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Journals European Archives of Psychiatr...

European Archives of Psychiatry and Clinical Neuroscience

https://read.qxmd.com/read/38878077/genetics-of-suicide-ideation-a-role-for-inflammation-and-neuroplasticity
#1
JOURNAL ARTICLE
Fabrizio Turiaco, Fiammetta Iannuzzo, Antonio Bruno, Antonio Drago
Suicide is a leading cause of death worldwide. Suicide ideation (SI) is a known risk factor for suicide behaviour (SB). The current psychobiology and genetic predisposition to SI and SB are poorly defined. Despite convincing relevance of a genetic background for SI, there is no current implementable knowledge about the genetic makeup that identifies subjects at risk for it. One of the possible reasons for the absence of a clear-cut evidence is the polygenetic nature of SI along with the very large sample sizes that are needed to observe significant genetic association result...
June 15, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38867084/treatment-demand-for-cannabis-use-problems-analyses-of-routine-data-from-30-european-countries
#2
JOURNAL ARTICLE
Jakob Manthey
Cannabis use and treatment demand has risen in the past decade. Previous analyses of treatment demand are limited by methodological constraints or are outdated. Cross-country differences and trends in cannabis treatment demand are described using data from the European Monitoring Centre for Drugs and Drug Addiction. Two novel indicators are employed: firstly, the cannabis-attributable treatment fraction (CATF) is obtained by dividing the number of treatment entrants for cannabis use problems by the number of treatment entrants for any substance use problem, accounting for possible changes in the reporting system...
June 12, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38861240/interaction-of-childhood-trauma-with-bdnf-and-fkbp5-gene-polymorphisms-in-predicting-burnout-in-general-occupational-groups
#3
JOURNAL ARTICLE
Yuling Li, Haiying Jia, Xueqian Wei, Shiqian Zhen, Shu-Chang He, Xiang Yang Zhang
Both the BDNF gene rs6265 and the FKBP5 gene rs1360780 polymorphisms are independently associated with adult psychotic-like experiences, when exposed to high childhood abuse; however, it remains unclear whether the relationship between childhood abuse and burnout is moderated by these two single nucleotide polymorphisms (SNPs). Furthermore, there is an interaction between glucocorticoid receptor transcriptional activity and BDNF signaling. Therefore, we investigated the interaction of these two SNPs with childhood trauma in predicting burnout...
June 11, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38861239/characterization-of-cannabis-users-and-products-and-the-experience-of-negative-mental-emotions-following-cannabis-use
#4
JOURNAL ARTICLE
Nir Treves, Noa Yakirevich-Amir, Wiessam Abu Ahmad, Omer Bonne, Elyad Davidson, Keenan Keeling, Branden Hall, Tyler Dautrich, Ilan Matok
There is a potential link between cannabis and mental disorders. Cannabis exposure involves in many cases negative mental emotions, which are unpleasant sensations or thoughts. Whereas mild cases of negative mental emotions inflict patient's quality of life, more severe cases lead to therapy discontinuations, or even hospitalizations and death. This study characterizes cannabis users who experienced negative mental emotions after cannabis exposure. The Releaf App database was utilized to evaluate the association between personal and cannabis use characteristics on reporting a negative mental emotion during cannabis exposure...
June 11, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38851655/naturalistic-comparison-of-clomethiazole-and-diazepam-treatment-in-alcohol-withdrawal-effects-on-oxidative-stress-inflammatory-cytokines-and-hepatic-biomarkers
#5
JOURNAL ARTICLE
David Strischewski, Amira Kalmar, Paul C Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Conrad J Schiffner, Wolfgang Jordan, Ulf J Müller, Katrin Borucki, Michael Böttcher, Borna Relja, Johann Steiner
Ethanol is metabolized by alcohol dehydrogenase to acetaldehyde and induces cytochrome P450 2E1 (CYP2E1), which generates reactive oxygen species that cause inflammatory liver damage. Clomethiazole, a drug approved for alcohol withdrawal treatment (AWT) in some European countries, inhibits CYP2E1. We hypothesized that clomethiazole would lead to a faster reduction in oxidative stress, inflammatory cytokines, and liver enzymes compared to diazepam treatment. We analysed respective biomarkers in 50 patients undergoing AWT and 25 healthy individuals but found no statistical difference between the two medication groups over 3-5 days...
