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Photodermatology, Photoimmunology & Photomedicine

C Vicentini, A S Vignion-Dewalle, E Thecua, F Lecomte, H Béhal, C Maire, J B Tylcz, H Abi-Rached, L Mortier, S Mordon
BACKGROUND/PURPOSE: Photodynamic therapy (PDT) is an established treatment for actinic keratosis (AK). Among the approved protocols in Europe, the most widely used involves irradiation with the Aktilite CL 128 (C-PDT). We aimed to assess the heterogeneity of irradiance over the treatment area when using C-PDT. We also investigated whether there is a cut-off value for protoporphyrin IX (PpIX)-weighted irradiance that may predict the treatment outcome of C-PDT. METHODS: An Ophir PD300 photodiode sensor connected to an Ophir Laser Star power meter was used to measure the irradiance delivered to 114 AKs of the scalp and forehead of 19 patients treated with C-PDT...
February 14, 2019: Photodermatology, Photoimmunology & Photomedicine
Jianhua Zhao, Sunil Kalia, Haishan Zeng, Harvey Lui
BACKGROUND AND PURPOSE: Although cutaneous autofluorescence has been utilized for evaluation of skin conditions, there is a paucity of data on normal human skin autofluorescence and its dependence on anatomical site. The objective of this study is to use excitation-emission matrix spectroscopy to quantify and characterize skin autofluorescence at different body sites. METHODS: Ten anatomical sites from 30 healthy volunteers were measured with a double-grating excitation-emission matrix spectrofluorometer...
February 10, 2019: Photodermatology, Photoimmunology & Photomedicine
Semra Koçtürk, Mehtap Yüksel Egrilmez, Şebnem Aktan, Gülgün Oktay, Halil Resmi, Hatice Şimşek Keskin, Belgin Sert Serdar, Tugba Erkmen, Gül Güner Akdogan, Şebnem Özkan
BACKGROUND: People living in Mediterranean countries are mostly exposed to solar ultraviolet (UV) radiation that damages skin and results in photoaging which involves activation of epidermal growth factor receptor (EGFR) and downstream signal transduction through mitogen-activated protein kinases (MAPKs) in fibroblasts. Generation of reactive oxygen/nitrogen species by UV radiation is also critical for EGFR and MAPKs activation. MAPKs are responsible for activation of AP-1 subunits in the nucleus which induce matrix metalloproteinases...
February 10, 2019: Photodermatology, Photoimmunology & Photomedicine
Tal Ben Ami, Ofer Sarig, Eli Sprecher, Ilan Goldberg
BACKGROUND: Glutathione S-transferases (GSTs) play a critical role in cellular protection against oxidative damage. Polymorphisms in three major GST loci have been described. A number of studies have looked for an association between GSTs and skin diseases. PURPOSE: To ascertain the possibility that polymorphisms in the GSTM1, GSTT1 and GSTP1 genes may predict the development of photo-induced and non-photo-induced drug eruptions. METHODS: A cohort of 40 patients with drug eruptions, 10 of whom had developed a photo-induced drug reaction, and matched controls (116 for GSTM1 and GSTT1, 120 for GSTP1) were studied...
February 8, 2019: Photodermatology, Photoimmunology & Photomedicine
M Aguilar-Bernier, D Rodríguez-Barón, F Rivas Ruiz, J M Segura-Palacios, M de Troya Martín
BACKGROUND: Photodynamic treatment with methyl aminolevulinate (MAL-PDT) is considered an effective and highly recommended treatment for Bowen's disease. However, its long-term efficacy remains to be established, as significant differences have been reported in this respect. OBJECTIVE: The aim of the present study is to describe the results of a retrospective analysis of patients with Bowen's disease treated with MAL-PDT during the period 2006-17 at the Costa del Sol Hospital (Marbella, Spain)...
January 28, 2019: Photodermatology, Photoimmunology & Photomedicine
I Bobyr, A Campanati, A Giacchetti, A Offidani
Actinic keratosis (AK) is the most common cutaneous intraepithelial neoplasm that typically develops on sun-damaged skin of elderly patients. Some untreated AK lesions may progress into invasive squamous cell carcinoma (iSCC) (1). Treatments for AKs could be classified in "lesion-directed treatments" including cryotherapy, laser, curettage, and dermabrasion; "field-directed treatments" including imiquimod, PDT, ingenol mebutate, diclofenac and piroxicam (1). This article is protected by copyright...
