Journal of Materials Science. Materials in Medicine | Page 2

Tereza Smrhova, Petra Junkova, Stepanka Kuckova, Tomas Suchy, Monika Supova
Bioapatite ceramics produced from biogenic sources provide highly attractive materials for the preparation of artificial replacements since such materials are not only more easily accepted by living organisms, but bioapatite isolated from biowaste such as xenogeneous bones also provides a low-cost material. Nevertheless, the presence of organic compounds in the bioapatite may lead to a deterioration in its quality and may trigger an undesirable immune response. Therefore, procedures which ensure the elimination of organic compounds through bioapatite isolation are being subjected to intense investigation and the presence of remaining organic impurities is being determined through the application of various methods...
March 9, 2020: Journal of Materials Science. Materials in Medicine
Lili Wang, Jia Yan, Xiaokun Hu, Xinchen Zhu, Shuying Hu, Jun Qian, Feimin Zhang, Mei Liu
To validate the feasibility of two types of bioactive glass that contains spherical and radical spherical nano-sized particles in promoting bone repair, we hypothesize that radical spherical nano-sized particles have higher bone repair effectiveness than spherical one due to the physicochemical properties. We rigorously compared the physicochemical properties and bioactivities of these two types of bioactive glass. Specifically, we measured the size, surface morphology, concentration of ionic-dissolution products, bioactivity, and biological effects of two groups of bioactive glass on rat bone marrow mesenchymal stem cells (rBMSCs) and evaluate their effect on proliferation and osteogenic differentiation of rBMSCs in vitro...
March 5, 2020: Journal of Materials Science. Materials in Medicine
Lívia Rodrigues de Menezes, Emerson Oliveira da Silva, Lizandra Viana Maurat da Rocha, Isabel Ferreira Barbosa, Marina Rodrigues Tavares
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
March 5, 2020: Journal of Materials Science. Materials in Medicine
Xiaoliang Chen, Dongliang Zhai, Bochu Wang, Shilei Hao, Jia Song, Zhiping Peng
Keratins derived from human hair have been suggested to be particularly effective in general surgical wound healing. However, the healing of a combined radiation-wound injury is a multifaceted regenerative process. Here, hydrogels fabricated with human hair keratins were used to test the wound healing effects on rats suffering from combined radiation-wound injuries. Briefly, the keratin extracts were verified by dodecyl sulfate polyacrylamide gel electrophoresis analysis and amino acid analysis, and the keratin hydrogels were then characterized by morphological observation, Fourier transform infrared spectroscopy analysis and rheology analyses...
March 3, 2020: Journal of Materials Science. Materials in Medicine
Helena Filipa Pereira, Ibrahim Fatih Cengiz, Filipe Samuel Silva, Rui Luís Reis, Joaquim Miguel Oliveira
Bone tissue has an astonishing self-healing capacity yet only for non-critical size defects (<6 mm) and clinical intervention is needed for critical-size defects and beyond that along with non-union bone fractures and bone defects larger than critical size represent a major healthcare problem. Autografts are, still, being used as preferred to treat large bone defects. Mostly, due to the presence of living differentiated and progenitor cells, its osteogenic, osteoinductive and osteoconductive properties that allow osteogenesis, vascularization, and provide structural support...
March 2, 2020: Journal of Materials Science. Materials in Medicine
Nicola Contessi Negrini, Maria Veronica Lipreri, Maria Cristina Tanzi, Silvia Farè
The regeneration of injured or damaged tissues by cell delivery approaches requires the fabrication of cell carriers (e.g., microspheres, MS) that allow for cell delivery to limit cells spreading from the injection site. Ideal MS for cell delivery should allow for cells adhesion and proliferation on the MS before the injection, while they should allow for viable cells release after the injection to promote the damaged tissue regeneration. We optimized a water-in-oil emulsion method to obtain gelatin MS crosslinked by methylenebisacrylamide (MBA)...
February 14, 2020: Journal of Materials Science. Materials in Medicine
Fabio Tentor, Giorgia Siccardi, Pasquale Sacco, Danilo Demarchi, Eleonora Marsich, Kristoffer Almdal, Sanjukta Bose Goswami, Anja Boisen
The intravaginal route of administration can be exploited to treat local diseases and for systemic delivery. In this work, we developed an alginate/chitosan membrane sufficiently stable in a simulated vaginal fluid and able to dissolve over time at a very slow and linear rate. The membrane demonstrated good mechanical properties both in its swollen and dry form. As a study case, we evaluated the viability of this potential drug delivery system for the treatment of bacterial vaginosis, a common disease affecting women in their reproductive age...
