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European Archives of Psychiatry and Clinical Neuroscience

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https://read.qxmd.com/read/30976917/stx1a-gene-variations-contribute-to-the-susceptibility-of-children-attention-deficit-hyperactivity-disorder-a-case-control-association-study
#1
Min Wang, Xue Gu, Xin Huang, Qi Zhang, Xinzhen Chen, Jing Wu
It was presumed syntaxin-1A (STX1A) might relate to the pathophysiology of attention-deficit/hyperactivity disorder (ADHD), but the results were inconsistent. The present study aims to confirm whether the STX1A gene is involved in the susceptibility of children ADHD. We genotyped three single nucleotide polymorphisms (SNPs) of STX1A gene using Sequenom MassARRAY technology. A case-control study was performed among Chinese Han population including 754 cases and 772 controls from two different provinces. The Conners Parent Symptom Questionnaire and Integrated Visual and Auditory Continuous Performance Test were used to assess ADHD clinical symptoms...
April 11, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30976916/relationship-between-motor-function-and-psychotic-symptomatology-in-young-adult-patients-with-schizophrenia
#2
Shu-Mei Wang, Wen-Chen Ouyang, Ming-Yi Wu, Li-Chieh Kuo
Motor abnormalities have been indicated to be a core manifestation of schizophrenia and not just motor side-effects of antipsychotics. However, little is known about whether all of the complete motor function, including fine motor function, muscle strength, and balance is linked to psychotic symptoms. Therefore, this study was to investigate association between complete motor function and psychotic symptoms in young-adult schizophrenia patients who had no extrapyramidal motor symptoms, which were assessed using the Extrapyramidal Symptom Rating Scale...
April 11, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30963264/towards-an-improved-access-to-psychiatric-rehabilitation-availability-and-effectiveness-at-1-year-follow-up-of-psychoeducation-cognitive-remediation-therapy-cognitive-behaviour-therapy-and-social-skills-training-in-the-fondamental-advanced-centers-of-expertise
#3
Julien Dubreucq, B Ycart, F Gabayet, C C Perier, A Hamon, P M Llorca, L Boyer, O Godin, E Bulzacka, M Andrianarisoa, B Aouizerate, F Berna, L Brunel, D Capdevielle, I Chereau, T D'Amato, C Dubertret, C Faget, J Mallet, D Misdrahi, C Passerieux, R Rey, R Richieri, A Schandrin, F Schürhoff, M Urbach, P Vidailhet, E Giraud-Baro, G Fond
Psychosocial Interventions (PIs) have shown positive effects on clinical and functional outcomes of schizophrenia (SZ) in randomized controlled trials. However their effectiveness and accessibility remain unclear to date in "real world" schizophrenia. The objectives of the present study were (i) to assess the proportion of SZ outpatients who benefited from PIs between 2010 and 2015 in France after an Expert Center Intervention in a national multicentric non-selected community-dwelling sample; (ii) to assess PIs' effectiveness at 1-year follow-up...
April 8, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30953129/correction-to-how-effective-and-safe-is-medical-cannabis-as-a-treatment-of-mental-disorders-a-systematic-review
#4
Eva Hoch, Dominik Niemann, Rupert von Keller, Miriam Schneider, Chris M Friemel, Ulrich W Preuss, Alkomiet Hasan, Oliver Pogarell
The article "How effective and safe is medical cannabis as a treatment of mental disorders? A systematic review", written by Eva Hoch, was originally published Online First without open access. After publication in volume 269, issue 1, page 87-105 the author decided to opt for Open Choice and to make the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4...
