Jingwen Deng, Emmerik Leijten, Yongzhan Zhu, Michel Olde Nordkamp, Shuyan Ye, Juliëtte Pouw, Weiyang Tao, Deepak Balak, Guangjuan Zheng, Timothy Radstake, Ling Han, José A M Borghans, Chuanjian Lu, Aridaman Pandit
BACKGROUND: Psoriasis is an immune-mediated inflammatory skin disease. Psoriasis severity evaluation is important for clinicians in the assessment of disease severity and subsequent clinical decision making. However, no objective biomarker is available for accurately evaluating disease severity in psoriasis. OBJECTIVE: To define and compare biomarkers of disease severity and progression in psoriatic skin. METHODS: We performed proteome profiling to study the proteins circulating in the serum from patients with psoriasis, psoriatic arthritis and ankylosing spondylitis, and transcriptome sequencing to investigate the gene expression in skin from the same cohort...
July 20, 2023: Journal of Dermatological Science