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P & T: a Peer-reviewed Journal for Formulary Management

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https://read.qxmd.com/read/30828236/research-briefs
#1
(no author information available yet)
No abstract text is available yet for this article.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828235/the-60th-american-society-of-hematology-annual-meeting-exposition
#2
Walter Alexander
We report on two presentations on β-thalassemia and myelodysplastic syndromes, three presentations on chronic lymphocytic leukemia, and others on perioperative oral anticoagulation, sickle-cell anemia, diffuse large B-cell lymphoma, and multiple myeloma.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828234/routine-use-of-vitamin-k-in-the-treatment-of-cirrhosis-related-coagulopathy-is-it-a-o-k-maybe-not-we-say
#3
Sarah M Aldrich, Randolph E Regal
Historically, coagulopathy related to cirrhosis has been managed primarily as a bleeding disorder. However, several recent studies have shown that patients with cirrhosis have an increased risk of both bleeding and clotting. These coagulopathic changes are a result of the decreased synthetic capabilities of the cirrhotic liver. Vitamin K is often given to correct prolonged prothrombin times (PT) in patients with cirrhosis. However, this practice is not well defined and its effectiveness is questionable. The objective of our literature review is to determine the effectiveness of vitamin K to correct coagulopathy in cirrhosis...
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828233/droxidopa-for-hypotension-of-different-etiologies-two-case-reports
#4
Jomi Oommen, Judy Chen, Shan Wang, Thomas Caraccio, Adel Hanna
Orthostatic hypotension is defined as a decrease in systolic blood pressure of at least 20 mmHg or a decrease in diastolic blood pressure of at least 10 mmHg (or both), within three minutes of moving from a supine to an upright or standing position. Droxidopa is a synthetic amino acid analog that is directly metabolized to norepinephrine by dopa-decarboxylase, subsequently providing alpha and beta-agonist effects to increase blood pressure. It is indicated in the treatment of neurogenic orthostatic hypotension caused by primary autonomic failure that is associated with Parkinson disease, multi-system atrophy, pure autonomic failure, dopamine beta-hydroxylase deficiency, and/or non-diabetic autonomic neuropathy...
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828232/lowering-the-boom-on-high-drug-prices-hhs-plans-not-a-boon-to-some-players
#5
Stephen Barlas
The Trump administration's multipronged effort to use regulatory tools to lower drug prices includes old and new initiatives. But opposition from some players is evident in each instance. Some of that opposition may be based on sound reasoning, some of it may be based on self-interest. The author discusses advertising, protected-class drugs, what's next for rebates, and more.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828231/forensic-analysis-in-drug-litigation-finds-most-errors-occur-with-commonly-used-therapies-and-practices
#6
James T O'Donnell, James J O'Donnell, F Randy Vogenberg
In the complex setting of obstetrics and reproductive medicine, the medication-related injuries leading to the most litigation involve some of the most commonly used drugs, rather than the newer, more complicated therapies. The authors present a number of cases illustrating how sophisticated treatment of high-risk pregnancies can be jeopardized by a simple negligent act.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828230/meropenem-vaborbactam-vabomere-%C3%A2-another-option-for-carbapenem-resistant-enterobacteriaceae
#7
Yuman Lee, Juliette Kim, Saralinh Trinh
Meropenem-Vaborbactam (Vabomere) for carbapenem-resistant Enterobacteriaceae.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828229/pharmaceutical-approval-update
#8
Michele B Kaufman
Inbrija (levodopa inhalation powder) for oral inhalation for the treatment of "off" episodes in Parkinson's disease; Ultomiris (ravulizumab) injection for treating adults with paroxysmal nocturnal hemoglobinuria; and Yupelri (revefenacin) inhalation solution for the maintenance treatment of patients with COPD.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828228/drug-and-device-news
#9
(no author information available yet)
Approvals, new indications and formulations, and safety issues.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828227/do-gpos-play-a-role-in-drug-shortages-long-standing-allegations-disputed-by-the-gpos
#10
Stephen Barlas
What role, if any, do group purchasing organizations play in drug shortages?
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30828226/paralyzed-by-mistakes-reassess-the-safety-of-neuromuscular-blockers-in-your-facility
#11
Matthew Grissinger
Neuromuscular blockers have been inadvertently administered to patients who were not receiving proper ventilatory assistance, causing death or permanent injuries.
March 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766013/research-briefs
#12
(no author information available yet)
No abstract text is available yet for this article.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766012/aligning-formulary-restrictions-across-a-health-system-and-improving-access-to-and-clarity-of-medication-restrictions
#13
Sarah Solano, Jordan Dow, Terry Audley, Nitish Bangalore
Background: In 2013, formulary medications were aligned among the three hospitals within our health system. However, as formulary medication restrictions were not aligned, the three hospitals continued to have inconsistent medication restrictions. This led to confusion among prescribers and pharmacists about which medications were restricted, what the restrictions were, and where to access information about the restrictions. To alleviate this confusion, we set out to align formulary restrictions and to provide medication restriction details at the points of entering and verifying medication orders...
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766011/biosimilars-considerations-for-payers
#14
James Smeeding, Daniel C Malone, Monica Ramchandani, Bradley Stolshek, Larry Green, Philip Schneider
Evaluating biosimilars requires payers to go beyond cost considerations: safety and efficacy, reliability of supply and logistics, and the impact of state laws on substitution and interchangeability must all be deliberated.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766010/american-heart-association-2018-scientific-sessions
#15
Walter Alexander
We report on sessions on the dapagliflozin effect on cardiovascular events; angiotensin receptor-neprilysin inhibition for acute decompensated heart failure; rivaroxaban's effect on thromboembolic events with heart failure, sinus rhythm, and coronary disease; trial results on the withdrawal of pharmacological heart failure therapy in recovered dilated cardiomyopathy; and more from AHA's November meeting.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766009/biosimilar-roadblock-removals-seem-tailor-made-for-trump-democrats-agreement-development-of-new-biosimilar-drugs-and-marketing-of-few-approved-drugs-stymied
#16
Stephen Barlas
The United States is lagging behind Europe in biosimilar use, and missing out on a wider range of medication options and huge savings in drug expenditures. What's causing the holdup?
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766008/pharmaceutical-approval-update
#17
Michele B Kaufman
Arikayce (amikacin liposome inhalation suspension) for Mycobacterium avium complex lung disease; Xofluza (baloxavir marboxil) for acute uncomplicated influenza; and Nuzyra (omadacycline) for community-acquired bacterial pneumonia and/or acute bacterial skin and skin structure infections.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766007/drug-and-device-news
#18
(no author information available yet)
Approvals, new indications, drug safety issues, and more.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766006/latest-opioid-abuse-bill-contains-over-100-provisions-but-no-far-reaching-pharmacy-mandates
#19
Stephen Barlas
Will the new opioid abuse bill prove more effective than its predecessor? A plethora of provisions will have little impact on pharmacists and pharmaceuticals.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
https://read.qxmd.com/read/30766005/prescribing-errors-with-levetiracetam-oral-solution
#20
Matthew Grissinger
Incorrectly prescribed medications can have serious implications, especially in young children. Safe practice recommendations include listing patients' age, weight, and date of birth on prescriptions, verifying discharge orders, and involving pharmacists in reconciliation.
January 2019: P & T: a Peer-reviewed Journal for Formulary Management
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