journal
https://read.qxmd.com/read/38740531/metabolome-analyses-of-skin-dialysate-insights-into-skin-interstitial-fluid-biomarkers
#1
JOURNAL ARTICLE
Akihiko Oharazawa, Gulinu Maimaituxun, Koichi Watanabe, Takeshi Nishiyasu, Naoto Fujii
BACKGROUND: Metabolites in biofluids can serve as biomarkers for diagnosing diseases and monitoring body conditions. Among the available biofluids, interstitial fluid (ISF) in the skin has garnered considerable attention owing to its advantages, which include inability to clot, easy access to the skin, and possibility of incorporating wearable devices. However, the scientific understanding of skin ISF composition is limited. OBJECTIVE: In this study, we aimed to compare metabolites between skin dialysate containing metabolites from the skin ISF and venous blood (plasma) samples, both collected under resting states...
April 26, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38734548/differences-in-activation-of-%C3%AE-catenin-in-outer-root-sheath-cells-between-the-type-of-jak-inhibitor-an-alternative-mechanism-promoting-hair-growth-by-jak-inhibitors-in-alopecia-areata
#2
LETTER
Jung-Min Shin, Yeounkuk Sung, Dongkyun Hong, Kyung-Eun Jung, Young-Joon Seo, Chang-Deok Kim, Young Lee
No abstract text is available yet for this article.
April 26, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38719727/obituary-thomas-fletcher-tedder-phd-1956-2024
#3
JOURNAL ARTICLE
Minoru Hasegawa, Manabu Fujimoto, Takafumi Kadono, Yasuhiro Fujisawa, Masahiro Kamata, Takashi Matsushita, Shinichi Sato
No abstract text is available yet for this article.
April 23, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38644096/lack-of-cutis-verticis-gyrata-is-associated-with-c-1279_1290del12-of-slco2a1-in-43-japanese-patients-with-pachydermoperiostosis
#4
LETTER
H Niizeki, R Tanaka, T Nomura, A Seki, M Miyasaka, Y Matsumoto, M Ishibashi, S Narumi, K Nakabayashi, K Yoshida
No abstract text is available yet for this article.
March 26, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38644095/visualization-of-intradermal-blood-vessel-structures-by-dual-wavelength-photoacoustic-microscopy-and-characterization-of-three-dimensional-construction-of-livedo-racemosa-in-cutaneous-polyarteritis-nodosa
#5
JOURNAL ARTICLE
Kazuyo Sujino, Keiji Tanese, Yasuko Saito, Junko Kuramoto, Hideaki Iwazaki, Taiichiro Ida, Sadakazu Aiso, Nobuaki Imanishi, Hiroki Kajita, Keitaro Fukuda, Masayuki Amagai, Akiko Tanikawa
BACKGROUND: Photoacoustic microscopy is expected to have clinical applications as a noninvasive and three-dimensional (3D) method of observing intradermal structures. OBJECTIVE: Investigate the applicability of a photoacoustic microscope equipped with two types of pulsed lasers that can simultaneously recognize hemoglobin and melanin. METHODS: 16 skin lesions including erythema, pigmented lesions, vitiligo and purpura, were analyzed to visualize 3D structure of melanin granule distribution and dermal blood vessels...
March 26, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38582700/anti-bp230-ige-autoantibodies-in-bullous-pemphigoid-intraindividually-correlate-with-disease-activity
#6
JOURNAL ARTICLE
Shirin Emtenani, Beke E Linnemann, Andreas Recke, Anabelle von Georg, Stephanie Goletz, Enno Schmidt, Nina van Beek
BACKGROUND: Bullous pemphigoid (BP), the most common subepidermal autoimmune blistering disease, is classically defined by the presence of IgG autoantibodies directed against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230 and the predominance of skin lesions. Several studies have addressed the role of anti-BP180 IgE in patients and experimental models, while data on anti-BP230 IgE are scarce. OBJECTIVE: To assess anti-BP230 IgE level by ELISA in BP sera and to correlate it with disease severity and clinical characteristics...
