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Journal of Materials Science. Materials in Medicine | Page 2

Sandra Rother, Vera Krönert, Nicolas Hauck, Albrecht Berg, Stephanie Moeller, Matthias Schnabelrauch, Julian Thiele, Dieter Scharnweber, Vera Hintze
Hyaluronan (HA)-based microgels generated in a microfluidic approach, containing an artificial extracellular matrix composed of collagen and high-sulfated hyaluronan (sHA3), were incorporated into a HA/collagen-based hydrogel matrix. This significantly enhanced the retention of noncrosslinked sHA3 within the gels enabling controlled sHA3 presentation. Gels containing sHA3 bound higher amounts of transforming growth factor-β1 (TGF-β1) compared to pure HA/collagen hydrogels. Moreover, the presence of sHA3-containing microgels improved the TGF-β1 retention within the hydrogels...
May 24, 2019: Journal of Materials Science. Materials in Medicine
K R Fernandes, J R Parisi, A M P Magri, H W Kido, P R Gabbai-Armelin, C A Fortulan, E D Zanotto, O Peitl, R N Granito, A C M Renno
The combination of different biomaterials can be a promising intervention for the composites manufacture, mainly by adding functional and structural characteristics of each material and guarantee the advantages of the use of these composites. In this context, the aim of this study was to develop and evaluated the influence of the incorporation of marine spongin (SPG) into Biosilicate® (BS) in different proportions be used during bone repair. For this purpose, it was to develop and investigate different BS/SPG formulations for physico-chemical and morphological characteristics by pH, loss mass, Fourier transform infrared spectrometer (FTIR) and scanning electron microscope (SEM) analysis...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Francesca Scognamiglio, Andrea Travan, Rossana Bussani, Massimiliano Borgogna, Ivan Donati, Joanna W A M Bosmans, Nicole D Bouvy, Eleonora Marsich
Implantable membranes based on alginate and hyaluronic acid (HA) were manufactured to obtain a rapidly resorbing pliable mesh for the in situ administration of HA to intestinal tissue. Morphological analyses of this interpenetrated matrix pointed out a homogeneous polymeric texture while degradation studies demonstrated that the material is able to dissolve in physiological solutions within few days. Biological studies in vitro showed that the membrane is biocompatible towards human dermal fibroblasts and that liquid extracts from the HA-containing membrane can stimulate wound healing...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Ibrahim Fatih Cengiz, Helder Pereira, João Espregueira-Mendes, Il Keun Kwon, Rui L Reis, Joaquim Miguel Oliveira
The menisci have crucial roles in the knee, chondroprotection being the primary. Meniscus repair or substitution is favored in the clinical management of the meniscus lesions with given indications. The outstanding challenges with the meniscal scaffolds include the required biomechanical behavior and features. Suturability is one of the prerequisites for both implantation and implant survival. Therefore, we proposed herein a novel highly interconnected suturable porous scaffolds from regenerated silk fibroin that is reinforced with 3D-printed polycaprolactone (PCL) mesh in the middle, on the transverse plane to enhance the suture-holding capacity...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Sarah Al-Maawi, Carlos Mota, Alica Kubesch, C James Kirkpatrick, Lorenzo Moroni, Shahram Ghanaati
In vivo experiments are accompanied by ethical issues, including sacrificing a large number of animals as well as large costs. A new in vivo 3D screening system was developed to reduce the number of required animals without compromising the results. The present pilot study examined a multiwell array system in combination with three different collagen-based biomaterials (A, B and C) using subcutaneous implantation for 10 days and histological and histomorphometrical evaluations. The tissue reaction towards the device itself was dominated by mononuclear cells...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Adilet Beishenaliev, Siew Shee Lim, Kim Yeow Tshai, Poi Sim Khiew, Hassan Nizar Moh'd Sghayyar, Hwei-San Loh
This study aimed to explore a potential use of fish scale-derived gelatin nanofibrous scaffolds (GNS) in tissue engineering due to their biological and economical merits. Extraction of gelatin was achieved via decalcification, sonication and lyophilization of mixed fish scales. To fabricate nano-scale architecture of scaffolds analogous to natural extracellular matrix, gelatin was rendered into nanofibrous matrices through 6-h electrospinning, resulting in the average diameter of 48 ± 12 nm. In order to improve the water-resistant ability while retaining their biocompatibility, GNS were physically crosslinked with ultraviolet (UV) irradiation for 5 min (UGN5), 10 min (UGN10) and 20 min (UGN20)...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Gry Hulsart-Billström, Oscar Janson, Håkan Engqvist, Ken Welch, Jaan Hong
