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Cerebrovascular Diseases

Radoslaw Litwinowicz, Magdalena Bartus, Michalina Malec-Litwinowicz, Michal Michalski, Krzysztof Banaszkiewicz, Boguslaw Kapelak, Dhanunjaya Lakkireddy, Krzysztof Bartus
BACKGROUND: Patients surviving an initial stroke present a significantly increased risk for further strokes. Left atrial appendage closure (LAAC) became an alternative treatment to pharmacological therapy for stroke prevention in atrial fibrillation (AF) patients. OBJECTIVE: To evaluate the long-term efficacy of LAAC in primary and secondary stroke prevention in patients with AF. METHODS: This retrospective study enrolled 139 patients following LAAC who were divided into 2 groups: 37 patients with prior stroke (Stroke Group) and 102 patients without stroke (Control Group)...
May 23, 2019: Cerebrovascular Diseases
Laurie Fraticelli, Julie Freyssenge, Clément Claustre, Marielle Buisson, Magali Bischoff, Norbert Nighoghossian, Laurent Derex, Carlos El Khoury
BACKGROUND: Literature has highlighted sex-based differences in the natural course of stroke and in response to treatment with intravenous tissue plasminogen activator (tPA). OBJECTIVES: We aimed to compare the management and outcome of acute ischemic stroke (AIS) among women and men on a French registry based on a federated network of emergency physicians and neurologists. METHOD: We included 2,790 patients received tPA between 2010 and 2016 from the stroke centers in the RESUVal area...
May 23, 2019: Cerebrovascular Diseases
Ryosuke Tashiro, Miki Fujimura, Masayuki Kameyama, Shunji Mugikura, Hidenori Endo, Yohei Takeuchi, Yasutake Tomata, Kuniyasu Niizuma, Teiji Tominaga
OBJECTIVE: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard surgical management for adult moyamoya disease (MMD) patients, but local cerebral hyperperfusion (CHP) and cerebral ischemia are potential complications of this procedure. Recent hemodynamic analysis of the acute stage after revascularization surgery for MMD revealed a more complex and unique pathophysiological condition, the so-called "watershed shift (WS) phenomenon," which is defined as a paradoxical decrease in the cerebral blood flow (CBF) at the adjacent cortex near the site of local CHP...
May 23, 2019: Cerebrovascular Diseases
Nazife Dinc, Sae-Yeon Won, Michael Eibach, Johanna Quick-Weller, Jürgen Konczalla, Joachim Berkefeld, Volker Seifert, Gerhard Marquardt
OBJECTIVE: Cerebral vasospasm (CVS) after a ruptured arteriovenous malformation (AVM) is rarely reported. This study is aimed at evaluating the predictive variables in AVM hemorrhage for CVS. METHODS: A total of 160 patients with ruptured AVMs were admitted to our neurosurgical department from 2002 to 2018. The frequency of cerebral vasospasm after AVM hemorrhage and the impact of AVM-associated aneurysms were evaluated. We compared different bleeding patterns, such as intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH) or a combination of both (ICH + SAH) and evaluated predictive variables for outcome in last follow-up...
May 8, 2019: Cerebrovascular Diseases
David Weisenburger-Lile, Raphaël Blanc, Maeva Kyheng, Jean-Philippe Desilles, Julien Labreuche, Michel Piotin, Mikael Mazighi, Arturo Consoli, Bertrand Lapergue, Benjamin Gory
BACKGROUND: To date, thrombectomy for large vessel occlusion (LVO) strokes can be performed only in comprehensive stroke centers with thrombectomy capacity. We compared the clinical outcome of patients first referred to a primary stroke center to those admitted directly to a comprehensive stroke center and treated on site in the multicentric observational Endovascular Treatment in Ischemic Stroke (ETIS) registry. METHODS: From our perspective, multicenter, observational ETIS registry, we analyzed anterior circulation stroke patients, treated within 8 h, who underwent thrombectomy after thrombolysis and were admitted to a comprehensive stroke center either with drip and ship or mothership...
May 7, 2019: Cerebrovascular Diseases
Dimitri Renard, Teodora Parvu, Eric Thouvenot
BACKGROUND: Recently, finger-like projections (FLP) and subarachnoid haemorrhage extension (SAHE) of lobar intracerebral haemorrhage (LH) on acute CT together with ApoE4 genotype have been used in a prediction model for histopathologically proven cerebral amyloid angiopathy (CAA). Our aim was to analyse FLP and SAHE on acute/early subacute magnetic resonance imaging (MRI) and to assess the association with probable CAA diagnosis according to modified Boston criteria. METHODS: We retrospectively studied MRI scans (and CT if available) performed <7 days in a cohort of consecutive acute LH patients >55 years...
