journal

Cerebrovascular Diseases | Page 2

journal
https://read.qxmd.com/read/32023610/computed-tomography-angiography-in-acute-stroke-patients-receiving-recombinant-tissue-plasminogen-activator-outcome-and-safety-evaluations-in-an-asian-population
#21
Chuan-Min Lin, Hsiu-Chuan Wu, Yi-Ming Wu, Chi-Hung Liu, Kuo-Hsuan Chang, Ting-Yu Chang, Kuo-Lun Huang, Yeu-Jhy Chang, Tsong-Hai Lee, Pei-Kwei Tsay, Chih-Kuang Cheng, Chien-Hung Chang
INTRODUCTION: The multiphase computed tomography angiography (mCTA) is superior to the noncontrast computed tomography (NCCT) in selecting patients that would benefit from mechanical thrombectomy following an acute ischemic stroke (AIS). It remains unclear whether the longer examination time of mCTA worsens outcomes of intravenous recombinant tissue plasminogen activator (IV r-tPA) or increases the risk of hemorrhagic transformation (HT) compared to NCCT in Asian stroke patients. METHODS: Between January 2011 and December 2017, 199 AIS patients receiving IV r-tPA with initial National Institute of Health Stroke Scale (NIHSS) scores between 6 and 25 were enrolled in a single medical center...
February 5, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/32023609/frequent-premature-atrial-contractions-in-cryptogenic-stroke-predict-atrial-fibrillation-detection-with-insertable-cardiac-monitoring
#22
Kenichi Todo, Tomonori Iwata, Ryosuke Doijiri, Hiroshi Yamagami, Masafumi Morimoto, Tetsuya Hashimoto, Kazutaka Sonoda, Hidekazu Yamazaki, Koge Junpei, Shuhei Okazaki, Tsutomu Sasaki, Hideki Mochizuki
OBJECTIVE: To determine whether frequent premature atrial contractions (PAC) predict atrial fibrillation (AF) in cryptogenic stroke patients, we analyzed the association between frequent PACs in 24-h Holter electrocardiogram recording and AF detected by insertable cardiac monitoring (ICM). METHODS: We retrospectively analyzed a database of 66 consecutive patients with cryptogenic stroke who received ICM implantation between October 2016 and March 2018 at 5 stroke centers...
February 5, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/32023608/depressive-symptoms-in-stroke-patients-are-there-sex-differences
#23
Eun-Jae Lee, Jong S Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon
BACKGROUND: We aimed to examine sex differences in symptom characteristics and pharmacological responses in post-stroke depressive (PSD) symptoms. METHODS: This is a post hoc analysis of EMOTION (ClinicalTrials.gov, NCT01278498), a randomized, placebo-controlled, double-blind trial that examined the efficacy of escitalopram for 3 months on depression in patients with acute stroke. Depressive symptoms were evaluated using the 10-item Montgomery-Åsberg Depression Rating Scale (MADRS)...
February 5, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31995799/rise-in-low-density-lipoprotein-cholesterol-during-hospitalization-is-related-with-poor-outcome-at-discharge-in-patients-with-acute-ischemic-stroke
#24
Huai Wu Yuan, Yi Na Yang, Han Feng Chen, Ren Jie Ji, Ya Jie Lin, Ren Yong Guo, Guo Ping Peng, Hui Liang, Benyan Luo
BACKGROUND: The statistical association between a short-term rise in low-density lipoprotein cholesterol (LDL-C) levels and the short-term outcome of acute ischemic stroke remains unknown. We aimed to evaluate the association in acute ischemic stroke patients during hospitalization. METHODS: Patients with acute ischemic stroke who received statin at discharge were enrolled in this multicenter registry study. LDL-C values were measured on the first day after admission and on the day before discharge to determine the rise in LDL-C levels...
January 29, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31962331/distribution-of-cardioembolic-stroke-a-cohort-study
#25
Ramon Pierik, Ale Algra, Ewoud van Dijk, Michiel E Erasmus, Isabella C van Gelder, Peter J Koudstaal, Gert-Jan R Luijckx, Paul J Nederkoorn, Robert J van Oostenbrugge, Ynte M Ruigrok, Thomas W L Scheeren, Maarten Uyttenboogaart, Marieke C Visser, Marieke J H Wermer, Walter M van den Bergh
BACKGROUND: A cardiac origin in ischemic stroke is more frequent than previously assumed, but it is not clear which patients benefit from cardiac work-up if obvious cardiac pathology is absent. We hypothesized that thromboembolic stroke with a cardiac source occurs more frequently in the posterior circulation compared with thromboembolic stroke of another etiology. METHODS: We performed a multicenter observational study in 3,311 consecutive patients with ischemic stroke who were enrolled in an ongoing prospective stroke registry of 8 University hospitals between September 2009 and November 2014 in The Netherlands...
