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Journal of Dermatological Science | Page 2

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https://read.qxmd.com/read/31196788/long-term-safety-and-efficacy-of-rupatadine-in-japanese-patients-with-itching-due-to-chronic-spontaneous-urticaria-dermatitis-or-pruritus-a-12-month-multicenter-open-label-clinical-trial
#21
Michihiro Hide, Takamasa Suzuki, Ayaka Tanaka, Hiroshi Aoki
BACKGROUND: Rupatadine is a novel H1 antihistamine with platelet-activating factor antagonist activity. Its efficacy and safety on pruritic skin diseases have been demonstrated by 10 mg/day rupatadine in a two weeks clinical trial. OBJECTIVE: To investigate the long-term efficacy and safety of rupatadine in the management of pruritus, and the clinical effect of updosing to 20 mg in Japanese adult and adolescent patients. METHODS: In this 52-week, multicenter, open-label clinical trial (JapicCTI-152787), 206 patients (132, eczema or dermatitis; 58, pruritus; and 16, chronic spontaneous urticaria) received the study medication...
June 1, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31138474/stratum-corneum-toll-like-receptor-3-expressions-correlate-with-the-severity-of-atopic-dermatitis-lesions
#22
LETTER
Naomi Nakamura, Risa Tamagawa-Mineoka, Mayumi Ueta, Eiichi Konishi, Risa Yasuike, Koji Masuda, Hiroshi Matsunaka, Yumi Murakami, Emiko Yokosawa, Norito Katoh
No abstract text is available yet for this article.
May 21, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31133503/current-understanding-of-the-role-of-dietary-lipids-in-the-pathophysiology-of-psoriasis
#23
REVIEW
Tetsuya Honda, Kenji Kabashima
Dietary lipids are fundamental nutrients for human health. They are typically composed of various long-chain fatty acids which include saturated fatty acids (SFAs) and unsaturated fatty acids (UFAs). UFAs are further classified into several groups, such as omega-3 polyunsaturated fatty acids (PUFAs) and omega-6 PUFAs, depending on their chemical structure. Epidemiological studies have suggested the involvement of dietary lipids in the progression or regulation of psoriasis, a common chronic inflammatory skin disease induced via the IL-23/IL-17 axis...
May 21, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31138473/microrna-664-functions-as-an-oncogene-in-cutaneous-squamous-cell-carcinomas-cscc-via-suppressing-interferon-regulatory-factor-2
#24
Xiangzhi Li, Cheng Zhou, Chen Zhang, Xiongxiong Xie, Zhaoming Zhou, Meijuan Zhou, Longhua Chen, Zhenhua Ding
BACKGROUND: Aberrant expression of microRNA-664 was involved in tumor growth and metastasis of various cancers. The specific role of miR-664 in cutaneous squamous cell carcinoma (cSCC) is yet to be elucidated. OBJECTIVE: The present study aimed to investigate the molecular mechanisms underpinning of cSCC development and provide translational insights for future therapeutics. METHODS: Human cSCC specimens were used to determine the miR-664 by in situhybridization and IRF2 by immunohistochemistry...
May 16, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31147242/efficiency-of-sirolimus-delivery-to-the-skin-is-dependent-on-administration-route-and-formulation
#25
LETTER
Kazuko Kitayama, Shinichiro Maeda, Ayumi Nakamura, Ichiro Katayama, Mari Wataya-Kaneda
No abstract text is available yet for this article.
May 13, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31122679/igf-1r-deficiency-in-human-keratinocytes-disrupts-epidermal-homeostasis-and-stem-cell-maintenance
#26
Taichi Muraguchi, Daisuke Nanba, Emi K Nishimura, Tomoko Tashiro
BACKGROUND: Epidermal stem cells (ESCs) are keratinocytes that reside in the basal layer of the epidermis and mediate epidermal homeostasis. Insulin-like growth factor 1 (IGF-1) signaling through its receptor (IGF-1R) has been identified as an important regulator in rodent skin development and differentiation. However, the role of IGF-1/IGF-1R signaling in human keratinocytes is not yet well understood. OBJECTIVE: This study aimed to clarify the role of IGF-1/IGF-1R signaling in human epidermal homeostasis...
