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Journal of Materials Science. Materials in Medicine

Zhengfei Huang, Zhifeng Wang, Chuanhua Li, Ning Zhou, Fei Liu, Jing Lan
The objective of this study was to investigate the adhesion, proliferation and mineralization of osteoblasts on arginine-glycine-aspartic acid (RGD)- and magnesium ion (Mg+ )-decorated zirconia coatings. The zirconia coatings were prepared via a plasma spray; RGD and Mg+ were immobilized via a silane-coupling agent and ion implantation, respectively. This study employed scanning electron microscopy (SEM) to observe the surface morphology of RGD- and Mg+ -decorated zirconia coatings; surface roughness and wettability were also measured...
August 14, 2019: Journal of Materials Science. Materials in Medicine
Nicole A P van Gestel, Gerke H Schuiringa, Juul H P H Hennissen, Anneke C A Delsing, Keita Ito, Bert van Rietbergen, Jacobus J Arts, Sandra Hofmann
Clinically, S53P4 bioactive glass (BAG) has shown very promising results in bone infection treatment, but it is also known to degrade very slowly in vivo. To evaluate which mechanisms (cellular or dissolution) can play a role in the degradation of S53P4 BAG and S53P4 BAG putty, in vitro degradation experiments at different pH (7.4 and 4.6) were performed. Micro computed tomography showed a rapid dissolution of the synthetic binder in the putty formulation, within 12 h is simulated body fluid (pH = 7.4), leaving behind only loose granules...
August 14, 2019: Journal of Materials Science. Materials in Medicine
Anitha Augustine, Robin Augustine, Anwarul Hasan, Varun Raghuveeran, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas
Critical size bone defects that do not heal spontaneously are among the major reasons for the disability in majority of people with locomotor disabilities. Tissue engineering has become a promising approach for repairing such large tissue injuries including critical size bone defects. Three-dimension (3D) porous scaffolds based on piezoelectric polymers like poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) have received a lot of attention in bone tissue engineering due to their favorable osteogenic properties...
August 14, 2019: Journal of Materials Science. Materials in Medicine
Jun Wang, Shunying Li, Tingting Chen, Wenjiao Xian, Huiwu Zhang, Lei Wu, Wenting Zhu, Qingbing Zeng
To enhance the bioavailability of protein therapeutants and improve the stability of storage and delivery, a series of branched amphiphilic block copolymers consisting of cholic acid (CA) initiated poly(D,L-lactide-co-glycolide) (CA-PLGA) and water-soluble polyethyleneimine cross-linked polyethylene glycol (PEI-PEG) denoted as CA-PLGA-b-(PEI-PEG) were synthesized and characterized. CA-PLGA-b-(PEI-PEG) presented low cytotoxicity by MTT and cck-8 assay. The cationic CA-PLGA-b-(PEI-PEG) micelles (diameter about 100 nm and zeta potential 34-61 mV) were prepared through self-assembly method, and complexed with insulin via electrostatic interaction to obtain nanoscale micelle/insulin complexes...
August 7, 2019: Journal of Materials Science. Materials in Medicine
A Saadati, H Aghajani
Having similar properties with natural bone, has made porous NiTi shape memory alloy (SMA) a promising material for biomedical applications. In this study porous NiTi SMA has synthesized with 30 and 40 vol.% green porosity by self propagating high temperature synthesis (SHS) from elemental Ni and Ti powders. After synthesizing, the average porosity of specimens reached to 36.8 and 49.8% for green compacts with 30 and 40 vol.% of green porosity, respectively. Combustion products were characterized by XRD, SEM, EDS and electrochemical polarization test...
