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International Journal of Experimental Pathology

Ying Zhang, Ying He, Dan Zhang, Meng Zhang, Mengying Wang, Ying Zhang, Tianyou Ma, Jinghong Chen
The purpose of this paper was to investigate chondrocyte distribution and death in the cartilage in Kashin-Beck disease (KBD). Apoptotic chondrocytes were detected by TUNEL assay. Ultrastructural changes were examined by transmission electron microscope (TEM). Biochemical markers associated with apoptosis (eg, caspase-3) and necroptosis (eg, RIP3) were investigated by immunohistochemistry. In KBD cartilage chondrocyte death was characterized by paler staining of the cells. Multiple chondral cell clusters surrounded the areas lacking cells in the deep zone...
January 24, 2019: International Journal of Experimental Pathology
Shogo Watanabe, Shota Kumazaki, Shusei Yamamoto, Ikumi Sato, Kazuya Kitamori, Mari Mori, Yukio Yamori, Satoshi Hirohata
Non-alcoholic steatohepatitis (NASH) is linked to increased cardiovascular risk, independent of the broad spectrum of metabolic syndrome risk factors. Stroke-prone (SP) spontaneously hypertensive rats (SHRSP5/Dmcr) fed a high-fat and high-cholesterol (HFC) diet developed hepatic lesions similar to those in human NASH pathology. These rats simultaneously developed lipid deposits in the mesenteric arteries, cardiac fibrosis, endothelial dysfunction and left ventricle (LV) diastolic dysfunction. However, the intermediary factors between NASH and cardiovascular disease are still unknown...
January 24, 2019: International Journal of Experimental Pathology
Abdulaziz Asiri, Teresa Pereira Raposo, Abdulaziz Alfahed, Mohammad Ilyas
Cten (C-terminal tensin-like) is a member of the tensin protein family found in complex with integrins at focal adhesions. It promotes epithelial-mesenchymal transition (EMT) and cell motility. The precise mechanisms regulating Cten are unknown, although we and others have shown that Cten could be under the regulation of several cytokines and growth factors. Since transforming growth factor beta 1 (TGF-β1) regulates integrin function and promotes EMT/cell motility, we were prompted to investigate whether TGF-β1 induces EMT and cell motility through Cten signalling in colorectal cancer...
January 15, 2019: International Journal of Experimental Pathology
Milan Holeček, Melita Vodeničarovová
The aim of the study was to examine whether a rat model of liver cirrhosis induced by carbon tetrachloride (CCl4) is a suitable model of muscle wasting and alterations in amino acid metabolism in cirrhotic humans. Rats were treated by intragastric gavage of CCl4 or vehicle for 45 days. Blood plasma and different muscle types-tibialis anterior (mostly white fibres), soleus (red muscle) and extensor digitorum longus (white muscle) - were analysed at the end of the study. Characteristic biomarkers of impaired hepatic function were found in the plasma of cirrhotic animals...
January 13, 2019: International Journal of Experimental Pathology
Jie Zhang, Hongmei Qiu, Jiajun Huang, Shumei Ding, Bo Huang, Qin Wu, Qingsong Jiang
The aim of this study was to establish a robust model of diabetic myocardial hypertrophy in Mus musculus castaneus mice. Mice were fed a high-fat diet for four weeks and then given streptozotocin (STZ, 40 mg kg-1  d-1 for 5 days, intraperitoneally) and fasting blood glucose (FBG) levels were tested after seven days. Mice with FBG levels above 11.1 mmol/L were considered diabetic. Diabetic mice continued to have access to the high-fat diet until cardiac hypertrophy developed. FBG and body weight (BW) were measured weekly...
January 6, 2019: International Journal of Experimental Pathology
Carmen Maria Sandoval Pacheco, Gabriela Venicia Araujo Flores, Aurea Favero Ferreira, Wilfredo Sosa Ochoa, Vânia Lúcia Ribeiro da Matta, Concepción Zúniga Valeriano, Carlos Eduardo Pereira Corbett, Marcia Dalastra Laurenti
In Honduras visceral leishmaniasis and non-ulcerated or atypical cutaneous leishmaniasis (NUCL) are caused by the species Leishmania (L.) infantum chagasi. NUCL is the most common clinical form in the southern regions of the country, mainly affecting the young. In view of the lack of knowledge about the pathogenesis of the disease pattern caused by L. (L) infantum chagasi in individuals affected by NUCL, the aim of the present study was to describe in detail the histopathological features of the skin lesion caused by the parasite...