June 8, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38839710/how-to-assess-response
#6
LETTER
Steffen Zitzmann, Christoph Lindner
No abstract text is available yet for this article.
June 5, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38829442/post-covid-depression-and-anxiety-are-multicausal-and-not-necessarily-due-to-sars-cov-2-infection
#7
LETTER
Josef Finsterer
No abstract text is available yet for this article.
June 3, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38824476/associations-of-tau-a%C3%AE-and-brain-volume-of-the-papez-circuit-with-cognition-in-alzheimer-s-disease
#8
JOURNAL ARTICLE
Yuxue Feng, Azka Laraib, Xiuqi Lin, Qin Li, Jiehong Zhan, Xiaofeng Li
This study aimed to investigate the cross-sectional associations between regional Alzheimer's disease (AD) biomarkers, including tau, β-amyloid (Aβ), and brain volume, within the Papez circuit, and neuropsychological functioning across the preclinical and clinical spectrum of AD. We utilized data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including 251 Aβ-positive participants. Participants were categorized into three groups based on the Clinical Dementia Rating (CDR): 73 individuals with preclinical AD (CDR = 0), 114 with prodromal AD (CDR = 0...
June 2, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38819463/unlocking-the-potential-of-the-3-hydroxykynurenine-kynurenic-acid-ratio-a-promising-biomarker-in-adolescent-major-depressive-disorder
#9
JOURNAL ARTICLE
Zhihan Ye, Shuran Yang, Liu Lu, Ming Zong, Lieying Fan, Chuanyuan Kang
Metabolites disruptions in tryptophan (TRP) and kynurenine pathway (KP) are believed to disturb neurotransmitter homeostasis and contribute to depressive symptoms. This study aims to investigate serum levels of KP metabolites in adolescent major depressive disorder (AMDD), and examine their relationship with depression severities. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to analyze serum levels of TRP, kynurenic acid (KYNA), kynurenine (KYN), and 3-hydroxy-kynurenine (3-HK) in 143 AMDD participants and 98 healthy controls (HC)...
May 31, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38806850/neuropsychological-profiles-in-first-episodes-psychosis-and-their-relationship-with-clinical-metacognition-and-social-cognition-variables
#10
JOURNAL ARTICLE
Victoria Espinosa, Alana Bagaeva, Raquel López-Carrilero, Ana Barajas, María Luisa Barrigón, Irene Birulés, Eva Frígola-Capell, Luciana Díaz-Cutraro, Fermín González-Higueras, Eva Grasa, Alfonso Gutiérrez-Zotes, Ester Lorente-Rovira, Trinidad Pélaez, Esther Pousa, Isabel Ruiz-Delgado, Marina Verdaguer-Rodríguez, Susana Ochoa
An increasing interest in the assessment of neuropsychological performance variability in people with first-episode psychosis (FEP) has emerged. However, its association with clinical and functional outcomes requires further study. Furthermore, FEP neuropsychological subgroups have not been characterized by clinical insight or metacognition and social cognition domains. The aim of this exploratory study was to identify specific groups of patients with FEP based on neuropsychological variables and to compare their sociodemographic, clinical, metacognition and social cognition profiles...
May 28, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38805071/reduced-contrast-sensitivity-pattern-electroretinogram-ratio-and-diminished-a-wave-amplitude-in-patients-with-major-depressive-disorder
#11
JOURNAL ARTICLE
Evelyn B N Friedel, Ludger Tebartz van Elst, Malina Beringer, Dominique Endres, Kimon Runge, Simon Maier, Jürgen Kornmeier, Michael Bach, Katharina Domschke, Sven P Heinrich, Kathrin Nickel
The electroretinogram (ERG), a non-invasive electrophysiological tool used in ophthalmology, is increasingly applied to investigate neural correlates of depression. The present study aimed to reconsider previous findings in major depressive disorder (MDD) reporting (1) a diminished contrast sensitivity and (2) a reduced patten ERG (PERG) amplitude ratio, and additionally, to assess (3) the photopic negative response (PhNR) from the flash ERG (fERG), with the RETeval® device, a more practical option for clinical routine use...
