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Journal of Dermatological Science

Cheng-Che E Lan, Yu-Ting Hung, Ai-Hui Fang, Wu Ching-Shuang
BACKGROUND: Ultraviolet A (UVA) radiation is the most relevant component of solar radiation-induced skin aging. Sunscreens were used to minimize the harmful effects of UV radiation on our skin by reducing UV irradiance. We previously found that at equivalent fluence, UVB radiation at low irradiance (LI) has higher photocarcinogenic potential as compared to its high irradiance (HI) counterpart. OBJECTIVES: To examine the effects of equivalent fluence of UVA radiation administered at different irradiance on photoaging...
March 28, 2019: Journal of Dermatological Science
Ting Fu, Bowen Chai, Yuling Shi, Yongyan Dang, Xiyun Ye
BACKGROUND: Fargesin is commonly used in the treatment of allergic rhinitis, inflammation, sinusitis and headache. OBJECTIVE: The aim of the study is to investigate a new function of fargesin against melanin production and its underlying molecular mechanism. METHODS: B16F10 mouse melanoma cells, Melan-a and human epidermal melanocytes were treated with different concentrations of fargesin for the indicated time. The extracellular and cellular melanin content was detected by spectrometry at 490 nm and 405 nm, respectively...
March 28, 2019: Journal of Dermatological Science
Kim Hyun Soo, Kim Yeo Jin, Kim Su Ji, Kang Doo Seok, Tae Ryong Lee, Kim Hyoung-June, Shin Dong Wook, Seo Young Rok
BACKGROUND: Ultraviolet B (UVB) radiation is a major cause of skin photodamage, including the damage associated with photodermatoses, aging, and cancer. Although many studies have shown that red light has photoprotective effects on skin, the mechanisms underlying these effects are still poorly understood. OBJECTIVE: The aim of this study was to identify the photoprotective effects of visible red light against UVB-induced skin damage in normal human dermal fibroblast cells using a transcriptomic approach...
March 23, 2019: Journal of Dermatological Science
Jun Muto, Koji Sayama, Richard L Gallo, Koji Kimata
Hyaluronan (HA), a linear non-sulfated glycosaminoglycan, participates in a variety of biological processes in the skin, such as cell-matrix interactions and activation of chemokines/cytokines, enzymes, and growth factors. In these activation events, HA acts as a damage-associated molecular pattern (DAMP). This review discusses the progress in functional research on HA, and its associated factors, in several aspects of cutaneous biology; e.g., immunity and wound repair.
March 19, 2019: Journal of Dermatological Science
Kozo Nakai, Sakiko Karita, Junske Igarashi, Ikuko Tsukamoto, Katsuya Hirano, Yasuo Kubota
BACKGROUND: Systemic sclerosis (SSc) is characterized by fibrosis of the skin and internal organs. Although transforming growth factor (TGF)-β1-induced connective tissue growth factor (CTGF/CCN2) expression has been presented in SSc fibrosis, the therapeutic potential of targeting CTGF in SSc has not been fully explored. COA-Cl is a novel nucleic acid analog, which is reported to have pleiotropic beneficial biologic effects. OBJECTIVE: We examine the effects of COA-Cl on TGF-β1-induced CTGF expression in normal human dermal fibroblast (NHDF)...
March 12, 2019: Journal of Dermatological Science
Tanya Sezin, Linda Kempen, Lisa-Maria Meyne, Sadegh Mousavi, Detlef Zillikens, Christian D Sadik
BACKGROUND: GPR15 has been implicated in the pathogenesis of T cell-driven inflammation of the skin and the gut. Expression levels of the GPR15 ligand GPR15 L are increased in psoriatic skin and considered as potential biomarker for the treatment response to anti-IL-17 antibody therapies. However, the significance of the GPR15 L/GPR15 for the pathogenesis of psoriasis and the mechanisms regulating GPR15 L expression are still elusive. OBJECTIVE: To determine the significance of GPR15 signaling in mouse models of psoriasis...