The release of growth factors from platelets, mediated by the coagulation and the complement system, plays an important role in the bone formation around implants. This study aimed at exploring the thromboinflammatory response of H2 O2 -alkali soaked commercially pure titanium grade 2 discs exposed to whole human blood, as a way to assess the bioactivity of the discs. Commercially pure titanium grade 2 discs were modified by soaking in H2 O2 , NaOH and Ca(OH)2 . The platelet aggregation, coagulation activation and complement activation was assessed by exposing the discs to fresh whole blood from human donors...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Cui Cheng, Yabin Meng, Zhihong Zhang, Ya Li, Chun Liu, Qiqing Zhang
Clinical application of cisplatin (CDDP) against various solid tumors is often limited due to its poor selectivity and severe side effect. Considering this, in our study, CDDP was incorporated in fluorescent PEG amine grafted aldehyde hyaluronic acid by imine bond and metal ion coordination bond linking and formed a complex, the complex was then self-assembled into nanoparticles in water simply. FT-IR, XRD, DLS and SEM analysis demonstrated that the nanoparticles were prepared successfully and exhibited a spherical structure with size ranged from 216...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Dongli Zhang, Wen Liu, Xiang-Dong Wu, Xiaoqiang He, Xiao Lin, Han Wang, Jidong Li, Jiaxing Jiang, Wei Huang
Recently, chronic osteomyelitis is still a challenging surgical problem. Unfortunately, the traditional clinical method using bone cement loaded antibiotics is restricted due to its non-biodegradability and limited release of antibiotics. Hydroxyapatite is a good adsorbent with good biocompatibility, an ideal bone repair material, and can avert the requirement for the secondary surgical procedure of removal. In this study, nano-hydroxyapatite combined with a polyurethane containing 3% silver (Ag/n-HA/PU) was synthesized, and investigated for its efficacy of treating chronic bone infection with bone defects...
May 24, 2019: Journal of Materials Science. Materials in Medicine
Yuta Kurashina, Atsushi Ezura, Ryo Murakami, Masayoshi Mizutani, Jun Komotori
In this paper, we study a process for modifying the surface microtopography of the Ti oxide layer using a nanosecond-pulsed laser (NPL). Even now, the mechanism by which hydroxyl groups are generated on the titanium surface treated by NPL is not clear. Hence, we evaluated the surface properties of the NPL defocus distances on pure titanium surfaces, and investigated the relationship between the generation of hydroxyapatites/cell viability and the titanium surface characteristics. The NPL defocus distance was varied from 0 to 4 mm...
May 13, 2019: Journal of Materials Science. Materials in Medicine
Anuradha Subramanian, Uma Maheswari Krishnan, Swaminathan Sethuraman
The original version of this article unfortunately contained a mistake. The presentation of Fig. 2e was incorrect. The corrected version of Fig. 2E1 is given below.
May 13, 2019: Journal of Materials Science. Materials in Medicine
Kazim K Moncal, Veli Ozbolat, Pallab Datta, Dong N Heo, Ibrahim T Ozbolat
Thermally-crosslinked hydrogels in bioprinting have gained increasing attention due to their ability to undergo tunable crosslinking by modulating the temperature and time of crosslinking. In this paper, we present a new bioink composed of collagen type-I and Pluronic® F-127 hydrogels, which was bioprinted using a thermally-controlled bioprinting unit. Bioprintability and rheology of the composite bioink was studied in a thorough manner in order to determine the optimal bioprinting time and extrusion profile of the bioink for fabrication of three-dimensional (3D) constructs, respectively...
April 30, 2019: Journal of Materials Science. Materials in Medicine
Lubomir Medvecky, Maria Giretova, Ruzena Kralikova, Simona Medvecka, Jaroslav Briancin
The in vitro cytotoxicity of both the multiwalled carbon nanotubes (MWCNT) in suspension with culture medium and the tetracalcium phosphate/monetite cement with addition of 0.8 wt% of MWCNTs on fibroblasts and osteoblasts were studied. The cytotoxicity was evaluated by MTS test (formazan) and live/dead staining. No cytotoxicity of MWCNT extract was measured contrary to about 60% reduction in proliferation of fibroblasts in MWCNT suspension as compared with negative control. The several contact cytotoxicity of MWCNT composite cement surfaces on seeded cells was demonstrated by MTS test and live/dead staining of damaged fibroblasts and dead osteoblasts after 72 h of culture...
April 30, 2019: Journal of Materials Science. Materials in Medicine
Yadong Liu, Kang Tian, Jun Hao, Tao Yang, Xiaoling Geng, Weiguo Zhang
Poly (glycerol sebacate) (PGS) is a synthetic polymeric material with the characteristics of controllable degradation, high plasticity and excellent biocompatibility. However, the time of PGS degradation is faster than that of cartilage regeneration, which limits its application in cartilage tissue engineering. Polycaprolactone (PCL), a widely used synthetic polymer, has appropriate biodegradability and higher mechanical strength. This study aims to make a scaffold from blends of fast degrading PGS and slowly degrading PCL, and to investigate its potential for cartilage tissue engineering applications...
