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Journal of Materials Science. Materials in Medicine

Xiaoyan Wang, Qianqian Liu, Wei Chen, Long Liu
Mesoporous bioactive glass (MBG) is performed as a bone tissue engineering material because of its good bioactivity, biocompatibility and osteoinducion characteristics. Here, we propose MBG with larger pores (MBG-L) adsorbed fibroblast growth factor (FGF) to facilitate osteoblast differentiation and matrix mineralization. Specifically, we observed that MBG-L promotes calcium deposit precipitation in vitro. In addition, adhesion, proliferation, differentiation and matrix mineralization were promoted after osteoblast cultured on MBG-L/FGF...
April 13, 2019: Journal of Materials Science. Materials in Medicine
Yan Xue, Mingyao Wu, Zongren Liu, Jinhua Song, Shuyu Luo, Hongjie Li, Yuan Li, Lichun Jin, Binbin Guan, Mingli Lin, Fuyu Chen, Chenxin Jin, Deping Liu, Yanqiu Li, Xu Zhang
The objective of this study was to fabricate and characterize chitosan combined with different amounts of simvastatin-loaded nanoparticles and to investigate their potential for guided bone regeneration in vitro and in vivo. Different SIM-CSN formulations were combined into a chitosan scaffold (SIM-CSNs-S), and the morphology, simvastatin release profile, and effect on cell proliferation and differentiation were investigated. For in vivo experiments, ectopic osteogenesis and the critical-size cranial defect model in SD rats were chosen to evaluate bone regeneration potential...
April 12, 2019: Journal of Materials Science. Materials in Medicine
Qifeng Jiang, Fahmi Zaïri, Caroline Fréderix, Amil Derrouiche, Zhu Yan, Zhengwei Qu, Xiaobing Liu, Fahed Zaïri
Degeneration of the intervertebral disc (IVD) is a leading source of chronic low back pain or neck pain, and represents the main cause of long-term disability worldwide. In the aim to relieve pain, total disc replacement (TDR) is a valuable surgical treatment option, but the expected benefit strongly depends on the prosthesis itself. The present contribution is focused on the synthetic mimic of the native IVD in the aim to optimally restore its functional anatomy and biomechanics, and especially its time-dependency...
April 5, 2019: Journal of Materials Science. Materials in Medicine
Benedetta Ghezzi, Paola Lagonegro, Roberta Pece, Ludovica Parisi, Massimiliano Bianchi, Roberta Tatti, Roberto Verucchi, Giovanni Attolini, Martina Quaretti, Guido M Macaluso
Robust cell adhesion is known to be necessary to promote cell colonization of biomaterials and differentiation of progenitors. In this paper, we propose the functionalization of Silicon Oxycarbide (SiOx Cy ) nanowires (NWs) with 3-mercaptopropyltrimethoxysilane (MPTMS), a molecule containing a terminal -SH group. The aim of this functionalization was to develop a surface capable to adsorb proteins and promote cell adhesion, proliferation and a better deposition of extracellular matrix. This functionalization can be used to anchor other structures such as nanoparticles, proteins or aptamers...
March 30, 2019: Journal of Materials Science. Materials in Medicine
Chee-Heong Ooi, Yew Pei Ling, Wan Zaidah Abdullah, Ahmad Zakwan Mustafa, Swee-Yong Pung, Fei-Yee Yeoh
Hydroxyapatite is an ideal biomaterial for bone tissue engineering due to its biocompatibility and hemocompatibility which have been widely studied by many researchers. The incorporation of nanoporosity into hydroxyapatite could transform the biomaterial into an effective adsorbent for uremic toxins removal especially in artificial kidney system. However, the effect of nanoporosity incorporation on the hemocompatibility of hydroxyapatite has yet to be answered. In this study, nanoporous hydroxyapatite was synthesized using hydrothermal technique and its hemocompatibility was determined...
March 30, 2019: Journal of Materials Science. Materials in Medicine
Li-Yu Zhang, Ze-Hui Fang, Quan-Li Li, Chris Ying Cao
Dental caries is primarily caused by pathogenic bacteria infection, and Streptococcus mutans is considered a major cariogenic pathogen. Moreover, antimicrobial peptides have been considered an alternative to traditional antibiotics in treating caries. This study aimed to design a tooth-binding antimicrobial peptide and evaluate its antimicrobial efficacy against S. mutans. An antimicrobial peptide of polyphemusin I (PI) was modified by grafting a tooth-binding domain of diphosphoserine (Ser(p)-Ser(p)-) to create the peptide of Ser(p)-Ser(p)-polyphemusin I (DPS-PI)...
