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Journal of Nephrology

Grazia Maria Virzì, Andrea Breglia, Chiara Castellani, Ghada Ankawi, Chiara Bolin, Massimo de Cal, Vito Cianci, Annalisa Angelini, Giorgio Vescovo, Claudio Ronco
BACKGROUND: Cardiorenal syndrome type 1 (CRS type 1) is characterized by a rapid worsening of cardiac function leading to acute kidney injury. In this study, we evaluate the role of lipopolysaccharide (LPS) and various inflammatory markers in the developing acute kidney injury (AKI) in acute heart failure (AHF) patients. METHODS: We enrolled 31 AHF patients and 20 CRS type 1 (the cause of AKI was presumed to be related to cardiac dysfunction) and 17 healthy volunteers without AHF, AKI or CKD, as control group (CTR)...
April 20, 2019: Journal of Nephrology
Carlo Basile, Francesco Gaetano Casino, Filippo Aucella
Management of older people on dialysis requires focus on the wider aspects of aging as well as dialysis. Recognition and assessment of frailty is vital in changing our approach in elderly patients. Current guidelines in dialysis have a limited evidence base across all age group, but particularly the elderly. We need to focus on new priorities of care when we design guidelines "for people not diseases". Patient-centered goal-directed therapy, arising from shared decision-making between physician and patient, should allow adaption of the dialysis regime...
April 19, 2019: Journal of Nephrology
Irene Capelli, Lorenzo Gasperoni, Marco Ruggeri, Gabriele Donati, Olga Baraldi, Giovanni Sorrenti, Maria Turchese Caletti, Valeria Aiello, Giuseppe Cianciolo, Gaetano La Manna
Aldosterone is a mineralocorticoid hormone with a well-known effect on the renal tubule leading to water retention and potassium reabsorption. Other major effects of the hormone include the induction of proinflammatory activity that leads to progressive fibrotic damage of the target organs, heart and kidney. Blocking the aldosterone receptor therefore represents an important pharmacological strategy to avoid the clinical conditions deriving from heart failure (CHF) and chronic kidney disease (CKD). However, steroidal mineralocorticoid receptor antagonists (MRA) have a low safety profile, especially in CKD patients due to the high incidence of hyperkalemia...
April 15, 2019: Journal of Nephrology
Nicola Coppola, Federica Portunato, Antonio Riccardo Buonomo, Laura Staiano, Riccardo Scotto, Biagio Pinchera, Stefania De Pascalis, Daniela Caterina Amoruso, Salvatore Martini, Mariantonietta Pisaturo, Carmine Coppola, Ivan Gentile
BACKGROUND AND AIM: The impact of directly acting antiviral agent (DAA) regimens on renal function is not well defined and quite controversial. We evaluated the effect of DAAs on kidney function and the factors associated with an improvement or worsening. PATIENTS AND METHODS: The changes in estimated glomerular filtration rate (eGFR) in a cohort of 403 patients treated with a DAA regimen were evaluated. RESULTS: The overall sustained virological response (SVR12) rate was 98%...
April 11, 2019: Journal of Nephrology
Hiroyuki Kiriyama, Hidehiro Kaneko, Hidetaka Itoh, Yuriko Yoshida, Koki Nakanishi, Yoshiko Mizuno, Masao Daimon, Hiroyuki Morita, Yutaka Yatomi, Issei Komuro
BACKGROUND: Risk factors for renal function deterioration in the general population are not fully understood. We aimed to clarify the determinants of estimated glomerular filtration rate (eGFR) decline using a community-based cohort. METHODS AND RESULTS: Among 3217 subjects who underwent repeated health check-ups, we excluded 478 subjects with eGFR ≤ 60 mL/min/1.73 m2 and examined 2739 subjects. EGFR decline rate was calculated from the difference in eGFR between the first and last visits...
April 6, 2019: Journal of Nephrology
Sabrina Milan Manani, Grazia Maria Virzì, Anna Giuliani, Carlo Crepaldi, Claudio Ronco
BACKGROUND: Catheter-related infections are important causes of morbidity in patients undergoing peritoneal dialysis (PD). There are different protocols of exit site care for the prevention of catheter-related infections. The aim of this study was to evaluate the incidence of catheter-related infections and their complications in our PD center. METHODS: We performed a retrospective, observational study for all patients receiving PD in our center. We observed prevalent patients every year for 5 years...
