Journals European Archives of Psychiatr...

European Archives of Psychiatry and Clinical Neuroscience
Eva Gussmann, Christoph Lindner, Susanne Lucae, Peter Falkai, Frank Padberg, Samy Egli, Johannes Kopf-Beck
Emerging evidence suggests the usefulness of psychological interventions targeting metacognitive change mechanisms in patients experiencing psychosis. Although many of these patients are treated in acute psychiatric contexts, only few studies have adapted such interventions for acute inpatient settings. The present study aimed to assess the feasibility, acceptability, and preliminary clinical outcomes of a novel modularized group intervention focusing on different aspects of metacognitive change mechanisms...
September 23, 2023: European Archives of Psychiatry and Clinical Neuroscience
Jianfei Zeng, Weizhi Zhang, Xiaobing Lu, Hui Zhou, Jing Huang, Zhenyu Xu, Hairong Liao, Jiaquan Liang, Meihong Liang, Chan Ye, Ting Sun, Yutong Hu, Qi She, Haixia Chen, Qian Guo, LiuJiao Yan, Renrong Wu, Zezhi Li
OBJECTIVES: Emerging evidence indicates a connection between oxidative stress, immune-inflammatory processes, and the negative symptoms of schizophrenia. In addition to possessing potent antioxidant and anti-inflammatory properties, sulforaphane (SFN) has shown promise in enhancing cognitive function among individuals with schizophrenia. This study aims to investigate the efficacy of combined treatment with SFN in patients with schizophrenia who experience negative symptoms and its effect on the levels of superoxide dismutase (SOD) and the inflammatory marker, high-sensitivity C-reactive protein (HsCRP)...
September 20, 2023: European Archives of Psychiatry and Clinical Neuroscience
Olof Lindberg, Felicia Ahlner, Theofanis Tsevis, Joana B Pereira, Eric Westman, Ingmar Skoog, Lars-Olof Wahlund
Brain gray- and white matter changes is well described in alcohol-dependent elderly subjects; however, the effect of lower levels of alcohol consumption on the brain is poorly understood. We investigated the impact of different amounts of weekly alcohol consumption on brain structure in a population-based sample of 70-year-olds living in Gothenburg, Sweden. Cross-sectional data from 676 participants from The Gothenburg H70 Birth Cohort Study 2014-16 were included. Current alcohol consumers were divided into seven groups based on self-reported weekly amounts of alcohol consumption in grams (g) (0-50 g/week, used as reference group, 51-100 g/week, 101-150 g/week, 151-200 g/week, 201-250 g/week, 251-300 g/week, and > 300 g/week)...
September 19, 2023: European Archives of Psychiatry and Clinical Neuroscience
Julian Wenzel, Nils Dreschke, Esther Hanssen, Marlene Rosen, Andrej Ilankovic, Joseph Kambeitz, Anne-Kathrin Fett, Lana Kambeitz-Ilankovic
Ecological momentary assessment (EMA), a structured diary assessment technique, has shown feasibility to capture psychotic(-like) symptoms across different study groups. We investigated whether EMA combined with unsupervised machine learning can distinguish groups on the continuum of genetic risk toward psychotic illness and identify individuals with need for extended healthcare. Individuals with psychotic disorder (PD, N = 55), healthy individuals (HC, N = 25) and HC with first-degree relatives with psychosis (RE, N = 20) were assessed at two sites over 7 days using EMA...
September 16, 2023: European Archives of Psychiatry and Clinical Neuroscience
Yonas Tesfaye, Bezaye Alemu, Matiwos Soboka, Shimelis Girma, Matthias A Reinhard, Stefanie Rek, Kristina Adorjan, Ana Zhelyazkova, Frank Padberg, Andrea Jobst, Mubarek Abera
The COVID-19 pandemic presents an unprecedented challenge to community wellbeing and mental health. However, quantifiable information on the extent of mental health problems and associated factors due to the pandemic is still lacking in low-income countries. Thus, this study aimed to investigate the levels of depression, anxiety, and stress and their association with risk and resilience factors among residents of Jimma town in Southwestern Ethiopia. A community-based cross-sectional study was conducted between October 2021 and November 2021...
September 15, 2023: European Archives of Psychiatry and Clinical Neuroscience
Milenko Kujovic, Daniel Benz, Mathias Riesbeck, Christian Bahr, Christian Kriegs, Dirk Reinermann, Michaela Jänner, Susanne Neufang, Zsofia Margittai, Daniel Kamp, Christian Plewnia, Eva Meisenzahl
Specialized psychotherapeutic treatments like dialectical behavioral therapy (DBT) are recommended as first treatment for borderline personality disorder (BPD). In recent years, studies have emerged that focus on repetitive transcranial magnetic stimulation (rTMS) in BPD. Both have independently demonstrated efficacy in the treatment of BPD. Intermitted theta burst stimulation (iTBS), a modified design of rTMS, is thought to increase the excitability of neurons and could be a supplement to psychotherapy in addition to being a standalone treatment...
