Noriko Kubota, Ryota Tanaka, Yuki Ichimura, Risa Konishi, J Yun Tso, Naoya Tsurushita, Toshifumi Nomura, Naoko Okiyama
BACKGROUND: Antigen-stimulated naïve T cells differentiate into effector and memory T cells, of which resident memory T (TRM ) cells reside permanently in organ tissues. Involvement of TRM cells has been indicated in pathological conditions of various skin diseases. CD122, which is the β chain subunit of interleukin (IL)- 2 and IL-15 receptors, is expressed on immune cells including TRM cells. OBJECTIVE: To investigate whether CD122 signaling in skin CD8+ TRM cells mediates the development of mucocutaneous graft-versus-host disease (GVHD)...
March 21, 2023: Journal of Dermatological Science
Shinji Kano, Motoki Nakamura, Yuka Nojiri, Tetsuya Magara, Maki Yoshimitsu, Hiroshi Kato, Akimichi Morita
BACKGROUND: Halo nevus, also called Sutton's nevus, is a nevus cell nevus surrounded by vitiligo thought to be caused by a T-cell mediated immune response to the nevus antigen. The immune microenvironment is mysterious, however, as vitiligo often does not improve even when the nevus cells are removed. OBJECTIVES: To analyze the clinical course and immune microenvironment of patients with halo nevus who had undergone nevus excision. METHODS: We collected 54 halo nevus patients and performed multivariate analysis and immunohistochemical analysis, including multiplexed immune cell phenotyping and spatial single-cell analyses using the PhenoCycler® assay...
March 21, 2023: Journal of Dermatological Science
Zhuoqing Gong, Xueke Zou, Ruoning Xue, Xuejun Zhu, Xingyuan Jiang
No abstract text is available yet for this article.
March 13, 2023: Journal of Dermatological Science
M M Hollstein, V Manzke, S E F Scheidmann, S Schrenker, M Schaffrinski, E Neubert, D Kramer, V K Raker, M P Schön, L Erpenbeck
No abstract text is available yet for this article.
March 2, 2023: Journal of Dermatological Science
Shih-Fan Lai, Wen-Yen Huang, Wei-Hung Wang, Jin-Bon Hong, Sung-Hsin Kuo, Sung-Jan Lin
BACKGROUND: Growing hair follicles (HFs) harbor actively dividing transit amplifying cells (TACs), rendering them highly sensitive to radiotherapy (RT). Clinically, there is still a lack of treatment options for radiotherapy-induced alopecia (RIA). OBJECTIVE: Our present study aimed to investigated the effect and mechanism of local prostaglandin E2 (PGE2) treatment in RIA prevention. METHODS: We compared the response of growing HFs to radiation with and without local PGE2 pretreatment in a mouse model in vivo...
February 20, 2023: Journal of Dermatological Science
Zhijia Li, Litian Zhang, Yinbo Jiang, Xiaoxin Lin, Yuhui Liao, Bin Yang, Muzhou Teng
BACKGROUND: Treponema pallidum (Tp) is a widespread and destructive pathogen that leads to syphilis. As the acknowledged executor of host immunity, macrophage plays vital roles in combating the invasion and migration of Tp. However, the mechanisms of these processes are largely unknown, especially the critical driver genes and associated modifications. OBJECTIVE: We aimed to systematically dissect the global N6-methyladenosine (m6 A) RNA modification patterns in Tp-infected macrophages...
February 19, 2023: Journal of Dermatological Science
Di Wang, Shuheng Li, Yishan Chen, Jialiang Luo, Lei Li, Bocheng Wang, Yingping Xu, Yunsheng Liang
BACKGROUND: Melanoma is the most common form of skin cancer. Given its high metastasis and high recurrence, its therapies are constantly updated. OBJECTIVE: The study aims to prove the efficacy of sodium thiosulfate (STS), an antidote to cyanide or nitroprusside poisoning, in melanoma treatment. METHODS: We tested the effect of STS by culturing melanoma cells (B16 and A375) in vitro and establishing melanoma mouse models in vivo. The proliferation and viability of melanoma cells were measured by the CCK-8 test, cell cycle assay, apoptosis analysis, wound healing assay, and transwell migration assay...
