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Journal of Nutritional Biochemistry

Even Fjære, Lene Secher Myrmel, Ditte Olsen Lützhøft, Hanne Andersen, Jacob Bak Holm, Pia Kiilerich, Rita Hannisdal, Bjørn Liaset, Karsten Kristiansen, Lise Madsen
Low-fat diets and exercise are generally assumed to ameliorate obesity-related metabolic dysfunctions, but the importance of exercise vs. dietary changes is debated. Male C57BL/6J mice were fed a high-fat/high-sucrose (HF/HS) diet to induce obesity and then either maintained on the HF/HS or shifted to low-fat (LF) diets containing either salmon or entrecote. For each diet, half of the animals exercised voluntarily for 8 weeks. We determined body composition, glucose tolerance, insulin sensitivity and hepatic triacylglycerol levels...
January 18, 2019: Journal of Nutritional Biochemistry
Kari Neier, Elizabeth M Marchlewicz, Leah D Bedrosian, Dana C Dolinoy, Craig Harris
White adipose tissue (WAT) plays an important role in obesity pathophysiology. Redox signaling underlies several aspects of WAT physiology; however, the thiol redox environment of WAT has not yet been fully characterized. Dietary and endocrine disrupting chemical (EDC) exposures during development can transiently impact the cellular redox environment, but it is unknown whether these exposures can reprogram the WAT thiol redox environment. To characterize the WAT thiol redox environment, we took a descriptive approach and measured thiol redox parameters using high-performance liquid chromatography in mouse mesenteric (mWAT), gonadal (gWAT) and subinguinal (sWAT) depots...
January 18, 2019: Journal of Nutritional Biochemistry
Mirian A Silva-Cutini, Simone A Almeida, Andrews M Nascimento, Gláucia R Abreu, Nazaré S Bissoli, Dominik Lenz, Denise C Endringer, Girlandia A Brasil, Ewelyne M Lima, Vinicia C Biancardi, Tadeu U Andrade
This work evaluated the effects of long-term kefir treatment in cardiac function (cardiac contractility and calcium-handling proteins) and the central nervous system (CNS) control of the sympathetic signaling in spontaneously hypertensive rats (SHR). Male normotensive rats [Wistar Kyoto rats (WKYs)] and SHRs were divided into three groups: WKYs and SHRs treated with vehicle, and SHRs treated with milk fermented by the grains of kefir (5%; SHR-Kefir; oral gavage, 0.3 ml/100 g daily/9 weeks). At the end of treatment, mean arterial pressure (MAP) and heart rate (HR) were measured by direct arterial catheterization...
January 18, 2019: Journal of Nutritional Biochemistry
Chrissa Petersen, Umesh D Wankhade, Divya Bharat, Kiana Wong, Jennifer Ellen Mueller, Sree V Chintapalli, Brian D Piccolo, Thunder Jalili, Zhenquan Jia, J David Symons, Kartik Shankar, Pon Velayutham Anandh Babu
Gut microbiota contributes to the biological activities of berry anthocyanins by transforming them into bioactive metabolites, and anthocyanins support the growth of specific bacteria, indicating a two-way relationship between anthocyanins and microbiota. In the present study, we tested the hypothesis that strawberry supplementation alters gut microbial ecology in diabetic db/db mice. Control (db/+) and diabetic (db/db) mice (7 weeks old) consumed standard diet or diet supplemented with 2.35% freeze-dried strawberry (db/db+SB) for 10 weeks...
January 18, 2019: Journal of Nutritional Biochemistry
Peijun Tian, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Chen
Depression disorder is rapidly advancing worldwide, and therapeutic strategy through gut-brain axis has been proven to be effective in the treatment. Here we studied the effect of lactic acid bacteria (LAB) treatment on depression. C57BL/6J mice were administered with LAB during a 5-week chronic unpredictable mild stress. Bifidobacterium longum subsp. infantis E41 and Bifidobacterium breve M2CF22M7, which improved the expression of Tph1 and secretion of 5-hydroxytryptophan (5-HTP) in RIN14B cells, significantly reduced depressive behaviors of mice in the forced swim test, sucrose preference test and step-down test, as well as increased the level of 5-hydroxytryptamine and brain-derived neurotrophic factor concentration in brain...