January 21, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31955156/analysis-of-factors-related-to-cerebral-infarction-after-direct-bypass-surgery-in-adults-with-moyamoya-disease
#26
Yun Qian, Bin Huang, Zongmin Hu, Jian Wang, Peng Zhao, Xingang Li
OBJECTIVE: High-risk factors of the patients with moyamoya disease (MMD) were analyzed to provide the basis for prediction and management of cerebral infarction after direct bypass surgery in adult MMD. METHODS: 1. Retrospective analysis of clinical data was collected from adult MMD patients (n = 250) following superficial temporal artery-middle cerebral artery bypass surgery performed in our hospital from July 2013 to December 2017. Of the 250 patients, all underwent hemispherical bypass surgery, and bilateral surgery was performed on 14 patients...
January 17, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31940632/protective-effects-of-transforming-growth-factor-%C3%AE-1-knockdown-in-human-umbilical-cord-mesenchymal-stem-cells-against-subarachnoid-hemorrhage-in-a-rat-model
#27
Hongwei Chen, Li Chen, Dongcheng Xie, Jianxing Niu
BACKGROUND: Emerging evidence indicates a beneficial effect of mesenchymal stem cell (MSC) transplantation in subarachnoid hemorrhage (SAH). Chronic hydrocephalus is a common complication after SAH, which is associated with subarachnoid fibrosis promoted by transforming growth factor-β1 (TGF-β1). This study investigated the effect of human umbilical cord derived MSCs (hUC-MSCs) with TGF-β1 knockdown on chronic hydrocephalus after SAH. METHODS: About 0.5 mL autologous blood was injected into the cerebellomedullaris cistern of 6-week SD rats to establish SAH model...
January 15, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31927543/microrna-384-5p-promotes-endothelial-progenitor-cell-proliferation-and-angiogenesis-in-cerebral-ischemic-stroke-through-the-delta-likeligand-4-mediated-notch-signaling-pathway
#28
Jia Fan, Weiwei Xu, Shanji Nan, Meiji Chang, Yizhi Zhang
BACKGROUND: MicroRNAs (miRs) have a crucial regulatory role in endothelial cell function and tumor angiogenesis by inhibiting the expressions of their target genes. The participation of microRNA-384-5p (miR-384-5p) has been prominently reported in various ischemia-induced diseases such as myocardial ischemia and atherosclerosis. Hence, the present study aimed at exploring the effect of miR-384-5p on proliferation, apoptosis, and angiogenesis of endothelial progenitor cells (EPCs) in cerebral ischemic stroke and investigating the associated underlying mechanism...
January 10, 2020: Cerebrovascular Diseases
https://read.qxmd.com/read/32069458/gradient-of-tissue-injury-after-stroke-rethinking-the-infarct-versus-noninfarcted-dichotomy
#29
Felix Ng, Vijay Venkatraman, Mark Parsons, Andrew Bivard, Gagan Sharma, Leonid Churilov, Patricia Desmond, Stephen M Davis, Nawaf Yassi, Bruce Campbell
AIM: To evaluate the degree of variability in microstructural injury within and adjacent to regions identified as infarcted tissue using diffusion tensor imaging (DTI). METHODS: In this prospective longitudinal study, 18 patients presenting within 12 h of anterior circulation acute ischemic stroke who underwent CT perfusion (CTP) at baseline followed by fluid-attenuated inversion recovery (FLAIR) and DTI 1-month were analyzed. Four regions of interest (ROI) corresponding to the severity of hypoperfusion on CTP within and beyond the radiological infarct lesion defined on FLAIR were segmented...
2020: Cerebrovascular Diseases
https://read.qxmd.com/read/32045911/late-neurological-deterioration-after-acute-intracerebral-hemorrhage-a-post-hoc-analysis-of-the-atach-2-trial
#30
Shuhei Okazaki, Haruko Yamamoto, Lydia D Foster, Mayumi Fukuda-Doi, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda, Yuko Y Palesch, Adnan I Qureshi
BACKGROUND: Neurological deterioration (ND) has a major influence on the prognosis of intracerebral hemorrhage (ICH); however, factors associated with ND occurring after 24 h of ICH onset are unknown. METHODS: We performed exploratory analyses of data from the Antihypertensive Treatment of Acute Cerebral Hemorrhage 2 trial, which compared intensive and standard blood pressure lowering treatment in ICH. NDs were captured on the adverse event case report form. Logistic regression analysis was performed to examine the independent predictors of late ND...
