Raefa Abou Khouzam, Bassam Janji, Jerome Thiery, Rania Faouzi Zaarour, Ali N Chamseddine, Hemma Mayr, Pierre Savagner, Claudine Kieda, Sophie Gad, Stéphanie Buart, Jean-Marie Lehn, Perparim Limani, Salem Chouaib
In cancer patients, immune cells are often functionally compromised due to the immunosuppressive features of the tumor microenvironment (TME) which contribute to the failures in cancer therapies. Clinical and experimental evidence indicates that developing tumors adapt to the immunological environment and create a local microenvironment that impairs immune function by inducing immune tolerance and invasion. In this context, microenvironmental hypoxia, which is an established hallmark of solid tumors, significantly contributes to tumor aggressiveness and therapy resistance through the induction of tumor plasticity/heterogeneity and, more importantly, through the differentiation and expansion of immune-suppressive stromal cells...
November 27, 2023: Seminars in Cancer Biology