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Cerebrovascular Diseases

Zurab Nadareishvili, Alexis N Simpkins, Emi Hitomi, Dennys Reyes, Richard Leigh
BACKGROUND AND PURPOSE: The role played by post-stroke inflammation after an ischemic event in limiting functional recovery remains unclear. One component of post-stroke inflammation is disruption of the blood-brain barrier (BBB). This study examines the relationship between post-stroke BBB disruption and functional outcome. METHODS: Acute stroke patients treated with thrombolysis underwent magnetic resonance imaging scanning 24 h and 5 days after their initial event...
April 10, 2019: Cerebrovascular Diseases
Kenichi Todo, Nobuyuki Sakai, Hirotoshi Imamura, Hiroshi Yamagami, Hidemitsu Adachi, Tomoyuki Kono, Junya Kobayashi, Shiro Yamamoto, Takeshi Morimoto, Shoichi Tani, Michi Kawamoto, Manabu Sakaguchi, Yasushi Ueno, Takeharu Kunieda, Osamu Narumi, Chiaki Sakai, Akira Ishii, Taku Hoshi, Masaomi Koyanagi, Yohei Mineharu, Tatsuya Ishikawa, Yoji Kuramoto, Shinsuke Sato, Nobuyuki Ohara, Koichi Arimura, Hajime Nakamura, Takeo Nishida, Yasufumi Gon, Toshiyuki Fujinaka, Kazuhisa Yoshiya, Haruhiko Kishima, Hideki Mochizuki, Nobuo Kohara
BACKGROUND AND PURPOSE: Recent studies have demonstrated that endovascular reperfusion therapy improves clinical outcomes at 90 days after ischemic stroke. However, the effects on long-term outcomes are not well known. We hypothesized that successful reperfusion might be associated with long-term improvement beyond 90 days after endovascular therapy. To assess the long-term effects beyond 90 days, we analyzed the association of successful reperfusion with a temporal change in modified Rankin Scale (mRS) score from 90 days to 1 year after endovascular therapy...
April 9, 2019: Cerebrovascular Diseases
Shunsuke Nomura, Koji Yamaguchi, Hiroyuki Akagawa, Akitsugu Kawashima, Yosuke Moteki, Tatsuya Ishikawa, Yasuo Aihara, Taiichi Saito, Yoshikazu Okada, Takakazu Kawamata
BACKGROUND: Homozygosity of this p.R4810K founder variant of RNF213 moyamoya disease (MMD) susceptibility gene is known to influence the severity of the clinical disease phenotype at disease onset. However, the association between this genotype and long-term clinical manifestations has remained unclear. OBJECTIVES: The principal goal of this study was to investigate whether and how the p.R4810K variant of RNF213 influences the long-term phenotype in Japanese patients with MMD...
April 4, 2019: Cerebrovascular Diseases
Xiao-Yu Xin, Lin Cheng, Zhao Yang, Yu Zhang, Li-Li Zeng, Jian-Rong Liu
BACKGROUND: Precise subtype classification based on underlying pathophysiology is important to prevent recurrent attack in minor stroke patients. A newly developed Atherosclerosis, Small vessel disease, Cardiac source, Others (ASCO) phenotypic classification system aims to characterize patients using different grades of evidence for stroke subtypes. However, this system has not been specifically applied to minor stroke population. In our study, the impact of using the newer ASCO criteria on minor stroke etiologies was investigated, and compared with that of Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification...
March 28, 2019: Cerebrovascular Diseases
Marc Fatar
No abstract text is available yet for this article.
March 28, 2019: Cerebrovascular Diseases
BaiLi Song, YuKai Liu, Linda Nyame, XiangLiang Chen, Teng Jiang, Wei Wang, Chao Sun, Dan Tang, Chen Chen, Mako Ibrahim, Jie Yang, JunShan Zhou, JianJun Zou
BACKGROUND: Accurate prognostication of unfavorable outcome made at the early onset of stroke is important to both the clinician and the patient management. This study was aimed to develop a nomogram based on the integration of parameters to predict the probability of 3-month unfavorable functional outcome in Chinese acute ischemic stroke patients. METHODS: We retrospectively collected patients who underwent acute ischemic stroke at Stroke Center of the Nanjing First Hospital (China) between May 2013 and May 2018...
March 21, 2019: Cerebrovascular Diseases
Michael G Hennerici
No abstract text is available yet for this article.
