Alireza Salarinejad, Khadije Esmaeilpour, Mohammad Shabani, Saeideh Jafarinejad-Farsangi, Abbas Pardakhty, Majid Asadi-Shekaari, Meysam Ahmadi-Zeidabadi
Temozolomide is used commonly in the treatment of some types of cancers, but it may also result in cognitive impairments such as memory deficits. l-Dopa, a well known medicine for the central nervous system, has been shown to have positive effects on some cognitive disorders. Here we sought to investigate the effect of l-Dopa on temozolomide-induced cognitive impairments. BALB/c mice were subjected to 3-days temozolomide and 6-days concomitant l-Dopa/benserazide administration in six groups (control, l-Dopa 25 mg/kg, l-Dopa 75 mg/kg, temozolomide, temozolomide + l-Dopa 25 mg/kg, and temozolomide + l-Dopa 75 mg/kg)...
June 26, 2023: Behavioural Pharmacology