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Journal of Materials Science. Materials in Medicine | Page 2

Song Wang, Xiaoning Sun, Yaping Wang, Kangning Sun, Jianqiang Bi
In this work, the setting process of reduced graphene (RGO)/carbon nanotubes (CNTs) reinforced calcium phosphate cement (CPC) were conducted in a microwave environment. The introduction of microwave can increase the reaction temperature, speed up the vibration of water molecules and eliminate bubbles from the interface between RGO, CNTs and the substrate. Comparing with CPC without microwave treatment, the final setting time of composites after microwave treatment are almost a half, the flexural strength and the compressive strength are increased by 19...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Yang Lei, Qinggong Ning, Yuyang Tang, Yunbing Wang
Glutaraldehyde (GLUT) crosslinked bioprosthetic heart valves (BHVs) might fail due to progressive degradation and calcification. GLUT cannot stabilize glycosaminoglycans (GAGs), which are important for BHVs' life time. In this current study we developed a new BHVs preparation strategy using exogenous hyaluronic acid (HA)/chondroitin sulfate (CS) supplement and sodium trimetaphosphate (STP) crosslinking method. Exogenous HA and CS provide additional GAGs for pericardiums. STP could link two GAGs by reacting with hydroxyl groups in GAGs' repeating polysaccharides units...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Shirin Toosi, Hojjat Naderi-Meshkin, Fatemeh Kalalinia, Hossein HosseinKhani, Asieh Heirani-Tabasi, Shahrzad Havakhah, Sirous Nekooei, Amir Hossein Jafarian, Fahimeh Rezaie, Mohammad Taghi Peivandi, Hooman Mesgarani, Javad Behravan
We have evaluated the capability of a collagen/poly glycolic acid (PGA) scaffold in regeneration of a calvarial bone defects in rabbits. 4 bone critical size defects (CSD) were created in the calvarial bone of each rabbit. The following 4 treatment modalities were tested (1) a collagen/PGA scaffold (0.52% w/w); (2) the collagen/PGA scaffold (0.52% w/w) seeded with adipose-derived mesenchymal stem cells (AD-MSCs, 1 × 106 cells per each defect); (3) AD-MSCs (1 × 106 cells) no scaffold material, and (4) blank control...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Sandra Stier, Lisa Rebers, Veronika Schönhaar, Eva Hoch, Kirsten Borchers
Biobased hydrogels are considered to mimic native extracellular matrix due to their high water content and are considered as adequate matrices for cell encapsulation. However, the equilibrium degree of swelling (EDS) and stiffness of simple hydrogel formulations are typically confined: Increasing polymer concentration results in increasing stiffness and simultaneously decreasing EDS. The aim of this contribution was to decouple this standard correlation between polymer content, stiffness and EDS as well as the assembly of hydrogels with graded composition of hydrogels by layer-wise printing...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Qianqian Guo, Tianyu Lan, Yi Chen, Yini Xu, Jianqing Peng, Ling Tao, Xiangchun Shen
Antimicrobial resistance to traditional antibiotics leads to a serious concern for medical care owing to ineffective antibiotic therapies. This study focused on the preparation of silver nanocomposites (AgNPs@Tob&PAGA) by modifying AgNPs with tobramycin (Tob) and carbohydrate polymer of poly(2-(acrylamido) glucopyranose) (PAGA). The enhanced antibacterial activities of nanocomposites against common pathogens of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were explored. The introduction of PAGA onto silver nanocomposites improved both citocompatibility and antibacterial activity...
March 6, 2019: Journal of Materials Science. Materials in Medicine
C F Marques, G S Diogo, S Pina, J M Oliveira, T H Silva, R L Reis
In the last few years, additive manufacturing (AM) has been gaining great interest in the fabrication of complex structures for soft-to-hard tissues regeneration, with tailored porosity, and boosted structural, mechanical, and biological properties. 3D printing is one of the most known AM techniques in the field of biofabrication of tissues and organs. This technique opened up opportunities over the conventional ones, with the capability of creating replicable, customized, and functional structures that can ultimately promote effectively different tissues regeneration...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Egor O Osidak, Pavel A Karalkin, Maria S Osidak, Vladislav A Parfenov, Dmitriy E Sivogrivov, Frederico D A S Pereira, Anna A Gryadunova, Elizaveta V Koudan, Yusef D Khesuani, Vladimir A Кasyanov, Sergei I Belousov, Sergey V Krasheninnikov, Timofei E Grigoriev, Sergey N Chvalun, Elena A Bulanova, Vladimir A Mironov, Sergey P Domogatsky
Collagen is one of the most promising materials for 3D bioprinting because of its distinguished biocompatibility. Cell-laden constructs made of pure collagen with or without incorporated growth supplements support engineered constructs persistence in culture and are perfectly suitable for grafting. The limiting factor for direct 3D collagen printing was poor printability of collagen solutions, especially admixed with cells or tissue spheroids. In our study, we showed that concentrated solutions of native collagen branded Viscoll were effective as bioinks with high fidelity performance...