April 29, 2019: Journal of Materials Science. Materials in Medicine
Wen Li, Yanwei Yang, Hongchen Zhang, Zexian Xu, Libo Zhao, Jinqing Wang, Yinong Qiu, Bin Liu
Microbial infection around dental implants is a major cause for the loss of devices, including soft tissue infection in early period, post-operation peri-implantitis, and osseointegration failure. Silver nanoparticles (AgNPs) with wide antimicrobial spectrum, strong antimicrobial effect and hypotoxicity, as well as low incidence of antibiotic resistance, are widely involved in biomedical applications. Herein, firmly anchoring AgNPs onto the surface of implants through physical-chemical reaction is likely to relieve the above issues...
April 23, 2019: Journal of Materials Science. Materials in Medicine
Ajinkya A Shitole, Piyush W Raut, Neeti Sharma, Prabhanjan Giram, Anand P Khandwekar, Baijayantimala Garnaik
Fabricating a bioartificial bone graft possessing structural, mechanical and biological properties mimicking the real bone matrix is a major challenge in bone tissue engineering. Moreover, the developed materials are prone to microbial invasion leading to biomaterial centered infections which might limit their clinical translation. In the present study, biomimetic nanofibrous scaffolds of Poly ɛ-caprolactone (PCL)/nano-hydroxyapatite (nHA) were electrospun with 1wt%, 5wt%, 10wt%, 15wt% and 30wt% of zinc oxide (ZnO) nanoparticles in order to understand the optimal concentration range of (ZnO) nanoparticles balancing both biocompatibility and osteoregeneration...
April 22, 2019: Journal of Materials Science. Materials in Medicine
Xiaotao Zheng, Kewei Wu, Jiqiang Wang, Linwei Ma, Jiuyang Yu, Jianmin Xu
The mechanical properties of medical grade ultrahigh molecular weight polyethylene (UHMWPE) are critical for the safety and integrity of UHMWPE implantation. Accordingly, the mechanical features of UHMWPE are tested under repeated stress-controlled and strain-controlled compression at room temperature. Some important effect factors, such as stress rate, mean stress, stress amplitude, strain rate, mean strain, strain range and multiple load steps are further considered in detail. Results indicate that the lower stress rate causes the greater accumulated plastic strain and the accumulated plastic strain rate becomes increasingly lower with increasing number of cycles...
April 19, 2019: Journal of Materials Science. Materials in Medicine
Jiaqi Song, Pengli Jin, Muqin Li, Jiguang Liu, Dongmei Wu, Haitao Yao, Jiaqi Wang
Bone infection and implant secondary removal remains a clinical challenge. We used ultrasonic micro-arc oxidation (UMAO) and conversion of phytic acid copper plating to prepare a pure magnesium polyhydric biofilm; we evaluated the surface microstructures, phase, element composition, and wettability of the film in vitro. The antibacterial activity of films with different Cu contents was confirmed by coating method, imaging examination, and microbiological cultures in vitro. The biocompatibility of biofilms was confirmed by cell proliferation, vitality, and morphology assays in vitro and histological evaluation in vivo...
April 16, 2019: Journal of Materials Science. Materials in Medicine
Xiaoyan Wang, Qianqian Liu, Wei Chen, Long Liu
Mesoporous bioactive glass (MBG) is performed as a bone tissue engineering material because of its good bioactivity, biocompatibility and osteoinducion characteristics. Here, we propose MBG with larger pores (MBG-L) adsorbed fibroblast growth factor (FGF) to facilitate osteoblast differentiation and matrix mineralization. Specifically, we observed that MBG-L promotes calcium deposit precipitation in vitro. In addition, adhesion, proliferation, differentiation and matrix mineralization were promoted after osteoblast cultured on MBG-L/FGF...
April 13, 2019: Journal of Materials Science. Materials in Medicine
Yan Xue, Mingyao Wu, Zongren Liu, Jinhua Song, Shuyu Luo, Hongjie Li, Yuan Li, Lichun Jin, Binbin Guan, Mingli Lin, Fuyu Chen, Chenxin Jin, Deping Liu, Yanqiu Li, Xu Zhang
The objective of this study was to fabricate and characterize chitosan combined with different amounts of simvastatin-loaded nanoparticles and to investigate their potential for guided bone regeneration in vitro and in vivo. Different SIM-CSN formulations were combined into a chitosan scaffold (SIM-CSNs-S), and the morphology, simvastatin release profile, and effect on cell proliferation and differentiation were investigated. For in vivo experiments, ectopic osteogenesis and the critical-size cranial defect model in SD rats were chosen to evaluate bone regeneration potential...
April 12, 2019: Journal of Materials Science. Materials in Medicine
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