journal
Journals Journal of the National Cancer...

Journal of the National Cancer Institute. Monographs

https://read.qxmd.com/read/37139978/key-takeaways-for-knowledge-expansion-of-early-career-scientists-conducting-transdisciplinary-research-in-energetics-and-cancer-trec-a-report-from-the-trec-training-workshop-2022
#21
JOURNAL ARTICLE
Che-Pei Kung, Meghan B Skiba, Erika J Crosby, Jessica Gorzelitz, Mary A Kennedy, Bethany A Kerr, Yun Rose Li, Sarah Nash, Melanie Potiaumpai, Amber S Kleckner, Dara L James, Michael F Coleman, Ciaran M Fairman, Gloria C Galván, David O Garcia, Max J Gordon, Mathilde His, Lyndsey M Hornbuckle, So-Youn Kim, Tae-Hyung Kim, Amanika Kumar, Mélanie Mahé, Karen K McDonnell, Jade Moore, Sangphil Oh, Xinghui Sun, Melinda L Irwin
The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139977/a-review-of-the-impact-of-energy-balance-on-triple-negative-breast-cancer
#22
REVIEW
Ngozi D Akingbesote, Dennis Owusu, Ryan Liu, Brenda Cartmel, Leah M Ferrucci, Michelle Zupa, Maryam B Lustberg, Tara Sanft, Kim R M Blenman, Melinda L Irwin, Rachel J Perry
Cancer cells cannot proliferate without sufficient energy to generate biomass for rapid cell division, as well as to fuel their functions at baseline. For this reason, many recent observational and interventional studies have focused on increasing energy expenditure and/or reducing energy intake during and after cancer treatment. The impact of variance in diet composition and in exercise on cancer outcomes has been detailed extensively elsewhere and is not the primary focus of this review. Instead, in this translational, narrative review we examine studies of how energy balance impacts anticancer immune activation and outcomes in triple-negative breast cancer (TNBC)...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139976/pharmacokinetics-of-cancer-therapeutics-and-energy-balance-the-role-of-diet-intake-energy-expenditure-and-body-composition
#23
REVIEW
Sarah A Purcell, Dieuwertje E Kok, Tyler Ketterl, Miriam B Garcia, Lenat Joffe, Justin C Brown, Christina M Dieli-Conwright, Grant R Williams
Energy balance accounts for an individual's energy intake, expenditure, and storage. Each aspect of energy balance has implications for the pharmacokinetics of cancer treatments and may impact an individual's drug exposure and subsequently its tolerance and efficacy. However, the integrated effects of diet, physical activity, and body composition on drug absorption, metabolism, distribution, and excretion are not yet fully understood. This review examines the existing literature on energy balance, specifically the role of dietary intake and nutritional status, physical activity and energy expenditure, and body composition on the pharmacokinetics of cancer therapeutics...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139975/looking-back-a-review-of-policy-implications-for-exercise-oncology
#24
REVIEW
Mary A Kennedy, Melanie Potiaumpai, Melissa Maitin-Shepard, Christopher M Wilson, Anna Campbell, Anna L Schwartz, Jessica Gorzelitz, Maxime Caru, Chloe Grimmett, Kathryn H Schmitz
The evidence to support the benefits of exercise for people living with and beyond cancer is robust. Still, exercise oncology interventions in the United States are only eligible for coverage by third-party payers within the restrictions of cancer rehabilitation settings. Without expanded coverage, access will remain highly inequitable, tending toward the most well-resourced. This article describes the pathway to third-party coverage for 3 programs that address a chronic disease and utilize exercise professionals: the Diabetes Prevention Program, Supervised Exercise Training for Peripheral Artery Disease, and Cancer Rehabilitation...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139974/translational-and-transdisciplinary-research-in-energy-balance-and-cancer-past-is-prologue
#25
JOURNAL ARTICLE
Melinda L Irwin, Dorothy D Sears, Jennifer Ligibel
No abstract text is available yet for this article.
