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Coronary Artery Disease

Lianjun Xu, Zhan Gao, Ying Song, Huanhuan Wang, Jingjing Xu, Ping Jiang, Lin Jiang, Xiaofang Tang, Jue Chen, Lijian Gao, Lei Song, Yin Zhang, Xueyan Zhao, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan
BACKGROUND: With the advancements of percutaneous coronary interventions (PCI), it is not clear whether unprotected left main (ULM) coronary artery disease (CAD) remains an independent predictor of adverse outcomes after PCI therapy. We have therefore carried out a large cohort study to investigate the impact of ULM disease on 2-year clinical outcomes in Chinese patients undergoing contemporary PCI treatment. METHODS AND RESULTS: From January 2013 to December 2013, 10 724 consecutive patients undergoing PCI were prospectively collected...
February 11, 2019: Coronary Artery Disease
Jakub Sulženko, Piotr Paluszek, Roman Machnik, Petr Widimský, Jiří Jarkovský, Piotr Pieniazek
INTRODUCTION: A relationship between carotid stenosis and coronary arterial disease (CAD) is widely accepted; however, data on the exact prevalence of coronary disease in patients with severe carotid stenosis are lacking. Information on the prevalence and predictors of CAD among these patients could impact diagnostic and treatment approaches. AIM: The primary aim of this study was to determine the prevalence of significant CAD among patients referred for carotid artery revascularization...
February 11, 2019: Coronary Artery Disease
Bulent B Altunkeser, Abdullah Tuncez, Bahadir Ozturk, Huseyin Tezcan, Muhammet S Ates, Canan Yilmaz, Muhammed U Yalcin, Nazif Aygul, Kenan Demir
AIM: Current guidelines recommend administration of high-dose statins in acute coronary syndrome (ACS). It has been reported that statins upregulate proprotein convertase subtilisin kexin 9 (PCSK9) mRNA expression and increase circulating PCSK9 levels. We aimed to compare the effects of high-dose atorvastatin and rosuvastatin on serum oxidized low-density lipoprotein (oxidized-LDL) and PCSK9 levels in statin-naive patients with ACS. PATIENTS AND METHODS: One hundred and six patients with ACS were enrolled in this study...
February 7, 2019: Coronary Artery Disease
Raquel B Santos, Inês Silveira, Maria Trêpa, Bruno Brochado, Rui Magalhães, Patrícia Rodrigues, Maria J Sousa, André Luz, João Silveira, Aníbal Albuquerque, Severo Torres, Adelino F Leite-Moreira, Henrique Carvalho
AIM: Remote ischemic conditioning may reduce acute kidney injury (AKI) in patients undergoing a coronary intervention. As preinfarct angina (PIA) might act as a preconditioning stimulus in patients with ST-elevation myocardial infarction (STEMI), we aimed to study whether PIA reduces AKI in accordance to pre-existing chronic kidney disease. PATIENTS AND METHODS: We conducted a retrospective study including 891 consecutive STEMI patients who underwent primary coronary intervention from January 2008 to March 2016...
February 7, 2019: Coronary Artery Disease
Yuhan Qin, Chengchun Tang, Changle Ma, Gaoliang Yan
BACKGROUND: Coronary artery ectasia (CAE) is the aneurysmal dilatation of the coronary artery, recognized as a special clinical form of coronary stenosis besides atherosclerosis. Its exact pathophysiological mechanism remains unknown. Moreover, few studies have focused on the relationship between triglyceride and CAE. We aimed to find the risk factors for CAE and analyze the relationship between serum lipid and CAE. PATIENTS AND METHODS: We conducted a prospective cohort study on patients admitted because of typical or atypical chest discomfort suggestive of angina in Zhongda Hospital affiliated to Southeast University from January 2010 to June 2018...
February 7, 2019: Coronary Artery Disease
Mingya Kong, Yan Zhao, Andong Chen, Aicui Lin
OBJECTIVE: The aim of this study was to investigate the effects of physiologic ischemia training (PIT) on the proliferation of endothelial progenitor cells (EPCs) and the corresponding changes in the influencing factors in atherosclerotic rabbits, including vascular endothelial growth factor (VEGF) and nitric oxide (NO). MATERIALS AND METHODS: Eighteen rabbits were assigned randomly to three groups: a high-fat diet (HD) group, an HD-with-training (HT) group, and a control group...
