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Journal of Dermatological Science

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https://read.qxmd.com/read/31405538/corrigendum-to-keratinocyte-derived-tgf%C3%AE-is-not-required-to-maintain-skin-immune-homeostasis-j-dermatol-sci-94-2-2019-290-297
#1
Yi Yang, Yukari Zenke, Javed A Shaik, Toshiro Hirai, Daniel H Kaplan
No abstract text is available yet for this article.
August 9, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31399284/decreased-expression-of-suprabasin-induces-aberrant-differentiation-and-apoptosis-of-epidermal-keratinocytes-possible-role-for-atopic-dermatitis
#2
Masahiro Aoshima, Pawit Phadungsaksawasdi, Shinsuke Nakazawa, Manami Iwasaki, Jun-Ichi Sakabe, Takatsune Umayahara, Tsuyoshi Yatagai, Shigeki Ikeya, Takatoshi Shimauchi, Yoshiki Tokura
BACKGROUND: Suprabasin (SBSN), a secreted protein, is expressed in various epithelial tissues. The role of SBSN in epidermal differentiation and atopic dermatitis (AD) pathology remains largely unknown. OBJECTIVE: To evaluate the effects of SBSN on epidermal keratinocytes and its role in AD. METHODS: We examined the SBSN expression levels in the stratum corneum and the epidermis by proteome analysis and immunohistochemistry, respectively. The serum SBSN concentration was measured by ELISA...
July 27, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31383390/dietary-supplementation-of-omega-3-fatty-acid-eicosapentaenoic-acid-does-not-ameliorate-pruritus-in-murine-models-of-atopic-dermatitis-and-psoriasis
#3
LETTER
Hyeon-Cheol Lee, Mitsutoshi Tominaga, Ken Yasukawa, Mai Ohba, Nobuaki Takahashi, Kotaro Honda, Toshiaki Okuno, Kenji Takamori, Takehiko Yokomizo
No abstract text is available yet for this article.
July 27, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31378661/overexpression-of-alkaline-phosphatase-improves-the-hair-inductive-capacity-of-cultured-human-dermal-papilla-spheres
#4
LETTER
Mi Hee Kwack, Yae Ji Jang, Gong Hee Won, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
No abstract text is available yet for this article.
July 27, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31378660/serum-squamous-cell-carcinoma-antigen-scca-2-correlates-with-clinical-severity-of-pediatric-atopic-dermatitis-in-ishigaki-cohort
#5
Satoshi Takeuchi, Norihiro Furusyo, Junya Ono, Yoshinori Azuma, Masaki Takemura, Hitokazu Esaki, Kazuhiko Yamamura, Yasutaka Mitamura, Gaku Tsuji, Mari Kiyomatsu-Oda, Jun Hayashi, Kenji Izuhara, Masutaka Furue
BACKGROUND: We sometimes encounter difficulties in assessing the severity of pediatric atopic dermatitis (AD) using currently available biomarkers such as thymus and activation-regulated chemokine (TARC) due to the higher baseline values in non-AD children. Recent case control studies have indicated the usefulness of squamous cell carcinoma antigens (SCCAs) in pediatric and adult AD. Notably, SCCAs are induced by IL-4 and IL-13, vital Th2 cytokines that play important roles in AD etiology...
July 24, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31362906/anti-il-17a-and-il-23p19-antibodies-but-not-anti-tnf%C3%AE-antibody-induce-expansion-of-regulatory-t-cells-and-restoration-of-their-suppressive-function-in-imiquimod-induced-psoriasiform-dermatitis
#6
Teruo Shimizu, Masahiro Kamata, Saki Fukaya, Kotaro Hayashi, Atsuko Fukuyasu, Takamitsu Tanaka, Takeko Ishikawa, Takamitsu Ohnishi, Yayoi Tada
BACKGROUND: Psoriasis is a chronic inflammatory skin disease. Anti-TNFα, IL-17A and IL-23p19 antibodies are effective for psoriasis. However, the contribution of regulatory T cells (Treg) in their effectiveness remains to be elucidated. OBJECTIVE: We investigated the effects of TNFα, IL-17A and IL-23p19 inhibition on Tregs in imiquimod-induced psoriasiform dermatitis. METHODS: Psoriasiform dermatitis was induced by imiquimod application on murine shaved back skin for six days...
July 23, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31327530/zinc-deficiency-exacerbates-pressure-ulcers-by-increasing-oxidative-stress-and-atp-in-the-skin
#7
Hideharu Nakamura, Akiko Sekiguchi, Youichi Ogawa, Tatsuyoshi Kawamura, Ryoko Akai, Takao Iwawaki, Takaya Makiguchi, Satoshi Yokoo, Osamu Ishikawa, Sei-Ichiro Motegi
BACKGROUND: Zinc deficiency is believed to be a predisposing factor for the development and intractable healing of pressure ulcers (PUs); however, the mechanisms of this association have not been elucidated. OBJECTIVE: Objective was to elucidate the mechanisms of the formation of severe and prolonged PUs under the zinc deficiency condition. METHODS: We assessed PUs formation after cutaneous ischemia-reperfusion (I/R) injury in mice fed with a zinc-adequate (ZA) or a zinc-deficient (ZD) diet from 2 weeks before I/R injury...