February 14, 2023: Journal of Dermatological Science
Kosuke Mochida, Shingo Nakahata, Yutaka Suzuki, Kentaro Inoue, Sayaka Moriguchi, Atsushi Yamashita, Masahiro Amano, Kazuhiro Morishita
BACKGROUND: Patients with smoldering ATLL often present with a skin eruption due to skin infiltration of ATLL cells. Although skin eruption type is known to be associated with prognosis based on its pattern, it is unknown why different types of skin eruptions are associated with different prognoses. OBJECTIVE: Genomic analysis of patients with skin eruptions of smoldering ATLL will be performed to determine the mechanism of ATLL development and its association with prognosis...
February 14, 2023: Journal of Dermatological Science
Chiranan Khantham, Warintorn Ruksiriwanich, Tanakarn Chaitep, Pichchapa Linsaenkart, Anurak Muangsanguan, Andrea Guzmán-Jiménez, Miriam Cerván-Martín, Lara Bossini-Castillo, Sara Gonzalez-Muñoz, Rogelio J Palomino-Morales, Nipapan Leetrakool, Banphot Shaengkhamnang, Chuda Chittasupho, Pensak Jantrawut, Sarana Rose Sommano, Yuthana Phimolsiripol, Francisco David Carmona
No abstract text is available yet for this article.
February 14, 2023: Journal of Dermatological Science
Zhenguo Cai, Yibin Zeng, Xunlong Shi, Xilin Zhang, Haiyan Zhu, Wuqing Wang
BACKGROUND: Benvitimod (Tapinarof), as a small-molecule topical therapeutical aryl hydrocarbon receptor (AHR)-modulating agent, is in clinical development for treating psoriasis and atopic dermatitis. Benvitimod reduces proinflammatory cytokines in psoriasis by specifically binding and activation of AHR. However, whether benvitimod can inhibit keratinocyte proliferation remains unclear. Minichromosome maintenance protein 6 (MCM6) is a key element of the prereplication complex (pre-RC) assembly which is one of the essential steps in the initiation of DNA replication for cell proliferation...
January 29, 2023: Journal of Dermatological Science
Fumiko Kumagai, Kiwako Yamamoto-Hanada, Mayako Saito-Abe, Miori Sato, Fumi Ishikawa, Makoto Irahara, Yumiko Miyaji, Shigenori Kabashima, Yukihiro Ohya, Masashi Akiyama, Michihiro Kono
No abstract text is available yet for this article.
January 25, 2023: Journal of Dermatological Science
Young Su Jang, Sugyeong Jeong, A-Ram Kim, Bo Ram Mok, Su Ji Son, Jae-Sang Ryu, Woo Sung Son, Seok Kyun Yun, Seunghyun Kang, Hyun Jung Kim, Dong Hyun Kim, Jung U Shin
BACKGROUND: Cannabidiol, a non-psychoactive phytocannabinoid, has antioxidant and anti-inflammatory activity in keratinocytes. However, the signaling pathway through which cannabidiol exerts its effect on keratinocytes or whether it can modulate keratinocyte differentiation has not been fully elucidated yet. OBJECTIVE: We investigated whether cannabidiol modulates epidermal differentiation and scavenges reactive oxygen species through the aryl hydrocarbon receptor (AhR) in keratinocytes and epidermal equivalents...
January 24, 2023: Journal of Dermatological Science
Yang-Yi Chen, Shu-Mei Huang, Yu-Wen Cheng, Meng-Chi Yen, Ya-Ling Hsu, Cheng-Che E Lan
BACKGROUND: Impaired wound healing is a serious diabetes complication compromising patients' quality of life. However, the pathogenesis of diabetic wounds (DWs) remains incompletely understood. Human epidermal keratinocyte (HEK) is the sentinel cell that initiates healing processes after the epidermal integrity has been disrupted. OBJECTIVE: This study aimed to investigate the functional roles of HEKs in wound healing and to identify candidate genes, signaling pathways and molecular signatures contributing to the DWs...
January 18, 2023: Journal of Dermatological Science
Katsuto Tamai
No abstract text is available yet for this article.