March 23, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38556435/proteome-characterization-of-xpc-deficient-melanocytes-generated-by-crispr-cas9-technology-reveals-alteration-in-the-expression-of-several-hundred-proteins
#7
LETTER
Muriel Cario, Julie Scalia, Walid Mahfouf, Elodie Muzotte, Vincent Michaud, Claudio Plaisant, Jean-William Dupuy, Thierry Douki, Fanny Morice-Picard, Jérôme Rambert, Eric Perrier, Sandra Trompezinski, Hamid-Reza Rezvani
No abstract text is available yet for this article.
March 23, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38556434/il-4-induced-decrease-in-both-the-number-and-ctla-4-expression-of-t-reg-impairs-suppression-of-th2-type-inflammation-in-severe-atopic-dermatitis
#8
JOURNAL ARTICLE
Bocheng Wang, Zhiying Yu, Jiao Liu, Yuyang Tian, Yijia Ruan, Tinghui Kong, Mingjun Hou, Bihui Yu, Shiqi Ling, Di Wang, Yishan Chen, Yingping Xu, Weiwei Deng, Yunsheng Liang
BACKGROUND: Treg plays a pivotal role in the suppression of Th2 cell and the maintenance of immune homeostasis. The precise molecular mechanism underlying the disruption of Treg suppression of Th2 cell and the promotion of Th2 type inflammation in allergic diseases remains elusive. OBJECTIVE: This study aims to investigate the molecular mechanism underlying quantitative and functional changes of Treg in AD. METHODS: The molecular mechanism was investigated using flow cytometry, mRNA sequencing, co-culture experiments, co-immunoprecipitation, chromatin immunoprecipitation, and bisulfite sequencing in vitro or in AD mice model and patients with AD...
March 23, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38508975/targeting-antibody-mediated-complement-independent-mechanism-in-bullous-pemphigoid-with-diacerein
#9
JOURNAL ARTICLE
Yung-Tsu Cho, Chih-Hung Lee, Jing-Yi Lee, Chia-Yu Chu
BACKGROUND: Bullous pemphigoid (BP) is an antibody-mediated blistering disease predominantly affecting the elderly. The pathogenesis involves both complement-dependent and complement-independent mechanisms. The therapeutic potential of targeting complement-independent mechanism has not yet been determined. The mainstay of treatment, corticosteroid, has many side effects, indicating the needs of better treatments. OBJECTIVE: We tempted to establish an in vitro model of BP which resembles complement-independent mechanism and to examine the therapeutic potential of a novel anti-inflammatory agent, diacerein...
March 6, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38514279/rh-family-c-glycoprotein-contributes-to-psoriatic-inflammation-through-regulating-the-dysdifferentiation-and-cytokine-secretion-of-keratinocytes
#10
JOURNAL ARTICLE
Wei Liu, Yaqi Wang, Yitian Zhang, Mingzhu Zhou, Hanjiang Gu, Mei Lu, Yumin Xia
BACKGROUND: Keratinocyte dysdifferentiation and proinflammatory cytokine production play a central role in psoriatic inflammation. According to recent studies, the Rh family C glycoprotein (RHCG) enhances cell proliferation and disrupts cell differentiation. However, the specific role of RHCG psoriasis development remains unclear. OBJECTIVE: We here explored the effect of RHCG on keratinocytes under psoriatic inflammation. METHODS: The cell counting kit‑8 assay was conducted to assess proliferation...
February 29, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38508974/high-%C3%AE-diversity-of-skin-microbiome-and-mycobiome-in-japanese-patients-with-vitiligo
#11
JOURNAL ARTICLE
Yasutaka Kuroda, Lingli Yang, Takakazu Shibata, Masahiro Hayashi, Yuta Araki, Makiko Nishida, Takeshi Namiki, Teruhiko Makino, Tadamichi Shimizu, Tamio Suzuki, Tetsuya Sayo, Yoshito Takahashi, Daisuke Tsuruta, Ichiro Katayama
BACKGROUND: Vitiligo is an acquired pigmentary disorder characterized by depigmented patches on the skin that majorly impact patients' quality of life. Although its etiology involves genetic and environmental factors, the role of microorganisms as environmental factors in vitiligo pathology remains under-researched. OBJECTIVES: Our study explored the presence of characteristic bacterial and fungal flora in vitiligo-affected skin and investigated their potential roles in vitiligo pathogenesis...