January 18, 2019: Journal of Nutritional Biochemistry
Carole Oudot, Andreia Gomes, Valérie Nicolas, Morgane Le Gall, Philippe Chaffey, Cédric Broussard, Giuseppe Calamita, Maria Mastrodonato, Patrizia Gena, Jean-Luc Perfettini, Jocelyne Hamelin, Antoinette Lemoine, Rodolphe Fischmeister, Helena L A Vieira, Claudia N Santos, Catherine Brenner
Berries contain bioactive polyphenols, whose capacity to prevent cardiovascular diseases has been established recently in animal models as well in human clinical trials. However, cellular processes and molecular targets of berries polyphenols remain to be identified. The capacity of a polyphenol-enriched diet (i.e., blueberries, blackberries, raspberries, strawberry tree fruits and Portuguese crowberries berries mixture) to promote animal survival and protect cardiovascular function from salt-induced hypertension was evaluated in a chronic salt-sensitive Dahl rat model...
January 8, 2019: Journal of Nutritional Biochemistry
Junyi Zeng, Jingjing Zhao, Bin Dong, Xingming Cai, Jingzhou Jiang, Ruicong Xue, Fengjuan Yao, Yugang Dong, Chen Liu
Oxidative stress is considered an important pathogenic process of cardiac hypertrophy. Lycopene is a kind of carotenoid antioxidant that protects the cardiovascular system, so we hypothesized that lycopene might inhibit cardiac hypertrophy by attenuating oxidative stress. Phenylephrine and pressure overload were used to set up the hypertrophic models in vitro and in vivo respectively. Our data revealed that treatment with lycopene can significantly block pressure overload-induced cardiac hypertrophy in in vitro and in vivo studies...
January 7, 2019: Journal of Nutritional Biochemistry
Runzhi Chen, Peng Wu, Zheng Cai, Yingying Fang, Hao Zhou, Yi Lasanajak, Lan Tang, Ling Ye, Chuqi Hou, Jie Zhao
The combination of Puerariae Lobatae Radix (PLR) and Chuanxiong Rhizoma (CXR) is commonly used to treat cerebrovascular diseases. This work aimed to clarify the mechanisms of their action in treating cerebral ischemic stroke from the perspective of gut microecology. The PLR and CXR combination effectively improved the neurological function, reduced the cerebral infarction and relieved the complications of cerebral ischemic stroke, including dyslipidemia, increased blood viscosity and thrombotic risk. Cerebral ischemic stroke triggered gut microbial disturbances by enriching pathogens and opportunistic microorganisms, including Bacteroides, Escherichia_Shigella, Haemophilus, Eubacterium_nodatum_group, Collinsella, Enterococcus, Proteus, Alistipes, Klebsiella, Shuttleworthia and Faecalibacterium...
December 21, 2018: Journal of Nutritional Biochemistry
Payal Gupta, Sreetama Choudhury, Sayan Ghosh, Sudeshna Mukherjee, Olivia Chowdhury, Arindam Sain, Sreya Chattopadhyay
Dietary supplementation of polyphenol-rich pomegranate extract (POMx) has been shown to have anti-oxidant and anti-inflammatory activities. Here, we evaluate the efficacy of POMx in mitigating pancreatitis in mice and provide a mechanistic outline of the process. Age-matched male Swiss albino mice were injected with Lipopolysaccharide (LPS) and given POMx supplement alone or in combination with LPS. After 4 weeks of treatment histological scoring for pancreatic edema and vacuolization was performed. Serum insulin levels were estimated and the glucose tolerance test (IPGTT) data revealed that POMx reduced inflammation induced hyperglycemia in mice...
December 21, 2018: Journal of Nutritional Biochemistry
Marine Milard, Armelle Penhoat, Annie Durand, Charline Buisson, Emmanuelle Loizon, Emmanuelle Meugnier, Karène Bertrand, Florent Joffre, David Cheillan, Lorna Garnier, Sébastien Viel, Fabienne Laugerette, Marie-Caroline Michalski
Milk polar lipids (MPL) are specifically rich in milk sphingomyelin (MSM) which represents 24% of MPL. Beneficial effects of MPL or MSM have been reported on lipid metabolism, but information on gut physiology is scarce. Here we assessed whether MPL and MSM can impact tight junction expression. Human epithelial intestinal Caco-2/TC7 cells were incubated with mixed lipid micelles devoid of MSM (Control) or with 0.2 or 0.4 mM of MSM via pure MSM or via total MPL. C57Bl/6 mice received 5 or 10 mg of MSM via MSM or via MPL (oral gavage); small intestinal segments were collected after 4 h...