January 28, 2019: Photodermatology, Photoimmunology & Photomedicine
Kasper Grandahl, Jonas Olsen, Kersti Brosbøl Engelund Friis, Ole Steen Mortensen, Kristina Sophie Ibler
BACKGROUND: The risk of photoaging and actinic keratosis caused by work related solar ultraviolet radiation exposure has not previously been investigated in Nordic countries. The objectives of this study was to describe the occurrence of photoaging, actinic keratosis and keratinocyte cancer in a population of Danish outdoor and indoor workers, and investigate the association between these clinical findings and semi-objective measures of work related solar ultraviolet radiation exposure in the same population...
January 28, 2019: Photodermatology, Photoimmunology & Photomedicine
Rebecca F Wang, Philip B Milam, Catherine Chung, Benjamin H Kaffenberger
No abstract text is available yet for this article.
January 16, 2019: Photodermatology, Photoimmunology & Photomedicine
Ploysyne Rattanakaemakorn, Phanitchanat Phusuphitchayanan, Kallapan Pakornphadungsit, Kunlawat Thadanipon, Poonkiat Suchonwanit
BACKGROUND: Scalp psoriasis is a major therapeutic challenge due to the hindrance caused by hair. Treatment with the 308-nm excimer lamp is purported to provide many benefits over conventional phototherapy. This retrospective study evaluates the efficacy, safety, and effective dosage of 308-nm excimer light in the treatment of scalp psoriasis. METHODS: We retrospectively reviewed the medical records of patients with scalp psoriasis who received treatment with 308-nm excimer light...
January 16, 2019: Photodermatology, Photoimmunology & Photomedicine
Leyla Baykal Selcuk, Deniz Aksu Arica, Elif Ates, Savaş Yayli, Sevgi Bahadir
BACKGROUND: The prevalence of skin cancers, including melanoma, has increased significantly in the past five decades. The main environmental factor implicated in their development is excessive sun exposure. Data on sun-protective behaviours in the Turkish population are very limited. OBJECTIVES: We aim to assess sun protection behaviours and the prevalence of exposure through broad participation among a young adult population in a national university in Turkey. METHODS: A multiple-choice questionnaire including 27 questions to evaluate sun protection behaviours was sent to e-mail addresses of all undergraduates...
January 16, 2019: Photodermatology, Photoimmunology & Photomedicine
Alexis B Lyons, Anjelica Peacock, Raheel Zubair, Iltefat H Hamzavi, Henry W Lim
Solar urticaria (SU) is an uncommon photodermatosis that presents with sensitivity to ultraviolet (UV) or visible light which triggers urticarial lesions. Treatment of SU is a challenge and usually involves antihistamines and photoprotection as a first line treatment. Phototherapy regimens are recommended if these first line treatments fail to control the disease. Induction of tolerance by phototherapy (UV hardening) has been commonly described as a treatment modality. UVA1 has deeper penetration to the dermis than UVA or NB-UVB; its use in SU has not been previously reported...
December 21, 2018: Photodermatology, Photoimmunology & Photomedicine
Akalya Mahendran, Xin Lin Wong, Steven Kao, Deshan Frank Sebaratnam
A 49-year-old female presented with an acneiform eruption induced by erlotinib. She had been diagnosed with Stage IV (T1N3M1) EGFR mutant adenocarcinoma of the lung and commenced on erlotinib 150mg daily. Within three days she developed an acneiform eruption prompting empiric treatment with topical hydrocortisone and systemic doxycycline 100mg daily. The acneiform eruption progressed with evolution to widespread pustules and papules with proud erythema involving the entire face with minor extension to the scalp, décolletage and back (Fig...
December 16, 2018: Photodermatology, Photoimmunology & Photomedicine
Teng-Li Lin, Chun-Ying Wu, Yun-Ting Chang, Chao-Keui Juan, Chi-Chiang Chen, Shi-Hang Yu, Yi-Ju Chen
BACKGROUND: Narrowband ultraviolet B (NB-UVB) phototherapy is a widely used treatment for various dermatoses. The risk of skin cancer following long-term NB-UVB phototherapy has rarely been explored in skin phototypes III-V. METHODS: We conducted a nationwide-matched cohort study and identified a total of 22 891 psoriasis patients starting NB-UVB phototherapy from the Taiwan National Health Insurance Database during the period 2000-2013. Cumulative incidences of skin cancers were compared between subjects receiving less than 90 UVB treatments (S-cohort, N = 13 260) and age- as well as propensity score-matched subjects receiving more than or equal to 90 UVB treatments (L-cohort, N = 3315)...