August 6, 2019: Journal of Materials Science. Materials in Medicine
Xiaofan Cheng, Shichao Liu, Chao Chen, Wei Chen, Min Liu, Ruidi Li, Xiaoyong Zhang, Kechao Zhou
Customized porous titanium alloys have become the emerging materials for orthopaedic implant applications. In this work, diamond and rhombic dodecahedron porous Ti-33Nb-4Sn scaffolds were fabricated by selective laser melting (SLM). The phase, microstructure and defects characteristics were investigated systematically and correlated to the effects of pore structure, unit cell size and processing parameter on the mechanical properties of the scaffolds. Fine β phase dendrites were obtained in Ti-33Nb-4Sn scaffolds due to the fast solidification velocity in SLM process...
August 6, 2019: Journal of Materials Science. Materials in Medicine
E Dávila, M Ortiz-Hernández, R A Perez, M Herrero-Climent, M Cerrolaza, F J Gil
The aim of this study was to evaluate the biomechanical behavior of Bone Level dental implants with four different neck designs in contact with cortical bone. Numerical simulations were performed using a Finite Element Method (FEM) based-model. In order to verify the FEM model, the in silico results were compared with the results obtained from histological analysis performed in an in vivo study with New Zealand rabbits. FEM was performed using a computerized 3D model of Bone Level dental implants inserted in the lower jaw bone with an applied axial load of 100 N...
July 25, 2019: Journal of Materials Science. Materials in Medicine
Huaixi Wang, Xiangyu Tang, Wenkai Li, Jingyuan Chen, Hao Li, Jiyuan Yan, Xuefeng Yuan, Hua Wu, Chaoxu Liu
As a non-invasive biophysical therapy, electromagnetic fields (EMF) have been widely used to promote the healing of fractures. In the present study, hydroxyapatite/collagen I (HAC) loaded with rabbit bone marrow mesenchymal stem cells (MSCs) were cultured in a dynamic perfusion bioreactor and exposed to EMF of 15 Hz/1mT. Osteogenic differentiation of the seeded cells was analyzed through the evaluation of ALP activity and osteogenesis-related genes expression in vitro. The in vivo osteogenesis efficacy of the cell laden HAC constructs treated with/without EMF was evaluated through a rabbit femur condyle defect model...
July 24, 2019: Journal of Materials Science. Materials in Medicine
Xiaofeng Cao, Haojun Lu, Junli Liu, Weipeng Lu, Lin Guo, Ming Ma, Bing Zhang, Yanchuan Guo
Calcium phosphate (CaP)-containing materials, such as hydroxyapatite and brushite, are well studied bone grafting materials owing to their similar chemical compositions to the mineral phase of natural bone and kidney calculi. In recent studies, magnesium phosphate (MgP)-containing compounds, such as newberyite and struvite, have shown promise as alternatives to CaP. However, the different ways in degradation and release of Mg2+ and Ca2+ ions in vitro may affect the biocompatibility of CaP and MgP-containing compounds...
July 19, 2019: Journal of Materials Science. Materials in Medicine
Yinghe Huang, Yao Lin, Mingdeng Rong, Weizhen Liu, Junbing He, Lei Zhou
Previous studies have demonstrated the significant roles of simvastatin (SVA) and oxysterols in the osteogenesis process. In this study, we evaluate the effect of a combination of SVA and 20(S)-hydroxycholesterol (20(S)OHC) on the cell viability and osteogenic differentiation of bone marrow stromal cells (BMSCs). After treatment with a control vehicle, SVA (0.025, 0.10, 0.25 or 1.0 μM), 20(S)OHC (5 μM), or a combination of both (0.25 μM SVA + 5 μM 20(S)OHC), the proliferation, apoptosis, ALP activity, mineralization, osteogenesis-related gene expression and Raf/MEK/ERK signaling activity in BMSCs were measured...