May 7, 2019: Cerebrovascular Diseases
Tomofumi Nishikawa, Naomi Miyamatsu, Aya Higashiyama, Masato Hojo, Yoko Nishida, Shunichi Fukuda, Takumi Hirata, Kayoko Ichiura, Yoshimi Kubota, Sachimi Kubo, Tetsuya Ueba, Aya Kadota, Daisuke Sugiyama, Tomonori Okamura
BACKGROUND: While water intake is frequently recommended to prevent cerebral infarction (CI), only few studies have been published on this topic. OBJECTIVES: This study retrospectively estimated the daily non-alcohol drink (NAD) intake in CI patients before CI onset and compared it with NAD in healthy subjects. METHODS: We performed a cross-sectional study on CI patients in 3 hospitals and healthy subjects in the Kobe Orthopedic and Biomedical Epidemiologic (KOBE) study...
May 3, 2019: Cerebrovascular Diseases
Francisco Purroy, Ana Vena, Carles Forné, Ana María de Arce, Antonio Dávalos, Blanca Fuentes, Juan Francisco Arenillas, Jerzy Krupinski, Manuel Gómez-Choco, Ernest Palomeras, Joan Martí-Fábregas, José Castillo, Xavier Ustrell, Javier Tejada, Jaime Masjuan, Moisés Garcés, Ikram Benabdelhak, Joaquin Serena
BACKGROUND: In-hospital stroke death rate is an important sanitary issue. Despite advances in the acute phase management of stroke patients, mortality and disability rates remain high. In aging populations and with different mortality between the sexes in general, the study of sex- and age-related differences becomes increasingly relevant for optimization of post-acute clinical care of stroke patients. METHODS: We designed a cohort follow-up study with 13,932 consecutive ischemic stroke (IS) patients from 19 Spanish hospitals...
May 3, 2019: Cerebrovascular Diseases
Zurab Nadareishvili, Alexis N Simpkins, Emi Hitomi, Dennys Reyes, Richard Leigh
BACKGROUND AND PURPOSE: The role played by post-stroke inflammation after an ischemic event in limiting functional recovery remains unclear. One component of post-stroke inflammation is disruption of the blood-brain barrier (BBB). This study examines the relationship between post-stroke BBB disruption and functional outcome. METHODS: Acute stroke patients treated with thrombolysis underwent magnetic resonance imaging scanning 24 h and 5 days after their initial event...
April 10, 2019: Cerebrovascular Diseases
Kenichi Todo, Nobuyuki Sakai, Hirotoshi Imamura, Hiroshi Yamagami, Hidemitsu Adachi, Tomoyuki Kono, Junya Kobayashi, Shiro Yamamoto, Takeshi Morimoto, Shoichi Tani, Michi Kawamoto, Manabu Sakaguchi, Yasushi Ueno, Takeharu Kunieda, Osamu Narumi, Chiaki Sakai, Akira Ishii, Taku Hoshi, Masaomi Koyanagi, Yohei Mineharu, Tatsuya Ishikawa, Yoji Kuramoto, Shinsuke Sato, Nobuyuki Ohara, Koichi Arimura, Hajime Nakamura, Takeo Nishida, Yasufumi Gon, Toshiyuki Fujinaka, Kazuhisa Yoshiya, Haruhiko Kishima, Hideki Mochizuki, Nobuo Kohara
BACKGROUND AND PURPOSE: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hypothesized that successful reperfusion might be associated with long-term improvement beyond 90 days after endovascular therapy. To assess the long-term effects beyond 90 days, we analyzed the association of successful reperfusion with a temporal change in modified Rankin Scale (mRS) score from 90 days to 1 year after endovascular therapy...
April 9, 2019: Cerebrovascular Diseases
Shunsuke Nomura, Koji Yamaguchi, Hiroyuki Akagawa, Akitsugu Kawashima, Yosuke Moteki, Tatsuya Ishikawa, Yasuo Aihara, Taiichi Saito, Yoshikazu Okada, Takakazu Kawamata
BACKGROUND: Homozygosity of this p.R4810K founder variant of RNF213 moyamoya disease (MMD) susceptibility gene is known to influence the severity of the clinical disease phenotype at disease onset. However, the association between this genotype and long-term clinical manifestations has remained unclear. OBJECTIVES: The principal goal of this study was to investigate whether and how the p.R4810K variant of RNF213 influences the long-term phenotype in Japanese patients with MMD...
April 4, 2019: Cerebrovascular Diseases
Xiao-Yu Xin, Lin Cheng, Zhao Yang, Yu Zhang, Li-Li Zeng, Jian-Rong Liu
BACKGROUND: Precise subtype classification based on underlying pathophysiology is important to prevent recurrent attack in minor stroke patients. A newly developed Atherosclerosis, Small vessel disease, Cardiac source, Others (ASCO) phenotypic classification system aims to characterize patients using different grades of evidence for stroke subtypes. However, this system has not been specifically applied to minor stroke population. In our study, the impact of using the newer ASCO criteria on minor stroke etiologies was investigated, and compared with that of Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification...