March 30, 2019: Journal of Materials Science. Materials in Medicine
Arash Ghalayani Esfahani, Lina Altomare, Elena M Varoni, Serena Bertoldi, Silvia Farè, Luigi De Nardo
Clobetasol propionate (CP) is a high-potency corticosteroid, representing the standard of care for the symptomatic treatment of different skin disorders as well as oral mucosal diseases. Several topical delivery systems are available for treating oral lesions, but the ideal one is still lacking. In this work, we propose a novel class of chitosan (CS) patches, loaded with CP, for the topical treatment of inflammatory chronic oral diseases. Chitosan patches have been fabricated via electrophoretic deposition (EPD), by using a one-pot approach in order to load controlled quantity of CP...
March 27, 2019: Journal of Materials Science. Materials in Medicine
Lina Wang, Weiwei Cao, Xi Wang, Peili Li, Jie Zhou, Gaoke Zhang, Xin Li, Xiaodong Xing
For cartilage tissue repairing, it remains a key challenge to design implant materials with antibacterial activity, proper degradation rate and mechanical property. In this research, antibacterial nanodiamonds (QND, QND-Ag) modified acrylate-terminated polyurethanes (APU) were prepared. By the addition of nanocomposites, the crystallinity of modified APU obviously increased, which indicates a strong interaction between NDs and APU. Tensile and compression tests were carried out to evaluate the improved mechanical properties...
March 27, 2019: Journal of Materials Science. Materials in Medicine
Dominik de Cassan, Anna Lena Hoheisel, Birgit Glasmacher, Henning Menzel
Biodegradable polymers such as polycaprolactone (PCL) are increasingly used for electrospinning substrates for tissue engineering. These materials offer great advantages such as biocompatibility and good mechanical properties. However, in order to be approved for human implantation they have to be sterilized. The impact of commonly used irradiation sterilization methods on electrospun PCL fiber mats was investigated systematically. Electron beam (β-irradiation), gamma and X-ray irradiation with two different doses (25 and 33 kGy) were investigated...
March 27, 2019: Journal of Materials Science. Materials in Medicine
Soham Wadnap, Srikumar Krishnamoorthy, Zhengyi Zhang, Changxue Xu
It has been widely recognized that one of the critical limitations in biofabrication of functional tissues/organs is lack of vascular networks which provide tissues and organs with oxygen and nutrients. Biofabrication of 3D vascular-like constructs is a reasonable first step towards successful printing of functional tissues and organs. In this paper, a dynamic optical projection stereolithography system has been implemented to successfully fabricate 3D Y-shaped tubular constructs with living cells encapsulated...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Jia Zhou, Quanchen Xu, Chun Fan, Hao Ren, Shuo Xu, Fang Hu, Lei Wang, Kai Yang, Qiuxia Ji
This study explores the possibility of adhering gingival tissue to a root surface that was restored with chitosan (CS)-modified glass ionomer cement (GIC) in the case of gingival recessions associated with root caries, which provides a theoretical basis for clinical application at the cellular level. The specimens were mixed after integrating 1, 2, and 4 wt% CS into the GIC fluid. The characteristics and cytocompatibility were then examined. As more CS was incorporated into the GIC fluid, the mechanical properties and cytocompatibility of chitosan-modified glass ionomer cement (CS-GIC) first improved but then reduced...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Song Wang, Xiaoning Sun, Yaping Wang, Kangning Sun, Jianqiang Bi
In this work, the setting process of reduced graphene (RGO)/carbon nanotubes (CNTs) reinforced calcium phosphate cement (CPC) were conducted in a microwave environment. The introduction of microwave can increase the reaction temperature, speed up the vibration of water molecules and eliminate bubbles from the interface between RGO, CNTs and the substrate. Comparing with CPC without microwave treatment, the final setting time of composites after microwave treatment are almost a half, the flexural strength and the compressive strength are increased by 19...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Yang Lei, Qinggong Ning, Yuyang Tang, Yunbing Wang
Glutaraldehyde (GLUT) crosslinked bioprosthetic heart valves (BHVs) might fail due to progressive degradation and calcification. GLUT cannot stabilize glycosaminoglycans (GAGs), which are important for BHVs' life time. In this current study we developed a new BHVs preparation strategy using exogenous hyaluronic acid (HA)/chondroitin sulfate (CS) supplement and sodium trimetaphosphate (STP) crosslinking method. Exogenous HA and CS provide additional GAGs for pericardiums. STP could link two GAGs by reacting with hydroxyl groups in GAGs' repeating polysaccharides units...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Shirin Toosi, Hojjat Naderi-Meshkin, Fatemeh Kalalinia, Hossein HosseinKhani, Asieh Heirani-Tabasi, Shahrzad Havakhah, Sirous Nekooei, Amir Hossein Jafarian, Fahimeh Rezaie, Mohammad Taghi Peivandi, Hooman Mesgarani, Javad Behravan