September 15, 2023: European Archives of Psychiatry and Clinical Neuroscience
Leonard P Wenger, Oliver Hamm, Christiane Mühle, Sabine Hoffmann, Iris Reinhard, Patrick Bach, Johannes Kornhuber, Georg W Alpers, Falk Kiefer, Tagrid Leménager, Bernd Lenz
BACKGROUND: Alcohol consumption to facilitate social interaction is an important drinking motive. Here, we tested whether alcohol influences trust in others via modulation of oxytocin and/or androgens. We also aimed at confirming previously shown alcohol effects on positive affect and risk-taking, because of their role in facilitating social interaction. METHODS: This randomized, controlled, within-subject, parallel group, alcohol-challenge experiment investigated the effects of alcohol (versus water, both mixed with orange juice) on perceived trustworthiness via salivary oxytocin (primary and secondary endpoint) as well as testosterone, dihydrotestosterone, positive affect, and risk-taking (additional endpoints)...
September 14, 2023: European Archives of Psychiatry and Clinical Neuroscience
Nina Biačková, Andrea Adamová, Monika Klírová
Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation method that, through its manipulation of endogenous oscillations, can affect cognition in healthy adults. Given the fact that both endogenous oscillations and cognition are impaired in various psychiatric diagnoses, tACS might represent a suitable intervention. We conducted a search of Pubmed and Web of Science databases and reviewed 27 studies where tACS is used in psychiatric diagnoses and cognition change is evaluated...
September 8, 2023: European Archives of Psychiatry and Clinical Neuroscience
Lucie Venet-Kelma, Yannick Morvan, Ahmed Jérôme Romain, Mauricette Mendy, Marjorie Meslier, Isabelle Thoisy, Emmanuel Mulin, Marion Chirio-Espitalier, Ghita Dadi, Mona Moualla, Isabelle Amado, Laurence Kern
Physical activity (PA) is recommended to optimize well-functioning in people with schizophrenia. PA has been found to improve quality of life, general symptomatology, depression, anxiety and stress symptoms, global and social functioning. In PA research, most of the interventions are based on one-on-one interventions but there is poor information about group-based PA interventions. Using a randomized controlled, clinician-blinded trial, subjects are randomized into two arms: the PA group or control group. Our first objective is about to evaluate the effects of a multimodal 6 week collective PA intervention on depression, anxiety, and stress symptoms in people with schizophrenia...
September 5, 2023: European Archives of Psychiatry and Clinical Neuroscience
Simona Leserri, Alba Segura-Amil, Andreas Nowacki, Ines Debove, Katrin Petermann, Lea Schäppi, Maria Giulia Preti, Dimitri Van De Ville, Claudio Pollo, Sebastian Walther, T A Khoa Nguyen
Treatment-resistant depression is a severe form of major depressive disorder and deep brain stimulation is currently an investigational treatment. The stimulation's therapeutic effect may be explained through the functional and structural connectivities between the stimulated area and other brain regions, or to depression-associated networks. In this longitudinal, retrospective study, four female patients with treatment-resistant depression were implanted for stimulation in the nucleus accumbens area at our center...
September 5, 2023: European Archives of Psychiatry and Clinical Neuroscience
M Luciano, G Sampogna, E D'Ambrosio, A Rampino, M Amore, P Calcagno, A Rossi, R Rossi, C Carmassi, L Dell'Osso, E Bianciardi, A Siracusano, Bianca Della Rocca, M Di Vincenzo, A Fiorillo
This multicentric randomized controlled trial (RCT), carried out in six Italian University mental health sites, aims to test the efficacy of a six-month psychosocial intervention (LYFESTYLE) on Body Mass Index (BMI), body weight, waist circumference, fasting glucose, triglycerides, cholesterol, Framingham and HOmeostasis Model Assessment of insulin resistance (HOMA-IR) indexes in patients with schizophrenia, bipolar disorder, and major depression. Moreover, the efficacy of the intervention has also been tested on several other physical and mental health domains...
September 4, 2023: European Archives of Psychiatry and Clinical Neuroscience
Joshua Levine, Leo Sher
No abstract text is available yet for this article.
September 2, 2023: European Archives of Psychiatry and Clinical Neuroscience
Matthias Besse, Michael Belz, Claudia Bartels, Bettina Herzig, Jens Wiltfang, David Zilles-Wegner
Electroconvulsive therapy (ECT) is an effective, safe, and mostly well-tolerated treatment for patients with severe or difficult to treat depression or psychotic disorders. However, a relevant number of patients experience subjective and/or objective cognitive side-effects. The mechanism of these transient deficits is not yet clear. Thus, our study prospectively investigated neurofilament light chain (NfL) concentrations as a highly sensitive biomarker for neuroaxonal damage along with cognitive performance during a course of ECT...