March 21, 2019: Cerebrovascular Diseases
Andreas Gammelgaard Damsbo, Kristian Lundsgaard Kraglund, Henriette Nørmølle Buttenschøn, Søren Paaske Johnsen, Grethe Andersen, Janne Kaergaard Mortensen
INTRODUCTION: Serotonin affects several brain functions including cognition. The serotonin transporter (SERT) regulates brain serotonin levels through reuptake into neurons. The gene encoding this transporter, the SERT gene, has several functional polymorphisms affecting the number of transporters and thereby the serotonin levels. SERT gene expression may be important for cognition and selective serotonin reuptake inhibitors (SSRI) may improve cognition post stroke. We therefore examined the association between SERT genotypes, cognitive function and early treatment with the SSRI citalopram among non-depressed Caucasian stroke patients...
March 7, 2019: Cerebrovascular Diseases
Mehdi K Rezai, Rajiv Advani, Ingvild Dalen, Lars Fjetland, Kathinka D Kurz, Martin W Kurz
OBJECTIVES: Endovascular treatment (EVT) has emerged as the gold standard therapy for stroke due to large vessel occlusion (LVO). There is however limited evidence to suggest that similar efficacy can be expected in elderly patients. We aimed to assess the efficacy and safety of EVT in elderly patients (aged > 80), comparing outcomes to younger patients (aged < 80). MATERIAL AND METHODS: A total of 195 patients with LVO stroke treated with EVT were included and dichotomized by age...
February 26, 2019: Cerebrovascular Diseases
Yasuyoshi Shimada, Masakazu Kobayashi, Kenji Yoshida, Kazunori Terasaki, Shunrou Fujiwara, Yoshitaka Kubo, Takaaki Beppu, Kuniaki Ogasawara
BACKGROUND: Hypoxic but viable neural tissue is seen on 1-(2-18F-fluoro-1-[hydroxymethyl]ethoxy) methyl-2-nitroimidazole (18F-FRP170) positron emission tomography (PET) in patients with chronic cerebral ischemia with a combination of misery perfusion and moderately reduced oxygen metabolism. Cognitive function sometimes improves after revascularization surgery in patients with chronic cerebral ischemia. OBJECTIVES: We used brain perfusion single-photon emission computed tomography (SPECT) and 18F-FRP170 PET to determine whether hypoxic tissue was reduced following the restoration of cerebral perfusion after carotid endarterectomy (CEA) in patients with severe stenosis of the cervical internal carotid artery (ICA) and whether the reduction in hypoxic tissue was associated with cognitive improvement...
February 15, 2019: Cerebrovascular Diseases
Mona Laible, Ekkehart Jenetzky, Markus A Möhlenbruch, Ulf Neuberger, Martin Bendszus, Peter A Ringleb, Timolaos Rizos
BACKGROUND AND PURPOSE: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far. MATERIALS AND METHODS: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed...
February 15, 2019: Cerebrovascular Diseases
Tanya N Turan, Sami Al Kasab, Alison Smock, George Cotsonis, David Bachman, Michael J Lynn, Azhar Nizam, Colin P Derdeyn, David Fiorella, Scott Janis, Bethany Lane, Jean Montgomery, Marc I Chimowitz
BACKGROUND: Cerebrovascular disease is an important cause of cognitive impairment. The aim of this study is to report the relationship between cognitive function and risk factors at baseline and during follow-up in the Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) trial. METHODS: Subjects in the SAMMPRIS trial were included in this study. In order to have an assessment of cognitive function independent of stroke, patients with a stroke as a qualifying event whose deficits included aphasia or neglect were excluded from these analyses as were those with a cerebrovascular event during follow-up...
February 14, 2019: Cerebrovascular Diseases
Minyoul Baik, Seung Up Kim, Sungwoo Kang, Hyung Jong Park, Hyo Suk Nam, Ji Hoe Heo, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Hye Sun Lee, Young Dae Kim
BACKGROUND: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models...
February 14, 2019: Cerebrovascular Diseases
Adnan I Qureshi, Mushtaq H Qureshi, Li-Ming Lien, Jiunn-Tay Lee, Jiann-Shing Jeng, Chaur-Jong Hu, Ta-Chang Lai, Chung-Hsiang Liu, Chih-Hung Chen, Po-Lin Chen, Tsang-Shan Chen, Jie-Yuan Li, Cheng-Li Lin, Chung Y Hsu
BACKGROUND: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied. METHODS: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation...