April 6, 2019: Journal of Nephrology
Alejandra Muñoz de Morales, Marian Goicoechea, Eduardo Verde, Javier Carbayo, Diego Barbieri, Andrés Delgado, Ursula Verdalles, Ana Perez de Jose, José Luño
BACKGROUND: Pentoxifylline could reduce proteinuria and slow renal disease progression. We previously conducted a single-blind, randomized, controlled trial that showed that pentoxifylline decreases inflammatory markers and stabilizes renal function. SETTING AND PARTICIPANTS: 91 participants (46 in the pentoxifylline group and 45 in the control group) followed up for 7 additional years. STUDY DESIGN: Post hoc analysis of a long-term follow-up after completion of the 12-months trial...
April 4, 2019: Journal of Nephrology
Isabella Guzzo, Lara de Galasso, Sevgi Mir, Ipek Kaplan Bulut, Augustina Jankauskiene, Vilmanta Burokiene, Mirjana Cvetkovic, Mirjana Kostic, Aysun Karabay Bayazit, Dincer Yildizdas, Claus Peter Schmitt, Fabio Paglialonga, Giovanni Montini, Ebru Yilmaz, Jun Oh, Lutz Weber, Christina Taylan, Wesley Hayes, Rukshana Shroff, Enrico Vidal, Luisa Murer, Francesca Mencarelli, Andrea Pasini, Ana Teixeira, Alberto Caldas Afonso, Dorota Drozdz, Franz Schaefer, Stefano Picca
The number of children with acute kidney injury (AKI) requiring dialysis is increasing. To date, systematic analysis has been largely limited to critically ill children treated with continuous renal replacement therapy (CRRT). We conducted a survey among 35 European Pediatric Nephrology Centers to investigate dialysis practices in European children with AKI. Altogether, the centers perform dialysis in more than 900 pediatric patients with AKI per year. PD and CRRT are the most frequently used dialysis modalities, accounting for 39...
April 4, 2019: Journal of Nephrology
Daiki Kobayashi, Nagato Kuriyama, Fumitaka Yanase, Osamu Takahashi, Kazuhiro Aoki, Yasuhiro Komatsu
BACKGROUND: The aim of this study was to evaluate whether angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker (ACEI/ARB) use prior to medical intensive care unit (ICU) admission was associated with in-hospital mortality and length of ICU stay. METHODS: A propensity score-matched cohort study was conducted at single center from 2004 to 2016. We included all adult patients who were admitted to the ICU due to internal medicine-related conditions...
April 1, 2019: Journal of Nephrology
Claudio Ponticelli, Richard J Glassock
Synthetic immunosuppressive drugs are largely used in immune-related renal diseases and in kidney transplantation. Most of these drugs have a low therapeutic index (the ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective), which means that the drug should be dosed carefully and the patient monitored frequently. In this review, we consider the categories of synthetic immunosuppressive agents more frequently and conventionally used in clinical nephrology: glucocorticoids, Aalkylating agents (cyclophosphamide, chlorambucil), purine synthesis inhibitors (azathioprine, mycophenolate salts) and calcineurin inhibitors (cyclosporine, tacrolimus)...
March 29, 2019: Journal of Nephrology
Jiachuan Xiong, Ting He, Min Wang, Ling Nie, Ying Zhang, Yiqin Wang, Yunjian Huang, Bing Feng, Jingbo Zhang, Jinghong Zhao
BACKGROUND: Previous studies reported that magnesium deficiency was associated with vascular calcifications, atherosclerosis and cardiovascular disease, which might play an independent pathogenic role in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. However, the results of these studies were somewhat underpowered and inconclusive. METHODS: Literature was identified by searching PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL)...
March 19, 2019: Journal of Nephrology
John W M Agar, Katherine A Barraclough, Giorgina B Piccoli
No abstract text is available yet for this article.
March 19, 2019: Journal of Nephrology
Matteo Tozzi, Maurizio Gallieni
No abstract text is available yet for this article.