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139973/the-omics-of-obesity-in-b-cell-acute-lymphoblastic-leukemia
#26
JOURNAL ARTICLE
Delaney K Geitgey, Miyoung Lee, Kirsten A Cottrill, Maya Jaffe, William Pilcher, Swati Bhasin, Jessica Randall, Anthony J Ross, Michelle Salemi, Marisol Castillo-Castrejon, Matthew B Kilgore, Ayjha C Brown, Jeremy M Boss, Rich Johnston, Anne M Fitzpatrick, Melissa L Kemp, Robert English, Eric Weaver, Pritha Bagchi, Ryan Walsh, Christopher D Scharer, Manoj Bhasin, Joshua D Chandler, Karmella A Haynes, Elizabeth A Wellberg, Curtis J Henry
The obesity pandemic currently affects more than 70 million Americans and more than 650 million individuals worldwide. In addition to increasing susceptibility to pathogenic infections (eg, SARS-CoV-2), obesity promotes the development of many cancer subtypes and increases mortality rates in most cases. We and others have demonstrated that, in the context of B-cell acute lymphoblastic leukemia (B-ALL), adipocytes promote multidrug chemoresistance. Furthermore, others have demonstrated that B-ALL cells exposed to the adipocyte secretome alter their metabolic states to circumvent chemotherapy-mediated cytotoxicity...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139972/embedding-lifestyle-interventions-into-cancer-care-has-telehealth-narrowed-the-equity-gap
#27
JOURNAL ARTICLE
Amy M Dennett, Kelly A Hirko, Kathleen J Porter, Kah Poh Loh, Yue Liao, Lin Yang, Hannah Arem, Jasmine S Sukumar, Elizabeth A Salerno
Lifestyle interventions targeting energy balance (ie, diet, exercise) are critical for optimizing the health and well-being of cancer survivors. Despite their benefits, access to these interventions is limited, especially in underserved populations, including older people, minority populations and those living in rural and remote areas. Telehealth has the potential to improve equity and increase access. This article outlines the advantages and challenges of using telehealth to support the integration of lifestyle interventions into cancer care...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139971/intermittent-fasting-interventions-to-leverage-metabolic-and-circadian-mechanisms-for-cancer-treatment-and-supportive-care-outcomes
#28
JOURNAL ARTICLE
Faiza Kalam, Dara L James, Yun Rose Li, Michael F Coleman, Violet A Kiesel, Elizabeth M Cespedes Feliciano, Stephen D Hursting, Dorothy D Sears, Amber S Kleckner
Intermittent fasting entails restricting food intake during specific times of day, days of the week, religious practice, or surrounding clinically important events. Herein, the metabolic and circadian rhythm mechanisms underlying the proposed benefits of intermittent fasting for the cancer population are described. We summarize epidemiological, preclinical, and clinical studies in cancer published between January 2020 and August 2022 and propose avenues for future research. An outstanding concern regarding the use of intermittent fasting among cancer patients is that fasting often results in caloric restriction, which can put patients already prone to malnutrition, cachexia, or sarcopenia at risk...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/37139970/skeletal-muscle-omics-signatures-in-cancer-cachexia-perspectives-and-opportunities
#29
JOURNAL ARTICLE
L Anne Gilmore, Traci L Parry, Gwendolyn A Thomas, Andy V Khamoui
Cachexia is a life-threatening complication of cancer that occurs in up to 80% of patients with advanced cancer. Cachexia reflects the systemic consequences of cancer and prominently features unintended weight loss and skeletal muscle wasting. Cachexia impairs cancer treatment tolerance, lowers quality of life, and contributes to cancer-related mortality. Effective treatments for cancer cachexia are lacking despite decades of research. High-throughput omics technologies are increasingly implemented in many fields including cancer cachexia to stimulate discovery of disease biology and inform therapy choice...
May 4, 2023: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36578172/correction-to-preface-engaging-older-adults-in-cancer-clinical-trials-conducted-in-the-national-cancer-institute-clinical-trials-network-opportunities-to-enhance-accrual
#30
(no author information available yet)
No abstract text is available yet for this article.
December 29, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519819/update-on-enrollment-of-older-adults-onto-national-cancer-institute-national-clinical-trials-network-trials
#31
JOURNAL ARTICLE
Grace E Mishkin, Andrea M Denicoff, Ana F Best, Richard F Little
BACKGROUND: Older adults are a large and growing proportion of cancer cases in the United States, but concerns persist about whether older adults are adequately represented in the cancer clinical trials that test new options for treatment and cancer care. METHODS: This paper describes adult patient enrollments by age group to the National Cancer Institute's National Clinical Trials Network (NCTN) from 2016 to 2021, compares patient enrollment by age with the estimated incident cancer population across cancer types, and explores possible associations between patient age and patient race, ethnicity, and sex...
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519818/trial-design-considerations-to-increase-older-adult-accrual-to-national-cancer-institute-clinical-trials
#32
JOURNAL ARTICLE
Jennifer Le-Rademacher, Supriya Mohile, Joseph Unger, Matthew F Hudson, Jared Foster, Stuart Lichtman, Jane Perlmutter, Efrat Dotan, Martine Extermann, Kevin Dodd, William Tew, Heidi Klepin, Tanya M Wildes, Mina S Sedrak, Aminah Jatoi, Richard F Little
Although adults aged 65 years or older make up a strong majority of cancer patients, their underrepresentation in cancer clinical trials leads to the lack of representative data to guide evidence-based therapeutic decisions in this patient population. The Trial Design Working Group, convened as part of the workshop titled, Engaging Older Adults in the National Cancer Institute Clinical Trials Network: Challenges and Opportunities, recommended study designs and design elements that could improve accrual of older adults in National Cancer Institute-funded clinical trials...