February 4, 2019: Coronary Artery Disease
Kongyong Cui, Shuzheng Lyu, Xiantao Song, Hong Liu, Fei Yuan, Feng Xu, Min Zhang, Wei Wang, Mingduo Zhang, Dongfeng Zhang, Jing Dai, Jinfan Tian
BACKGROUND: The long-term relative benefit of culprit-only percutaneous coronary intervention (PCI) and staged PCI in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease remains disputable. This study aimed to compare the long-term outcomes of culprit-only PCI and in-hospital staged complete revascularization in real-world patients with STEMI and multivessel coronary artery disease. PATIENTS AND METHODS: A total of 452 patients were treated with in-hospital staged complete revascularization (n=133) or culprit-only PCI (n=319) between May 2012 and December 2015 in our center...
February 4, 2019: Coronary Artery Disease
Łukasz Piątek, Krzysztof Wilczek, Agnieszka Janion-Sadowska, Marek Gierlotka, Mariusz Gąsior, Marcin Sadowski
BACKGROUND: Elderly patients (≥75 years old) with non-ST-segment elevation myocardial infarction (NSTEMI) represent a large subgroup of all cases. They are rarely included in randomized trials because of comorbidities and concerns about complications. Furthermore, invasive treatments are used less frequently in this patient group. The aim of this study was to analyze trends in invasive procedures and outcomes in elderly patients with NSTEMI from 2005 to 2014. PATIENTS AND METHODS: We analyzed 68 978 elderly patients with NSTEMI enrolled in the prospective, nationwide Polish Registry of Acute Coronary Syndromes from 2005 to 2014...
February 4, 2019: Coronary Artery Disease
Boyu Kong, Nan Wang, Le Dou, Dianbo Cao
No abstract text is available yet for this article.
January 30, 2019: Coronary Artery Disease
Ling Li, Hui Wang, Yini Wang, Xueqin Gao, Guojie Liu, Zhenjuan Zhao, Ping Lin
OBJECTIVES: This cross-sectional study aimed to investigate the long-term quality of life (QOL) influencing of patients following a percutaneous coronary intervention (PCI) as well as its influencing factors. PATIENTS AND METHODS: From June 2013 to April 2014, 428 PCI patients were enrolled in this questionnaire survey. The demographic and clinical data, Social Support Rating Scale, Medical Coping Modes Questionnaire, Social Disability Screening Schedule, and Short Form 36 Health Status Questionnaire were collected...
January 30, 2019: Coronary Artery Disease
Yuichi Saito, Hideki Kitahara, Takeshi Nishi, Yoshihide Fujimoto, Yoshio Kobayashi
OBJECTIVES: Coronary endothelial and circulatory dysfunction plays important roles in the pathogenesis of vasospastic angina (VSA). However, a complete understanding of the entire coronary circulation including microvasculature in patients with VSA is lacking. PATIENTS AND METHODS: A total of 32 patients without obstructive coronary artery disease in the left descending coronary artery, who underwent an intracoronary acetylcholine (ACh) provocation test for diagnosis of VSA, were enrolled prospectively...
January 29, 2019: Coronary Artery Disease
Chandana Shekar, Lavanya Cherukuri, Christopher Dailing, Matthew J Budoff, Sion K Roy
No abstract text is available yet for this article.
January 29, 2019: Coronary Artery Disease
Akanksha Agrawal, Marvin Lu, Napatt Kanjanahattakij, Hee Do Jeon, Abel Romero-Corral, Vincent Figueredo, Gregg Pressman
BACKGROUND: Rapid diagnosis of ST-segment elevation myocardial infarction (STEMI) is crucial for appropriate management. Catheterization for a false STEMI activation has risks including exposure to contrast agent and radiation, increased healthcare costs and delay in treatment of the primary medical condition. PATIENTS AND METHODS: This was a single center retrospective study including all 'cath alerts' between January 2012 and December 2015. 'Cath alert' is a term used to activate the interventional cardiology team when STEMI is suspected by the emergency department physicians based on review of the initial ECG...
January 28, 2019: Coronary Artery Disease
Hiroyoshi Mori, Hiromoto Sone, Yosuke Takei, Kazuma Tashiro, Masahiro Sasai, Atsuo Maeda, Tokutada Sato, Hiroshi Suzuki
No abstract text is available yet for this article.
