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Journal of Dermatological Science | Page 2

Hideyuki Masuda, Makoto Kimura, Akiko Nishioka, Hiroshi Kato, Akimichi Morita
BACKGROUND: Photosensitizers used for photodynamic therapy (PDT) to treat dermatologic disease are metabolized into mainly protoporphyrin IX (PpIX), which has five absorption wavelength peaks: 410 nm, 510 nm, 545 nm, 580 nm, and 630 nm. Although only red light around 635 nm and blue light around 400 nm are used as light sources for PDT, the efficiency of PDT might be improved by using multiple wavelengths, including those that correspond to the other absorption peaks of PpIX...
February 2019: Journal of Dermatological Science
Michihiro Kono, Masashi Akiyama
Dyschromatosis symmetrica hereditaria (DSH) and reticulate acropigmentation of Kitamura (RAK) are rare, inherited pigmentary diseases. DSH shows a mixture of pigmented and depigmented macules on the extremities. RAK shows reticulated, slightly depressed pigmented macules on the extremities. The causative gene of DSH was clarified as ADAR1 by positional cloning including linkage analysis and haplotype analysis in 2003. Ten years later, the causative gene of RAK was identified as ADAM10 by whole-exome sequencing, in 2013...
February 2019: Journal of Dermatological Science
Li Zhang, Yuli Kang, Shujun Chen, Li Wang, Min Jiang, Leihong Xiang
BACKGROUND: Vitiligo is an autoimmune disease with varying pathological features. Activation of the CCL20-CCR6 axis plays an important role in chronic inflammatory diseases. However, whether CCL20-CCR6 and Th1/17 cells are indicative of active vitiligo is unclear. OBJECTIVE: To investigate the potential role of CCL20 and the involvement of Th1/17 and Tc1/17 cells in the mechanism in vitiligo. METHODS: One hundred patients with vitiligo, and 20 healthy controls were included...
February 2019: Journal of Dermatological Science
Hideyuki Masuda, Makoto Kimura, Akimichi Morita
No abstract text is available yet for this article.
January 29, 2019: Journal of Dermatological Science
Sei-Ichiro Motegi, Chisako Fujiwara, Akiko Sekiguchi, Sahori Yamazaki, Yoko Yokoyama, Masahito Yasuda, Osamu Ishikawa
No abstract text is available yet for this article.
January 16, 2019: Journal of Dermatological Science
Saki Maeda-Otsuka, Ikko Kajihara, Yukino Tasaki, Saori Yamada-Kanazawa, Ryoko Sakamoto, Soichiro Sawamura, Mamiko Masuzawa, Mikio Masuzawa, Yasuyuki Amoh, Daichi Hoshina, Riichiro Abe, Yoshihiro Komohara, Hironobu Ihn
BACKGROUND: Angiosarcoma is a rare malignant tumor with a poor prognosis. It is known that hypoxic condition activates tumor progression in several cancers. Additionally, hypoxic tumor microenvironment accelerates immune escape. However, the presence and significance of hypoxia in angiosarcoma has not been adequately investigated. OBJECTIVE: To study the role of hypoxia in the progression of angiosarcoma. METHODS: The protein level of hypoxia inducible factor-1α (HIF-1α) in angiosarcoma was examined using immunohistochemistry and immunoblotting...
January 15, 2019: Journal of Dermatological Science
Hsiao-Chi Lai, Chang-Shen Lin, Ching-Shuang Wu, Cheng-Che E Lan
BACKGROUND: Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The biological impact of UVB radiation emitted at different irradiance on cutaneous immunity remains obscure. OBJECTIVE: This study aimed to explore the impacts of UVB radiation administered at equivalent fluence (mJ/cm2 ) but different irradiance (mW/cm2 ) on cutaneous immune response...
January 11, 2019: Journal of Dermatological Science
Natsuko Noguchi, Tomonori Hirose, Tomoko Suzuki, Masami Kagaya, Kazuhiro Chida, Shigeo Ohno, Motomu Manabe, Shin-Ichi Osada
BACKGROUND: The epidermis possesses regenerative properties that become apparent only after wounding. Atypical protein kinase C (aPKC) isoforms aPKCζ and aPKCλ form a ternary complex with Par3 and Par6, and play crucial roles in establishing and maintaining epithelial cell polarity. The epidermal loss of aPKCλ results in progressive depletion of hair follicle stem cells. However, it is unclear whether aPKCs have equivalent activities in epidermal regeneration. OBJECTIVES: To clarify functional differences between aPKCζ and aPKCλ in cutaneous wound healing...
January 8, 2019: Journal of Dermatological Science
Michiyoshi Kouno, Yurie Akiyama, Masaki Minabe, Naohiko Iguchi, Takeshi Nomura, Kazuyuki Ishihara, Shinichi Takahashi
No abstract text is available yet for this article.
January 2, 2019: Journal of Dermatological Science
Jae Eun Choi, Tyler Werbel, Zhenping Wang, Chia Chi Wu, Tony L Yaksh, Anna Di Nardo
BACKGROUND: Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown. OBJECTIVES: To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions. METHODS: Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control...
January 2019: Journal of Dermatological Science
Mohmmad Shoab Mansuri, Mala Singh, Shahnawaz D Jadeja, Rasheedunnisa Begum
No abstract text is available yet for this article.
December 23, 2018: Journal of Dermatological Science
Sooah Kim, Byung Woo Kim, Vicky P Prizmic, Eugene Oh, Victoria Yu, Benjamin Evans, Dongwon Kim, Luis A Garza
No abstract text is available yet for this article.