February 14, 2020: Journal of Materials Science. Materials in Medicine
Gry Hulsart-Billström, Christina Stelzl, Philip Procter, Michael Pujari-Palmer, Gerard Insley, Håkan Engqvist, Sune Larsson
A new class of materials, bone adhesives, could revolutionise the treatment of highly fragmented fractures. We present the first biological safety investigation of a bio-inspired bone adhesive. The formulation was based upon a modified calcium phosphate cement that included the amino acid phosphoserine. This material has recently been described as substantially stronger than other bioresorbable calcium phosphate cements. Four adhesive groups with the active substance (phosphoserine) and two control groups without phosphoserine were selected for in vitro and in vivo biocompatibility testing...
February 8, 2020: Journal of Materials Science. Materials in Medicine
Julia Tolksdorf, Raymund E Horch, Jasmin S Grüner, Rafael Schmid, Annika Kengelbach-Weigand, Dirk W Schubert, Siegfried Werner, Dominik Schneidereit, Oliver Friedrich, Ingo Ludolph
Capsular contracture remains a challenge in plastic surgery and represents one of the most common postoperative complications following alloplastic breast reconstruction. The impact of the surface structure of silicone implants on the foreign body reaction and the behaviour of connective tissue-producing cells has already been discussed. The aim of this study was to investigate different pore sizes of silicone surfaces and their influence on human fibroblasts in an in vitro model. Four different textures (no, fine, medium and coarse texture) produced with the salt-loss technique, have been assessed in an in vitro model...
February 3, 2020: Journal of Materials Science. Materials in Medicine
Mariela Agotegaray, María Gabriela Blanco, Adrián Campelo, Elba García, Roberto Zysler, Virginia Massheimer, María José De Rosa, Verónica Lassalle
The role Beta-cyclodextrin (βCD) on improving biocompatibility on healthy cellular and animal models was studied upon a formulation obtained from the development of a simple coating procedure. The obtained nanosystems were thoroughly characterized by FTIR, TGA, atomic absorption spectroscopy, dynamic light scattering and zeta potential, TEM/HR-TEM and magnetic properties. βCD might interact with the magnetic core through hosting OA. It is feasible that the nanocomposite is formed by nanoparticles of MG@OA dispersed in a βCD matrix...
January 30, 2020: Journal of Materials Science. Materials in Medicine
Fabian Obregon-Miano, Ali Fathi, Catherine Rathsam, Isbel Sandoval, Fariba Deheghani, Axel Spahr
Extracellular matrix (ECM) has a major role in the structural support and cellular processes of organs and tissues. Proteins extracted from the ECM have been used to fabricate different scaffolds for tissue engineering applications. The aims of the present study were to extract, characterize and fabricate a new class of hydrogel with proteins isolated from pig bone ECM and combine them with a synthetic polymer so it could be used to promote bone regeneration. Porcine bone demineralized and digested extracellular matrix (pddECM) containing collagen type I was produced, optimized and sterilized with high pressurized CO2 method...
January 27, 2020: Journal of Materials Science. Materials in Medicine
Aysenur Topsakal, Nazmi Ekren, Osman Kilic, Faik N Oktar, Mahir Mahirogullari, Ozan Ozkan, Hilal Turkoglu Sasmazel, Mustafa Turk, Iuliana M Bogdan, George E Stan, Oguzhan Gunduz
Powders of β-tricalcium phosphate [β-TCP, β-Ca3 (PO4 )2 ] and composite powders of β-TCP and polyvinyl alcohol (PVA) were synthesized by using wet precipitation methods. First, the conditions for the preparation of single phase β-TCP have been delineated. In the co-precipitation procedure, calcium nitrate and diammonium hydrogen phosphate were used as calcium and phosphorous precursors, respectively. The pH of the system was varied in the range 7-11 by adding designed amounts of ammonia solution. The filtered cakes were desiccated at 80 °C and subsequently calcined at different temperatures in the range between 700-1100 °C...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Nathan J Thyparambil, Lisa C Gutgesell, Cassandra C Hurley, Lauren E Flowers, Delbert E Day, Julie A Semon
Bioactive glasses have transformed healthcare due to their versatility. Bioactive borate glass, in particular, has shown remarkable healing properties for both hard and soft tissues. Incorporating dopants into the composition of bioactive glass helps to control mechanical properties, and it increases their usefulness for clinical applications. Using a bioactive borate glass, 13-93B3 (B3), we investigated eleven dopants on the viability and migration potential of adipose stem cells (ASCs), a therapeutic source of cells used in tissue engineering and cell therapy...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Chenbing Wang, Jinlong Liu, Yanbo Liu, Boheng Qin, Dongning He