February 29, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38448340/ktn1-mediated-unfolded-protein-response-protects-keratinocytes-from-ionizing-radiation-induced-dna-damage
#12
JOURNAL ARTICLE
Xinli Niu, Yi Shen, Yunhan Wen, Xing Mi, Jing Xie, Ying Zhang, Zhenhua Ding
BACKGROUND: The unfolded protein response (UPR) is one of the cytoprotective mechanisms against various stresses and essential for the normal function of skin. Skin injury caused by ionizing radiation (IR) is a common side effect of radiotherapy and it is unclear how UPR affects IR-induced skin injury. OBJECTIVES: To verify the effect of UPR on IR-induced DNA damage in keratinocytes and the relation between an endoplasmic reticulum (ER) protein KTN1 and UPR. METHODS: All experiments were performed on keratinocytes models: HaCaT and HEK-A...
February 24, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38429137/combined-effect-of-neurotropin%C3%A2-and-methylcobalamin-on-postherpetic-neuralgia-in-mice-infected-with-herpes-simplex-virus-type-1
#13
JOURNAL ARTICLE
Tsugunobu Andoh, Takashi Kikukawa, Atsushi Kotani, Yoko Kurokawa, Wakana Asakura, Kengo Houmoto, Daisuke Fukutomi, Daisuke Uta, Hisashi Okai, Koji Koike
BACKGROUND: Postherpetic pain (PHP) is difficult to control. Although Neurotropin® (NTP) and methylcobalamin (MCB) are often prescribed to treat the pain, the efficacy of combined treatment for PHP remains imcompletely understood. OBJECTIVE: In this study, we investigate the combined effects of NTP and MCB on PHP in mice. METHODS: NTP and MCB were administered from day 10-29 after herpes simplex virus type-1 (HSV-1) infection. The pain-related responses were evaluated using a paint brush...
March 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38326167/proteomic-changes-related-to-actin-cytoskeleton-function-in-the-skin-of-vildagliptin-treated-mice
#14
JOURNAL ARTICLE
Antti Nätynki, Nina Kokkonen, Jussi Tuusa, Steffen Ohlmeier, Ulrich Bergmann, Kaisa Tasanen
BACKGROUND: Vildagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4i) is a widely used type 2 diabetes medication that is associated with an up-to 10-fold increased risk for the development of bullous pemphigoid (BP), an autoimmune skin disease. The mechanism by which vildagliptin promotes the development of BP remains unknown. OBJECTIVE: To elucidate effects of vildagliptin treatment on the mouse cutaneous proteome. METHODS: We analyzed the cutaneous proteome of nondiabetic mice treated for 12 weeks with vildagliptin using label-free shotgun mass spectrometry (MS), two-dimensional difference gel electrophoresis (2D-DIGE), immunohistochemistry, immunoblotting, and quantitative real-time polymerase chain reaction...
March 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38326166/jak-inhibitors-for-the-treatment-of-vitiligo
#15
REVIEW
Shintaro Inoue, Tamio Suzuki, Shigetoshi Sano, Ichiro Katayama
Vitiligo is an autoimmune disease involving melanocyte-targeting T cells initiated by environmental and genetic factors. Steroids and tacrolimus have been used as topical treatments. Recently, novel topical agents targeting Janus kinase (JAK), a family of tyrosine kinases that regulates cytokine signaling, have emerged. Ruxolitinib is the first approved in vitiligo therapy. Furthermore, ritlecitinib is currently under clinical trials for oral treatment of active vitiligo. In this review, we discuss the possibility of topical JAK inhibitors as promising options for the treatment of vitiligo with regard to their mechanism of action, efficacy and safety...