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519817/through-the-lens-of-patient-partners-challenges-in-accrual-of-older-adults-to-nci-clinical-trials
#33
JOURNAL ARTICLE
Karlynn BrintzenhofeSzoc, Beverly Canin, Esmeralda Casas-Silva, Andrea Denicoff, Christa Braun-Inglis, Izumi Okado, Alexis Bakos
The workshop "Engaging Older Adults in Cancer Clinical Trials Conducted in the NCI Clinical Trials Network: Challenges and Opportunities" included a Patient Stakeholder Workgroup that explored the needs and concerns of older adults with cancer regarding clinical trials. To accomplish this, the workgroup conducted patient focus groups in which participants were interviewed, recorded conversations were analyzed and coded, and salient themes were identified. The focus groups identified general barriers to accrual such as complex consent forms, general communication, restrictive eligibility, nonreferrals, patient costs, cultural insensitivity, limited accessibility in community settings, and transportation issues...
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519816/integrating-geriatric-assessment-measures-into-national-cancer-institute-clinical-trials
#34
JOURNAL ARTICLE
Allison Magnuson, Noam Van der Walde, June M McKoy, Tanya M Wildes, Melisa L Wong, Jennifer Le-Rademacher, Richard F Little, Heidi D Klepin
To improve the care of older adults with cancer, the traditional approach to clinical trial design needs to be reconsidered. Older adults are underrepresented in clinical trials with limited or no information on geriatric-specific factors, such as cognition or comorbidities. To address this knowledge gap and increase relevance of therapeutic clinical trial results to the real-life population, integration of aspects relevant to older adults is needed in oncology clinical trials. Geriatric assessment (GA) is a multidimensional tool comprising validated measures assessing specific health domains that are more frequently affected in older adults, including aspects related to physical function, comorbidity, medication use (polypharmacy), cognitive and psychological status, social support, and nutritional status...
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519815/enrolling-older-adults-onto-national-cancer-institute-funded-clinical-trials-in-community-oncology-clinics-barriers-and-solutions
#35
JOURNAL ARTICLE
Judith O Hopkins, Christa Braun-Inglis, Sofia Guidice, Meg Wells, Kiran Moorthi, Jeffrey Berenberg, Diane St Germain, Supriya Mohile, Matthew F Hudson
In April 2021, the National Cancer Institute (NCI) Division of Cancer Prevention collaborated with the NCI Division of Cancer Treatment and Diagnosis to produce a virtual workshop that developed recommendations for enhancing NCI-sponsored clinical trial accrual of older adults. Prior to the workshop, a multidisciplinary group of stakeholders (eg, community oncologists, advanced practice practitioners, clinic and research staff, and patient advocates) gathered information related to accrual of older adults to clinical trials from the literature...
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519814/infrastructure-to-support-accrual-of-older-adults-to-national-cancer-institute-clinical-trials
#36
JOURNAL ARTICLE
Gretchen Kimmick, Mina S Sedrak, Grant Williams, Nadine J McCleary, Ashley E Rosko, Jeffrey L Berenberg, Rachel A Freedman, Mary Lou Smith, Amina Ahmed, Hyman B Muss, Selina Chow, William Dale
As part of ongoing efforts to meaningfully improve recruitment, enrollment, and accrual of older adults into cancer clinical trials, the National Cancer Institute (NCI) sponsored a workshop with experts across the country entitled Engaging Older Adults in the NCI Clinical Trials Network: Challenges and Opportunities. Three working groups, including Study Design, Infrastructure, and Stakeholders, were formed, who worked together to offer synergistic improvements in the system. Here, we summarize the workshop discussions of the Infrastructure Working Group, whose goal was to address infrastructural challenges, identify underlying resources, and offer solutions to facilitate accrual of older adults into cancer clinical trials...
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36519813/preface-engaging-older-adults-in-cancer-clinical-trials-conducted-in-the-national-cancer-institute-clinical-trials-network-opportunities-to-enhance-accrual
#37
JOURNAL ARTICLE
Diane St Germain, Supriya G Mohile
No abstract text is available yet for this article.
December 15, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/36469806/correction-to-epidemiological-studies-of-low-dose-ionizing-radiation-and-cancer-summary-bias-assessment-and-meta-analysis
#38
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/35983687/correction-to-enhancing-health-equity-through-cancer-health-economics-research
#39
(no author information available yet)
No abstract text is available yet for this article.
August 19, 2022: Journal of the National Cancer Institute. Monographs
https://read.qxmd.com/read/35788383/current-state-of-funded-national-cancer-institute-grants-that-include-economic-analyses
#40
JOURNAL ARTICLE
Michael T Halpern, Sharon McCarthy, Priyanga Tuovinen
BACKGROUND: Health economics research is an integral part of the transdisciplinary research supported by the National Cancer Institute (NCI). To better understand NCI activities in this area, we conducted a portfolio analysis of funded NCI grants including health economics research. METHODS: We examined all competitive grants funded by NCI from fiscal years 2015 to 2020 that included economic analyses or outcomes. Grant titles, abstracts, and specific aims were independently reviewed by 2 study team members; content of included grants was then coded for analysis...
July 5, 2022: Journal of the National Cancer Institute. Monographs
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