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European Cytokine Network

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https://read.qxmd.com/read/30714575/assessment-of-an-ultra-sensitive-ifn%C3%AE-immunoassay-prototype-for-latent-tuberculosis-diagnosis
#1
Elyes Ben Salah, Karim Dorgham, Mylène Lesénéchal, Camille Pease, Laure Allard, Céline Dragonetti, Guy Gorochov, Amélie Guihot, Delphine Sterlin
Worldwide there are about 1.7 billion individuals with latent tuberculosis infection (LTBI) and only 5% to 15% will develop active tuberculosis (TB). It is recommended to treat only those most at risk of developing active TB to avoid problems of drug resistance. LTBI diagnosis involves reviewing the individual's medical history, physical examination, and biological tests. Interferon gamma release assays (IGRA) can yield "undeterminate" or "uncertain" results, which makes clinical management decisions difficult...
February 4, 2019: European Cytokine Network
https://read.qxmd.com/read/30698159/in-vitro-study-of-hax1-gene-therapy-by-retro-viral-transduction-as-a-therapeutic-target-in-severe-congenital-neutropenia
#2
Hamid Farajifard, Mahdi Zavvar, Taraneh Rajaei, Farshid Noorbakhsh, Mahin Nikougoftar-Zarif, Kayhan Azadmanesh, Farzad Kompani, Nima Rezaei
Severe congenital neutropenia (SCN) is a primary immunodeficiency disease in which a number of underlying gene defects are responsible for abnormalities in neutrophil development. The HCLS1-associated protein X1 (HAX1) mutation is associated with an autosomal-recessive form of SCN. Considering the potential of gene therapy approaches for the treatment of monogenic disorders, in this study we aimed to develop retroviral vectors expressing coding sequences (CDS) to be used for the removal of the genetic blockade in deficient hematopoietic cells...
January 28, 2019: European Cytokine Network
https://read.qxmd.com/read/30698158/toll-like-receptors-pathway-in-common-variable-immune-deficiency-cvid-and-x-linked-agammaglobulinemia-xla
#3
Parsova Tavasolian, Laleh Sharifi, Asghar Aghamohammadi, Farshid Noorbakhsh, Rouzbeh Sanaei, Mahsima Shabani, Nima Rezaei
Common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are two major humoral immunodeficiencies, causing a high rate of early age mortality in children. In order to identifiy the possible factors involved in the pathogenesis of CVID and XLA, recent studies have focused on Toll-like receptors (TLRs) and demonstrate the defects in different TLR pathways in immune cells of CVID and XLA patients. Herein, we measured TLR-4 and TLR-9 RNA levels and consequently TNF-α and IFN-α production in peripheral blood mononuclear cells (PBMCs) of patients with CVID and XLA...
January 28, 2019: European Cytokine Network
https://read.qxmd.com/read/30698144/rac1-expression-and-role-in-il-1%C3%AE-production-and-oxidative-stress-generation-in-familial-mediterranean-fever-fmf-patients
#4
José-Noel Ibrahim, Rania Jounblat, Nadine Jalkh, Joelle Abou Ghoch, Cynthia Al Hageh, Eliane Chouery, André Mégarbané, Jean-Claude Lecron, Myrna Medlej-Hashim
Familial Mediterranean fever (FMF) is a recessively inherited autoinflammatory disorder. The caspase-1-dependent cytokine, IL-1β, plays an important role in FMF pathogenesis, and RAC1 protein has been recently involved in IL-1β secretion. This study aims to investigate RAC1 expression and role in IL-1β and caspase-1 production and oxidative stress generation in FMF. The study included 25 FMF patients (nine during attack and remission, and 16 during remission only), and 25 controls. RAC1 expression levels were analyzed by real-time PCR...