2020: Cerebrovascular Diseases
https://read.qxmd.com/read/32023607/isolated-insular-stroke-clinical-presentation
#31
Fabrizio Giammello, Domenico Cosenza, Carmela Casella, Francesca Granata, Cristina Dell'Aera, Maria Carolina Fazio, Paolino La Spina, Francesco Grillo, Masina Cotroneo, Antonio Toscano, Rosa Fortunata Musolino
The symptoms related to insular ischemia have been the object of several studies in patients affected by stroke, although they are often accompanied by other ischemic alteration of adjacent brain structures supplied by the middle cerebral artery (MCA). The insula is vulnerable because of an ischemia due to thromboembolic vascular occlusion of the M1 MCA segment and the 2 main MCA branches (M2), mainly when they abruptly arise from the principal stem at a right angle. This topographical and anatomical peculiarity could enable an embolic formation, especially due to atrial fibrillation (AF), to occlude the transition pathway between M1 and M2, while the proximal origin of vascular supply protects the insula from ischemia due to hemodynamic factors...
2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31910410/convexity-subarachnoid-hemorrhage-accompanied-by-hyperacute-ischemic-stroke
#32
Takeo Sato, Kenichiro Sakai, Masahiro Mimori, Teppei Komatsu, Kenichi Sakuta, Yuka Terasawa, Tadashi Umehara, Shusaku Omoto, Hidetaka Mitsumura, Hidetomo Murakami, Tetsuya Shimizu, Satoshi Matsushima, Yasuyuki Iguchi
INTRODUCTION AND OBJECTIVES: The clinical characteristics of convexity subarachnoid hemorrhage (cSAH) accompanying hyperacute ischemic stroke are unknown. We aimed to investigate the incidence and clinical characteristics of cSAH with hyperacute ischemic stroke. METHODS: Participants comprised symptomatic ischemic stroke patients with ≤4.5 h from onset to door who also underwent initial MRI ≤4.5 h from onset. We reviewed initial and follow-up MRI during admission to identify cSAH...
2020: Cerebrovascular Diseases
https://read.qxmd.com/read/31851968/evaluation-of-patients-with-high-national-institutes-of-health-stroke-scale-as-thrombectomy-candidates-using-the-kentucky-appalachian-stroke-registry
#33
Parneet Grewal, Michael R Dobbs, Keith Pennypacker, Richard J Kryscio, Patrick Kitzman, Marc Wolfe, Kelley Elkins, Gregory J Bix, Justin F Fraser
INTRODUCTION: Mechanical thrombectomy has become standard of care for emergent large vessel occlusive stroke. Estimates of incidence for thrombectomy eligibility vary significantly. National Institutes of Health Stroke Scale (NIHSS) of 10 or greater is highly predictive of large vessel occlusion. Using our Kentucky Appalachian Stroke Registry (KApSR), we evaluated temporal trends in stroke admissions with NIHSS ≥10 to determine patient characteristics among that group along with effects and needs in thrombectomy utilization...
December 18, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31846970/risk-stratification-for-ischemic-cerebrovascular-events-and-mortality-among-intracerebral-hemorrhage-patients-with-and-without-atrial-fibrillation-a-nationwide-cohort-study
#34
Peter Brønnum Nielsen, Thure Filskov Overvad, Søren Due Andersen, Torben Bjerregaard Larsen, Flemming Skjøth, Mette Søgaard, Gregory Y H Lip
BACKGROUND: Intracerebral hemorrhage is a devastating clinical event, and secondary prevention is pivotal to avoid further cerebral complications, but no clear guidance exist for selecting high-risk patients. The CHA2DS2-VASc score is a widespread tool to assess the risk of stroke among patients with atrial fibrillation (AF). OBJECTIVES: We investigated the ability of the CHA2DS2-VASc score for estimating cerebrovascular ischemic events in patients with recent intracerebral hemorrhage with or without comorbid AF...
December 17, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31825939/the-effect-of-body-mass-index-on-outcome-after-endovascular-treatment-in-acute-ischemic-stroke-patients-a-post-hoc-analysis-of-the-mr-clean-trial
#35
France Anne Victoire Pirson, Wouter H Hinsenveld, Julie Staals, Bianca T A de Greef, Wim H van Zwam, Diederik W J Dippel, Jan Albert Vos, Wouter J Schonewille, Robert J van Oostenbrugge
BACKGROUND: Though obesity is a well-known risk factor for vascular disease, the impact of obesity on stroke outcome has been disputed. Several studies have shown that obesity is associated with better functional outcome after stroke. Whether obesity influences the benefit of endovascular treatment (EVT) in stroke patients is unknown. We evaluated the association between body mass index (BMI) and outcome in acute ischemic stroke patients with large vessel -occlusion (LVO), and assessed whether BMI affects the -benefit of EVT...