April 5, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30953128/cortico-thalamic-dysconnection-in-early-stage-schizophrenia-a-functional-connectivity-magnetic-resonance-imaging-study
#5
Mu-Hong Chen, Wan-Chen Chang, Ya-Mei Bai, Kai-Lin Huang, Pei-Chi Tu, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Shih-Jen Tsai, Ju-Wei Hsu
Studies have indicated thalamus-related network dysfunction in schizophrenia and psychotic disorders. However, whether thalamus-related functional connectivity (FC) contributes to the psychopathology and cognitive deficits of early-stage schizophrenia requires further investigation. A total of 34 patients with early-stage schizophrenia (illness duration = 1.62 ± 1.16 years; age = 26.00 ± 6.34 years) and 34 age- and sex-matched healthy controls were enrolled in our study and underwent comprehensive assessments of the clinical symptoms of schizophrenia, working memory tasks, and resting-state FC magnetic resonance imaging...
April 5, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30937516/a-proteomic-signature-associated-to-atypical-antipsychotic-response-in-schizophrenia-patients-a-pilot-study
#6
Daniel Martins-de-Souza, Paul C Guest, Johann Steiner
A major hurdle faced by most schizophrenia patients is the poor efficacy of current antipsychotic medications. This stems from a poor understanding of the underlying pathophysiology and the lack of biomarkers for the prediction of a positive medication response. By employing state-of-the-art proteomic analysis of blood plasma from 58 patients who were either drug-naive or drug-free at the time of sample collection, we identified potential biomarkers that were predictive of a positive response after 6 weeks of treatment with antipsychotics...
April 1, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30937515/reduced-gray-matter-volume-in-the-left-prefrontal-occipital-and-temporal-regions-as-predictors-for-posttraumatic-stress-disorder-a-voxel-based-morphometric-study
#7
Jan Christopher Cwik, Nils Vahle, Marcella Lydia Woud, Denise Potthoff, Henrik Kessler, Gudrun Sartory, Rüdiger J Seitz
The concept of acute stress disorder (ASD) was introduced as a diagnostic entity to improve the identification of traumatized people who are likely to develop posttraumatic stress disorder (PTSD). Neuroanatomical models suggest that changes in the prefrontal cortex, amygdala, and hippocampus play a role in the development of PTSD. Using voxel-based morphometry, this study aimed to investigate the predictive power of gray matter volume (GMV) alterations for developing PTSD. The GMVs of ASD patients (n = 21) were compared to those of PTSD patients (n = 17) and healthy controls (n = 18) in whole-brain and region-of-interest analyses...
April 1, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30929061/longitudinal-multi-level-biomarker-analysis-of-bdnf-in-major-depression-and-bipolar-disorder
#8
Katrin Schröter, Murielle Brum, Nathalie Brunkhorst-Kanaan, Franziska Tole, Christiane Ziegler, Katharina Domschke, Andreas Reif, Sarah Kittel-Schneider
Preliminary evidence suggests that BDNF (brain derived neurotrophic factor) rs6265 genetic polymorphism, BDNF gene promotor methylation and BDNF serum levels might play an important role in the pathogenesis of affective disorders. As studies testing the BDNF system across molecular levels are sparse, this study aimed at investigating the BDNF val66met genotype, BDNF DNA methylation changes and peripheral BDNF serum levels in acute and remitted phases of MDD (major depressive disorder) and BD (bipolar disorder) and healthy controls...
March 30, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30929060/higher-bdnf-plasma-levels-are-associated-with-a-normalization-of-memory-dysfunctions-during-an-antidepressant-treatment
#9
Jan Engelmann, Stefanie Wagner, Daniel Wollschläger, Sabine Kaaden, Konrad F Schlicht, Nadine Dreimüller, Dieter F Braus, Marianne B Müller, Oliver Tüscher, Helge Frieling, André Tadić, Klaus Lieb
One important symptom of patients with major depressive disorder (MDD) is memory dysfunction. However, little is known about the relationship between memory performance and depression severity, about the course of memory performance during antidepressant treatment as well as about the relationship between memory performance and brain-derived neurotrophic factor (BDNF). Memory function [learning and delayed recall) was assessed in 173 MDD patients (mean age 39.7 ± 11.3 years] treated by a pre-defined treatment algorithm within the early medication change (EMC) study at baseline, days 28 and 56...