March 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38670889/dna-repair-ability-in-a-patient-with-voriconazole-related-squamous-cell-carcinoma-that-required-differential-diagnosis-from-xeroderma-pigmentosum
#16
LETTER
Takeshi Fukumoto, Tomoka Harada, Takamichi Ito, Satoshi Fukushima, Ryusuke Ono, Masutaka Furue, Chikako Nishigori
No abstract text is available yet for this article.
February 18, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38431439/acquired-curved-hair-is-caused-by-fusion-of-multiple-hair-matrix-cells
#17
JOURNAL ARTICLE
Ippei Horibe, Sara Izumi, Yuru Ke, Nanami Tanahashi, Yusuke Takagi, Ryoji Ishihara, Takaya Nakano, Takaaki Sumiyoshi, Yasuo Nagaoka
BACKGROUND: "Curved hair" caused by acquired factors is considered to have adverse cosmetic effects, but the detailed mechanism behind curved hair remains obscure. OBJECTIVE: We attempted to clarify the causes of curved hair that appeared to have occurred via acquired factors. METHODS: Outer root sheath cells (ORSC) isolated from plucked human hair follicles were used to evaluate the expression of type IV collagen. Straight and curved hairs with hair follicle tissue attached were also collected from the same individuals and subjected to morphological, immunohistochemical, and gene expression analyses...
February 12, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38383230/the-grhl3-regulated-long-non-coding-rna-lnc-dc-modulates-keratinocytes-differentiation-by-interacting-with-igf2bp2-and-up-regulating-znf750
#18
JOURNAL ARTICLE
Xue-Ting Hu, Xiao-Feng Wu, Lu-Min Sui, Luo-Quan Ao, Cheng-Xiu Pu, Mu Yuan, Wei Xing, Xiang Xu
BACKGROUND: Aberrant keratinocytes differentiation has been demonstrated to be associated with a number of skin diseases. The roles of lncRNAs in keratinocytes differentiation remain to be largely unknown. OBJECTIVE: Here we aim to investigate the role of lnc-DC in regulating epidermal keratinocytes differentiation. METHODS: Expression of lnc-DC in the skin was queried in AnnoLnc and verified by FISH. The lncRNA expression profiles during keratinocytes differentiation were reanalyzed and verified by qPCR and FISH...
February 12, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38448341/calcitriol-modulates-epidermal-tight-junction-barrier-function-in-human-keratinocytes
#19
JOURNAL ARTICLE
Juan Valentin Trujillo-Paez, Ge Peng, Hai Le Thanh Nguyen, Masahiro Nakamura, Yoshie Umehara, Hainan Yue, Risa Ikutama, Miho Takahashi, Shigaku Ikeda, Hideoki Ogawa, Ko Okumura, François Niyonsaba
BACKGROUND: The aberrant expression of tight junction (TJ) proteins play an important role in several diseases with impaired skin barriers, including atopic dermatitis, psoriasis, and chronic wounds. The evidence provided thus far suggests an important role of calcitriol in skin homeostasis. However, it is not known whether calcitriol improves the impaired skin barrier. OBJECTIVE: To investigate the effect of calcitriol on TJ barrier function in human primary keratinocytes...
February 7, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38395669/a-staphylococcus-epidermidis-strain-inhibits-the-uptake-of-staphylococcus-aureus-derived-from-atopic-dermatitis-skin-into-the-keratinocytes
#20
JOURNAL ARTICLE
Tomofumi Numata, Kazumasa Iwamoto, Kyouka Matsunae, Ryu Miyake, Masataka Suehiro, Nozomi Yanagida, Takanobu Kan, Shunsuke Takahagi, Michihiro Hide, Akio Tanaka
BACKGROUND: Various bacterial species form a microbiome in the skin. In the past, dead Staphylococcus aureus derived from atopic dermatitis (AD) are taken up by keratinocytes; however, whether live S. aureus can be taken up by keratinocytes is unknown. OBJECTIVE: This study aimed to examine whether live AD strains of S. aureus internalize into the keratinocytes and how the internalization changes under conditions in which other bacterial species including S. epidermidis are present...
January 30, 2024: Journal of Dermatological Science
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