January 28, 2019: European Cytokine Network
https://read.qxmd.com/read/30698143/serum-levels-of-transforming-growth-factor-%C3%AE-1-and-c-reactive-protein-as-possible-markers-of-intra-uterine-insemination-outcome
#5
Ayse Sahin, Yaprak Engin-Ustun, Aytekin Tokmak, Hasan Sahin, Salim Erkaya, A Seval Ozgu-Erdinc
Maternal immunity is important for the implantation phase, and exaggerated inflammatory responses may reduce the chance of implantation and pregnancy. Transforming growth factor β1 (TGF-β1) plays a role in the modulation of cellular growth, maturation and differentiation, extracellular matrix formation, immunoregulation, and apoptosis. In this study, we aimed to evaluate the changes in serum TGF-β1 and C-reactive protein (CRP) levels in infertile women following intrauterine insemination (IUI) according to the presence of pregnancy...
January 28, 2019: European Cytokine Network
https://read.qxmd.com/read/30547891/increased-il-1%C3%AE-levels-are-associated-with-an-imbalance-of-oxidant-antioxidant-status-during-beh%C3%A3-et-s-disease
#6
Arezki Chekaoui, Karima Lahmar, Houda Belguendouz, Fettoum Mazari, Malika Terahi, Djenette Hakem, Pierre Youinou, Chafia Touil-Boukoffa
Behçet's disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet's patients. Behçet's disease patients (n = 78: active stage, n = 28; inactive stage, n = 50) and 41 healthy controls have been included in our study. In this context, we investigated the plasma levels of IL-1β and the nitrosative/oxidative markers: nitric oxide (NO), advanced oxidative protein products (AOPP) and fatty acids peroxidation-malondialdehyde (MDA)...
September 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30547890/obesity-and-inflammation
#7
Jacek Karczewski, Ewelina Śledzińska, Alina Baturo, Izabela Jończyk, Aleksander Maleszko, Aleksander Maleszko, Paweł Samborski, Beata Begier-Krasińska, Agnieszka Dobrowolska
The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the development of these pathologies...
September 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30547889/cytokines-and-male-infertility
#8
Vassiliki Syriou, Dimitrios Papanikolaou, Ariadni Kozyraki, Dimitrios G Goulis
Many male infertility cases have no apparent cause, being characterized as idiopathic. Both inflammation and obesity have long been associated with infertility. On one hand, inflammation, such as orchitis and male accessory gland infections (MAGIs), are regulated by inflammatory cytokines. The latter are also produced in the testis by Leydig and Sertoli cells, being associated with gap junctional communication at the blood-testis barrier. Furthermore, they regulate spermatogenesis through cell interaction, Toll-like receptors and production of reactive oxygen species...
September 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30547888/elevated-adiponectin-and-stnfrii-serum-levels-can-predict-progression-to-hepatocellular-carcinoma-in-patients-with-compensated-hcv1-cirrhosis
#9
Jean-Philippe Bastard, Soraya Fellahi, Étienne Audureau, Richard Layese, Françoise Roudot-Thoraval, Carole Cagnot, Valérie Mahuas-Bourcier, Angela Sutton, Marianne Ziol, Jacqueline Capeau, Pierre Nahon
An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis. We selected 56 HCV1-infected patients who subsequently developed HCC (cases), and 96 controls matched for age, gender and diabetes, not developing HCC after a similar period...
September 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30547887/cytokine-and-molecular-networks-in-sepsis-cases-a-network-biology-approach
#10
Dong Wook Jekarl, Kyung Soo Kim, Seungok Lee, Myungshin Kim, Yonggoo Kim
Sepsis is a life-threatening condition of organ dysfunction caused by a dysregulated host immune response to infection. We performed network analysis of cytokine molecules and compared network structures between a systematic inflammatory response syndrome (SIRS) or normal control (NC) group and a sepsis group. We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available...
September 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30148452/characterization-of-new-anti-il-6-antibodies-revealed-high-potency-candidates-for-intracellular-cytokine-detection-and-specific-targeting-of-il-6-receptor-binding-sites
#11
Karinna Chouman, Birgit Korioth-Schmitz, Markus Sack, Jörn Engelbert Schmitz, Anh Tuan Pham, Rainer Fischer, Stefan Barth, Torsten Klockenbring, Rolf Fendel
Interleukin-6 (IL-6) expression and secretion, induced by inflammatory processes, stimulate the acute phase response cascade. The overexpression of IL-6 contributes to a variety of inflammatory diseases, e.g. rheumatoid arthritis, Castleman's disease, multiple myeloma, and prostate cancer. Screening for high amounts of IL-6 in the patients' blood serum can be crucial for an adequate treatment. In this study, five novel murine monoclonal antibodies (mAbs) reactive to human IL-6 were generated. The mAbs were characterized for potential diagnostic purposes and recombinant antibodies were derived thereof...
