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Journal of Materials Science. Materials in Medicine

Yuta Kurashina, Atsushi Ezura, Ryo Murakami, Masayoshi Mizutani, Jun Komotori
In this paper, we study a process for modifying the surface microtopography of the Ti oxide layer using a nanosecond-pulsed laser (NPL). Even now, the mechanism by which hydroxyl groups are generated on the titanium surface treated by NPL is not clear. Hence, we evaluated the surface properties of the NPL defocus distances on pure titanium surfaces, and investigated the relationship between the generation of hydroxyapatites/cell viability and the titanium surface characteristics. The NPL defocus distance was varied from 0 to 4 mm...
May 13, 2019: Journal of Materials Science. Materials in Medicine
Anuradha Subramanian, Uma Maheswari Krishnan, Swaminathan Sethuraman
The original version of this article unfortunately contained a mistake. The presentation of Fig. 2e was incorrect. The corrected version of Fig. 2E1 is given below.
May 13, 2019: Journal of Materials Science. Materials in Medicine
Kazim K Moncal, Veli Ozbolat, Pallab Datta, Dong N Heo, Ibrahim T Ozbolat
Thermally-crosslinked hydrogels in bioprinting have gained increasing attention due to their ability to undergo tunable crosslinking by modulating the temperature and time of crosslinking. In this paper, we present a new bioink composed of collagen type-I and Pluronic® F-127 hydrogels, which was bioprinted using a thermally-controlled bioprinting unit. Bioprintability and rheology of the composite bioink was studied in a thorough manner in order to determine the optimal bioprinting time and extrusion profile of the bioink for fabrication of three-dimensional (3D) constructs, respectively...
April 30, 2019: Journal of Materials Science. Materials in Medicine
Lubomir Medvecky, Maria Giretova, Ruzena Kralikova, Simona Medvecka, Jaroslav Briancin
The in vitro cytotoxicity of both the multiwalled carbon nanotubes (MWCNT) in suspension with culture medium and the tetracalcium phosphate/monetite cement with addition of 0.8 wt% of MWCNTs on fibroblasts and osteoblasts were studied. The cytotoxicity was evaluated by MTS test (formazan) and live/dead staining. No cytotoxicity of MWCNT extract was measured contrary to about 60% reduction in proliferation of fibroblasts in MWCNT suspension as compared with negative control. The several contact cytotoxicity of MWCNT composite cement surfaces on seeded cells was demonstrated by MTS test and live/dead staining of damaged fibroblasts and dead osteoblasts after 72 h of culture...
April 30, 2019: Journal of Materials Science. Materials in Medicine
Yadong Liu, Kang Tian, Jun Hao, Tao Yang, Xiaoling Geng, Weiguo Zhang
Poly (glycerol sebacate) (PGS) is a synthetic polymeric material with the characteristics of controllable degradation, high plasticity and excellent biocompatibility. However, the time of PGS degradation is faster than that of cartilage regeneration, which limits its application in cartilage tissue engineering. Polycaprolactone (PCL), a widely used synthetic polymer, has appropriate biodegradability and higher mechanical strength. This study aims to make a scaffold from blends of fast degrading PGS and slowly degrading PCL, and to investigate its potential for cartilage tissue engineering applications...
April 29, 2019: Journal of Materials Science. Materials in Medicine
Wen Li, Yanwei Yang, Hongchen Zhang, Zexian Xu, Libo Zhao, Jinqing Wang, Yinong Qiu, Bin Liu
Microbial infection around dental implants is a major cause for the loss of devices, including soft tissue infection in early period, post-operation peri-implantitis, and osseointegration failure. Silver nanoparticles (AgNPs) with wide antimicrobial spectrum, strong antimicrobial effect and hypotoxicity, as well as low incidence of antibiotic resistance, are widely involved in biomedical applications. Herein, firmly anchoring AgNPs onto the surface of implants through physical-chemical reaction is likely to relieve the above issues...
April 23, 2019: Journal of Materials Science. Materials in Medicine
Ajinkya A Shitole, Piyush W Raut, Neeti Sharma, Prabhanjan Giram, Anand P Khandwekar, Baijayantimala Garnaik
Fabricating a bioartificial bone graft possessing structural, mechanical and biological properties mimicking the real bone matrix is a major challenge in bone tissue engineering. Moreover, the developed materials are prone to microbial invasion leading to biomaterial centered infections which might limit their clinical translation. In the present study, biomimetic nanofibrous scaffolds of Poly ɛ-caprolactone (PCL)/nano-hydroxyapatite (nHA) were electrospun with 1wt%, 5wt%, 10wt%, 15wt% and 30wt% of zinc oxide (ZnO) nanoparticles in order to understand the optimal concentration range of (ZnO) nanoparticles balancing both biocompatibility and osteoregeneration...