May 11, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31118160/keratinocyte-derived-tgf%C3%AE-is-not-required-to-maintain-skin-immune-homeostasis
#27
Yi Yang, Yukari Zenke, Toshiro Hirai, Daniel H Kaplan
BACKGROUND: Transforming growth factor beta 1 (TGFβ) is known to be a regulator of autoimmunity. Loss of TGFβ leads to severe multi-organ autoimmunity in mice. In skin, role of TGFβ in suppressing autoimmunity is unclear. OBJECTIVE: Determine whether Keratinocyte (KC)-derived TGFβ is required for skin immune homeostasis. METHODS: We generated K14-CreERT2 TGFβ1fl/fl (TGFβΔKC ) mice allowing for tamoxifen-induced deletion of TGFβ1 in KC...
May 7, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31109652/efficacy-and-safety-of-dupilumab-monotherapy-in-adults-with-moderate-to-severe-atopic-dermatitis-a-pooled-analysis-of-two-phase-3-randomized-trials-liberty-ad-solo-1-and-liberty-ad-solo-2
#28
Diamant Thaçi, Eric L Simpson, Mette Deleuran, Yoko Kataoka, Zhen Chen, Abhijit Gadkari, Laurent Eckert, Bolanle Akinlade, Neil M H Graham, Gianluca Pirozzi, Marius Ardeleanu
BACKGROUND: Two phase 3 trials with identical design, LIBERTY AD SOLO 1 (NCT02277743) and LIBERTY AD SOLO 2 (NCT02277769), confirmed dupilumab efficacy and safety versus placebo in adults with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To report a pooled analysis of these trials to further explore dupilumab's effects on AD clinical parameters, patient-reported outcomes (PROs), symptoms of anxiety/depression, health-related quality of life (HRQoL), and safety...
May 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31079997/systemic-sclerosis-is-the-epithelium-a-missing-piece-of-the-pathogenic-puzzle
#29
REVIEW
Yoshihide Asano, Takehiro Takahashi, Ryosuke Saigusa
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by three cardinal pathological features, such as autoimmunity/inflammation, vasculopathy and extensive organ fibrosis. Therefore, numerous interests have been put on the roles of immune cells, vascular cells (endothelial cells and pericytes/vascular smooth muscle cells) and interstitial fibroblasts as well as their precursors in the field of SSc research. However, recent studies with clinical samples and animal models have drawn much attention to the potential role of epithelial cells as a member of critical drivers and/or modifiers in the pathogenesis of SSc...
May 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31036445/trif-and-mavs-signaling-pathways-regulate-rab27a-induction-and-melanosome-transfer-by-tlr3-signaling-in-human-epidermal-melanocytes
#30
LETTER
Saaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Ryoko Shimada-Omori, Kenichiro Tsuchiyama, Setsuya Aiba
No abstract text is available yet for this article.
May 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31167711/3d-in-vivo-imaging-of-the-keratin-filament-network-in-the-mouse-stratum-granulosum-reveals-profilaggrin-dependent-regulation-of-keratin-bundling
#31
LETTER
Keiko Usui, Nanako Kadono, Yuki Furuichi, Keiichiro Shiraga, Takashi Saitou, Hiroshi Kawasaki, Kiminori Toyooka, Hiroomi Tamura, Akiharu Kubo, Masayuki Amagai, Takeshi Matsui
No abstract text is available yet for this article.
April 30, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31079998/toll-like-receptor-2-utilizes-rab11a-for-melanosome-transfer-from-melanocytes-to-keratinocytes
#32
LETTER
Saaya Koike, Kenshi Yamasaki, Takeshi Yamauchi, Ryoko Shimada-Omori, Kenichiro Tsuchiyama, Setsuya Aiba
No abstract text is available yet for this article.