Chitosan with hydroxyapatite composition, a natural polymer, may be a biomaterial of importance for bone regeneration. Carbon nanotube, a nanoscale material, has been another focus for bone restoration. Zinc, an essential trace element, contributes to the development and growth of skeletal system. The purpose of the current research was to investigate the effects of Zinc-loaded Carbon Nanotubes/Chitosan composite biomaterials in the restoration of rat skull defects, and to verify the hypothesis that these zinc ions of appropriate concentration would strengthen the osteogenesis of rat defects...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Daiki Nakagawa, Mariko Nakamura, Shigenori Nagai, Mamoru Aizawa
Immunotherapy without side effects has been expected as a novel medical treatment for cancer. However, drugs such as cytokines typically used for immunotherapy are very expensive. Therefore, we propose the concept of immunoceramics that affect the immune system. Previous studies have shown that polymers including the phenylboronic acid group activate lymphocytes. This activation may be due to interaction between the sugar chains in cells and the OH group in B(OH)3 formed via dissociation of the BO2 group. In the present study, boron-containing apatite (BAp; Ca9...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Vincenza Ragone, Elena Canciani, Massimo Arosio, Matteo Olimpo, Lisa Adele Piras, Mitzy Mauthe von Degerfeld, Davide Augusti, Riccardo D'Ambrosi, Claudia Dellavia
The additive manufacturing techniques (AM) are able to realize three-dimensional trabecular structures that mimic the trabecular structure of the bone. An in vivo study in sheep was carried out with the aim of assessing the bone response and the trend of osteointegration of a randomized trabecular titanium structure produced by the AM technique. In 6 sheep were implanted 84 specimens with a trabecular titanium structure (4 implants in the femur distal epiphysis; 4 implants in the tibial plate; 6 implants in the tibial shaft)...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Pedro Akira Bazaglia Kuroda, Fernanda de Freitas Quadros, Karolyne Dos Santos Jorge Sousa, Tatiani Ayako Goto Donato, Raul Oliveira de Araújo, Carlos Roberto Grandini
Titanium alloys have been widely used as biomaterials, especially for orthopedic prostheses and dental implants, but these materials have Young's modulus almost three times greater than human cortical bones. Because of this, new alloys are being produced for the propose of decreasing Young's modulus to achieve a more balanced mechanical compatibility with the bone. In this paper, it is reported the development of Ti-25Ta alloys as a base material, in which was introduced zirconium, with concentration varying between 0 and 40 wt%, with the aim of biomedical applications...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Fernanda Ferrrari Esteves Torres, Reinhilde Jacobs, Mostafa EzEldeen, Juliane Maria Guerreiro-Tanomaru, Bernardo Camargo Dos Santos, Éverton Lucas-Oliveira, Tito José Bonagamba, Mario Tanomaru-Filho
The aim of this study was to evaluate volumetric and morphological stability of 3 root-end filling materials in addition to porosity and interface voids, using micro-computed tomography (µCT) in high resolution and a highly accurate approach for image analysis. Following root-end resection and apical preparation, two-rooted maxillary premolars were divided into three groups, according to the filling materials: White MTA Angelus, Biodentine, and IRM. Samples were scanned by µCT at 5 µm after the setting time and at time intervals of 7 and 30 days after immersion in phosphate-buffered saline (PBS)...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Virginia Campani, Lorena Scotti, Teresa Silvestri, Marco Biondi, Giuseppe De Rosa
This work describes the development of liposomes encapsulating curcumin (CURC) aiming to provide insights on the influence of CURC on the thermodynamic and skin permeation/penetration features of the vesicles. CURC-loaded liposomes were prepared by hydration of lipid film, in the 0.1-15% CURC:DPPC w/w ratio range. The obtained formulations were characterized for their size distribution, zeta potential and vesicle deformability, along with their thermodynamic properties and ex vivo skin penetration/permeation ability...
January 21, 2020: Journal of Materials Science. Materials in Medicine
Jerry Howard, Levi Gardner, Zahra Saifee, Aladdin Geleil, Isaac Nelson, John S Colombo, Steven E Naleway, Krista Carlson
Evaluation of the physicochemical behavior and setting reactions of a novel inorganic pulp capping cement which makes use of the unique corrosion properties of sodium metasilicate (NaSi) glass. NaSi and calcium phosphate (CaP) glass powders were synthesized through a melt-quench method. Cements were created by mixing various amounts of the glasses with deionized water at a powder-to-liquid ratio of 2.5 g mL-1 . Working and setting times were measured using the indentation standard ISO 9917-1. Sealing ability was tested by placing set samples of each composition in methylene blue dye solution for 24 h...
January 2, 2020: Journal of Materials Science. Materials in Medicine
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