March 12, 2019: Journal of Dermatological Science
Ying Liu, Linli Xue, Hang Gao, Lucheng Chang, Xiuju Yu, Zhiwei Zhu, Xiaoyan He, Jianjun Geng, Yanjun Dong, Hongquan Li, Liping Zhang, Haidong Wang
BACKGROUND: Pigmentation is controlled by complex mechanisms. Evidence suggests that miRNAs can regulate pigmentation. However, the mechanism has not been fully elucidated. Objective In this study, we revealed a novel mechanism that regulates pigmentation involving exosomes, miRNAs and the crosstalk between keratinocytes and melanocytes. METHODS: The expression and localization of exosome specific marker TSG101 in keratinocytes and melanocytes; Changes of melanin content in melanocytes after co-culture of exosome and melanocytes; Expression changes of target gene TYR and its related genes and inhibitory effect of miR-330-5p on pigmentation were studied by using various molecular biological techniques...
March 12, 2019: Journal of Dermatological Science
Jungyoon Ohn, Kyu Han Kim, Ohsang Kwon
Androgenetic alopecia (AGA) is the most common form of hair loss disorder. As the prevalence of AGA rises, the demand for AGA treatments is rising accordingly, prompting research to identify therapeutic candidates to treat AGA. Because AGA is caused by crosstalk among multiple hair follicle (HF) cell components, understanding the effects of candidate molecules on HF cells is essential to determining therapeutic candidates for treatment. To date, research has centered on HF dermal papilla and outer root sheath cells and has indicated that the hair growth effects of candidate substances may be mediated via alterations in several signaling pathways and signature genes in these HF cells...
March 12, 2019: Journal of Dermatological Science
Chihiro Imura, Azumi Ueyama, Yoshikazu Sasaki, Masaya Shimizu, Yoko Furue, Nobuyuki Tai, Kenichiro Tsujii, Kazufumi Katayama, Takayuki Okuno, Michitaka Shichijo, Kiyoshi Yasui, Mina Yamamoto
BACKGROUND: Retinoic acid receptor-related orphan receptor gamma t (RORγt) has critical roles in the development, maintenance and function of interleukin (IL)-17-producing cells and is a highly attractive target for the treatment of IL-17-mediated autoimmune disease, particularly psoriasis. On the other hand, RORγt is also critical for controlling apoptosis during thymopoiesis, and genetic RORγt ablation or systematic RORγt inhibition cause progressive thymic aberrations leading to T cell lymphomas...
March 8, 2019: Journal of Dermatological Science
Yu-Jing Zhang, Yang Han, Yu-Zhe Sun, Hang-Hang Jiang, Min Liu, Rui-Qun Qi, Xing-Hua Gao
BACKGROUND: Malassezia is one of the commensal microorganisms colonized on human skin and has been shown to be related to several inflammatory cutaneous disorders. Previous studies indicated that Malassezia. sympodialis (M. sympodialis) can produce extracellular vesicles, however, the immunoregulatory function of Malassezia extracellular vesicles on keratinocytes has not been studied. OBJECTIVE: To investigate the extracellular vesicular production capability of Malassezia...
March 7, 2019: Journal of Dermatological Science
Hideyuki Masuda, Makoto Kimura, Akimichi Morita
No abstract text is available yet for this article.
January 29, 2019: Journal of Dermatological Science
Chanat Kumtornrut, Takeshi Yamauchi, Saaya Koike, Setsuya Aiba, Kenshi Yamasaki
BACKGROUND: The main pathogenesis of acne vulgaris is increase in sebum production and abnormal keratinization of the hair infundibulum. The androgens are involved in acne pathogenesis by modulating sebaceous glands to enhance sebum production. However, the molecular mechanisms of abnormal keratinization of the hair infundibulum are not fully elucidated. OBJECTIVE: We hypothesized that the androgens affect the dermal fibroblasts, another androgen receptor-positive cells in the skin, resulting in abnormal keratinization through keratinocyte-fibroblast interaction...
January 26, 2019: Journal of Dermatological Science
Hideyuki Masuda, Makoto Kimura, Akiko Nishioka, Hiroshi Kato, Akimichi Morita
BACKGROUND: Photosensitizers used for photodynamic therapy (PDT) to treat dermatologic disease are metabolized into mainly protoporphyrin IX (PpIX), which has five absorption wavelength peaks: 410 nm, 510 nm, 545 nm, 580 nm, and 630 nm. Although only red light around 635 nm and blue light around 400 nm are used as light sources for PDT, the efficiency of PDT might be improved by using multiple wavelengths, including those that correspond to the other absorption peaks of PpIX...