March 4, 2019: Journal of Materials Science. Materials in Medicine
Tatjana Flora, I González de Torre, M Alonso, J Carlos Rodríguez-Cabello
The development of new capillary networks in engineered constructs is essential for their survival and their integration with the host tissue. It has recently been demonstrated that ELR-based hydrogels encoding different bioactivities are able to modulate their interaction with the host after injection or implantation, as indicated by an increase in cell adhesion and the ability to trigger vascularization processes. Accordingly, the aim of this study was to increase their angiogenic ability both in vitro and in vivo using a small VEGF mimetic peptide named QK, which was tethered chemically to ELR-based hydrogels containing cell-adhesion sequences in their backbone, such as REDV and RGD, as well as a proteolytic site (VGVAPG)...
February 14, 2019: Journal of Materials Science. Materials in Medicine
Sebastian P Boelch, Martin C Jordan, Joerg Arnholdt, Andre F Steinert, Maximilian Rudert, Martin Luedemann
The effect of doubling the immersion fluid (eluate) volume on antibiotic concentrations and on mechanical stability from vancomycin and gentamicin loaded bone cements was investigated in vitro. Antibiotic loaded bone cements containing premixed 1.34% gentamicin antibiotic concentration in the cement powder (wt), premixed 1.19% gentamicin wt and 4.76% vancomycin wt and premixed 1.17% wt gentamicin additionally manually blended with 4.68% wt vancomycin were tested. Six specimens per group were immersed in 4 ml and 8 ml for 6 weeks while the eluate was exchanged every 24 h...
February 14, 2019: Journal of Materials Science. Materials in Medicine
Olivia Kérourédan, Jean-Michel Bourget, Murielle Rémy, Sylvie Crauste-Manciet, Jérôme Kalisky, Sylvain Catros, Noëlie B Thébaud, Raphaël Devillard
Development of a microvasculature into tissue-engineered bone substitutes represents a current challenge. Seeding of endothelial cells in an appropriate environment can give rise to a capillary-like network to enhance prevascularization of bone substitutes. Advances in biofabrication techniques, such as bioprinting, could allow to precisely define a pattern of endothelial cells onto a biomaterial suitable for in vivo applications. The aim of this study was to produce a microvascular network following a defined pattern and preserve it while preparing the surface to print another layer of endothelial cells...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Karol P Steckiewicz, Ewelina Barcinska, Anna Malankowska, Agata Zauszkiewicz-Pawlak, Grzegorz Nowaczyk, Adriana Zaleska-Medynska, Iwona Inkielewicz-Stepniak
Due to development of nanotechnology and gold nanoparticles (AuNPs) increasing use in different areas of medicine, especially in oncology, better understanding of their potential cytotoxicity is necessary to protect patients safety. Shape and size of AuNPs is an important modulator of their cytotoxicity. Therefore, we investigated the cytotoxicity of AuNPs rods (≈39 nm length, 18 nm width), AuNPs stars (≈ 215 nm) and AuNPs spheres (≈ 6.3 nm) against human fetal osteoblast (hFOB 1.19), osteosarcoma (143B, MG63) and pancreatic duct cell (hTERT-HPNE) lines by MTT and neutral-red uptake assay...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Hanaa H Ahmed, Hadeer A Aglan, Mostafa Mabrouk, Ahmed A Abd-Rabou, Hanan H Beherei
The main target of this work was to explore the proliferative impact of selenium dioxide nanoparticles (SeO2 ) and selenium dioxide/titanium dioxide nanocomposites (Se/Ti (I), (II) and (III)) on mesenchymal stem cells (MSCs). For this purpose, SeO2 and Se/Ti (I), (II) and (III) were prepared by facile one step method and characterized by transmission electron microscopy (TEM), Zetasizer, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscope (SEM) along with energy-dispersive X-ray spectrometry (EDX) with reference to SeO2 nanoparticles...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Aranka Ilea, Oana-Gabriela Vrabie, Anida-Maria Băbțan, Viorel Miclăuş, Flavia Ruxanda, Melinda Sárközi, Lucian Barbu-Tudoran, Voicu Mager, Cristian Berce, Bianca Adina Boșca, Nausica Bianca Petrescu, Oana Cadar, Radu Septimiu Câmpian, Réka Barabás
The aim of this study was to assess the osseointegration of two series of titanium (Ti) scaffolds with 0.8 and 1 mm cell size obtained by Selective Laser Melting (SLM) technique. One of the series had the Ti surface unmodified, while the other had the Ti surface coated with silicon-substituted nano-hydroxyapatite (nano-HapSi). The scaffolds were implanted in the femur bone defects of 6 White Californian male rabbits: three animals were implanted with 0.8 mm cell size scaffolds and three animals with 1 mm cell size scaffolds, respectively...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Catarina Geão, Ana R Costa-Pinto, Cassilda Cunha-Reis, Viviana P Ribeiro, Sílvia Vieira, Joaquim M Oliveira, Rui L Reis, Ana L Oliveira
Guided tissue regeneration (GTR) is a surgical procedure applied in the reconstruction of periodontal defects, where an occlusive membrane is used to prevent the fast-growing connective tissue from migrating into the defect. In this work, silk fibroin (SF) membranes were developed for periodontal guided tissue regeneration. Solutions of SF with glycerol (GLY) or polyvinyl alcohol (PVA) where prepared at several weight ratios up to 30%, followed by solvent casting and thermal annealing at 85 °C for periods of 6 and 12 h to produce high flexible and stable membranes...