July 19, 2019: Journal of Materials Science. Materials in Medicine
Breno Rocha Barrioni, Elizabeth Norris, Siwei Li, Parichart Naruphontjirakul, Julian R Jones, Marivalda de Magalhães Pereira
Bioactive glasses (BGs) are widely used for bone regeneration, and allow the incorporation of different ions with therapeutic properties into the glass network. Amongst the different ions with therapeutic benefits, manganese (Mn) has been shown to influence bone metabolism and activate human osteoblasts integrins, improving cell adhesion, proliferation and spreading. Mn has also been incorporated into bioceramics as a therapeutic ion for improved osteogenesis. Here, up to 4.4 mol% MnO was substituted for CaO in the 58S composition (60 mol% SiO2 , 36 mol% CaO, 4 mol% P2 O5 ) and its effects on the glass properties and capability to influence the osteogenic differentiation were evaluated...
July 13, 2019: Journal of Materials Science. Materials in Medicine
Monika Astasov-Frauenhoffer, Sally Koegel, Tuomas Waltimo, Andrea Zimmermann, Cyril Walker, Irmgard Hauser-Gerspach, Christiane Jung
The aim of this in vitro study was to quantify the antibacterial effect of a copper-deposited titanium surface as a model for dental implants on the peri-implantitis-associated strain Porphyromonas gingivalis (DSM 20709). A spark-assisted anodization method in a combined deposition-anodization process was applied to deposit copper on discs made of titanium. This method allows the deposition of different concentrations of copper on the surface by varying the process time. Conventional culturing was used to investigate the adhesion of P...
July 10, 2019: Journal of Materials Science. Materials in Medicine
Liancheng Xu, Yan Huang, Dongzhi Wang, Shajun Zhu, Zhiwei Wang, Yumin Yang, Yibing Guo
Pancreatic transplantation remains the only cure for diabetes, but the shortage of donors limits its clinical application. Whole organ decellularized scaffolds offer a new opportunity for pancreatic organ regeneration; however inadequate endothelialization and vascularization can prevent sufficient transport of oxygen and nutrient supplies to the transplanted organ, as well as leading unwanted thrombotic events. In the present study, we explored the re-endothelialization of rat pancreatic acellular scaffolds via circulation perfusion using human skin fibroblasts (FBs) and human umbilical vein endothelial cells (HUVECs)...
July 10, 2019: Journal of Materials Science. Materials in Medicine
Jing Zhao, Zhiqiang Cao, Hao Lin, Hui Yang, Jianzhong Li, Xin Li, Bingchun Zhang, Ke Yang
Infection and encrustation limit the use of ureteral stent and to data no device can completely solve these complications. The Cu-bearing stainless steel is a novel material with properties of inhibiting infection and decreasing encrustation in vitro. In this work, ureteral stents were fabricated and implanted into the bladder of New Zealand rabbits, aiming to further investigate the effects of material on bacterial survival and growth as well as the implant related encrustation. Less adherent microbes and deposited crystals on Cu-bearing stainless steel stents were found, with significant differences in comparison with stainless steel stents, which further support the development of biofunctional ureteral stents...
July 4, 2019: Journal of Materials Science. Materials in Medicine
Jianyi Gao, Lei Zhang, Yusheng Wei, Tianyan Chen, Xianyan Ji, Kai Ye, Jiahong Yu, Bin Tang, Xiaochun Sun, Jiabo Hu
Axon regeneration and functional recovery after peripheral nerve injury remains a clinical challenge. Injury leads to axonal disintegration after which Schwann cells (SCs) and macrophages re-engage in the process of regeneration. At present, biomaterials are regarded as the most promising way to repair peripheral nerve damage. As a natural material, keratin has a wide range of sources and has good biocompatibility and biodegradability. Here, a keratin was extracted from human hair by reducing method and a keratin sponge with porous structure was obtained by further processing...