April 22, 2019: Journal of Materials Science. Materials in Medicine
Xiaotao Zheng, Kewei Wu, Jiqiang Wang, Linwei Ma, Jiuyang Yu, Jianmin Xu
The mechanical properties of medical grade ultrahigh molecular weight polyethylene (UHMWPE) are critical for the safety and integrity of UHMWPE implantation. Accordingly, the mechanical features of UHMWPE are tested under repeated stress-controlled and strain-controlled compression at room temperature. Some important effect factors, such as stress rate, mean stress, stress amplitude, strain rate, mean strain, strain range and multiple load steps are further considered in detail. Results indicate that the lower stress rate causes the greater accumulated plastic strain and the accumulated plastic strain rate becomes increasingly lower with increasing number of cycles...
April 19, 2019: Journal of Materials Science. Materials in Medicine
Jiaqi Song, Pengli Jin, Muqin Li, Jiguang Liu, Dongmei Wu, Haitao Yao, Jiaqi Wang
Bone infection and implant secondary removal remains a clinical challenge. We used ultrasonic micro-arc oxidation (UMAO) and conversion of phytic acid copper plating to prepare a pure magnesium polyhydric biofilm; we evaluated the surface microstructures, phase, element composition, and wettability of the film in vitro. The antibacterial activity of films with different Cu contents was confirmed by coating method, imaging examination, and microbiological cultures in vitro. The biocompatibility of biofilms was confirmed by cell proliferation, vitality, and morphology assays in vitro and histological evaluation in vivo...
April 16, 2019: Journal of Materials Science. Materials in Medicine
Xiaoyan Wang, Qianqian Liu, Wei Chen, Long Liu
Mesoporous bioactive glass (MBG) is performed as a bone tissue engineering material because of its good bioactivity, biocompatibility and osteoinducion characteristics. Here, we propose MBG with larger pores (MBG-L) adsorbed fibroblast growth factor (FGF) to facilitate osteoblast differentiation and matrix mineralization. Specifically, we observed that MBG-L promotes calcium deposit precipitation in vitro. In addition, adhesion, proliferation, differentiation and matrix mineralization were promoted after osteoblast cultured on MBG-L/FGF...
April 13, 2019: Journal of Materials Science. Materials in Medicine
Yan Xue, Mingyao Wu, Zongren Liu, Jinhua Song, Shuyu Luo, Hongjie Li, Yuan Li, Lichun Jin, Binbin Guan, Mingli Lin, Fuyu Chen, Chenxin Jin, Deping Liu, Yanqiu Li, Xu Zhang
The objective of this study was to fabricate and characterize chitosan combined with different amounts of simvastatin-loaded nanoparticles and to investigate their potential for guided bone regeneration in vitro and in vivo. Different SIM-CSN formulations were combined into a chitosan scaffold (SIM-CSNs-S), and the morphology, simvastatin release profile, and effect on cell proliferation and differentiation were investigated. For in vivo experiments, ectopic osteogenesis and the critical-size cranial defect model in SD rats were chosen to evaluate bone regeneration potential...
April 12, 2019: Journal of Materials Science. Materials in Medicine
Qifeng Jiang, Fahmi Zaïri, Caroline Fréderix, Amil Derrouiche, Zhu Yan, Zhengwei Qu, Xiaobing Liu, Fahed Zaïri
Degeneration of the intervertebral disc (IVD) is a leading source of chronic low back pain or neck pain, and represents the main cause of long-term disability worldwide. In the aim to relieve pain, total disc replacement (TDR) is a valuable surgical treatment option, but the expected benefit strongly depends on the prosthesis itself. The present contribution is focused on the synthetic mimic of the native IVD in the aim to optimally restore its functional anatomy and biomechanics, and especially its time-dependency...
April 5, 2019: Journal of Materials Science. Materials in Medicine
Benedetta Ghezzi, Paola Lagonegro, Roberta Pece, Ludovica Parisi, Massimiliano Bianchi, Roberta Tatti, Roberto Verucchi, Giovanni Attolini, Martina Quaretti, Guido M Macaluso
Robust cell adhesion is known to be necessary to promote cell colonization of biomaterials and differentiation of progenitors. In this paper, we propose the functionalization of Silicon Oxycarbide (SiOx Cy ) nanowires (NWs) with 3-mercaptopropyltrimethoxysilane (MPTMS), a molecule containing a terminal -SH group. The aim of this functionalization was to develop a surface capable to adsorb proteins and promote cell adhesion, proliferation and a better deposition of extracellular matrix. This functionalization can be used to anchor other structures such as nanoparticles, proteins or aptamers...
