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Journals European Archives of Psychiatr...

European Archives of Psychiatry and Clinical Neuroscience

https://read.qxmd.com/read/38536473/interaction-between-baseline-bmi-and-baseline-disease-severity-predicts-greater-improvement-in-negative-symptoms-in-first-episode-schizophrenia
#1
JOURNAL ARTICLE
Xiaobing Sun, Ruiqing He, Yuan Xiao, Meihong Xiu, Maodi Sun, Fengchun Wu, Xiang Yang Zhang
Several studies have reported that baseline symptom severity in patients with schizophrenia (SCZ) is associated with the efficacy of antipsychotic medication. Overweight/obesity is common in SCZ and has also been reported to be correlated with therapeutic response to antipsychotics. This study aimed to evaluate whether baseline body mass index (BMI) and disease severity were associated with improvements in negative symptoms in patients with first-episode and medication-naïve (FEMN) SCZ. A total of 241 FEMN patients were recruited in this study and treated with oral risperidone over 3 months...
March 27, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38530443/childhood-abuse-and-craving-in-methamphetamine-dependent-individuals-the-mediating-role-of-alexithymia
#2
JOURNAL ARTICLE
Jiajing Chen, Dong Mei Wang, Yang Tian, Rongrong Zhu, Yuqing Li, Lianglun Jia, Fabing Fu, Shanshan Tang, Xiaotao Wang, Li Wang, Xiang Yang Zhang
Individuals with a history of childhood abuse (CA, including neglect and abuse by caregivers before the age of 18 years) have more severe substance dependence problems than those without a history of childhood abuse. However, whether a history of CA exacerbates craving and the mechanism of this effect remain largely unknown. The aim of this study was to explore the role of alexithymia in the effects of CA on craving in a large sample of methamphetamine-dependent individuals based on latent vulnerability theory...
March 26, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38519738/from-pathogenesis-of-stress-related-mental-disorders-to-treatment-beyond-the-brain
#3
EDITORIAL
Xiaoxing Liu, Lin Lu
No abstract text is available yet for this article.
March 22, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38509230/deciphering-the-interplay-between-psychopathological-symptoms-sensorimotor-cognitive-and-global-functioning-a-transdiagnostic-network-analysis
#4
JOURNAL ARTICLE
Stefan Fritze, Geva A Brandt, Sebastian Volkmer, Jonas Daub, Maria Krayem, Jacqueline Kukovic, Emanuel Schwarz, Urs Braun, Georg Northoff, Robert Christian Wolf, Katharina M Kubera, Andreas Meyer-Lindenberg, Dusan Hirjak
BACKGROUND: Understanding the relationship between psychopathology and major domains of human neurobehavioral functioning may identify new transdiagnostic treatment targets. However, studies examining the interrelationship between psychopathological symptoms, sensorimotor, cognitive, and global functioning in a transdiagnostic sample are lacking. We hypothesized a close relationship between sensorimotor and cognitive functioning in a transdiagnostic patient sample. METHODS: We applied network analysis and community detection methods to examine the interplay and centrality [expected influence (EI) and strength] between psychopathological symptoms, sensorimotor, cognitive, and global functioning in a transdiagnostic sample consisting of 174 schizophrenia spectrum (SSD) and 38 mood disorder (MOD) patients...
March 20, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38502208/endocannabinoid-system-alterations-in-schizophrenia-association-with-cannabis-use-and-antipsychotic-medication
#5
JOURNAL ARTICLE
Natalia Mansur Haddad, Leonardo Peroni De Jesus, Mauricio Serpa, Martinus Van De Bilt, Leda Talib, Alana Costa, Wagner Gattaz, Alexandre Andrade Loch
Determining peripheral modulation of the endocannabinoid system (ECS) may be important for differentiating individuals with schizophrenia. Such differentiation can also be extended to subgroups of individuals, those who use cannabis and antipsychotic medications, particularly those who are treatment resistant. Patients and controls were recruited from the outpatient clinic of the Psychosis Group of the University of São Paulo, Brazil. A final sample of 93 individuals was divided into 3 groups: patients with schizophrenia using clozapine (treatment-resistant) (n = 29), patients with schizophrenia using another antipsychotic (n = 31), and controls (n = 33)...