February 12, 2019: Journal of Materials Science. Materials in Medicine
J Renwick Beattie, Antonia Sophocleous, M Clare Caraher, Olive O'Driscoll, Niamh M Cummins, Steven E J Bell, Mark Towler, Alireza Rahimnejad Yazdi, Stuart H Ralston, Aymen I Idris
Pharmacological therapy of osteoporosis reduces bone loss and risk of fracture in patients. Modulation of bone mineral density cannot explain all effects. Other aspects of bone quality affecting fragility and ways to monitor them need to be better understood. Keratinous tissue acts as surrogate marker for bone protein deterioration caused by oestrogen deficiency in rats. Ovariectomised rats were treated with alendronate (ALN), parathyroid hormone (PTH) or estrogen (E2). MicroCT assessed macro structural changes...
February 12, 2019: Journal of Materials Science. Materials in Medicine
S Aarthy, D Thenmuhil, G Dharunya, P Manohar
The current work describes the influence of sintering temperatures on biological and mechanical properties of naturally derived hydroxyapatite (HAp). The phase pure hydroxyapatite developed from the goat bone has been obtained by optimizing the calcination temperature from 600-900 °C. Further, HAp calcined at 900 °C was subjected to various sintering temperature (1100-1400 °C). Finally, the influence of sinter temperatures on mechanical (hardness) and biological properties (in vitro bioactivity, MTT and hemocompatibility assays) were ascertained...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Jegan Athinarayanan, Vaiyapuri Subbarayan Periasamy, Akram Ahmed Qasem, Reshod A Al-Shagrawi, Ali A Alshatwi
Silica nanostructures were fabricated from Pennisetum glaucum (pearl millet) seed husk by acid-pretreatment and calcination. The fabricated silica nanostructure (SN) functional groups, crystalline nature, surface morphology, and particle size were analyzed by Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy, respectively. Additionally, the cytocompatibility of SNs was analyzed on human mesenchymal stem cells (hMSCs) in an MTT assay, propidium iodine (PI) staining, and acridine orange/ethidium bromide (AO/EB) staining...
February 12, 2019: Journal of Materials Science. Materials in Medicine
Saba Abdulghani, Pedro G Morouço
Biofabrication allows the formation of 3D scaffolds through a precise spatial control. This is of foremost importance when aiming to mimic heterogeneous and anisotropic architecture, such as that of the osteochondral tissue. Osteochondral defects are a supreme challenge for tissue engineering due to the compositional and structural complexity of stratified architecture and contrasting biomechanical properties of the cartilage-bone interface. This review highlights the advancements and retreats witnessed by using developed bioinks for tissue regeneration, taking osteochondral tissue as a challenging example...
January 28, 2019: Journal of Materials Science. Materials in Medicine
Telmo M Andrade, Daphne C R Mello, Conceição M V Elias, Julia M A Abdala, Edmundo Silva, Luana M R Vasconcellos, Carla R Tim, Fernanda R Marciano, Anderson O Lobo
Herein, poly(ɛ-caprolactone) (PCL) mats with different amounts of nanohydroxyapatite (nHAp) were produced using rotary-jet spinning (RJS) and evaluated in vitro and in vivo. The mean fiber diameters of the PCL, PCL/nHAp (3%), PCL/nHAp (5%), and PCL/nHAp (20%) scaffolds were 1847 ± 1039, 1817 ± 1044, 1294 ± 4274, and 845 ± 248 nm, respectively. Initially, all the scaffolds showed superhydrophobic behavior (contact angle around of 140o C), but decreased to 80° after 30 min. All the produced scaffolds were bioactive after soaking in simulated body fluid, especially PCL/nHAp (20%)...
January 28, 2019: Journal of Materials Science. Materials in Medicine
Mohammad M Farag, Zainab M Al-Rashidy, Manar M Ahmed
Ce-containing bioactive glasses are known to decrease reactive oxygen activities inside the body. That is because of their excellent catalytic activities which come from the fast interchange of Ce3+ /Ce4+ oxidation states. This research was mainly aimed at preparing new Ce-doped nano-bioactive glasses based on 60SiO2 -(10-x)B2 O3 -25CaO-5P2 O5 -xCeO2 , in mole% (x = 0 and 5 mol%) as multifunctional bone fillings. Moreover, the glasses were used as a delivery system for ciprofloxacin to intensely solve the bone infection complications...
January 22, 2019: Journal of Materials Science. Materials in Medicine
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