December 10, 2018: Photodermatology, Photoimmunology & Photomedicine
Linda Tognetti, Elisa Cinotti, Jean-Luc Perrot, Giovanni Neri, Elisa Pianigiani, Michele Fimiani, Pietro Rubegni
Graves' orbitopathy (GO) and pre-tibial mixedema (PTM) are autoimmune manifestation sharing the same etiology and histopathology, a chronic course and a frustrating treatment. Current management include topical and systemic corticosteroid as first line therapy, whereas cyclosporine, surgery and orbital radiotherapy are indicated for severe GO with variable results and mostly temporary remissions. In particular, keratopath and photophobia, due to exophthalmos and eyelid retraction, impaired eye mobility and diplopia due to the compression of optic nerve and extra-ocular muscles are usually minimally modified, as well as leg plaques/nodules and lymphoedema...
December 6, 2018: Photodermatology, Photoimmunology & Photomedicine
Chelsea A Luther, Henry W Lim
Solar angioedema is a rare photodermatosis, with only 11 reported patients worldwide. Patients develop facial (predominately eyelids, lips) and/or acral swelling hours after sun exposure, especially while on vacation to tropical areas. Management includes photoprotection and sun avoidance; preemptive antihistamines have been tried with minimal effect. Short courses of oral corticosteroids may be needed when these measures fail. Recognition of solar angioedema is important for dermatologists, allergists, emergency physicians, and primary care physicians as this condition can significantly affect the quality of life...
December 5, 2018: Photodermatology, Photoimmunology & Photomedicine
Denise Falcone, Natallia E Uzunbajakava, Frank van Abeelen, Piet E J van Erp, Peter C M van de Kerkhof
In an original article recently published in Photodermatology, Photoimmunology and Photomedicine (1), we aimed to prove therapeutic effects of photobiomodulation (PBM) based on clinical outcomes by investigating the impact of UV-free blue light at 453 nm on the recovery of the skin barrier and on the cutaneous inflammatory response elicited by acute perturbation of the skin of healthy human volunteers. In this Letter we describe a study of same design and scope in which we investigated the impact of LED red light at 656 nm...
December 5, 2018: Photodermatology, Photoimmunology & Photomedicine
Veera Nikkola, Maija E Miettinen, Piia Karisola, Mari Grönroos, Lasse Ylianttila, Harri Alenius, Erna Snellman, Timo Partonen
BACKGROUND: Recent findings suggest that circadian time regulates cellular functions in the skin and may affect protection against ultraviolet radiation (UVR). It is not known, however, whether UVR through skin directly affects the expression of circadian genes. We investigated the effect of ultraviolet-B (UVB) exposure on cryptochrome circadian clock 1 (CRY1), cryptochrome circadian clock 2 (CRY2), and circadian associated repressor of transcription (CIART) genes. METHODS: Healthy volunteers (n=12) were exposed to narrow-band UVB radiation of 4 standard erythemal dose (SED)...
November 25, 2018: Photodermatology, Photoimmunology & Photomedicine
Zoe Apalla, Alexandra Koukouthaki, Theodoros Sidiropoulos, Eftychios Psarakis, Christina Nikolaidou, Mattheos Bobos, Evaggelia Kampouropoulou, Aimilios Lallas
Papuloerythroderma of Ofuji is a clinical entity originally described in 1984, with a predilection in elderly Asian males.1 It is clinically characterized by coalescent flat-topped papules on an erythematous base that spare the skin folds.2 We herein report a new case of papuloerythroderma of Ofuji in a Caucasian male individual, and we describe the characteristic dermoscopic pattern of the syndrome for the first time in the literature. This article is protected by copyright. All rights reserved.
November 25, 2018: Photodermatology, Photoimmunology & Photomedicine
Samantha L Schneider, Henry W Lim
Photoprotection has become integral in the prevention of keratinocyte cancer and photoaging. Organic UV filters such as oxybenzone and octinoxate have become controversial due to their potential impact on the environmental and their potential human health risks. As such, inorganic UV filters, ZnO and TiO2, have become paramount in discussions about photoprotection. ZnO and TiO2 are used in sunscreens as nanoparticles, which denotes a size less than 100nm. The smaller size of these mineral particles increases their cosmetic acceptability by users as they are much less visible after application...
November 16, 2018: Photodermatology, Photoimmunology & Photomedicine
Novi Kusumaningrum, Jang-Hee Oh, Dong Hun Lee, Chang-Yup Shin, Jee-Hee Jang, Yeon Kyung Kim, Jin Ho Chung
BACKGROUND: Ultraviolet light (UV) exposure contributes various effects to skin including damage of the basement membrane. Cathepsin G (CTSG) belongs to serine protease family and its upregulation is involved in wrinkle formation by chronic UV irradiation. However, the effect of CTSG on the basement membrane damage in skin remains unclear. PURPOSE: To investigate the effects of topical treatment with a CTSG inhibitor, β-keto-phosphonic acid (KPA), on basement membrane damage in chronically UV-irradiated hairless mouse skin...
November 10, 2018: Photodermatology, Photoimmunology & Photomedicine
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