April 30, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31023613/classification-of-3097-patients-from-the-japanese-melanoma-study-database-using-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-system
#33
Yasuhiro Fujisawa, Shusuke Yoshikawa, Akane Minagawa, Tatsuya Takenouchi, Kenji Yokota, Hiroshi Uchi, Naoki Noma, Yasuhiro Nakamura, Jun Asai, Junji Kato, Susumu Fujiwara, Satoshi Fukushima, Jiro Uehara, Toshihiko Hoashi, Tatsuya Kaji, Taku Fujimura, Kenjiro Namikawa, Manabu Yoshioka, Naoki Murata, Dai Ogata, Kanako Matsuyama, Naohito Hatta, Yoshitsugu Shibayama, Toshiharu Fujiyama, Masashi Ishikawa, Daisuke Yamada, Akiko Kishi, Yoshiyuki Nakamura, Takatoshi Shimiauchi, Kazuyasu Fujii, Manabu Fujimoto, Hironobu Ihn, Norito Katoh
BACKGROUND: The American Joint Committee on Cancer (AJCC) 8th Edition Cancer Staging System was implemented in 2018; however, it has not been validated in an Asian melanoma population. OBJECTIVE: The purpose of this study was to validate the new system using a cohort of Japanese melanoma patients. METHODS: The AJCC 7th and 8th Editions were used for TNM classification of patients in a database established by the Japanese Melanoma Study Group...
April 17, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31010609/cyto-chemokine-profile-of-in-vitro-scratched-keratinocyte-model-implications-of-significant-upregulation-of-ccl20-cxcl8-and-il36g-in-koebner-phenomenon
#34
Kazuhisa Furue, Takamichi Ito, Yuka Tanaka, Ayako Yumine, Akiko Hashimoto-Hachiya, Masaki Takemura, Maho Murata, Kazuhiko Yamamura, Gaku Tsuji, Masutaka Furue
BACKGROUND: Scratch injury induces Koebner phenomenon in psoriasis. Smoking is also a risk factor for psoriasis. Keratinocytes can produce various psoriasis-related molecules including TNF, IL1 A, IL1B, IL6, IL12B, IL17C, IL23 A, IL36 A, IL36B, IL36 G, CXCL1, CXCL2, CXCL8, CXCL9, CXCL10, CCL20, IFNB, and CAMP. However, the scratch-induced molecular profiling remains elusive. OBJECTIVE: To profile the induction pattern of above-mentioned psoriasis-related and keratinocyte-derived molecules by scratch injury in the presence or absence of anti-psoriatic drugs or benzo[a]pyrene, a major environmental pollutant of tobacco smoke...
April 13, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31023612/identification-of-genetic-alterations-in-extramammary-paget-disease-using-whole-exome-analysis
#35
Yukiko Kiniwa, Jun Yasuda, Sakae Saito, Rumiko Saito, Ikuko N Motoike, Inaho Danjoh, Kengo Kinoshita, Nobuo Fuse, Masayuki Yamamoto, Ryuhei Okuyama
BACKGROUND: Extramammary Paget disease (EMPD) is a rare cutaneous malignant neoplasm, and the genomic alterations underlying its pathogenesis are unknown. OBJECTIVE: To identify tumor-specific genomic alterations in EMPD. METHODS: Exome analysis was performed in specimens from three EMPD patients, and target amplicon sequencing was done for genes frequently mutated in other adenocarcinomas. RESULTS: Exome analysis revealed recurrent somatic mutations in several genes, includingTP53, PIK3CA, and ERBB2...