March 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38502207/post-covid-breathlessness-a-mathematical-model-of-respiratory-processing-in-the-brain
#6
JOURNAL ARTICLE
Dina von Werder, Franziska Regnath, Daniel Schäfer, Rudolf Jörres, Nadine Lehnen, Stefan Glasauer
Breathlessness is among the most common post-COVID symptoms. In a considerable number of patients, severe breathlessness cannot be explained by peripheral organ impairment. Recent concepts have described how such persistent breathlessness could arise from dysfunctional processing of respiratory information in the brain. In this paper, we present a first quantitative and testable mathematical model of how processing of respiratory-related signals could lead to breathlessness perception. The model is based on recent theories that the brain holds an adaptive and dynamic internal representation of a respiratory state that is based on previous experiences and comprises gas exchange between environment, lung and tissue cells...
March 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38502206/does-cannabis-use-substitute-for-opioids-a-preliminary-exploratory-survey-in-opioid-maintenance-patients
#7
JOURNAL ARTICLE
Nina Kim Bekier, Ulrich Frischknecht, Katharina Eidenmueller, Franz Grimm, Patrick Bach, Manuel Stenger, Falk Kiefer, Derik Hermann
Various studies showed that people with substance use disorder use cannabis to reduce withdrawal or dose of their main drug. Using a questionnaire about their cannabis use, 118 participants in an opioid maintenance treatment (OMT) in Germany were examined regarding this strategy. 60% reported to use cannabis. Of those, 72% were using cannabis in the suggested way. Cannabis was used to substitute for, e.g., heroin (44.8%) and benzodiazepines (16.4%). We also asked for an estimation of how good cannabis was able to substitute for several substances (in German school grades (1 till 6)); heroin average grade: 2...
March 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38502205/cannabis-use-health-problems-and-criminal-offences-in-germany-national-and-state-level-trends-between-2009-and-2021
#8
JOURNAL ARTICLE
Jakob Manthey, Sinja Klinger, Moritz Rosenkranz, Larissa Schwarzkopf
The German federal government plans to decriminalise cannabis. The impact of this policy on use prevalence, cannabis-related health and legal problems cannot be fully anticipated and should be viewed in context with current trends. We used routine data on (a) cannabis use (population-based surveys), (b) cannabis-related diagnoses (ICD-10 code F12) in outpatient medical settings and (c) minor law offences (registered violations against the narcotics law for possessing small amounts) to analyse age and sex-specific trends by federal state between 2009 and 2021...
March 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38502204/the-impact-of-aerobic-endurance-training-on-cognitive-performance-in-schizophrenic-inpatients-in-a-clinical-routine-setting
#9
JOURNAL ARTICLE
Elisa Semler, Florian Herpich, Leonhard Zellner, Sarah Zwick, Peter Zwanzger, Alexander Brunnauer
The primary aim of this study was to investigate the impact of aerobic endurance training in schizophrenic inpatients on cognitive performance in a clinical routine setting. Of secondary interest was the influence on psychopathological symptoms. A total of 31 schizophrenic inpatients were randomly assigned to receive either controlled endurance training or occupational therapy. The experimental group underwent endurance training of 20-30 min each, 3 times per week for a total of up to 22 training sessions...
March 19, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38499795/evolution-of-the-profiles-of-new-psychotropic-drug-users-before-and-during-the-covid-19-crisis-an-original-longitudinal-approach-through-multichannel-sequence-analysis-using-the-french-health-care-database
#10
JOURNAL ARTICLE
Marion Istvan, Mélanie Duval, Karl Hodel, Aurélie Aquizerate, Anicet Chaslerie, Pascal Artarit, Edouard-Jules Laforgue, Caroline Victorri-Vigneau
The COVID-19 pandemic has had a substantial impact on mental health. An increase in the use of anxiolytic, hypnotic, and antidepressant drugs has been highlighted in France, but with no information at the individual level (trajectories) or concerning patient characteristics. The objective of this study was to describe the profile of new psychotropic drug users since the beginning of the pandemic. We formed two historical cohorts using the Pays-de-la-Loire regional component of the National Health Data System (SNDS): a "COVID-19 crisis cohort" (2020-2021) and a "control cohort" (2018-2019)...