December 21, 2018: Journal of Nutritional Biochemistry
Rizaldy C Zapata, Arashdeep Singh, Adel Pezeshki, Prasanth K Chelikani
Moderate dietary protein restriction promotes hyperphagia and thermogenesis; however, little is known of whether these responses are due to restriction of the essential amino acids tryptophan and histidine. Here, we determined whether restriction of tryptophan and histidine alone recapitulate the effects of total amino acid restriction on energy balance, and whether the metabolic responses are age-dependent. We fed young (12 weeks old) and older (29 weeks old) diet-induced obese rats with one of four high-fat diets: control (CON, 100% amino acid requirement), total amino acid restriction (TAA, 67% amino acid restriction), tryptophan restriction (TRP, 67% tryptophan restriction) or histidine restriction (HIS, 67% histidine restriction) for 21 days...
December 21, 2018: Journal of Nutritional Biochemistry
Keila Karine Duarte Campos, Camila de Oliveira Ramos, Thais Lourenço Martins, Guilherme de Paula Costa, André Talvani, Camila Carrião Machado Garcia, Laser Antônio Machado Oliveira, Sílvia Dantas Cangussú, Daniela Caldeira Costa, Frank Silva Bezerra
Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by a non-fully reversible airflow limitation comprising chronic bronchitis and pulmonary emphysema both being induced by cigarette smoke (CS) exposure. Lycopene has shown antioxidant and anti-inflammatory properties that can prevent acute lung inflammation and emphysema. We hypothesized that administration with lycopene would repair lung damage in emphysema caused by CS exposure. Mice were administered with two different doses of lycopene (25 or 50 mg/kg/day, diluted in sunflower oil by orogastric gavage) and then exposed to 60 days of CS or not (CG)...
December 21, 2018: Journal of Nutritional Biochemistry
Asadollah Mohammadi, Christopher N Blesso, George E Barreto, Maciej Banach, Muhammed Majeed, Amirhossein Sahebkar
Monocytes and macrophages are important cells of the innate immune system that have diverse functions, including defense against invading pathogens, removal of dead cells by phagocytosis, antigen presentation in the context of MHC class I and class II molecules, and production of various pro-inflammatory cytokines and chemokines such as IL-1β, IL-6, TNF-α and MCP-1. In addition, pro-inflammatory (M1) and anti-inflammatory (M2) macrophages clearly play important roles in the progression of several inflammatory diseases...
December 21, 2018: Journal of Nutritional Biochemistry
Rafael Calais Gaspar, Camilla Bertuzzo Veiga, Mariana Pereira Bessi, Marcella Neves Dátilo, Marcella Ramos Sant'Ana, Patrícia Brito Rodrigues, Leandro Pereira de Moura, Adelino Sanchez Ramos da Silva, Gustavo Aparecido Santos, Rodrigo Ramos Catharino, Eduardo Rochete Ropelle, José Rodrigo Pauli, Dennys Esper Cintra
GPR120 and GPR40 were recently reported as omega-3 (ω3) receptors with anti-inflammatory properties. Physical exercise could increase the expression of these receptors in the liver, improving hepatic metabolism in obesity and type 2 diabetes. Our aim was to investigate GPR120/40 in the liver of lean and obese mice after acute or chronic physical exercise, with or without the supplementation of ω3 rich flaxseed oil (FS), as well as assess the impact of exercise and FS on insulin signaling and inflammation...