March 19, 2019: Journal of Nephrology
Juan C Ramirez-Sandoval, Mauricio Arvizu-Hernandez, Cristino Cruz, Barbara Vazquez-Cantu, Luis J Rojas-Concha, Luis Tamez, Fagundo Reynerio, F Enrique Gomez, Ricardo Correa-Rotter
BACKGROUND: Vitamin D deficiency is common in peritoneal dialysis (PD) patients, so its supplementation has been advocated as potentially beneficial. METHODS: Double-blind, placebo-controlled, randomized clinical trial. Subjects on PD treated with high calcium peritoneal dialysate (Ca 3.5 mEq/l) and serum levels of 25-hydroxi vitamin D (25D) < 20 ng/ml were randomized to receive cholecalciferol (4800 IU/daily) or placebo for 16 weeks. The outcome measures were the effects on the osteogenic biomarkers osteoprotegerin (primary endpoint), intact fibroblast growth factor-23 (iFGF23), osteocalcin, osteopontin, iPTH, 1,25-dyhydroxivitamin D (1,25D), and interleukin-6...
March 19, 2019: Journal of Nephrology
John W M Agar, Katherine A Barraclough, Giorgina B Piccoli
No abstract text is available yet for this article.
February 22, 2019: Journal of Nephrology
Davide Viggiano, Natale G De Santo, Nagoth Joseph Amruthraj, Giovanna Capolongo, Giovambattista Capasso, Pietro Anastasio
AIM: Different factors have been hypothesized to play a role in the cascade of events associated with the protein-induced glomerular response. However, scant data are available on the possible functional effect of vasopressin (VP) on the glomerular filtration rate (GFR) in humans with central diabetes insipidus (CDI), which was the aim of the present study. METHOD: Renal function was studied under fasting conditions (baseline) and after a meat meal in 16 patients with CDI before and after treatment with desmopressin (DDAVP) and in 16 control subjects...
February 19, 2019: Journal of Nephrology
Richard B Thompson, Paolo Raggi, Natasha Wiebe, Martin Ugander, Jannike Nickander, Scott W Klarenbach, Stephanie Thompson, Marcello Tonelli
BACKGROUND: The cardiovascular morphology and function in long-term survivors of hemodialysis are not well described. METHODS: Single-center cross-sectional study nested within a prospective cohort study of 15 long-term (> 7.5 years) and 15 matched incident (< 6 months) hemodialysis patients with 15 external matched controls. Evaluations included heart structure, function and fibrosis (myocardial longitudinal relaxation time, native T1), and aortic dimensions and elasticity, using cardiovascular magnetic resonance (CMR)...
February 18, 2019: Journal of Nephrology
Maria Fusaro, Maurizio Gallieni, Andrea Aghi, Maria Antonietta Rizzo, Giorgio Iervasi, Thomas L Nickolas, Fabrizio Fabris, Maria Cristina Mereu, Sandro Giannini, Stefania Sella, Andrea Giusti, Annalisa Pitino, Graziella D'Arrigo, Maurizio Rossini, Davide Gatti, Maura Ravera, Luca Di Lullo, Antonio Bellasi, Giuliano Brunori, Antonio Piccoli, Giovanni Tripepi, Mario Plebani
BACKGROUND AND AIMS: Diabetes mellitus is recognized as one of the major causes of end stage kidney disease. Bone Gla protein (BGP) is a vitamin K-dependent protein involved in bone mineralization and vascular calcifications (VC). Our goal was to characterize BGP and undercarboxylated BGP (ucBGP) in DM patients on HD, compared to HD patients without DM, and their association with vascular and bone disease. METHODS: 387 HD patients from 18 dialysis centers in Italy...
February 13, 2019: Journal of Nephrology
Deidra C Crews, Aminu K Bello, Gamal Saadi
Kidney disease is a global public health problem, affecting over 750 million persons worldwide. The burden of kidney disease varies substantially across the world, as does its detection and treatment. In many settings, rates of kidney disease and the provision of its care are defined by socio-economic, cultural, and political factors leading to significant disparities. World Kidney Day 2019 offers an opportunity to raise awareness of kidney disease and highlight disparities in its burden and current state of global capacity for prevention and management...
February 1, 2019: Journal of Nephrology
David Zahler, Keren-Lee Rozenfeld, Maya Stein, Assi Milwidsky, Shlomo Berliner, Shmuel Banai, Yaron Arbel, Yacov Shacham
BACKGROUND: Elevated C-reactive protein (CRP) was shown to be associated with an increased risk for acute kidney injury (AKI) in ST elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI), however, the optimal time frame to measure CRP for risk stratification is not known. We evaluated the relation between the change in CRP over time (CRP velocity-CRPv) and AKI among STEMI patients treated with primary PCI. METHODS: We included 801 STEMI who presented between 2007 and 2017 and had their CRP measured with a wide range assay (wr-CRP) at least twice during the 24 h after admission...
January 31, 2019: Journal of Nephrology
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