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Journals Blood Coagulation & Fibrinolys...

Blood Coagulation & Fibrinolysis : An International Journal in Haemostasis and Thrombosis

https://read.qxmd.com/read/37942747/glanzmann-s-thrombasthenia-associated-with-gastrointestinal-angiodysplasias-successfully-treated-with-bevacizumab
#21
JOURNAL ARTICLE
Agustina Saladino, María L Gonzalez, Fernando A Chuliber, Marcelo M Serra
Glanzmann's Thrombasthenia (GT) is a rare hemorrhagic condition caused by a platelet surface receptor disorder of the glycoprotein (GP) IIb/IIIa. Symptoms of GT are various forms of hemorrhages, such as purpura, epistaxis and menorrhagia. Gastrointestinal bleeding (GIB) is a rare expression of the condition and may occur due to traumas in the GI tract or as a consequence of gastrointestinal angiodysplasia (GIADs). In this case report, we present a middle-aged woman with recurrent GIB consequent to GIADs with persistent melena and iron deficiency anemia...
December 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37942746/epidemiological-study-of-hereditary-hemorrhagic-disorders-in-najaf-province-iraq
#22
JOURNAL ARTICLE
Ezzate Hasson Ajeena, Ali Adil Saleem
Hemophilia and Von Willbrand disease (VWD) are the most well known types of hereditary hemorrhagic disorders (HHD). Hemophilia affects about 200 000 people worldwide, while VWD affects about 80 000. Because there is a scarcity of epidemiologic studies on hemophilia in Iraq, this study was carried out to evaluate the prevalence and incidence trends, as well as to identify some clinical and epidemiological features of hemophilia patients in Najaf province, Iraq. This study was carried out in the Najaf's hemophilia center...
December 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37942745/new-score-for-predicting-thromboembolic-events-in-patients-with-atrial-fibrillation-using-direct-oral-anticoagulants
#23
MULTICENTER STUDY
Fuxin Ma, Jiana Chen, Sijie Chang, Nianxu Huang, Wang Zhang, Hengfen Dai, Qiaowei Zheng, Ruijuan Li, Xiangsheng Lin, Yuxin Liu, Xiaoming Du, Jun Su, Xiaohong Huang, Xia Chen, Wei Hu, Xiumei Liu, Yanxia Zhang, Ping Gu, Jinhua Zhang
Determinants of thrombotic events remain uncertain in patients with atrial fibrillation treated with direct oral anticoagulants (DOACs). Our aim was to identify risk factors associated with thromboembolism in patients with at atrial fibrillation on DOACs and to construct and externally validate a predictive model that would provide a validated tool for clinical assessment of thromboembolism. In the development cohort, prediction model was built by logistic regression, the area under the curve (AUC), and Nomogram...
December 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37942744/combination-of-aspirin-and-rosuvastatin-for-reduction-of-venous-thromboembolism-in-severely-injured-patients-a-double-blind-placebo-controlled-pragmatic-randomized-phase-ii-clinical-trial-the-stat-trial
#24
RANDOMIZED CONTROLLED TRIAL
Christopher D Barrett, Hunter B Moore, Ernest E Moore, James Chandler, Angela Sauaia
INTRODUCTION: Venous thromboembolism (VTE) remains a significant source of postinjury morbidity and mortality. Beta-hydroxy beta-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (rosuvastatin) significantly reduced pathologic clotting events in healthy populations in a prior trial. Furthermore, acetylsalicylic acid (ASA) has been shown to be noninferior to prophylactic heparinoids for VTE prevention following orthopedic surgery. We hypothesized that a combination of rosuvastatin/ASA, in addition to standard VTE chemoprophylaxis, would reduce VTE in critically ill trauma patients...
December 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37756208/evaluation-of-acquired-and-hereditary-risk-factors-for-the-development-of-thromboembolism-in-patients-with-systemic-lupus-erythematosus
#25
JOURNAL ARTICLE
Vildan Gürsoy, Sevil Sadri, Selime Ermurat
Although the contribution of antiphospholipid antibodies (aPL) to thrombolembolism in systemic lupus erythematosus (SLE) is well known, there is not enough data on the contribution of various hereditary thrombophilic factors. In this study, we aimed to determine acquired and hereditary thrombophilic factors in adult patients with SLE. A total of 93 SLE patients (87 women and 6 men) were included. Data on clinical, demographic and laboratory characteristics, and disease activity scores (SLEDAI) of the patients were evaluated...