March 30, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30927076/the-limitations-associated-with-measuring-cannabis-dependence-a-response-to-budney-and-colleagues
#10
LETTER
Ian Hamilton
No abstract text is available yet for this article.
March 29, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30927075/lack-of-dopamine-d-1-receptors-in-the-antidepressant-actions-of-r-ketamine-in-a-chronic-social-defeat-stress-model
#11
Lijia Chang, Kai Zhang, Yaoyu Pu, Youge Qu, Si-Ming Wang, Zhongwei Xiong, Yukihiko Shirayama, Kenji Hashimoto
It is reported that dopamine D1 receptors in the medial prefrontal cortex play a role in the antidepressant actions of (R,S)-ketamine. However, its role in the antidepressant actions of (R)-ketamine, which is more potent than (S)-ketamine, is unknown. In the locomotion test, tail suspension test, forced swimming test and 1% sucrose preference test, pretreatment with dopamine D1 receptor antagonist SCH-23390 did not block the antidepressant effects of (R)-ketamine in the susceptible mice after chronic social defeat stress...
March 29, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30923939/association-of-tph1-and-serotonin-transporter-genotypes-with-treatment-response-for-suicidal-ideation-a-preliminary-study
#12
David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frueh
Variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (TPH1) rs1799913, serotonin transporter (SLC6A4) 5-HTTLPR, and serotonin receptor 2A (HTR2A) rs6311, were evaluated for association with suicidal ideation (SI) and with recovery from SI in a psychiatric inpatient population. Five hundred and eighty-two adult inpatients, including 390 patients who had SI, collected from December 2012 to April 2016 were assessed. SI recovery, calculated as change in SI between the first two-week period after admission and weeks 5 and 6, was appraised for association with the three variants...
March 28, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30923938/pharmacokinetic-correlates-of-venlafaxine-associated-adverse-reactions
#13
Georgios Schoretsanitis, Ekkehard Haen, Christoph Hiemke, Katharina Endres, Florian Ridders, Tanja Veselinovic, Gerhard Gründer, Michael Paulzen
To address the potential correlation between plasma concentrations of venlafaxine (VEN), its active metabolite O-desmethylvenlafaxine (ODVEN) and the active moiety, AM, (ODVEN + VEN) and adverse drug reactions (ADR) in a large naturalistic sample of in- and outpatients. We compared plasma concentrations of VEN, ODVEN and AM and dose-adjusted (C/D) levels as well the ODVEN/VEN ratios between patients complaining ADRs, following the Udvalg for Kliniske Undersogelser side effect rating scales (UKU) (n = 114) and patients without ADRs (control group, n = 688) out of a naturalistic database...
March 28, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30903270/the-neural-correlates-of-low-social-integration-as-a-risk-factor-for-suicide
#14
Ricardo Cáceda, G Andrew James, Zachary N Stowe, Pedro L Delgado, Nolan Kordsmeier, Clint D Kilts
Low social integration is commonly described in acutely suicidal individuals. Neural mechanisms underlying low social integration are poorly understood in depressed and suicidal patients. We sought to characterize the neural response to low social integration in acutely suicidal patients. Adult depressed patients within 3 days of a suicide attempt (n = 10), depressed patients with suicidal ideation (n = 9), non-suicidal depressed patients (n = 15), and healthy controls (N = 18) were administered the Cyberball Game while undergoing functional magnetic resonance imaging...
March 23, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30868216/using-interaction-based-phenotyping-to-assess-the-behavioral-and-neural-mechanisms-of-transdiagnostic-social-impairments-in-psychiatry
#15
EDITORIAL
Leonhard Schilbach
No abstract text is available yet for this article.