May 28, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38801534/exploring-the-latent-cognitive-structure-in-schizophrenia-implications-for-antipsychotic-treatment-responses
#12
JOURNAL ARTICLE
Weiyan Wang, Xingjie Peng, Gangrui Hei, Yujun Long, Jingmei Xiao, Tiannan Shao, Li Li, Ye Yang, Xiaoyi Wang, Chuhan Song, Yuyan Huang, Jingda Cai, Jing Huang, Dongyu Kang, Ying Wang, Jingping Zhao, Hui Tang, Renrong Wu
BACKGROUND: Individuals diagnosed with schizophrenia present diverse degrees and types of cognitive impairment, leading to variations in responses to antipsychotic treatments. Understanding the underlying cognitive structures is crucial for assessing this heterogeneity. Utilizing latent profile analysis (LPA) enables the delineation of latent categories of cognitive function. Integrating this approach with a dimensional perspective allows for the exploration of the relationship between cognitive function and treatment response...
May 27, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38780801/effectiveness-of-cannabis-use-and-cannabis-use-disorder-interventions-a-european-and-international-data-synthesis
#13
REVIEW
Jason P Connor, Jakob Manthey, Wayne Hall, Daniel Stjepanović
This data synthesis examined the effectiveness of behavioural and pharmacological approaches for cannabis treatment. We integrated findings from high level evidence studies and prioritised data from Europe when available. The synthesis found that only a relatively small number of published behavioural and pharmacological studies on cannabis interventions have been conducted in Europe. Applying both European and non-European data, it was found that Cognitive Behavioural Therapy (CBT) and/or Motivational Enhancement Therapy (MET) improved short-term outcomes in the frequency of cannabis use and dependency severity, although abstinence outcomes were less consistent...
May 23, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38780800/long-term-ayahuasca-use-is-associated-with-preserved-global-cognitive-function-and-improved-memory-a-cross-sectional-study-with-ritual-users
#14
JOURNAL ARTICLE
Arilton Martins Fonseca, Rafael Guimarães Dos Santos, Lívia Soman de Medeiros, Thiago André Moura Veiga, Fernando Cassas, Carla Poleselli Bruniera, Giordano Novak Rossi, José Carlos Bouso, Jaime E Cecílio Hallak, Fabiana Pereira Santos, Beatriz Aparecida Passos Bismara Paranhos, Mauricio Yonamine, Eliana Rodrigues
Although several studies have been conducted to elucidate the relationship between psychedelic consumption and cognition, few have focused on understanding the long-term use influence of these substances on these variables, especially in ritualistic contexts.  To verify the influence of ritualistic ayahuasca consumption on the cognition of experienced ayahuasca religious users (> 20 years) and beginners (< 3 years), which participated in rituals of the Centro Luz Divina (CLD), a Santo Daime church in Brazil...
May 23, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38775817/facial-emotion-recognition-function-and-white-matter-microstructural-alterations-in-drug-naive-comorbidity-free-autism
#15
JOURNAL ARTICLE
Xing Su, Siuching Kat, Hui Wang, Zenghui Ma, Tingni Yin, Liyang Zhao, Shuchen Peng, Xiaoyun Gong, Qinyi Liu, Gangqiang Han, Xue Li, Yanqing Guo, Jing Liu
Individuals with autism spectrum disorder have deficits in facial emotion recognition and white matter microstructural alterations. Nonetheless, most previous studies were confounded by different variables, such as psychiatric comorbidities and psychotropic medications used by ASD participants. Also, it remains unclear how exactly FER deficits are related to white matter microstructural alterations in ASD. Accordingly, we aimed to investigate the FER functions, white matter microstructure, and their relationship in drug-naive and comorbidity-free ASD individuals...
May 22, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38772940/oral-ketamine-effects-on-dynamics-of-functional-network-connectivity-in-patients-treated-for-chronic-suicidality
#16
JOURNAL ARTICLE
Zack Y Shan, Adem T Can, Abdalla Z Mohamed, Megan Dutton, Daniel F Hermens, Vince D Calhoun, Leanne M Williams, Maxwell Bennett, Jim Lagopoulos
The underlying brain mechanisms of ketamine in treating chronic suicidality and the characteristics of patients who will benefit from ketamine treatment remain unclear. To address these gaps, we investigated temporal variations of brain functional synchronisation in patients with suicidality treated with ketamine in a 6-week open-label oral ketamine trial. The trial's primary endpoint was the Beck Scale for Suicide Ideation (BSS). Patients who experienced greater than 50% improvement in BSS scores or had a BSS score less than 6 at the post-treatment and follow-up (10 weeks) visits were considered responders and persistent responders, respectively...