December 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/38051652/hereditary-coagulation-factor-xi-deficiency-a-rare-or-neglected-disease-results-from-a-retrospective-single-centre-cohort-in-northern-italy
#26
JOURNAL ARTICLE
Simone Canovi, Maria Cristina Leone, Luca Depietri, Maria Rosaria Veropalumbo, Annalisa Pilia, Maria Granito, Antonio Bonanno, Annamaria Casali, Rossana Colla, Angelo Ghirarduzzi
To examine real-life clinical data regarding hereditary factor XI (FXI) deficiency from a secondary care centre. Retrospective review of clinical records for every FXI:C 0.7 IU/ml or less reported from 2012 to 2020. Seventy-nine patients were included. Six (7.6%) had a severe deficiency (FXI:C <0.2 IU/ml). Only 55 (69.6%) patients were referred to the Haemostasis Centre. Among them, six (15%) were subsequently not identified at increased haemorrhagic risk before a surgical/obstetrical procedure...
November 30, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/38051662/commercial-human-frozen-plasmas-for-local-cross-site-and-long-term-comparability-of-coagulation-analysers
#27
JOURNAL ARTICLE
Amélie Launois, Sara Zia Chahabi, Floriane Devaux, Isabelle Amouroux, Claire Flaujac
Laboratory compliance implies to correlate instruments for coagulation parameter with a wide range of measure using patient samples or commercialized sets of frozen plasmas. The aim of this study was to evaluate the intra, inter-reproducibility and long-term stability of ExpertCor Routine (ECR) plasma sets (Stago) on different parameters. The study was realized in two laboratories on four different instruments. Inter-site and intra-site correlation of ECR sets for PT, aPTT, Fibrinogen, INR, factor V (FV) UFH and LMWH anti-Xa and intra-reproducibility of DDimer (DDI), factor VIII (FVIII:C) and antithrombin (AT) assays were tested...
November 27, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37994627/clot-waveform-analysis-in-acute-promyelocytic-leukemia
#28
JOURNAL ARTICLE
Malek Terras, Wijden El Borgi, Wafa Betbout, Rabeb Jaied, Fatma Ben Lakhal, Sarra Fekih Salem, Ons Ghali, Emna Gouider
The aim of this study was to evaluate the activated partial thromboplastin time (APTT) and prothrombin time (PT)-based clot waveform analysis (CWA) in patients diagnosed with acute promyelocytic leukemia (APL). APTT-based and PT-based CWA parameters of patients diagnosed with APL were analyzed and compared with healthy volunteers. Four APTT-CWA parameters were noted, maximum velocity corresponding to the first peak of the first derivative (max1), maximum acceleration corresponding to the first peak of the second derivative (max2) and the corresponding peak times of max1 and max2 (Tmax1, Tmax2)...
November 9, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37994630/utility-of-the-international-society-on-thrombosis-and-hemostasis-bleeding-assessment-tool-in-the-diagnosis-of-patients-who-suspected-of-platelet-function-disorders
#29
JOURNAL ARTICLE
Massoumeh Shahbazi, Minoo Ahmadinejad, Amir Teimourpour
The ISTH-BAT is a structured bleeding assessment tool to record and help diagnose patients with possible bleeding disorders. However, a few studies evaluated the utility of ISTH-BAT in diagnosing patients with platelet function defects (PFDs). In this study, we evaluated the diagnostic utility of ISTH-BAT in predicting PFDs among patients suspected of PFDs. Forty patients suspected of PFDs and 21 normal healthy controls were evaluated by the ISTH-BAT scoring system, light transmission aggregometry (LTA), ATP-releasing assays (lumi-aggregometry), and expression of CD62P for diagnosis of PFDs...
November 3, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37823437/assessment-of-coagulation-assays-on-roche-cobas-t711-analyzer-performance-and-clinical-implications
#30
JOURNAL ARTICLE
María Ordóñez-Robles, Oscar D Pons-Belda, María José Moína, Ángel Bernardo-Gutiérrez, Belén Prieto-García
OBJECTIVES: We performed an analytical assessment of five coagulation tests [i.e. prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, thrombin time (TT) and D-dimer] on the Roche Cobas t711 analyzer and a comparison study with the methodology in use at our laboratory (i.e. Werfen ACL Top 750 analyzer), expanding the analysis to the clinical implications of Cobas t711 implementation. METHODS: Imprecision studies were performed following the Clinical and Laboratory Standards Institute (CLSI) H57 A:2008 guideline...