June 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30078783/role-of-il-18-in-transplant-biology
#12
Chen Liu, Juntao Chen, Baoqing Liu, Shunzong Yuan, Dawei Shou, Liang Wen, Xiaoying Wu, Weihua Gong
Since pro-inflammatory cytokine IL-18 and its receptor (IL-18R) are closely involved in regulating both adaptive and innate immune responses, it is conceivable that they might play an important role in organ transplantation. IL-18 can stimulate lymphocytes to produce the IFN-γ and regulate macrophage activity, thereby increasing the expression of proinflammatory cytokines including IL-1β, IL-6, CCL4 (macrophage inflammatory protein-1 β), CXCL2 (macrophage inflammatory protein-2), and CCL2 (monocyte chemotactic protein-1)...
June 1, 2018: European Cytokine Network
https://read.qxmd.com/read/30078770/clinical-significance-of-serum-leptin-level-in-patients-with-gastric-cancer
#13
Faruk Tas, Senem Karabulut, Kayhan Erturk, Derya Duranyildiz
Leptin may support the proliferation and hinder the apoptosis of tumor cells. Although leptin expression has been studied in several human tumors, its potential clinical significance remains uncertain in patients with gastric carcinoma. Furthermore, the majority of available findings have been determined from preclinical studies using stomach carcinoma tissue section and, to date, few studies have evaluated the clinical significance of leptin in the serum or plasma of gastric carcinoma patients. In the current study, the serum concentration of soluble leptin was assessed in gastric carcinoma patients, and its contributions to the clinical parameters and prognosis of patients were determined...
June 1, 2018: European Cytokine Network
https://read.qxmd.com/read/29748157/interleukin-32-plays-an-essential-role-in-human-calcified-aortic-valve-cells
#14
Chung-Lin Tsai, Ying-Ming Chiu, Yi-Ju Lee, Chin-Tung Hsieh, Dong-Chen Shieh, Gregory J Tsay, Da-Tian Bau, Yi-Ying Wu
Interleukin-32 (IL-32) is an inflammatory cytokine produced mainly by T, natural killer, and epithelial cells. Previous studies on IL-32 have primarily investigated its proinflammatory properties. The IL-32 also has been described as an activator of the p38 mitogen-activated protein kinase (MAPK) and NF-κB, and induces several cytokines. In this study, we hypothesized that the inflammatory regulators NF-κB, MAP kinase, STAT1, and STAT3 are associated with the expression of the IL-32 protein in human calcified aortic valve cells...
March 1, 2018: European Cytokine Network
https://read.qxmd.com/read/29748156/tl1a-mediates-fibroblast-like-synoviocytes-migration-and-indian-hedgehog-signaling-pathway-via-tnfr2-in-patients-with-rheumatoid-arthritis
#15
Mahmoud Al-Azab, Jing Wei, Xunli Ouyang, Abdalkhalig Elkhider, Williams Walana, Xiaotong Sun, Yawei Tang, Bing Wang, Xia Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joints inflammation. One of the aggressive characteristics of RA fibroblast-like synoviocytes (FLS) is the tendency for migration in the local environment, which plays a central role in the RA pathogenesis. Tumor Necrosis Factor (TNF)-like cytokine 1A (TL1A) is a member of TNF superfamily, which has a role in autoimmunity and influences the RA-FLS behavior through TNF receptor 2 (TNFR2). We investigated the effect of TNF-like cytokine 1A (TL1A) on RA-FLS migration using patients' samples...