February 2019: Journal of Dermatological Science
Michihiro Kono, Masashi Akiyama
Dyschromatosis symmetrica hereditaria (DSH) and reticulate acropigmentation of Kitamura (RAK) are rare, inherited pigmentary diseases. DSH shows a mixture of pigmented and depigmented macules on the extremities. RAK shows reticulated, slightly depressed pigmented macules on the extremities. The causative gene of DSH was clarified as ADAR1 by positional cloning including linkage analysis and haplotype analysis in 2003. Ten years later, the causative gene of RAK was identified as ADAM10 by whole-exome sequencing, in 2013...
February 2019: Journal of Dermatological Science
Li Zhang, Yuli Kang, Shujun Chen, Li Wang, Min Jiang, Leihong Xiang
BACKGROUND: Vitiligo is an autoimmune disease with varying pathological features. Activation of the CCL20-CCR6 axis plays an important role in chronic inflammatory diseases. However, whether CCL20-CCR6 and Th1/17 cells are indicative of active vitiligo is unclear. OBJECTIVE: To investigate the potential role of CCL20 and the involvement of Th1/17 and Tc1/17 cells in the mechanism in vitiligo. METHODS: One hundred patients with vitiligo, and 20 healthy controls were included...
February 2019: Journal of Dermatological Science
Sei-Ichiro Motegi, Chisako Fujiwara, Akiko Sekiguchi, Sahori Yamazaki, Yoko Yokoyama, Masahito Yasuda, Osamu Ishikawa
No abstract text is available yet for this article.
January 16, 2019: Journal of Dermatological Science
Saki Maeda-Otsuka, Ikko Kajihara, Yukino Tasaki, Saori Yamada-Kanazawa, Ryoko Sakamoto, Soichiro Sawamura, Mamiko Masuzawa, Mikio Masuzawa, Yasuyuki Amoh, Daichi Hoshina, Riichiro Abe, Yoshihiro Komohara, Hironobu Ihn
BACKGROUND: Angiosarcoma is a rare malignant tumor with a poor prognosis. It is known that hypoxic condition activates tumor progression in several cancers. Additionally, hypoxic tumor microenvironment accelerates immune escape. However, the presence and significance of hypoxia in angiosarcoma has not been adequately investigated. OBJECTIVE: To study the role of hypoxia in the progression of angiosarcoma. METHODS: The protein level of hypoxia inducible factor-1α (HIF-1α) in angiosarcoma was examined using immunohistochemistry and immunoblotting...
January 15, 2019: Journal of Dermatological Science
Hsiao-Chi Lai, Chang-Shen Lin, Ching-Shuang Wu, Cheng-Che E Lan
BACKGROUND: Ultraviolet B (UVB) is commonly used for treating dermatologic conditions. Recently, high irradiance UVB (HIUVB) has been suggested to be more effective for treating skin conditions as compared to its low irradiance (LI) counterpart. The biological impact of UVB radiation emitted at different irradiance on cutaneous immunity remains obscure. OBJECTIVE: This study aimed to explore the impacts of UVB radiation administered at equivalent fluence (mJ/cm2 ) but different irradiance (mW/cm2 ) on cutaneous immune response...
January 11, 2019: Journal of Dermatological Science
Natsuko Noguchi, Tomonori Hirose, Tomoko Suzuki, Masami Kagaya, Kazuhiro Chida, Shigeo Ohno, Motomu Manabe, Shin-Ichi Osada
BACKGROUND: The epidermis possesses regenerative properties that become apparent only after wounding. Atypical protein kinase C (aPKC) isoforms aPKCζ and aPKCλ form a ternary complex with Par3 and Par6, and play crucial roles in establishing and maintaining epithelial cell polarity. The epidermal loss of aPKCλ results in progressive depletion of hair follicle stem cells. However, it is unclear whether aPKCs have equivalent activities in epidermal regeneration. OBJECTIVES: To clarify functional differences between aPKCζ and aPKCλ in cutaneous wound healing...
January 8, 2019: Journal of Dermatological Science
Michiyoshi Kouno, Yurie Akiyama, Masaki Minabe, Naohiko Iguchi, Takeshi Nomura, Kazuyuki Ishihara, Shinichi Takahashi
No abstract text is available yet for this article.
January 2, 2019: Journal of Dermatological Science
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