October 12, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37823427/fibrinogen-a%C3%AE-gene-genotyping-in-patients-with-inherited-afibrinogenemia-deficiency-a-novel-mutation-in-iranian-afibrinogenemia-patients
#31
JOURNAL ARTICLE
Ali Moazzeni, Majid Naderi, Akbar Dorgalaleh, Shaban Alizadeh
BACKGROUND: Congenital fibrinogen deficiencies (CFD) are a group of rare bleeding disorders (RBD). Afibrinogenemia as a subclass of these disorders would occurs as a result of mutations in fibrinogen gene. Here in, the sequences of Aα chain of fibrinogen (FGA) in patients with inherited afibrinogenemia disorder in south-eastern of Iran were analysed. METHODS: The FGA gene exons were amplified using PCR method and the DNA sequences were analysed to study the mutations in Aα chain of Fibrinogen...
October 11, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37831624/diagnosis-and-treatment-of-coagulopathy-using-thromboelastography-with-platelet-mapping-is-associated-with-decreased-risk-of-pulmonary-failure-in-covid-19-patients
#32
JOURNAL ARTICLE
Tjasa Hranjec, Mackenzie Mayhew, Bradley Rogers, Rachele Solomon, Deborah Hurst, Michael Estreicher, Alberto Augusten, Aaron Nunez, Melissa Green, Shivali Malhotra, Randy Katz, Andrew Rosenthal, Sara Hennessy, Paul Pepe, Robert Sawyer, Juan Arenas
INTRODUCTION: Treatment of coronavirus disease 2019 (COVID-19) patients may require antithrombotic and/or anti-inflammatory medications. We hypothesized that individualized anticoagulant (AC) management, based on diagnosis of coagulopathy using thromboelastography with platelet mapping (TEG-PM), would decrease the frequency of pulmonary failure (PF) requiring mechanical ventilation (MV), mitigate thrombotic and hemorrhagic events, and, in-turn, reduce mortality. METHODS: Hospital-admitted COVID-19 patients, age 18 or older, with escalating oxygen requirements were included...
October 4, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37823430/efficacy-of-adjusted-weight-based-dosing-of-desmopressin-1-deamino-8-d-arginine-vasopressin-in-type-1-von-willebrand-disease
#33
JOURNAL ARTICLE
Craig D Seaman
No abstract text is available yet for this article.
October 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37695569/acquired-bleeding-disorders-secondary-to-immune-checkpoint-inhibitors-a-case-report-and-systematic-literature-review
#34
JOURNAL ARTICLE
William J Archibald, Peter A Kouides, Majed A Refaai, Neil A Lachant
Acquired bleeding disorders because of an autoimmune phenomenon are rare events. Acquired von Willebrand disease (aVWD) has been estimated as having a prevalence of 400 per million in the general population. Acquired hemophilia A (AHA), the most common of the acquired hemophilias, has an estimated incidence of 1.3-1.5 cases per million per year. Immune checkpoint inhibitors (ICI) targeting PD-1, PD-L1, and CTLA-4 are being used with increasing frequency for hematologic and oncologic disorders. Acquired hemophilias and aVWD have been reported with the use of ICI therapy...
October 1, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37823419/the-impact-of-vascular-endothelial-glycocalyx-on-the-pathogenesis-and-treatment-of-disseminated-intravascular-coagulation
#35
JOURNAL ARTICLE
Jingjing Cao, Yi Chen
Disseminated intravascular coagulation (DIC) is a complex disorder characterized by widespread activation of blood clotting mechanisms throughout the body. Understanding the role of vascular endothelial glycocalyx in the pathogenesis and treatment of DIC is crucial for advancing our knowledge in this field. The vascular endothelial glycocalyx is a gel-like layer that coats the inner surface of blood vessels. It plays a significant role in maintaining vascular integrity, regulating fluid balance, and preventing excessive clotting...