March 1, 2018: European Cytokine Network
https://read.qxmd.com/read/29748155/associations-between-interleukin-10-polymorphisms-and-susceptibility-to-juvenile-idiopathic-arthritis-a-systematic-review-and-meta-analysis
#16
REVIEW
Sara Harsini, Amene Saghazadeh, Saharnaz Nedjat, Nima Rezaei
BACKGROUND: Cytokine genes, including interleukin-10 (IL-10), are known to play important roles in the pathogenesis of juvenile idiopathic arthritis (JIA). This study aims to determine whether the IL-10 polymorphisms confer susceptibility to JIA. METHODS: A meta-analysis was performed on the associations between the IL-10 -1082 G/A, -592 C/A, and -819 C/T polymorphisms and JIA. A total number of 7 studies involving 1,785 patients and 6,142 controls were considered in the meta-analysis...
March 1, 2018: European Cytokine Network
https://read.qxmd.com/read/29748154/interleukin-6-and-cardiac-operations
#17
REVIEW
Shi-Min Yuan
Interleukin (IL)-6 is a pleiotropic inflammatory cytokine with both pro- and anti-inflammatory capacities, produced by different cells and tissues, such as leukocytes, adipocytes, and endothelium. From the viewpoint of cardiologists, this cytokine is a reliable biomarker of cardiac dysfunction, occurrence of atrial fibrillation, cardiac myxoma with recurrence, remote metastasis or embolization, and atherosclerotic processes. Although IL-6 levels were detected in patients undergoing cardiac operations and reported sporadically, the perioperative kinetics of IL-6 in cardiac surgical patients was insufficiently elaborated...
March 1, 2018: European Cytokine Network
https://read.qxmd.com/read/29478965/the-prognostic-time-dependence-of-intra-tumoural-ifn%C3%AE-mrna-and-protein-in-patients-with-breast-cancer-followed-for-14-years-after-surgery-and-radiotherapy-without-subsequent-systemic-therapy
#18
Nataša Todorović-Raković, Marko Radulovic, Tijana Vujasinović, Jelena Milovanović, Dragica Nikolić-Vukosavljević
There is increasing evidence for the importance of immunity in breast cancer. IFNγ is expected to have a prognostic value based on its major role in innate and specific cell-mediated immunity. In this retrospective study, based on the 14-year follow-up of 73 patients with breast cancer after surgery and radiotherapy but no subsequent systemic therapy, we investigated the prognostic time dependence of intra-tumoural IFNγ mRNA and protein levels. Over the entire 14 years of follow-up, neither IFNγ mRNA nor protein was significantly associated with metastasis outcome by AUC and Cox regression criteria...
November 1, 2017: European Cytokine Network
https://read.qxmd.com/read/29478964/seminal-plasma-adipokines-involvement-in-human-reproductive-functions
#19
REVIEW
Yaelle Elfassy, Chloe McAvoy, Soraya Fellahi, Joëlle Dupont, Bruno Fève, Rachel Levy, Jean-Philippe Bastard
Infertility, which increased worldwide over the past few decades, has recently been linked to obesity prevalence. Adipokines, produced by adipose tissue, could be the link between obesity and infertility. The association between circulating adipokines and female infertility has been extensively studied in the last ten years. However, the male aspect has been less investigated, although some adipokines are present in seminal plasma. We have attempted to analyze published studies that measured seminal plasma adipokines and their relationships with semen parameters...
November 1, 2017: European Cytokine Network
https://read.qxmd.com/read/29478963/interleukin-18-a-regulator-of-cancer-and-autoimmune-diseases
#20
REVIEW
Maryam Esmailbeig, Abbas Ghaderi
Interleukin (IL)-18, structurally similar to IL-1β, is a member of IL-1 superfamily of cytokines. This cytokine, which is expressed by many human lymphoid and nonlymphoid cells, has an important role in inflammatory processes. The main function of IL-18 is mediated through induction of interferon-γ (IFN-γ) secretion from T helper (Th1) cells. This cytokine synergistically with IL-12 contributes to Th1 differentiation and, therefore, is important in host defense mechanisms against intracellular bacteria, viruses, and fungi...
November 1, 2017: European Cytokine Network
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