May 21, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38771330/applying-machine-learning-to-international-drug-monitoring-classifying-cannabis-resin-collected-in-europe-using-cannabinoid-concentrations
#17
JOURNAL ARTICLE
Tom P Freeman, Edward Beeching, Sam Craft, Marta Di Forti, Giampietro Frison, Christian Lindholst, Pieter E Oomen, David Potter, Sander Rigter, Kristine Rømer Thomsen, Luca Zamengo, Andrew Cunningham, Teodora Groshkova, Roumen Sedefov
In Europe, concentrations of ∆9 -tetrahydrocannabinol (THC) in cannabis resin (also known as hash) have risen markedly in the past decade, potentially increasing risks of mental health disorders. Current approaches to international drug monitoring cannot distinguish between different types of cannabis resin which may have contrasting health effects due to THC and cannabidiol (CBD) content. Here, we compared concentrations of THC and CBD in different types of cannabis resin collected in Europe (either Moroccan-type, or Dutch-type)...
May 21, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38767715/assessing-the-joint-effects-of-mitochondrial-genes-and-physical-activity-on-the-psychiatric-phenotype-of-subjective-well-being-based-on-the-uk-biobank-data
#18
JOURNAL ARTICLE
Panxing Shi, Bingyi Wang, Sirong Shi, Xiaoge Chu, Chen Liu, Meijuan Kang, Jingni Hui, Yifan Gou, Ruixue Zhou, Ye Liu, Yumeng Jia, Feng Zhang, Yan Wen
Subjective well-being (SWB) is an important measure for mental health status. Previous research has shown that physical activity can affect an individual's well-being, yet the underlying molecular mechanism remains to be clarified. In this study, we aim to evaluate the potential interactions between mitochondrial genes and physical activity (PA) as well as their combined effects on individual well-being. SWB phenotype data in UK Biobank were enrolled for this study including nine aspects such as work/job satisfaction, health satisfaction, family relationship satisfaction, friendships satisfaction, financial situation satisfaction, ever depressed for a whole week, general happiness, general happiness with own health and belief that own life is meaningful...
May 20, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38753192/correction-the-association-between-childhood-trauma-and-tobacco-smoking-in-patients-with-psychosis-unaffected-siblings-and-healthy-controls
#19
Justine de With, Heleen S van der Heijden, Therese van Amelsvoort, Maud Daemen, Claudia Simons, Behrooz Alizadeh, Daphne van Aalst, Lieuwe de Haan, Jentien Vermeulen, Frederike Schirmbeck
No abstract text is available yet for this article.
May 16, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38753191/glutamate-imbalance-in-key-structure-of-the-default-mode-network-in-adults-with-attention-deficit-hyperactivity-disorder
#20
JOURNAL ARTICLE
Marcos Vinícius Vidor, Eduardo Schneider Vitola, Cibele Edom Bandeira, Alexandre Ribeiro Martins, Maria Eduarda de Araujo Tavares, Renata Basso Cupertino, Alana Castro Panzenhagen, Bruna Santos da Silva, Isabel Ghirardi Falkenberg, Pedro Olavo Barreto, Stefania Pigatto Teche, Felipe Almeida Picon, Luis Augusto Rohde, Diego L Rovaris, Claiton Henrique Dotto Bau, Eugenio Horacio Grevet
The default mode network (DMN) is atypically active in patients with ADHD, likely contributing to the inattention patterns observed in patients with the disorder. Nonetheless, magnetic resonance spectroscopy (MRS) studies have rarely targeted the posterior cingulate cortex, a key DMN region, and little is known about the biochemical setting within this network in patients with ADHD. We aimed to assess the differences in metabolite profiles of the posterior cingulate cortex-a key region of the DMN-between patients with ADHD and controls...
May 16, 2024: European Archives of Psychiatry and Clinical Neuroscience
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