September 29, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37823397/coagulation-parameters-in-very-preterm-infants
#36
JOURNAL ARTICLE
Beril Yasa, Elif Kirit, Asuman Coban, Leyla Bilgin, Gizem Kavram, Zeynep Ince
The aim of this study was to define normal percentile values of coagulation parameters in preterm infants below 32 weeks of gestational age. This retrospective cohort study was conducted at Istanbul Medical Faculty. Preterm infants who were born prior to 32 weeks of gestation, between 2011 and 2021 were included and evaluated for coagulation parameters. Blood samples obtained through umbilical catheters prior to administration of heparinized flushes/fluids, vitamin K or fresh frozen plasma (FFP)...
September 29, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37756207/is-dynamic-change-in-mean-platelet-volume-related-with-composite-endpoint-development-after-transcatheter-aortic-valve-replacement
#37
JOURNAL ARTICLE
Orhan Ince, Kamil Gulsen, Sevgi Ozcan, Esra Donmez, Murat Ziyrek, Irfan Sahin, Ertugrul Okuyan
Aortic valve stenosis (AS) is the most common valvular disease, and surgical or transcatheter aortic valve replacement (TAVR) are the treatment options. Diminish in platelet production or dysfunction may occur due to shear stress, advanced age, and other coexisting diseases in AS patients. Bleeding is one of the complications of TAVR and associated with increased mortality. MPV (mean platelet volume) indicates platelet's thrombogenic activity. Overproduction or consumption of platelets in various cardiac conditions may affect MPV values...
September 21, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37756203/venous-thromboembolism-prophylaxis-practices-for-patients-with-sickle-cell-disease-prior-to-and-during-the-covid-19-pandemic
#38
JOURNAL ARTICLE
Jennifer Davila, William B Mitchell, Kerry Morrone, Ellen J Silver, Caterina P Minniti, Henny H Billett, Payal C Desai, Sarah H O'Brien, Deepa Manwani
Patients with sickle cell disease (SCD) are predisposed to a hypercoagulable state due to alterations in the coagulation system. Despite concern for the development of venous thromboembolism (VTE) in this population, there are no standardized guidelines for routine thromboprophylaxis. The objective of this study was to assess thromboprophylaxis practices of adult and pediatric treaters of SCD before and during the coronavirus disease of 2019 (COVID-19) pandemic. A cross-sectional electronic survey was distributed to pediatric and adult hematology oncology practitioners through seven SCD-specific interest groups between May 29, 2020, and July 13, 2020...
September 21, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37756218/quantifying-time-from-last-dose-do-direct-oral-anticoagulant-assays-correlate-with-patient-s-reported-last-dose
#39
JOURNAL ARTICLE
Brandon Stretton, Joshua Kovoor, Stephen Bacchi, Aashray Gupta, Suzanne Edwards, Jir Ping Boey, Samuel Gluck, Benjamin Reddi, Guy Maddern, Mark Boyd
INTRODUCTION: In the absence of a patient's last direct oral anticoagulant (DOAC) dose time, best practice regarding preoperative DOAC cessation remains unclear. The aim of this study was to investigate, in a real-life patient cohort, if there was an association between subjective patient recall and objective DOAC assay titre. METHODS/MATERIALS: A multicentre cohort study of consecutive surgical inpatients was conducted. DOAC assays were 'expected' if they satisfied both time and titre-based guidelines...
September 19, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://read.qxmd.com/read/37724475/protein-c-and-protein-s-deficiencies-are-associated-with-increased-risk-of-deep-vein-thrombosis-in-pregnant-women-using-oral-contraceptives
#40
JOURNAL ARTICLE
Elyasa M Elfaki, Abdulrahman Algarni, Tagwa Yousif Elsayed Yousif, Alneil Hamza, Ezeldine K Abdalhabib, Husham O Elzein, Eldaw M Habiballah, Osama A B Ahmed, Hussam Ali Osman, Praveen Kumar, Asaad M A Babker, Ayman H Alfeel, Muhammad Saboor
BACKGROUND: Oral contraceptives are commonly taken by women and are known to increase the risk of venous thromboembolism (VTE). OBJECTIVE: The aim of this study was to investigate the association between oral contraceptive use and natural anticoagulants, that is, protein C (PC), protein S (PS), and antithrombin in pregnant women with deep vein thrombosis (DVT). MATERIALS AND METHODS: This case-control study was conducted on 330 pregnant women, that is, cases 165 (who used oral contraceptives) and controls 165 (who did not use oral contraceptives)...
September 13, 2023: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
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