November 27, 2018: International Journal of Experimental Pathology
Viviane N Pacheco, Renan Langie, Jules R D Benfica, Jéssica C Munaretto, Adriana Etges, Deise Ponzoni, Edela Puricelli
This study aimed to evaluate the alveolar bone tissue inflammatory response in rats undergoing zoledronic acid therapy. The study sample was composed of 28 Wistar rats. Animals from the test group GTa received a weekly intraperitoneal dose of 0.2 mg/kg of zoledronic acid for 3 weeks, while test group GTb received the same dose for 8 weeks. A physiological saline dose, equivalent to that of the medication, was administered to the controls in groups GCa and GCb. A defect was created in the dental crown of the lower first molars using a drill to simulate pulp and periapical injury...
November 20, 2018: International Journal of Experimental Pathology
Kellen Cristina Torres Costa, Bruna Barbosa de Sousa, Edigar Henrique Vaz Dias, Déborah Fernanda da Cunha Pereira, Mariana Santos Matias, Wilson Júnior Oliveira, Antônio Vicente Mundim, Carla Cristine Neves Mamede, Luíz Fernando Moreira Izidoro, Júnia de Oliveira Costa, Fábio de Oliveira
Ophidic accidents are among the problems of public health in Brazil. The components from bothropic venom are responsible for many systemic clinical complications resulting from envenomation. The present work aimed to analyse the systemic changes induced in mice after intraperitoneal administration of BmooTX-I, a myotoxic acidic phospholipase A2 isolated from Bothrops moojeni venom. Urinalysis was performed and the following plasma biochemical markers were documented: urea, creatinine and uric acid (renal function); glucose and amylase (pancreatic function); alanine aminotransferase, alkaline phosphatase and gamma-GT (intra- and extrahepatic function); creatine kinase and enzymatic lactate (muscle function)...
November 20, 2018: International Journal of Experimental Pathology
Juliana Tomaz Pacheco Latini, Gabriela Câmara Vicente, Luis Guillermo Coca Velarde, Hildebrando Gomes Benedicto, Ângela de Castro Resende, Michelle Teixeira Teixeira, Kátia Calvi Lenzi de Almeida, Gilson Teles Boaventura
The aim of this study was to evaluate the use of flaxseed in animals subjected to ethanol-induced hepatotoxicity. Twenty-four male rats were divided into four groups (n = 6): control group (CG) which received a control diet and water ad libitum; flaxseed group (FG) which received control diet with an addition of 25% flaxseed flour and water ad libitum; ethanol control group (ECG) which received control diet and a solution of 10% ethanol (v/v) as the only liquid source; and ethanol flaxseed group (EFG) which received control diet with an addition of 25% flaxseed flour and a solution of 10% ethanol (v/v) as the only liquid source...
October 19, 2018: International Journal of Experimental Pathology
Lúcia de Fátima Almeida de Deus Moura, Marina de Deus Moura de Lima, Cacilda Castelo Branco Lima, Ana Victória Lopes Bandeira, Marcoeli Silva de Moura, Airton Mendes Conde Júnior, Márcia Dos Santos Rizzo
The interradicular region of primary molars is permeated by many foramina, channels and accessories that connect the pulp cavity with the periapical tissues anatomically. Thus, pulp decomposition products or drugs used in endodontic treatment can trigger inflammatory reactions. The aim of this study was to evaluate the blood cell profile of the alveolar region after extraction of primary molars treated with CTZ paste. Forty-eight primary molars were selected with clinical and radiographic signs of extraction...
October 15, 2018: International Journal of Experimental Pathology
Cauê B Scarim, Cleverton R de Andrade, João A da Rosa, Jean L Dos Santos, Chung M Chin
Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in mice with a Y strain of Trypanosoma cruzi and analysed the histopathological data about the effects of NFOH and BZN on different tissues, including the heart, skeletal muscle, liver, kidney, colon, spleen and brain...
October 15, 2018: International Journal of Experimental Pathology
Nihong Lu, Yingrong Du, Haiyuan Li, Yu Luo, Bing Ouyang, Yangjun Chen, Yongrui Yang, Lixia Yang
The present study investigated the therapeutic potential of omega-6 fatty acids, according to their effects on antioxidant markers and matrix metalloproteinases (MMPs), in coronary heart disease-induced rats. Rats were grouped into group I (sham control), group II (control), group III (0.5 g/kg bwt of omega-6 fatty acids) and group IV (1 g/kg bwt of omega-6 fatty acids). Reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), catalase, glutathione peroxidase (Gpx) and acetylcholinesterase (AChE) enzyme activities were determined...
October 2018: International Journal of Experimental Pathology
Bianca R de Souza, Luiz Gustavo de Almeida Chuffa, Vinícius Augusto Simão, Isabel C C Camargo
Nandrolone decanoate (ND) is a synthetic steroid, which promotes adverse effects on the ovarian tissue, and melatonin (MLT) exhibits a number of beneficial properties in the reproductive system. This study evaluated the general features of the ovarian tissue and the immunoexpression of sex steroid receptors in ND-treated rats that were submitted to short-term melatonin treatment. Adult rats received mineral oil (control group) and ND at doses of 7.5 mg/kg for 15 days (ND-treated group). The treatment with MLT (10mg/kg for 7 days) was given alone, before or in combination with ND...