March 30, 2019: Journal of Materials Science. Materials in Medicine
Chee-Heong Ooi, Yew Pei Ling, Wan Zaidah Abdullah, Ahmad Zakwan Mustafa, Swee-Yong Pung, Fei-Yee Yeoh
Hydroxyapatite is an ideal biomaterial for bone tissue engineering due to its biocompatibility and hemocompatibility which have been widely studied by many researchers. The incorporation of nanoporosity into hydroxyapatite could transform the biomaterial into an effective adsorbent for uremic toxins removal especially in artificial kidney system. However, the effect of nanoporosity incorporation on the hemocompatibility of hydroxyapatite has yet to be answered. In this study, nanoporous hydroxyapatite was synthesized using hydrothermal technique and its hemocompatibility was determined...
March 30, 2019: Journal of Materials Science. Materials in Medicine
Li-Yu Zhang, Ze-Hui Fang, Quan-Li Li, Chris Ying Cao
Dental caries is primarily caused by pathogenic bacteria infection, and Streptococcus mutans is considered a major cariogenic pathogen. Moreover, antimicrobial peptides have been considered an alternative to traditional antibiotics in treating caries. This study aimed to design a tooth-binding antimicrobial peptide and evaluate its antimicrobial efficacy against S. mutans. An antimicrobial peptide of polyphemusin I (PI) was modified by grafting a tooth-binding domain of diphosphoserine (Ser(p)-Ser(p)-) to create the peptide of Ser(p)-Ser(p)-polyphemusin I (DPS-PI)...
March 30, 2019: Journal of Materials Science. Materials in Medicine
Arash Ghalayani Esfahani, Lina Altomare, Elena M Varoni, Serena Bertoldi, Silvia Farè, Luigi De Nardo
Clobetasol propionate (CP) is a high-potency corticosteroid, representing the standard of care for the symptomatic treatment of different skin disorders as well as oral mucosal diseases. Several topical delivery systems are available for treating oral lesions, but the ideal one is still lacking. In this work, we propose a novel class of chitosan (CS) patches, loaded with CP, for the topical treatment of inflammatory chronic oral diseases. Chitosan patches have been fabricated via electrophoretic deposition (EPD), by using a one-pot approach in order to load controlled quantity of CP...
March 27, 2019: Journal of Materials Science. Materials in Medicine
Lina Wang, Weiwei Cao, Xi Wang, Peili Li, Jie Zhou, Gaoke Zhang, Xin Li, Xiaodong Xing
For cartilage tissue repairing, it remains a key challenge to design implant materials with antibacterial activity, proper degradation rate and mechanical property. In this research, antibacterial nanodiamonds (QND, QND-Ag) modified acrylate-terminated polyurethanes (APU) were prepared. By the addition of nanocomposites, the crystallinity of modified APU obviously increased, which indicates a strong interaction between NDs and APU. Tensile and compression tests were carried out to evaluate the improved mechanical properties...
March 27, 2019: Journal of Materials Science. Materials in Medicine
Dominik de Cassan, Anna Lena Hoheisel, Birgit Glasmacher, Henning Menzel
Biodegradable polymers such as polycaprolactone (PCL) are increasingly used for electrospinning substrates for tissue engineering. These materials offer great advantages such as biocompatibility and good mechanical properties. However, in order to be approved for human implantation they have to be sterilized. The impact of commonly used irradiation sterilization methods on electrospun PCL fiber mats was investigated systematically. Electron beam (β-irradiation), gamma and X-ray irradiation with two different doses (25 and 33 kGy) were investigated...
March 27, 2019: Journal of Materials Science. Materials in Medicine
Soham Wadnap, Srikumar Krishnamoorthy, Zhengyi Zhang, Changxue Xu
It has been widely recognized that one of the critical limitations in biofabrication of functional tissues/organs is lack of vascular networks which provide tissues and organs with oxygen and nutrients. Biofabrication of 3D vascular-like constructs is a reasonable first step towards successful printing of functional tissues and organs. In this paper, a dynamic optical projection stereolithography system has been implemented to successfully fabricate 3D Y-shaped tubular constructs with living cells encapsulated...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Jia Zhou, Quanchen Xu, Chun Fan, Hao Ren, Shuo Xu, Fang Hu, Lei Wang, Kai Yang, Qiuxia Ji
This study explores the possibility of adhering gingival tissue to a root surface that was restored with chitosan (CS)-modified glass ionomer cement (GIC) in the case of gingival recessions associated with root caries, which provides a theoretical basis for clinical application at the cellular level. The specimens were mixed after integrating 1, 2, and 4 wt% CS into the GIC fluid. The characteristics and cytocompatibility were then examined. As more CS was incorporated into the GIC fluid, the mechanical properties and cytocompatibility of chitosan-modified glass ionomer cement (CS-GIC) first improved but then reduced...
March 6, 2019: Journal of Materials Science. Materials in Medicine
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