March 28, 2019: Cerebrovascular Diseases
BaiLi Song, YuKai Liu, Linda Nyame, XiangLiang Chen, Teng Jiang, Wei Wang, Chao Sun, Dan Tang, Chen Chen, Mako Ibrahim, Jie Yang, JunShan Zhou, JianJun Zou
BACKGROUND: Accurate prognostication of unfavorable outcome made at the early onset of stroke is important to both the clinician and the patient management. This study was aimed to develop a nomogram based on the integration of parameters to predict the probability of 3-month unfavorable functional outcome in Chinese acute ischemic stroke patients. METHODS: We retrospectively collected patients who underwent acute ischemic stroke at Stroke Center of the Nanjing First Hospital (China) between May 2013 and May 2018...
March 21, 2019: Cerebrovascular Diseases
Michael G Hennerici
No abstract text is available yet for this article.
March 21, 2019: Cerebrovascular Diseases
Yasuyoshi Shimada, Masakazu Kobayashi, Kenji Yoshida, Kazunori Terasaki, Shunrou Fujiwara, Yoshitaka Kubo, Takaaki Beppu, Kuniaki Ogasawara
BACKGROUND: Hypoxic but viable neural tissue is seen on 1-(2-18F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (18F-FRP170) positron emission tomography (PET) in patients with chronic cerebral ischemia with a combination of misery perfusion and moderately reduced oxygen metabolism. Cognitive function sometimes improves after revascularization surgery in patients with chronic cerebral ischemia. OBJECTIVES: We used brain perfusion single-photon emission computed tomography (SPECT) and 18F-FRP170 PET to determine whether hypoxic tissue was reduced following the restoration of cerebral perfusion after carotid endarterectomy (CEA) in patients with severe stenosis of the cervical internal carotid artery (ICA) and whether the reduction in hypoxic tissue was associated with cognitive improvement...
February 15, 2019: Cerebrovascular Diseases
Mona Laible, Ekkehart Jenetzky, Markus A Möhlenbruch, Ulf Neuberger, Martin Bendszus, Peter A Ringleb, Timolaos Rizos
BACKGROUND AND PURPOSE: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far. MATERIALS AND METHODS: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed...
February 15, 2019: Cerebrovascular Diseases
Tanya N Turan, Sami Al Kasab, Alison Smock, George Cotsonis, David Bachman, Michael J Lynn, Azhar Nizam, Colin P Derdeyn, David Fiorella, Scott Janis, Bethany Lane, Jean Montgomery, Marc I Chimowitz
BACKGROUND: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial. METHODS: Subjects in the SAMMPRIS trial were included in this study. In order to have an assessment of cognitive function independent of stroke, patients with a stroke as a qualifying event whose deficits included aphasia or neglect were excluded from these analyses as were those with a cerebrovascular event during follow-up...
February 14, 2019: Cerebrovascular Diseases
Minyoul Baik, Seung Up Kim, Sungwoo Kang, Hyung Jong Park, Hyo Suk Nam, Ji Hoe Heo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Hye Sun Lee, Young Dae Kim
BACKGROUND: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models...
February 14, 2019: Cerebrovascular Diseases
Adnan I Qureshi, Mushtaq H Qureshi, Li-Ming Lien, Jiunn-Tay Lee, Jiann-Shing Jeng, Chaur-Jong Hu, Ta-Chang Lai, Chung-Hsiang Liu, Chih-Hung Chen, Po-Lin Chen, Tsang-Shan Chen, Jie-Yuan Li, Cheng-Li Lin, Chung Y Hsu
BACKGROUND: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied. METHODS: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation...
February 14, 2019: Cerebrovascular Diseases
Yoshitaka Yamaguchi, Tomotaka Tanaka, Yoshiaki Morita, Sohei Yoshimura, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda
BACKGROUND: Aortic complicated lesions (ACLs) are key parameters for evaluating aortic embolic sources in embolic stroke, and are usually diagnosed using transesophageal echocardiography (TEE). However, alternative methods for diagnosing ACLs have not been well established. We investigated associations between high-intensity areas on T1-weighted imaging (T1WI) with magnetization-prepared rapid acquisition with gradient echo (MPRAGE) and ACLs on TEE among ischemic stroke patients. METHODS: Participants comprised 135 patients (mean age, 71 years; 35 women) with ischemic stroke or transient ischemic attack who underwent TEE for evaluation of embolic sources and plaque imaging using MPRAGE for evaluation of aortic or carotid plaques...
February 14, 2019: Cerebrovascular Diseases
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