Miaoyu Wang, Fangzhen Tian, Qi Xin, Huizhen Ma, Ling Liu, Shuyu Yang, Si Sun, Nan Song, KeXin Tan, Zhenhua Li, Lijie Zhang, Qi Wang, Liefeng Feng, Hao Wang, Zhidong Wang, Xiao-Dong Zhang
Ultrasmall Au25 (MPA)18 clusters show great potential in biocatalysts and bioimaging due to their well-defined, tunable structure and properties. Hence, in vivo pharmacokinetics and toxicity of Au nanoclusters (Au NCs) are very important for clinical translation, especially at high dosages. Herein, the in vivo hematological, tissue, and neurological effects following exposure to Au NCs (300 and 500 mg kg-1 ) were investigated, in which the concentration is 10 times higher than in therapeutic use. The biochemical and hematological parameters of the injected Au NCs were within normal limits, even at the ultrahigh level of 500 mg kg-1 ...
April 1, 2024: Bioconjugate Chemistry