July 4, 2019: Journal of Materials Science. Materials in Medicine
Luana Marotta Reis de Vasconcellos, Renata Falchete do Prado, Elisa Mattias Sartori, Daniela Baccelli Silveira Mendonça, Gustavo Mendonça, Fernanda Roberta Marciano, Anderson Oliveira Lobo
Carbon nanotubes combine high bend and mechanical strength, which is advantageous for many structural and biomedical purposes. Recently, some biomaterials, based on carbon nanostructures and nanohydroxyapatite (nHAp), have been investigated as bone substitutes in order to improve regeneration. The aim of this study was to access the expression of some RNA transcripts (involved in the process of osteoblast differentiation) by mesenchymal stem cells cultured over different nanocomposite surfaces. A multi-walled carbon nanotube (MWCNT) was firstly grown using chemical vapor deposition and then exfoliated using chemical and oxygen plasma treatments to obtain graphene nanoribbons (GNR)...
June 28, 2019: Journal of Materials Science. Materials in Medicine
Izabella Rajzer, Michał Dziadek, Anna Kurowska, Katarzyna Cholewa-Kowalska, Magdalena Ziąbka, Elżbieta Menaszek, Timothy E L Douglas
In this work, composite membranes were investigated as future components of a layered implant for the reconstruction of nasal septum. Incorporation of zinc ions into nasal implants could potentially provide antibacterial properties to decrease or eliminate bacterial infections and subsequent surgical complications. Two types of membranes were prepared using an electrospinning method: PCL with bioglass and PCL with bioglass doped with Zn. The aim of this work was to investigate the influence of bioglass addition on the morphology, fiber diameter and composition of the membranes...
June 26, 2019: Journal of Materials Science. Materials in Medicine
A Kristen Means, Ping Dong, Fred J Clubb, Molly C Friedemann, Lydia E Colvin, Courtney A Shrode, Gerard L Coté, Melissa A Grunlan
Long-term, subcutaneously implanted continuous glucose biosensors have the potential to improve diabetes management and reduce associated complications. However, the innate foreign body reaction (FBR) both alters the local glucose concentrations in the surrounding tissues and compromises glucose diffusion to the biosensor due to the recruitment of high-metabolizing inflammatory cells and the formation of a dense, collagenous fibrous capsule. Minimizing the FBR has mainly focused on "passively antifouling" materials that reduce initial cellular attachment, including poly(ethylene glycol) (PEG)...
June 25, 2019: Journal of Materials Science. Materials in Medicine
Cheng-Hsin Cheng, Yi-Wen Chen, Alvin Kai-Xing Lee, Chun-Hsu Yao, Ming-You Shie
3D printing is a versatile technique widely applied in tissue engineering due to its ability to manufacture large quantities of scaffolds or constructs with various desired architectures. In this study, we demonstrated that poly (lactic acid) (PLA) scaffolds fabricated via fused deposition not only retained the original interconnected microporous architectures, the scaffolds also exhibited lower lactic acid dissolution as compared to the freeze-PLA scaffold. The 3D-printed scaffolds were then grafted with human bone morphogenetic protein-2 (BMP-2) via the actions of polydopamine (PDA) coatings...
June 20, 2019: Journal of Materials Science. Materials in Medicine
Xiangyu Sun, Bing Liu, Xianli Chen, Huichao Lin, Yanbo Peng, Yanyu Li, Haoran Zheng, Yibin Xu, Xulin Ou, Siqi Yan, Zonghai Wu, Shujun Deng, Luyong Zhang, Ping Zhao
Superparamagnetic iron oxide nanoparticles (SPION) were widely employed as targeted drug delivery platform due to their unique magnetic property and effortless surface modification. However, the lack of targeting accuracy has been a big obstacle for SPION used in precise medicine. Herein, the tumor-targeting of SPION was enhanced by the conjugation of an aptamer-hybridized nucleic acid structure. The aptamer modified on the surface of SPION was composed of a double-stranded DNA (dsDNA) and a G-quadruplex DNA (AS1411) structure, which carried a chemical anticancer drug, daunomycin (DNM) and a photosensitizer molecule, namely 5, 10, 15, 20-tetra (phenyl-4-N-methyl-4-pyridyl) porphyrin (TMPyP), respectively...
June 19, 2019: Journal of Materials Science. Materials in Medicine
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