September 1, 2023: European Archives of Psychiatry and Clinical Neuroscience
Burcu Ersoy, Marie-Louise Herzog, Wen Pan, Simone Schilling, Matthias Endres, Ria Göttert, Golo D Kronenberg, Karen Gertz
Proregenerative and neuroprotective effects of antidepressants are an important topic of inquiry in neuropsychiatric research. Oxygen-glucose deprivation (OGD) mimics key aspects of ischemic injury in vitro. Here, we studied the effects of 24-h pretreatment with serotonin (5-HT), citalopram (CIT), fluoxetine (FLU), and tianeptine (TIA) on primary mouse cortical neurons subjected to transient OGD. 5-HT (50 μM) significantly enhanced neuron viability as measured by MTT assay and reduced cell death and LDH release...
September 1, 2023: European Archives of Psychiatry and Clinical Neuroscience
Eugenia Kulakova, Livia Graumann, An Bin Cho, Christian Eric Deuter, Oliver T Wolf, Stefan Roepke, Christian Otte, Katja Wingenfeld
Stressful social situations like social exclusion are particularly challenging for patients with borderline personality disorder (BPD) and often lead to dysfunctional reactive behaviour of aggression and withdrawal. The autonomous signature of these core symptoms of BPD remains poorly understood. The present study investigated the parasympathetic response to social exclusion in women with BPD (n = 62) and healthy controls (HC; n = 87). In a between-subjects design, participants experienced objective social exclusion or overinclusion in the Cyberball task, a virtual ball-tossing game...
August 31, 2023: European Archives of Psychiatry and Clinical Neuroscience
Claudia Espinoza, Diana Martella
Post-COVID syndrome has been defined as signs and symptoms that develop after an infection consistent with COVID-19 and continue for more than 12 weeks, including neurocognitive signs and symptoms that have an impact on the functioning and quality of life of middle-aged adult and older survivors. This systematic review describes the current knowledge of long-term cognitive impairments in COVID-19 survivors, approaches strategies, and their impact on public and private health services worldwide. The systematic review was conducted under the criteria and flowchart established in the PRISMA statement, considering studies from the PubMed, Scopus, and Web of Science databases between 2020 and 2023...
August 30, 2023: European Archives of Psychiatry and Clinical Neuroscience
Arman Shafiee, Niloofar Seighali, Mohammad Teymouri Athar, Abolfazl King Abdollahi, Kyana Jafarabady, Mahmood Bakhtiyari
Many individuals have been suffering from consistent neurological and neuropsychiatric manifestations even after the remission of coronavirus disease (COVID-19). Brain-derived neurotrophic factor (BDNF) is a protein involved in the regulation of several processes, including neuroplasticity, neurogenesis, and neuronal differentiation, and has been linked to a range of neurological and psychiatric disorders. In this study, we aimed to synthesize the available evidence on the profile of BDNF in COVID-19. A comprehensive search was done in the Web of Science core collection, Scopus, and MEDLINE (PubMed), and Embase to identify relevant studies reporting the level of BDNF in patients with COVID-19 or those suffering from long COVID...
August 30, 2023: European Archives of Psychiatry and Clinical Neuroscience
Iven-Alex von Mücke-Heim, Julius C Pape, Norma C Grandi, Angelika Erhardt, Jan M Deussing, Elisabeth B Binder
Electroconvulsive therapy (ECT) is commonly used to treat treatment-resistant depression (TRD). However, our knowledge of the ECT-induced molecular mechanisms causing clinical improvement is limited. To address this issue, we developed the single-center, prospective observational DetECT study ("Multimodal Biomarkers of ECT in TRD"; registered 18/07/2022, , NCT05463562). Its objective is to identify molecular, psychological, socioeconomic, and clinical biomarkers of ECT response in TRD...
August 30, 2023: European Archives of Psychiatry and Clinical Neuroscience
Massimiliano Ruggeri, Monica Ricci, Michela Pagliaro, Carmela Gerace
Recovered COVID-19 patients frequently suffer of cognitive disorders. Several etiopathogenetic mechanisms have been considered for the brain complications in COVID-19 but results are uncertain. Amongst them, an olfactory route to SARS-CoV-2 brain infection might explain cognitive and memory disturbances in post-COVID-19 patients, given the cooccurrence of anosmia and possible underlying limbic involvement. The aims of the study are to investigate cognition of patients with post-COVID-19 syndrome, and to find clinical factors predicting cognitive and memory impairments...
August 30, 2023: European Archives of Psychiatry and Clinical Neuroscience
Lara E Marten, Aditya Singh, Anna M Muellen, Sören M Noack, Vladislav Kozyrev, Renate Schweizer, Roberto Goya-Maldonado
Although implicated in unsuccessful treatment, psychomotor deficits and their neurobiological underpinnings in bipolar (BD) and unipolar (UD) depression remain poorly investigated. Here, we hypothesized that motor performance deficits in depressed patients would relate to basal functional coupling of the hand primary motor cortex (M1) and the posterior cingulate cortex (PCC) with the supplementary motor area (SMA). We performed a longitudinal, naturalistic study in BD, UD and matched healthy controls comprising of two resting-state functional MRI measurements five weeks apart and accompanying assessments of motor performance using a finger tapping task (FTT)...
August 28, 2023: European Archives of Psychiatry and Clinical Neuroscience
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