December 11, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31825937/predictors-of-significant-coronary-artery-disease-in-patients-with-cerebral-artery-atherosclerosis
#36
Ji Woong Roh, Beom-Jun Kwon, Sang-Hyun Ihm, Sungmin Lim, Chan-Seok Park, Kiyuk Chang, Wook Sung Chung, Dong-Bin Kim, Seong-Rim Kim, Hee-Yeol Kim
OBJECTIVE: There are few existing data on the status of coronary artery disease (CAD) in patients with atherosclerosis of the cerebral artery detected by brain imaging studies. We aimed to analyze the predictors of asymptomatic angiographically significant CAD detected by simultaneous cerebral and coronary angiography. METHODS: This retrospective cohort study screened data obtained between August 2009 and April 2019; 11,047 patients underwent cerebral angiography for atherosclerotic change (>50% stenosis or aneurysm) seen in brain magnetic resonance angiography (MRA) or computed tomography angiography (CTA) at a single center by endovascular neurosurgeon's decision...
December 11, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31812956/interaction-of-blood-pressure-lowering-and-alteplase-dose-in-acute-ischemic-stroke-results-of-the-enhanced-control-of-hypertension-and-thrombolysis-stroke-study
#37
Xia Wang, Lili Song, Jie Yang, Lingli Sun, Tom J Moullaali, Else Charlotte Sandset, Candice Delcourt, Richard I Lindley, Thompson G Robinson, Jatinder S Minhas, Hisatomi Arima, John Chalmers, Jong S Kim, Vijay Sharma, Ji-Guang Wang, Octávio Pontes-Neto, Pablo M Lavados, Verónica V Olavarría, Tsong-Hai Lee, Christopher Levi, Sheila O Martins, Nguyen H Thang, Craig S Anderson
OBJECTIVE: To determine the extent to which the effects of intensive blood pressure (BP) lowering are modified by doses of alteplase in thrombolysis-eligible acute ischemic stroke (AIS) patients. METHODS: Prespecified analyses of the Enhanced Control of Hypertension and Thrombolysis Stroke Study for patients enrolled in both arms: (i) low-dose (0.6 mg/kg body weight) or standard-dose (0.9 mg/kg) alteplase and (ii) intensive (target systolic BP [SBP] 130-140 mm Hg) or guideline-recommended (target SBP <180 mm Hg) BP management...
December 6, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31786566/association-between-red-blood-cell-distribution-width-and-hemorrhagic-transformation-in-acute-ischemic-stroke-patients
#38
Changyi Wang, Lu Wang, Di Zhong, Linghui Deng, Shi Qiu, Yuxiao Li, Ming Liu, Bo Wu
BACKGROUND: Hemorrhagic transformation (HT) is a frequent complication of acute ischemic stroke (AIS). Red blood cell distribution width (RDW) is a cost-effective parameter associated with incidence and prognosis of cerebrovascular diseases. The purpose of this study was to assess whether RDW is associated with HT in AIS patients. METHODS: AIS patients within 24 h from stroke onset between January 1, 2014, and December 31, 2018, were consecutively enrolled. Blood samples were collected...
November 29, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31770765/diagnostic-value-of-contrast-enhanced-magnetic-resonance-vessel-wall-imaging-on-the-onset-type-of-vertebral-artery-dissection
#39
Atsushi Saito, Miki Fujimura, Hidenori Endo, Shunsuke Omodaka, Atsushi Kanoke, Kenichi Sato, Teiji Tominaga
BACKGROUND: Circumferential enhancement along the aneurysm wall (CEAW) by magnetic resonance (MR) vessel wall imaging has been reported to be a useful indicator for the biological activity of intracranial aneurysms such as growth and rupture. However, the significance of CEAW in vertebral artery dissection (VAD) has not been examined in detail. We quantitatively analyzed CEAW on VAD focusing on the differences in the clinical onset type. METHODS: The subjects were 37 patients diagnosed with VAD who were evaluated by MR imaging in the acute phase of onset between January 2014 and May 2019...
November 26, 2019: Cerebrovascular Diseases
https://read.qxmd.com/read/31747667/recanalization-of-emergent-large-intracranial-vessel-occlusion-through-intravenous-thrombolysis-frequency-clinical-outcome-and-reperfusion-pattern
#40
Carmen Serna Candel, Marta Aguilar Pérez, Victoria Hellstern, Muhammad AlMatter, Hansjörg Bäzner, Hans Henkes
BACKGROUND: According to a recent meta-analysis, 1 out of 10 patients with emergent large intracranial vessel occlusion (ELVO) causing stroke have recanalization after intravenous thrombolysis (IVT) alone. However, rate, clinical outcome, and recanalization pattern of this phenomenon are poorly understood. OBJECTIVES AND METHODS: Patients with ELVO recanalized only by IVT were analyzed, and frequency of recanalization, clinical outcome, safety variables, and reperfusion pattern were assessed...
November 20, 2019: Cerebrovascular Diseases
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