December 22, 2018: Journal of Dermatological Science
Gizem Onal, Ozlem Kutlu, Ebru Ozer, Devrim Gozuacik, Aysen Karaduman, Serap Dokmeci Emre
BACKGROUND: Autosomal Recessive Congenital Ichthyosis (ARCI) is a group of epidermal keratinization disorders. One of the disease-associated proteins, patatin-like phospholipase domain-containing protein-1 (PNPLA1), plays a key role in the epidermal omega-O-acylceramide synthesis and localizes on the surface of lipid droplets (LDs). OBJECTIVE: Previously, routine clinical test results showed abnormal LD accumulation in blood smear samples of our ARCI patients with PNPLA1 mutations...
December 4, 2018: Journal of Dermatological Science
Mai Kanemaru, Jun Asai, Jun-Ichiro Jo, Takahiro Arita, Minako Kawai-Ohnishi, Miho Tsutsumi, Makoto Wada, Yasuhiko Tabata, Norito Katoh
BACKGROUND: Nanoparticle-loaded delivery systems have attracted much attention recently. Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful biodegradable polymers for biomedical applications. There are only a few studies on the treatment of dermal fibrosis with sustained-release drugs. Peroxisome proliferator-activated receptor-γ (PPAR-γ) plays an important role in endogenous anti-fibrotic defense mechanisms. Recent studies have suggested that pioglitazone, a synthetic PPAR-γ activator, has effects beyond reducing blood sugar and it can reduce fibrosis and inflammation when used systemically...
December 1, 2018: Journal of Dermatological Science
Thierry Passeron
No abstract text is available yet for this article.
December 1, 2018: Journal of Dermatological Science
Yasuhiro Fujisawa, Takeru Funakoshi, Yoshiyuki Nakamura, Maki Ishii, Jun Asai, Takatoshi Shimauchi, Kazuyasu Fujii, Manabu Fujimoto, Norito Katoh, Hironobu Ihn
BACKGROUND: There are limited treatment options for advanced non-melanoma skin cancers (NMSCs). To overcome this issue, we need to conduct clinical studies, however, there is a lack of information on how many patients with advanced NMSCs are treated annually in Japan. OBJECTIVE: To investigate the actual number of advanced NMSC patients in Japan. METHODS: A questionnaire survey was sent to 668 institutes to educe information on: 1) the numbers of patients with squamous cell carcinoma (SCC), extramammary Paget disease (EMPD), other skin origin carcinomas, and cutaneous angiosarcoma (CAS) admitted in 2016 and 2017; 2) the preferred first- and second-line chemotherapies; and 3) the anticipated for future development...
December 2018: Journal of Dermatological Science
Liangliang Zhou, Minxuan Cai, Yingying Ren, Huali Wu, Meng Liu, Haijuan Chen, Jing Shang
BACKGROUND: 5-HT1A receptor was participated in fluoxetine induced melanogenesis in melanocytes and in normal C57BL/6 mice, but we know little about whether other 5-HT receptors are involved in regulation of fluoxetine promotes pigmentation. OBJECTIVE: To investigate the role of 5-HT receptors in regulation of fluoxetine ameliorates chronic unpredictable mild stress (CUMS) and chronic restraint stress (CRS) induce hypopigmentation in C57BL/6 mice. METHODS: CUMS and CRS were used to induce depigmentation in mice and evaluate the effect of fluoxetine...
December 2018: Journal of Dermatological Science
Andrew W Farrell, Gary M Halliday, J Guy Lyons
BACKGROUND: Ultraviolet radiation (UVR) is the principal cause of keratinocyte skin cancers. Previous work found that levels of the chromatin remodelling protein, Brahma (Brm), are diminished during the progression from actinic keratoses to cutaneous squamous cell carcinomas in humans, and its loss in UV-irradiated mouse skin causes epidermal hyperplasia and increased tumour incidence. METHODS: The skins of mice and mouse and human keratinocytes deficient in Brm were exposed to UVR and evaluated for cell cycle progression and DNA damage response...
December 2018: Journal of Dermatological Science
Yan Zhou, Taylor Follansbee, Xuesong Wu, Dan Han, Sebastian Yu, Dan T Domocos, Zhenrui Shi, Mirela Carstens, Earl Carstens, Samuel T Hwang
BACKGROUND: Transient Receptor Potential Vanilloid 1 (TRPV1) is known to mediate itch and neurogenic inflammation, but the role of TRPV1 in psoriasiform dermal inflammation is poorly understood. OBJECTIVE: To investigate the function of TRPV1 in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice. METHODS: Following daily treatment of topical IMQ cream for consecutive 5 days in C57BL/6 wide-type (WT) and TRPV1 gene knockout (KO) mice, we assessed the psoriasis severity index (PSI) scores, transepidermal water loss (TEWL), dermal inflammatory infiltrates, as well as gene expression levels for psoriasis related genes in mouse skin lesions...
November 26, 2018: Journal of Dermatological Science
Ke Huang, Lei Ran, Wei Wang, Rong Zhou, Xiaowei Cai, Ran Li, Yuanchao Li, Chunli Zhou, Wei He, Rupeng Wang
BACKGROUND: staphylococcal enterotoxin plays an important role in patients with glucocorticoid (GC)-resistant atopic dermatitis (AD), but the exact mechanism is not fully understood. OBJECTIVE: The aim of this study was to investigate the mechanisms underlying the ability of staphylococcal enterotoxin B (SEB) to induce steroid insensitivity through impaired nuclear translocation of GRα in keratinocytes. METHODS: The steroid-resistant AD induced by SEB was assessed by analyzing dermatitis score, dermal thickness, scratching behavior, infiltrating cells/HPF, levels of SEB-specific IgE and IgG2a antibody...
November 26, 2018: Journal of Dermatological Science
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