-Rodríguez, S A Martel-Estrada
BACKGROUND: The development of biomaterial scaffolds and implementation of tissue engineering techniques are necessary. Therefore, Polycaprolactone/Sodium Hyaluronate/Multiwalled Carbon Nanotubes/Extract of Mimosa tenuiflora composites have been produced by a thermally-induced phase separation method. OBJECTIVE: The objective of this research was to evaluate the in vitro bioactivity and in vitro biocompatibility of the composites. METHODS: The in vitro bioactivity of the composites was assessed by soaking them in simulated body fluid for 7, 14, 21, and 28 days...
December 12, 2018: Bio-medical Materials and Engineering
Jomjai Peerapattana, Yusuke Hattori, Makoto Otsuka
BACKGROUND: In order to manufacture pharmaceutical products, real-time monitoring in the manufacturing process is necessary, but large equipment cost is required to achieve it. OBJECTIVE: The aim of this research is to use ultra-violet-visible spectroscopy along with chemometrics procedure to simultaneously quantitative analysis of indomethacin (IMC) and benzoic acid (BA) in the gel during pharmaceutical manufacturing process. METHODS: The gel preparations were contained of 0...
December 12, 2018: Bio-medical Materials and Engineering
Chenghu Liu, Zhenhua Lin, Chunxia Qiao, Zenglin Zhao, Changbin Wang, Xiaoxia Sun, Yanping Shi
For medical devices directly or indirectly contacted with blood, hemocompatibility assay is of great importance during the biological evaluation. In ISO 10993-4:2017 - Biological evaluation of medical devices part 4, a selection of tests for interactions with blood is given with the rationale for selection of tests based on their intended use specified, however, the specific testing protocols may vary significantly when performing the hemocompatibility assays. In recent years, medical catheters have been widely used in clinical practice...
December 12, 2018: Bio-medical Materials and Engineering
Sergei G Kalinichenko, Natalya Yu Matveeva, Roman Ye Kostiv, Sergey S Edranov
BACKGROUND: Biodegradable implant coatings promote proliferation and expression of BMP-2, VEGF, and TGF-β2 genes and enhance BMP-2, VEGF, and TGF-β2 regulatory effects at different stages of reparative osteogenesis. OBJECTIVE: To study the topography and ratio of PCNA-, VEGF-, BMP-2-, and TGF-β2-immunoreactive cells in rat femoral bone after closed fracture and implantation of titanium implants with biodegradable calcium phosphate and hydroxyapatite coatings...
December 10, 2018: Bio-medical Materials and Engineering
Tatsunori Takahashi, Soichiro Itoh, Masakazu Kida
OBJECTIVE: We conducted ultrasonography (US) examination for asymptomatic elbow injuries in judo athletes to confirm availability of US screening for elbow. MATERIALS AND METHODS: One hundred and thirty-two black belts in judo (85 males and 47 females; mean age, 20.0 ± 1.6 years) participated in this screening. Forty-eight participants had a history of elbow injury (elbow-injury group), and 84 did not (no-elbow-injury group). All participants completed a survey in the form of a questionnaire...
December 10, 2018: Bio-medical Materials and Engineering
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