July 12, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31331740/alterations-in-connexin-26-protein-structure-from-lethal-keratitis-ichthyosis-deafness-syndrome-mutations-a88v-and-g45e
#8
LETTER
Evelyn Lilly, Michael Strickler, Leonard M Milstone, Christopher G Bunick
No abstract text is available yet for this article.
July 10, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31395434/skin-bacterial-transplant-in-atopic-dermatitis-knowns-unknowns-and-emerging-trends
#9
REVIEW
Aleksi J Hendricks, Brandy W Mills, Vivian Y Shi
Dysbiosis is a key pathogenic factor in the cycle of skin barrier impairment and inflammation in atopic dermatitis (AD). Skin microbial composition in AD is characterized by increased presence of Staphylococcus aureus (S. aureus) and decrease in microbial diversity and commensal bacterial species. Attenuation of S. aureus-driven inflammation aids in breaking the itch-scratch cycle via modulation of the cutaneous immune response. Skin bacterial transplant (SBT), a form of bacteriotherapy, is an intriguing treatment modality for restoration of a healthy skin microbiome in AD patients...
July 5, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31324514/topical-delivery-of-mtor-inhibitor-halts-scarring
#10
LETTER
Liana P Webber, Brian Yip, Carlos H V do Nascimento Filho, Ha B Park, Rogerio M Castilho, Cristiane H Squarize
No abstract text is available yet for this article.
July 4, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31399283/autoantibodies-detected-in-patients-with-vitiligo-vulgaris-but-not-in-those-with-rhododendrol-induced-leukoderma
#11
LETTER
Noriko Arase, Atsushi Tanemura, Hui Jin, Megumi Nishioka, Yumi Aoyama, Naoki Oiso, Kayoko Matsunaga, Tamio Suzuki, Chikako Nishigori, Tatsuyoshi Kawamura, Tadamichi Shimizu, Akiko Ito, Kazuyoshi Fukai, Yuko Abe, Lingli Yang, Daisuke Tsuruta, Keiko Takeoka, Yoshinori Iwatani, Yoh Hidaka, Makoto Nishida, Keiko Yamauchi-Takihara, Hisashi Arase, Manabu Fujimoto, Ichiro Katayama
No abstract text is available yet for this article.
July 2, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31307861/baicalein-protects-normal-human-epidermal-keratinocytes-against-bullous-pemphigoid-immunoglobulin-g-induced-alteration
#12
LETTER
Xia Da, Duerna Tie, Yasuyuki Ochi, Eishin Morita
BACKGROUND: Bullous pemphigoid (BP) is a common autoimmune bullous dermatosis in the elderly, with immunoglobulin G (IgG) autoantibodies playing a major role in its pathogenesis. Kampo medicine has been used to ameliorate BP. OBJECTIVE: To determine whether baicalein, a major compound in Ou-gon, a crude drug used in Kampo medicine, protects normal human epidermal keratinocytes (NHEKs) against BP-IgG-induced damage. METHODS: Microscopic examination of living cells, ELISA, a SYTOX green uptake assay, and an intracellular reactive oxygen species (ROS) accumulation assay were used to determine the effects of baicalein on BP-IgG-induced cell damage...
July 2, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31279501/physiological-and-pathological-roles-of-kallikrein-related-peptidases-in-the-epidermis
#13
REVIEW
Mari Kishibe
Identifying the function of kallikrein-related peptidases (KLKs) in the epidermis has elicited great interest over recent decades. KLKs comprise 15 serine proteases, and their activities are regulated by complex and fine-tuned mechanisms involving the proteolytic activation cascade, endogenous inhibitors, and environmental factors. When the balance is disrupted, excessive or insufficient protease activity can impair epidermal barrier homeostasis. KLKs are involved in various events, such as skin inflammation, wound healing, pruritus, anti-bacterial activity, and viral susceptibility...
June 27, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31255469/development-of-de-novo-epithelialization-method-for-treatment-of-cutaneous-ulcers
#14
REVIEW
Masakazu Kurita, Juan Carlos Izpisua Belmonte, Keiichiro Suzuki, Mutsumi Okazaki
Cutaneous ulcers are a common cause of morbidity. We have developed a de novo epithelialization method for treating cutaneous ulcers by means of reprogramming wound-resident mesenchymal cells in vivo into cells able to form a stratified epithelium: induced stratified epithelial progenitors (iSEPs). Administration of 4 transcription factors (DNP63A, GRHL2, TFAP2A, and cMYC) expressed via adeno-associated viral vectors enabled generation of epithelial cells and tissues, thereby acheiving de novo epithelialization from the surfaces of cutaneous ulcers in a mouse model...