January 14, 2023: Journal of Dermatological Science
Hideyuki Ujiie, Makoto Arakawa, Yumi Aoyama
BACKGROUND: In Japan, intravenous immunoglobulin (IVIG) has been approved for corticosteroid-unresponsive bullous pemphigoid (BP); however, its usage, efficacy, and safety in clinical settings remain unclear. OBJECTIVE: To elucidate IVIG efficacy, we examined the improvement in disease severity based on the Bullous Pemphigoid Disease Area Index (BPDAI). METHODS: In this 3-year (April 2016-March 2019), prospective, post-marketing, observational surveillance study, we enrolled 379 patients (51...
January 12, 2023: Journal of Dermatological Science
Yuta Yanagisawa, Kosuke Shido, Kaname Kojima, Kenshi Yamasaki
BACKGROUND: For dermatological practices, non-standardized conventional photo images are taken and collected as a mixture of variable fields of the image view, including close-up images focusing on designated lesions and long-shot images including normal skin and background of the body surface. Computer-aided detection/diagnosis (CAD) models trained using non-standardized conventional photo images exhibit lower performance rates than CAD models that detect lesions in a localized small area, such as dermoscopic images...
January 11, 2023: Journal of Dermatological Science
Andrew Blauvelt, David M Pariser, Stephen Tyring, Jerry Bagel, Andrew F Alexis, Jennifer Soung, April W Armstrong, Elisa Muscianisi, Farid Kianifard, Jennifer Steadman, Rajendra Prasad Sarkar, Sandra Garcet, James G Krueger
BACKGROUND: The IL-17A inhibitor secukinumab has demonstrated consistent efficacy and safety in patients with moderate-to-severe plaque psoriasis, with normalization of molecular and histopathologic psoriasis markers. OBJECTIVE: To investigate treatment effects of secukinumab on clinical signs and psoriatic inflammation markers over 52 weeks in patients with psoriasis. METHODS: In the ObePso-S study (NCT03055494), patients with psoriasis were randomized 2:1 to receive secukinumab 300 mg (n = 54) or placebo (n = 28), stratified by body weight (<90 or ≥90 kg), for 52 weeks...
January 9, 2023: Journal of Dermatological Science
Shanshan Shi, Qiuchen Li, Yanxin Liu, Rui Zhang, Huaxia Chen
BACKGROUND: Keloid, an aggressive fibroproliferative disease of the skin, is usually caused by infectious skin diseases, burns, and trauma. OBJECTIVE: This study aimed to assess the effect of SPARC on the keloid pathogenesis. METHODS: In normal skin and keloid scar tissues, changes in SPARC expression were analysed by qRT-PCR, western blotting, and immunohistochemistry. Keloid fibroblasts were isolated from human keloid tissue. GSEA was performed to investigate the signalling pathways related to SPARC...
January 7, 2023: Journal of Dermatological Science
Wenling Tu, Shaokai Tang, Tao Yan, Yahui Feng, Wei Mo, Bin Song, Jinlong Wang, Shuanghua Cheng, Fenghao Geng, Yuhong Shi, Daojiang Yu, Shuyu Zhang
BACKGROUND: Radiation-induced skin injury is a serious concern during radiotherapy and accidental exposure to radiation. OBJECTIVE: This study aims to investigate the molecular events in early response to ionizing radiation of skin tissues and underlying mechanism. METHODS: Mice and rats were irradiated with an electron beam. Skin tissues were used for liquid chromatography-mass spectrometry (LC-MS)-based metabolomics, mRNA-Seq and single-cell RNA sequencing (scRNA-Seq)...
January 7, 2023: Journal of Dermatological Science
Yasuhiro Katahira, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Shinya Inoue, Hideaki Hasegawa, Izuru Mizoguchi, Kazuyuki Yo, Fumiya Yamaji, Akemi Toyoda, Takayuki Yoshimoto
BACKGROUND: The tyrosinase inhibitor rhododendrol (RD), used as a skin whitening agent, reportedly has the potential to induce leukoderma. OBJECTIVE: Although an immune response toward melanocytes was demonstrated to be involved in leukoderma, the molecular mechanism is not fully understood. METHODS: We hypothesized that if RD is a pro-hapten and tyrosinase-oxidized RD metabolites are melanocyte-specific sensitizers, the sensitizing process could be reproduced by the human cell line activation test (h-CLAT) cocultured with melanocytes (h-CLATw/M) composed of human DC THP-1 cells and melanoma SK-MEL-37 cells...
December 30, 2022: Journal of Dermatological Science
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