March 18, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38493284/predictors-of-effective-therapy-among-individuals-with-cannabis-use-disorder-a-review-of-the-literature
#11
JOURNAL ARTICLE
Daniel Feingold, Dana Tzur Bitan, Marica Ferri, Eva Hoch
Treatment demand for Cannabis Use Disorder (CUD) has increased in the past decade in almost all European countries, and CUD is currently the most common reason for first-time drug-related treatment admission in the European Union. Even though several therapeutic approaches have been shown to benefit individuals with CUD, there is a lack of knowledge regarding factors associated with effective therapy and the underlying mechanisms of change among individuals with CUD presenting for treatment. The aim of the present paper was to review current knowledge on factors that have been shown to contribute to positive outcomes in CUD treatment...
March 16, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38492052/proinflammatory-cytokine-levels-cognitive-function-and-suicidal-symptoms-of-adolescents-and-young-adults-with-major-depressive-disorder
#12
JOURNAL ARTICLE
Mu-Hong Chen, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Shih-Jen Tsai
Whether proinflammatory cytokine dysregulation and cognitive dysfunction are associated with suicidal symptoms in adolescents and young adults with major depressive disorder (MDD) remains uncertain. We assessed the cognitive function and proinflammatory cytokine levels of 43 and 51 patients aged 15-29 years with MDD and severe and mild suicidal symptoms, respectively, as well as those of 85 age- and sex-matched healthy controls. Specifically, we measured serum levels of C-reactive protein, tumor necrosis factor-α (TNF-α), interleukin-2, and interleukin-6 and assessed cognitive function by using working memory and go/no-go tasks...
March 16, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38492051/association-between-psychiatric-admissions-in-patients-with-schizophrenia-and-il-6-plasma-levels-polygenic-score
#13
JOURNAL ARTICLE
Fernando Facal, Manuel Arrojo, Mario Páramo, Javier Costas
Schizophrenia diagnosis and admission history were associated with a polygenic score (PGS) for schizophrenia based on a subset of variants that act by modifying the expression of genes whose expression is also modified by antipsychotics. This gene set was enriched in cytokine production. Interleukin-6 (IL-6) is the only cytokine whose plasma levels were associated both with schizophrenia diagnosis and with acute decompensations in the largest meta-analysis. Therefore, we hypothesized that an IL-6 PGS, but not other cytokines PGSs, would be associated with schizophrenia chronicity/psychiatric admissions...
March 16, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38489067/cannabis-use-and-cannabis-use-disorders-and-their-treatment-in-the-europe
#14
JOURNAL ARTICLE
Wayne Hall, Jakob Manthey, Daniel Stjepanović
This paper introduces the special issue on cannabis use in Europe. It describes data on the prevalence of cannabis use in Europe and the more limited data on the prevalence of cannabis use disorders, one of the most common forms of drug problem treated in many countries in Europe. It summarises what research has indicated about the adverse effects of acute and chronic cannabis use and discusses potential health system responses that may reduce some of these harms. These include public education about the risks of cannabis use; screening and brief interventions in primary medical settings; and specialist treatment for cannabis use disorders...
March 15, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38485814/prevalence-and-associated-factors-of-obesity-in-patients-with-major-depressive-disorder-at-different-ages-of-onset
#15
JOURNAL ARTICLE
Xiaoen Liu, Xue Tian, Lina Wang, Xiangyang Zhang
Major depressive disorder (MDD) and obesity are two serious public health problems. Although there have been some research on both, there have few studies on differences in obesity among MDD patients at different ages of onset. The study aims to evaluate the prevalence and factors associated with obesity in MDD patients at different ages of onset. This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60 years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18-45 years) and mid-adulthood onset (MAO, 45-60 years)...