June 22, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31300254/significance-of-il-17a-producing-cd8-cd103-skin-resident-memory-t-cells-in-psoriasis-lesion-and-their-possible-relationship-to-clinical-course
#15
Kazuo Kurihara, Toshiharu Fujiyama, Pawit Phadungsaksawasdi, Taisuke Ito, Yoshiki Tokura
BACKGROUND: A number of studies have shown the relationship between the pathogenesis of psoriasis and skin resident memory T (TRM ) cells. OBJECTIVE: To investigate the cytokine profile of TRM cells from skin lesions of psoriasis and the relationship of skin TRM cells to the future clinical course of psoriasis. METHODS: We used stocked samples of T cells that were ex vivo expanded from skin biopsies of 10 patients with psoriasis vulgaris. A half of 4-mm punch biopsy specimens was subjected to expansion of skin-infiltrating T cells using IL-2 and anti-CD3/CD28 antibody-coated microbeads...
June 20, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31262443/cd22-and-cd72-cooperatively-contribute-to-the-development-of-the-reverse-arthus-reaction-model
#16
Vinh Thi Ha Nguyen, Takashi Matsushita, Chunyan Zhao, Manabu Fujimoto, Kazuhiko Takehara, Thomas F Tedder, Yasuhito Hamaguchi
BACKGROUND: Local type III hypersensitivity reactions are acute inflammatory events induced by immune complex (IC) deposition. CD22 and CD72 are B cell-specific cell surface molecules that negatively regulate B cell function. OBJECTIVE: To elucidate the roles of CD22 and CD72 in the development of IgG-mediated type III hypersensitivity reactions. METHOD: The reverse Arthus reaction model in the skin was induced in mice lacking CD22 (CD22-/- ), CD72 (CD72-/- ), and both of them (CD22-/- /CD72-/- )...
June 20, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31272851/protective-and-pathogenic-roles-of-resident-memory-t-cells-in-human-skin-disorders
#17
REVIEW
Rei Watanabe
The human skin is populated by recirculating T cells and skin-sessile resident memory T cells (TRM ). Skin TRM are constructed during immune responses against antigens that the host immune system encounters in the skin. TRM persist in the same sites for a long time and play important protective roles in skin immune responses in collaboration with other skin-composing cells such as dendritic cells and keratinocytes. These TRM with strong effector functions possibly also engender skin inflammatory disorders. Since human skin T cells, especially TRM , are phenotypically distinct from T cells in the blood circulation, T cells residing in the skin should be directly investigated, without presuming from the activities of blood T cells, in order to understand the functional characteristics of skin T cells in skin disorders...
June 19, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31255470/a-proinflammatory-role-of-klk6-protease-in-netherton-syndrome
#18
Eleni Zingkou, Georgios Pampalakis, Eleni Charla, Pauline Nauroy, Dimitra Kiritsi, Georgia Sotiropoulou
BACKGROUND: Netherton syndrome (NS) is a rare but severe type of ichthyosis characterized by atopy, allergies, and potentially lethal skin overdesquamation associated with highly elevated proteolytic activities in LEKTI-deficient epidermis. NS symptoms are recapitulated in Spink5-/- mouse where the gene encoding Lekti has been invalidated. Spink5-/- mice die within 5 h from birth due to their severe skin barrier defect leading to dehydration. Spink5-/- mice also serve as a model for atopic dermatitis...
June 16, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31272852/inhibition-of-atp-binding-cassette-transporter-b1-sensitizes-human-hair-follicles-to-chemotherapy-induced-damage
#19
LETTER
Ellie Smart, Nilofer Farjo, Bessam Farjo, Iain S Haslam, Ralf Paus
No abstract text is available yet for this article.
June 14, 2019: Journal of Dermatological Science
https://read.qxmd.com/read/31213388/long-term-western-diet-intake-leads-to-dysregulated-bile-acid-signaling-and-dermatitis-with-th2-and-th17-pathway-features-in-mice
#20
Prasant Kumar Jena, Lili Sheng, Kyle Mcneil, Thinh Q Chau, Sebastian Yu, Maija Kiuru, Maxwell A Fung, Samuel T Hwang, Yu-Jui Yvonne Wan
BACKGROUND: Dietary interventions are implicated in the development of atopic dermatitis, psoriasis, and acne. OBJECTIVE: To investigate the effect of diet and the bile acid (BA) receptors, such as TGR5 (Takeda G protein receptor 5) and S1PR2 (sphingosine-1-phosphate receptor 2) in the development of dermatitis. METHODS: C57BL/6 mice were fed a control diet (CD) or Western diet (WD) since weaning until they were 10 months old followed by analyzing histology, gene expression, and BA profiling...
June 8, 2019: Journal of Dermatological Science
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