April 11, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31208857/transcriptional-repression-of-the-tyrosinase-related-protein-2-gene-by-transforming-growth-factor-%C3%AE-and-the-kruppel-like-transcription-factor-gli2
#36
Marie-Jeanne Pierrat, Véronique Marsaud, Alain Mauviel, Delphine Javelaud
BACKGROUND: Tyrosinase-Related Protein 2 (TRP2) is an enzyme involved in melanogenesis, that also exerts proliferative, anti-apoptotic and immunogenic functions in melanoma cells. TRP2 transcription is regulated by the melanocytic master transcription factor MITF. GLI2, a transcription factor that acts downstream of Hedgehog signaling, is also a direct transcriptional target of the TGF-β/SMAD pathway that contributes to melanoma progression and exerts transcriptional antagonistic activities against MITF...
April 6, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/30987854/berberine-protects-immortalized-line-of-human-melanocytes-from-h-2-o-2-induced-oxidative-stress-via-activation-of-nrf2-and-mitf-signaling-pathway
#37
Wei Jiang, Shuli Li, Xuguang Chen, Weigang Zhang, Yuqian Chang, Yuanmin He, Shaolong Zhang, Xin Su, Tianwen Gao, Chunying Li, Zhe Jian
BACKGROUND: Oxidative stress plays important roles in the pathogenesis of vitiligo. The removal of hydrogen peroxided (H2 O2 ) has been established to be beneficial to vitiligo patients. Berberine (BBR), a natural isoquinoline alkaloid, has antioxidant activity, however, whether BBR can defend human melanocytes against oxidative injury remains to be elucidated. OBJECTIVE: In the present study, we investigated the potential protective effect of BBR against oxidative stress on an immortalized normal human melanocyte cell line PIG1...
April 2, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/30935778/gpr15-is-not-critically-involved-in-the-regulation-of-murine-psoriasiform-dermatitis
#38
Tanya Sezin, Linda Kempen, Lisa-Maria Meyne, Sadegh Mousavi, Detlef Zillikens, Christian D Sadik
BACKGROUND: GPR15 has been implicated in the pathogenesis of T cell-driven inflammation of the skin and the gut. Expression levels of the GPR15 ligand GPR15 L are increased in psoriatic skin and considered as potential biomarker for the treatment response to anti-IL-17 antibody therapies. However, the significance of the GPR15 L/GPR15 for the pathogenesis of psoriasis and the mechanisms regulating GPR15 L expression are still elusive. OBJECTIVE: To determine the significance of GPR15 signaling in mouse models of psoriasis...
April 2019: Journal of Dermatological Science
https://read.qxmd.com/read/30956032/effects-of-irradiance-on-uva-induced-skin-aging
#39
Cheng-Che E Lan, Yu-Ting Hung, Ai-Hui Fang, Wu Ching-Shuang
BACKGROUND: Ultraviolet A (UVA) radiation is the most relevant component of solar radiation-induced skin aging. Sunscreens were used to minimize the harmful effects of UV radiation on our skin by reducing UV irradiance. We previously found that at equivalent fluence, UVB radiation at low irradiance (LI) has higher photocarcinogenic potential as compared to its high irradiance (HI) counterpart. OBJECTIVES: To examine the effects of equivalent fluence of UVA radiation administered at different irradiance on photoaging...
March 28, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/30956031/fargesin-inhibits-melanin-synthesis-in-murine-malignant-and-immortalized-melanocytes-by-regulating-pka-creb-and-p38-mapk-signaling-pathways
#40
Ting Fu, Bowen Chai, Yuling Shi, Yongyan Dang, Xiyun Ye
BACKGROUND: Fargesin is commonly used in the treatment of allergic rhinitis, inflammation, sinusitis and headache. OBJECTIVE: The aim of the study is to investigate a new function of fargesin against melanin production and its underlying molecular mechanism. METHODS: B16F10 mouse melanoma cells, Melan-a and human epidermal melanocytes were treated with different concentrations of fargesin for the indicated time. The extracellular and cellular melanin content was detected by spectrometry at 490 nm and 405 nm, respectively...
March 28, 2019: Journal of Dermatological Science
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