March 15, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38483682/the-curious-absence-of-psychosis-in-grin1-related-neurodevelopmental-disorder
#16
LETTER
Mark A Colijn, Robert M Stowe
No abstract text is available yet for this article.
March 14, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38478156/the-impact-of-the-covid-19-pandemic-on-perceptions-of-social-relationships-negative-affect-and-paranoid-ideation
#17
JOURNAL ARTICLE
Ryan D Orth, Christina L G Savage, Melanie E Bennett, Jack J Blanchard
The COVID-19 pandemic contributed to worsening mental health across the globe. The pandemic may have been especially impactful on those experiencing heightened psychosis spectrum symptomatology given greater pre-pandemic social isolation and increased vulnerability to stress. Yet, few studies exploring the impact of the COVID-19 pandemic on perceptions of social relationships and mental health have sampled individuals high in psychosis spectrum symptomatology, including those with psychosis spectrum disorders...
March 13, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38478155/association-of-empathy-with-clinical-symptoms-and-cognitive-function-in-chronic-schizophrenia-patients-with-and-without-suicide-attempts
#18
JOURNAL ARTICLE
Zheng Ma, Yang Tian, Jiaxin Li, Junyao Liu, Dong-Mei Wang, Xiang-Yang Zhang
Cognitive impairment is recognized as a risk factor for suicide in schizophrenia (SZ) patients. Despite empathy being an important aspect of social cognition, the association between suicidal behavior and empathy has received little attention. We aimed to compare empathy and neurocognition in SZ patients with and without suicide attempts (SAs), and to explore the relationship between empathy, neurocognition, and clinical symptoms in SZ patients with and without SAs. Data on SAs and socio-demographic characteristics were collected from 628 chronic SZ patients...
March 13, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38472469/borderline-personality-disorder-vs-schizophrenia-spectrum-disorders-in-young-people-recruited-within-an-early-intervention-in-psychosis-service-clinical-and-outcome-comparisons
#19
JOURNAL ARTICLE
Lorenzo Pelizza, Emanuela Leuci, Emanuela Quattrone, Silvia Azzali, Giuseppina Paulillo, Simona Pupo, Pietro Pellegrini, Lorenzo Gammino, Arianna Biancalani, Marco Menchetti
Borderline Personality Disorder (BPD) is under-recognized in First-Episode Psychosis (FEP) and its psychotic manifestations are difficult to differentiate from Schizophrenia Spectrum Disorders (SSD). The aim of this investigation was to compare clinical, sociodemographic, and outcome characteristics between FEP patients with BPD vs. FEP subjects with SSD both at baseline and across a 2-year follow-up period. Participants completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome Scale (PANSS), and the Global Assessment of Functioning (GAF) scale both at entry and every 12 months during the follow-up...
March 12, 2024: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/38470538/correlative-relationship-between-body-mass-index-and-heart-rate-variability-in-psychiatric-disorders
#20
JOURNAL ARTICLE
WenZheng Wang, LinLin Zhou, Qiang Hu, YuQing Gao, YanYan Wei, XiaoChen Tang, YeGang Hu, LiHua Xu, HaiChun Liu, ZiXuan Wang, Tao Chen, ChunBo Li, HaiSu Wu, JiJun Wang, TianHong Zhang
Indicators of heart rate variability (HRV) have been used to assess the autonomic activity. However, the influence of obesity on HRV in these patients remains to be determined. This study aimed to examine how obesity (measured with the body mass index [BMI]) affects HRV and determine whether the effect varies among different psychiatric disorders. We recruited 3159 consecutive patients, including 1744 with schizophrenia, 966 with mood disorders, and 449 with anxiety disorders. Patients were divided into four groups based on BMI: underweight (< 18...
March 12, 2024: European Archives of Psychiatry and Clinical Neuroscience
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