We have evaluated the capability of a collagen/poly glycolic acid (PGA) scaffold in regeneration of a calvarial bone defects in rabbits. 4 bone critical size defects (CSD) were created in the calvarial bone of each rabbit. The following 4 treatment modalities were tested (1) a collagen/PGA scaffold (0.52% w/w); (2) the collagen/PGA scaffold (0.52% w/w) seeded with adipose-derived mesenchymal stem cells (AD-MSCs, 1 × 106 cells per each defect); (3) AD-MSCs (1 × 106 cells) no scaffold material, and (4) blank control...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Sandra Stier, Lisa Rebers, Veronika Schönhaar, Eva Hoch, Kirsten Borchers
Biobased hydrogels are considered to mimic native extracellular matrix due to their high water content and are considered as adequate matrices for cell encapsulation. However, the equilibrium degree of swelling (EDS) and stiffness of simple hydrogel formulations are typically confined: Increasing polymer concentration results in increasing stiffness and simultaneously decreasing EDS. The aim of this contribution was to decouple this standard correlation between polymer content, stiffness and EDS as well as the assembly of hydrogels with graded composition of hydrogels by layer-wise printing...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Qianqian Guo, Tianyu Lan, Yi Chen, Yini Xu, Jianqing Peng, Ling Tao, Xiangchun Shen
Antimicrobial resistance to traditional antibiotics leads to a serious concern for medical care owing to ineffective antibiotic therapies. This study focused on the preparation of silver nanocomposites (AgNPs@Tob&PAGA) by modifying AgNPs with tobramycin (Tob) and carbohydrate polymer of poly(2-(acrylamido) glucopyranose) (PAGA). The enhanced antibacterial activities of nanocomposites against common pathogens of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) were explored. The introduction of PAGA onto silver nanocomposites improved both citocompatibility and antibacterial activity...
March 6, 2019: Journal of Materials Science. Materials in Medicine
C F Marques, G S Diogo, S Pina, J M Oliveira, T H Silva, R L Reis
In the last few years, additive manufacturing (AM) has been gaining great interest in the fabrication of complex structures for soft-to-hard tissues regeneration, with tailored porosity, and boosted structural, mechanical, and biological properties. 3D printing is one of the most known AM techniques in the field of biofabrication of tissues and organs. This technique opened up opportunities over the conventional ones, with the capability of creating replicable, customized, and functional structures that can ultimately promote effectively different tissues regeneration...
March 6, 2019: Journal of Materials Science. Materials in Medicine
Egor O Osidak, Pavel A Karalkin, Maria S Osidak, Vladislav A Parfenov, Dmitriy E Sivogrivov, Frederico D A S Pereira, Anna A Gryadunova, Elizaveta V Koudan, Yusef D Khesuani, Vladimir A Кasyanov, Sergei I Belousov, Sergey V Krasheninnikov, Timofei E Grigoriev, Sergey N Chvalun, Elena A Bulanova, Vladimir A Mironov, Sergey P Domogatsky
Collagen is one of the most promising materials for 3D bioprinting because of its distinguished biocompatibility. Cell-laden constructs made of pure collagen with or without incorporated growth supplements support engineered constructs persistence in culture and are perfectly suitable for grafting. The limiting factor for direct 3D collagen printing was poor printability of collagen solutions, especially admixed with cells or tissue spheroids. In our study, we showed that concentrated solutions of native collagen branded Viscoll were effective as bioinks with high fidelity performance...
March 4, 2019: Journal of Materials Science. Materials in Medicine
Tatjana Flora, I González de Torre, M Alonso, J Carlos Rodríguez-Cabello
The development of new capillary networks in engineered constructs is essential for their survival and their integration with the host tissue. It has recently been demonstrated that ELR-based hydrogels encoding different bioactivities are able to modulate their interaction with the host after injection or implantation, as indicated by an increase in cell adhesion and the ability to trigger vascularization processes. Accordingly, the aim of this study was to increase their angiogenic ability both in vitro and in vivo using a small VEGF mimetic peptide named QK, which was tethered chemically to ELR-based hydrogels containing cell-adhesion sequences in their backbone, such as REDV and RGD, as well as a proteolytic site (VGVAPG)...
February 14, 2019: Journal of Materials Science. Materials in Medicine
Sebastian P Boelch, Martin C Jordan, Joerg Arnholdt, Andre F Steinert, Maximilian Rudert, Martin Luedemann
The effect of doubling the immersion fluid (eluate) volume on antibiotic concentrations and on mechanical stability from vancomycin and gentamicin loaded bone cements was investigated in vitro. Antibiotic loaded bone cements containing premixed 1.34% gentamicin antibiotic concentration in the cement powder (wt), premixed 1.19% gentamicin wt and 4.76% vancomycin wt and premixed 1.17% wt gentamicin additionally manually blended with 4.68% wt vancomycin were tested. Six specimens per group were immersed in 4 ml and 8 ml for 6 weeks while the eluate was exchanged every 24 h...
February 14, 2019: Journal of Materials Science. Materials in Medicine
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