January 28, 2019: Coronary Artery Disease
Takashi Nakamura, Masakazu Yasuda, Masafumi Ueno, Kazuhiro Kobuke, Yoshitaka Iwanaga, Shunichi Miyazaki
No abstract text is available yet for this article.
January 28, 2019: Coronary Artery Disease
Young Soo Oh, Hyun Jong Lee, Juneyoung Lee, Young Jin Choi, Rak Kyeung Choi, Cheol Woong Yu, Jinsik Park, Jin-Oh Choi, Je Sang Kim, Tae Hoon Kim, Ho-Jun Jang, Seung Woo Park, Sang Hoon Lee
BACKGROUND: Major randomized clinical trials assessing clinical outcomes in patients who underwent a percutaneous coronary intervention (PCI) for left main coronary artery disease excluded some high-risk subsets. Whether the effectiveness and safety of a percutaneous approach in this group of patients are comparable with those observed in clinical trials is unclear. We aimed to explore the long-term outcomes of contemporary drug-eluting stent (DES)-based revascularization for left main coronary artery disease in patients presenting with one or more clinical or angiographic characteristics who would have precluded inclusion in randomized trials...
January 25, 2019: Coronary Artery Disease
Muhammad Rashid, David L Fischman, Sara C Martinez, Quinn Capers, Michael Savage, Azfar Zaman, Nick Curzen, Joie Ensor, Jessica Potts, Mohamed O Mohamed, Chun Shing Kwok, Tim Kinnaird, Rodrigo Bagur, Mamas Mamas
OBJECTIVE: This study aims to investigate the temporal trends in utilization of invasive coronary angiography (CA) at different time points and changing profiles of patients undergoing CA following non-ST-elevation acute coronary syndrome (NSTEACS). We also describe the association between timing of CA and in-hospital clinical outcomes. PATIENTS AND METHODS: We queried the National Inpatient Sample to identify all admissions with a primary diagnosis of NSTEACS from 2004 to 2014...
January 22, 2019: Coronary Artery Disease
Benjamin Z Galper, Matthew R Reynolds, Pallav Garg, Eric A Secemsky, Linda R Valsdottir, David J Cohen, Robert W Yeh
BACKGROUND: The cost-effectiveness of newer drug-eluting stents (DES) such as biodegradable-polymer or polymer-free stents with shorter dual antiplatelet therapy (DAPT) duration is unknown. We evaluated the cost-effectiveness of treatment with newer DES that may allow for shorter DAPT duration. PATIENTS AND METHODS: We performed a cost-effectiveness analysis of treatment with newer DES platforms followed by 1 or 3 months of DAPT compared with standard second-generation DES followed by 6 or 12 months of DAPT in patients with stable coronary disease...
January 22, 2019: Coronary Artery Disease
Sharmaine Thiru, Alexandros Alexopoulos, Adrian Chenzbraun
BACKGROUND: An optimal investigation strategy for patients with suspected angina pectoris (AP) remains elusive. Present guidelines use the Duke Clinical Score (DCS) or the Diamond-Forrester (DF) model to compute the likelihood of coronary artery disease (CAD). This prospective study of patients referred to a chest pain clinic compares the relative values of these two historical models and of pain characteristics only to predict the presence of CAD. PATIENTS AND METHODS: Overall, 1376 patients reviewed in a chest pain clinic were assigned to five CAD likelihood groups (<10, 10-29, 30-60, 61-90 and >90%) using DCS and to three CAD likelihood groups (<15, 15-85 and >85%) using the DF model...
January 22, 2019: Coronary Artery Disease
Rajiv Rampat, Timothy Williams, Thomas Mayo, Manuela Mengozzi, Pietro Ghezzi, David Hildick-Smith, James Cockburn
INTRODUCTION: The ABSORB bioresorbable vascular scaffold (BVS) is associated with greater neointimal proliferation and thrombotic rate than the metal stent. The role of inflammatory biomarkers on neointimal proliferation has not been studied in the setting of BVS implantation. PATIENTS AND METHODS: Thirty patients had arterial blood sampling before elective percutaneous coronary intervention with the ABSORB BVS and at 9-months follow-up. Plasma levels of interleukin-6, soluble CD40 ligand, monocyte chemotactic protein-1 and C-reactive protein were measured using enzyme-linked immunosorbent assay...
January 22, 2019: Coronary Artery Disease
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