Harold I Saavedra, Lizhao Wu, Alain de Bruin, Cynthia Timmers, Thomas J Rosol, Michael Weinstein, Michael L Robinson, Gustavo Leone
The Rb/E2F pathway plays a critical role in the control ofcellular proliferation. Here, we report that E2F1, E2F2, and E2F3 make major individual contributions toward the in vivo phenotypic consequences of Rb deficiency. In the developing lens of Rb(-/-) embryos, loss of E2F1, E2F2, or E2F3 reduces the unscheduled proliferation of fiber cells, with the loss of E2F3 having the most pronounced effect. In Rb-deficient retinas, all three E2Fs contribute equally to the ectopic proliferation of postmitotic neuronal cells...
May 2002: Cell Growth & Differentiation: the Molecular Biology Journal of the American Association for Cancer Research