August 2018: International Journal of Experimental Pathology
Soumia Hammadi, Owen Chan, Mohamed Abdellali, Maha Medjerab, Hadjer Agoun, Zineb Bellahreche, Ali Khalkhal, Yasmina Dahmani
This study was designed to investigate the HPA-axis impairment in the streptozotocin (STZ)-diabetic gerbils (Gerbillus gerbillus). Twenty-six male gerbils (body weight ~27 g) were divided into 3 groups: vehicle control (n = 10), 2 days of diabetes (n = 09) and 30 days of diabetes (n = 07). The latter 2 groups received an intraperitoneal injection of STZ (150 mg/kg of body weight). At 2 and 30 days of diabetes, streptozotocin-diabetic gerbils underwent a retro-orbital puncture for assessment of biochemical and hormonal parameters...
August 2018: International Journal of Experimental Pathology
Michelle Meier, Kasper Jarlhelt Andersen, Anders Riegels Knudsen, Jens Randel Nyengaard, Stephen Hamilton-Dutoit, Frank Viborg Mortensen
In this study we investigated the dynamics of hepatocyte hyperplasia and hypertrophy in rats subjected to increasing sizes of partial hepatectomy (PH). A total of 104 rats were randomized according to the size of PH. On postoperative days (PODs) 1, 3 and 5, blood was drawn and the remnant liver removed for stereological analysis. Liver parameters and regeneration rate were significantly affected by size of PH. On POD 1, hepatocyte volumes had increased significantly in all PH groups. On POD 3, all groups showed hepatocyte volumes approximating baseline...
August 2018: International Journal of Experimental Pathology
Laura Colín-Barenque, Patricia Bizarro-Nevares, Adriana González Villalva, Jose Pedraza-Chaverri, Omar Noel Medina-Campos, Ruben Jimenez-Martínez, Daniela S Rodríguez-Rangel, Stefanie Reséndiz, Teresa I Fortoul
Carnosine (β-alanyl-L-histidine) is synthesized in the olfactory system, has antioxidant activity as a scavenger of free radicals and has been reported to have neuroprotective action in diseases which have been attributed to oxidative damage. In neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, impairment of olfactory function has been described. Vanadium derivatives are environmental pollutants, and its toxicity has been associated with oxidative stress. Vanadium toxicity on the olfactory bulb was reported previously...
August 2018: International Journal of Experimental Pathology
Airton Pereira E Silva, João R A Soares, Erika Bertozzi de Aquino Mattos, Claudia Josetti, Isabelle M Guimarães, Sylvia M N Campos, Gerlinde A P B Teixeira
Gut-associated intestinal lymphoid tissue, the largest secondary lymphoid organ in the human body, constantly samples antigens from the gut lumen, presenting as a default response the activation of TCD4+ FOXP3+ regulatory T cells that secrete a profile of anti-inflammatory cytokines maintaining gut homeostasis denominated from an immunological perspective as mucosal tolerance. However, when antigens are sampled in an inflammatory setting, the immune response may either be protective, in the case of harmful pathogens, or cause further inflammatory reactions as in food allergy, inflammatory bowel diseases, coeliac disease or food protein-induced enterocolitis syndrome...
August 2018: International Journal of Experimental Pathology
Peng Zhang, Changsheng Fan, Jun Du, Xueli Mo, Qikang Zhao
Our study aimed to clarify the correlation between miR-1247-5p expression and clinicopathological parameters and survival of patients with breast cancer (BC). We evaluated the expression level of miR-1247-5p in 224 formalin-fixed, paraffin-embedded specimens (112 BC and matched cancer free tissues) by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR). miR-1247-5p expression in BC tissues was found to be decreased compared with matched normal tissues (P < 0.01). Additionally, low miR-1247-5p expression in BC tissues was significantly associated with the advanced TNM stage (P = 0...
August 2018: International Journal of Experimental Pathology
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June 2018: International Journal of Experimental Pathology
Wang Qiong, Gu Xiaofeng, Wang Junfang
Precartilaginous stem cells (PSCs) are adult stem cells which could self-renew or differentiate into chondrocytes to promote bone growth. In this study, we aimed to understand the role of transforming growth factor-β1 (TGF-β1) in precartilaginous stem cell (PSC) differentiation and to study the mechanisms that underlie this role. We purified PSCs from the neonatal murine perichondrial mesenchyme using immunomagnetic beads, and primary cultured them. Their phenotype was confirmed by the PSC marker fibroblast growth factor receptor-3 (FGFR-3) overexpression...
June 2018: International Journal of Experimental Pathology
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