February 14, 2019: Cerebrovascular Diseases
Yoshitaka Yamaguchi, Tomotaka Tanaka, Yoshiaki Morita, Sohei Yoshimura, Masatoshi Koga, Masafumi Ihara, Kazunori Toyoda
BACKGROUND: Aortic complicated lesions (ACLs) are key parameters for evaluating aortic embolic sources in embolic stroke, and are usually diagnosed using transesophageal echocardiography (TEE). However, alternative methods for diagnosing ACLs have not been well established. We investigated associations between high-intensity areas on T1-weighted imaging (T1WI) with magnetization-prepared rapid acquisition with gradient echo (MPRAGE) and ACLs on TEE among ischemic stroke patients. METHODS: Participants comprised 135 patients (mean age, 71 years; 35 women) with ischemic stroke or transient ischemic attack who underwent TEE for evaluation of embolic sources and plaque imaging using MPRAGE for evaluation of aortic or carotid plaques...
February 14, 2019: Cerebrovascular Diseases
Cheryl Carcel, Sara Farnbach, Beverley M Essue, Qiang Li, Nick Glozier, Stephen Jan, Richard Lindley, Maree L Hackett
BACKGROUND: While returning to paid work is a crucial marker of stroke recovery, little is known about the differences in unpaid work by sex following stroke. We aimed to determine the sex differences in participation in unpaid work 12 months after stroke. METHODS: Psychosocial outcomes in stroke were a prospective, multicentre observational study that recruited individuals, 18-64 years, within 28 days of stroke from New South Wales, Australia. Unpaid work was defined as ≥5 h per week of one or more of: unpaid domestic work for the household; unpaid care of others; looking after own children without pay or looking after someone else's children without pay...
January 17, 2019: Cerebrovascular Diseases
Jun Young Chang, Sang Beom Jeon, Jung Hwa Lee, O-Ki Kwon, Moon-Ku Han
BACKGROUND: Blood pressure variability (BPV) is associated with target organ damage progression and increased cardiovascular events, including stroke. The aim of this study was to evaluate the associations between short-term BPV during acute periods and recanalization degree, early neurological deterioration (END) occurrence, and functional outcomes in acute ischemic stroke patients who had undergone intra-arterial thrombectomy (IAT). METHODS: We retrospectively analyzed 303 patients with large vessel occlusive stroke who underwent IAT...
January 15, 2019: Cerebrovascular Diseases
Gustavo C Santo, Inês Baldeiras, Rita Guerreiro, Joana A Ribeiro, Rosário Cunha, Taryn Youngstein, Sira Nanthapisal, João Leitão, Carolina Fernandes, Francisco Caramelo, Maria do Rosário Almeida, José Brás, Isabel Santana
BACKGROUND: The association that exists between livedo reticularis (LR) and stroke is known as Sneddon's syndrome (SnS). The disorder is classified as primary SnS (PSnS), if the cause remains unknown and secondary SnS. The condition is rare and it occurs mainly sporadically. In 2014, 2 independent teams described a new genetic disorder with childhood-onset, which was called deficiency of adenosine deaminase 2 (DADA2), characterized by recurrent fevers and vascular pathologic features that included LR and stroke...
January 15, 2019: Cerebrovascular Diseases
Yaowaree Leavell, Mian Khalid, Stanley Tuhrim, Mandip S Dhamoon
BACKGROUND: There are limited epidemiologic data on cerebral venous sinus thrombosis (CVST). We aim to summarize baseline characteristics and outcomes using a large nationally representative administrative database. METHODS: Using the 2013 Nationwide Readmissions Database, we used validated International Classification of Disease, Ninth Revision codes to identify baseline characteristics of patients admitted with CVST. We calculated readmission rates (per 100,000 index hospitalizations) for neurological complications...
January 2, 2019: Cerebrovascular Diseases
Changyi Wang, Linghui Deng, Shi Qiu, Haiyang Bian, Lu Wang, Yuxiao Li, Ming Liu, Bo Wu
BACKGROUND AND OBJECTIVE: Hemorrhagic transformation (HT) is a major complication of acute ischemic stroke (AIS). Serum albumin is known for its neuroprotective effects and is a marker of improved AIS patient outcomes. However, it is not known whether there is a relationship between serum albumin and HT. METHODS: AIS patients admitted to the Department of Neurology of West China Hospital from 2012 to 2016 were prospectively and consecutively enrolled. Baseline characteristics were collected...
2019: Cerebrovascular Diseases
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