March 13, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30859295/ribosomal-dna-transcription-in-prefrontal-pyramidal-neurons-is-decreased-in-suicide
#16
Marta Krzyżanowska, Johann Steiner, Dorota Pieśniak, Karol Karnecki, Michał Kaliszan, Marek Wiergowski, Krzysztof Rębała, Ralf Brisch, Katharina Braun, Zbigniew Jankowski, Monika Kosmowska, Joanna Chociej, Tomasz Gos
Prefrontal cortical regions, which are crucial for the regulation of emotionally influenced behaviour, play most probably a dominant role in the pathogenesis of suicide. The study was carried out on paraffin-embedded brain tissue blocks containing specimens from the anterior cingulate cortex (dorsal and ventral parts), the orbitofrontal cortex, and the dorsolateral cortex obtained from 23 suicide completers (predominantly violent) with unknown psychiatric diagnosis and 25 non-suicidal controls. The transcriptional activity of ribosomal DNA (rDNA) as a surrogate marker of protein biosynthesis was evaluated separately in layers III and V pyramidal neurons in regions of interest (ROIs) mentioned above by the AgNOR silver staining method bilaterally...
March 11, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30847623/cortical-thickness-20-years-after-diagnosis-of-anorexia-nervosa-during-adolescence
#17
Josefina Castro-Fornieles, Elena de la Serna, Anna Calvo, José Pariente, Susana Andrés-Perpiña, Maria Teresa Plana, Sonia Romero, Itziar Flamarique, Miguel Gárriz, Núria Bargalló
OBJECTIVE: The objective of the present study is to evaluate cortical thickness (CT) abnormalities using FreeSurfer in adult subjects who had an onset of anorexia nervosa during their adolescence some 20 years previously, and to compare them with control subjects. METHODS: Fifty-four participants, including 26 women who were diagnosed and treated for AN during adolescence some 20 years previously and 28 healthy women of similar age and geographical area were assessed using structured interviews and MRI scans...
March 7, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30826974/a-randomized-controlled-trial-of-training-of-affect-recognition-tar-in-schizophrenia-shows-lasting-effects-for-theory-of-mind
#18
Anja Vaskinn, André Løvgren, Maj K Egeland, Frida K Feyer, Tiril Østefjells, Ole A Andreassen, Ingrid Melle, Kjetil Sundet
Schizophrenia is characterized by social cognitive impairments that predict functioning. Social cognitive training aims to target these impairments. Although it can improve the targeted social cognitive domain, it is unclear if the training generalizes to non-targeted domains and to functioning, with lasting effects. This randomized controlled trial examined the effect of a targeted facial affect recognition training program, Training of Affect Recognition (TAR), in persons with schizophrenia. Individuals with schizophrenia were randomized to receive treatment as usual and TAR (n = 24) or treatment as usual (n = 24) after assessments with a comprehensive protocol at baseline (T1)...
March 2, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30806772/altered-risky-decision-making-in-patients-with-early-non-affective-psychosis
#19
Luk Msk, Chang Wc, Chong Csy, Siu Cmw, Chan Skw, Lee Emh, Hui Clm, Sun Yn, Lee Tmc, Lo Tl, Chen Eyh
Abnormal risky decision making may represent an important factor contributing to functional impairment in psychotic disorders. Previous research revealed impaired decision making under risk in patients with chronic schizophrenia. However, risky decision making is under-studied in the early course of illness. We examined risky decision making in 33 patients with early non-affective psychosis and 32 demographically matched controls, using two well-validated experimental paradigms, balloon analogue risk task (BART) and Risky-Gains task (RGT), which modeled and assessed actual risk-taking behaviors in deliberative and time-pressured decision-making situations, respectively...
February 26, 2019: European Archives of Psychiatry and Clinical Neuroscience
https://read.qxmd.com/read/30806771/binding-varicella-zoster-virus-an-underestimated-facet-of-insulin-degrading-enzyme%C3%A2-s-implication-for-alzheimer%C3%A2-s-disease-pathology
#20
LETTER
Hans-Gert Bernstein, Gerburg Keilhoff, Henrik Dobrowolny, Johann Steiner
We shortly discuss a possible contribution of insulin-degrading enzyme to Alzheimer´s disease pathology by binding varicella zoster virus glycoprotein E, which increases the infectivity and cell-cell spread of the virus.
February 26, 2019: European Archives of Psychiatry and Clinical Neuroscience
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