December 12, 2018: Journal of Nutritional Biochemistry
Ahmed Ben Mohamed, Didier Rémond, Christophe Chambon, Thierry Sayd, Michel Hébraud, Frédéric Capel, Benoit Cohade, Noureddine Hafnaoui, Daniel Béchet, Cécile Coudy-Gandilhon, Carole Migné, Jeremie David, Dominique Dardevet, Joel Doré, Sergio Polakof, Isabelle Savary-Auzeloux
Obesity induced by overfeeding ultimately can lead to nonalcoholic fatty liver disease, whereas dietary fiber consumption is known to have a beneficial effect. We aimed to determine if a supplementation of a mix of fibers (inulin, resistant starch and pectin) could limit or alleviate overfeeding-induced metabolic perturbations. Twenty female minipigs were fed with a control diet (C) or an enriched fat/sucrose diet supplemented (O + F) or not (O) with fibers. Between 0 and 56 days of overfeeding, insulin (+88%), HOMA (+102%), cholesterol (+45%) and lactate (+63%) were increased, without any beneficial effect of fibers supplementation...
December 8, 2018: Journal of Nutritional Biochemistry
Veedamali S Subramanian, Subrata Sabui, Jonathan S Marchant, Hamid M Said
Intestinal absorption of ascorbic acid (AA) occurs via a Na+ -dependent carrier-mediated process facilitated through the human sodium-dependent vitamin C transporters-1 &-2 (hSVCT1 and hSVCT2). Many studies have shown that hSVCT1 (product of the SLC23A1 gene) is expressed on the apical membrane of polarized enterocytes where it mediates AA absorption. hSVCT1 expression levels are therefore an important determinant of physiological vitamin C homeostasis. However, little is known about posttranscriptional mechanisms that regulate hSVCT1 expression in intestinal epithelia...
December 7, 2018: Journal of Nutritional Biochemistry
Thanutchaporn Kumrungsee, Dwi Eva Nirmagustina, Takeshi Arima, Kai Onishi, Kanako Sato, Norihisa Kato, Noriyuki Yanaka
Vitamin B6 deficiency is associated with cardiovascular disease (CVD). Although plasma biomarkers have been proposed, no studies have yet directly profiled heart tissue, and the mechanisms have to be fully defined. Thus, in order to provide better insight into vitamin B6 -deficient effects on cardiac functions, we sought to identify the metabolic profile in heart tissue consequent to change in dietary vitamin B6 levels by applying metabolomics. Heart tissues of rats fed a basal diet containing a marginal vitamin B6 -deficient, vitamin B6 -recommended or vitamin B6 -supplemented level were analyzed by metabolomics analysis...
December 4, 2018: Journal of Nutritional Biochemistry
Laura Moody, Daniel Kougias, Paul M Jung, Isabel Digan, Aaron Hong, Aleksandra Gorski, Hong Chen, Janice Juraska, Yuan-Xiang Pan
Environmental factors such as diet and endocrine-disrupting chemicals have individually been shown to mediate metabolic function. However, the underlying mechanism by which the combination disrupts adipocyte morphology and fat storage remains unknown. The current study evaluated early-life programming by diet and phthalate exposure. During gestation and lactation, pregnant Long-Evans hooded rat dams were fed either a control (C) or high-fat (HF) diet and were orally administered one of three phthalate dosages (0, 200 or 1000 μg/kg/day), yielding six groups of offspring: C-0, C-200, C-1000, HF-0, HF-200 and HF-1000...
December 4, 2018: Journal of Nutritional Biochemistry
Tianyu Zhang, Xiyu Mei, Hao Ouyang, Bin Lu, Zengyang Yu, Zhengtao Wang, Lili Ji
Hyperglycemia-induced blood-retinal barrier (BRB) breakdown is an early and typical event of diabetic retinopathy (DR). Although chronic inflammation plays an important role in DR development, the concrete mechanism remains unclear. This study aims to investigate the role of microglia cells-triggered inflammatory response in hyperglycemia-induced BRB breakdown and the amelioration of galangin, a natural flavonoid. Galangin alleviated BRB breakdown in streptozotocin-induced diabetic mice. D-glucose (25 mM)-stimulated microglia BV2 cells induced BRB damage in vitro, but galangin reversed this injury...
December 4, 2018: Journal of Nutritional Biochemistry
Shyamchand Mayengbam, Jennifer E Lambert, Jill A Parnell, Jasmine M Tunnicliffe, Alissa C Nicolucci, Jay Han, Troy Sturzenegger, Jane Shearer, Beata Mickiewicz, Hans J Vogel, Karen L Madsen, Raylene A Reimer
Low dietary fiber intake is associated with higher rates of microbiota-associated chronic diseases such as obesity. Low-fiber diets alter not only microbial composition but also the availability of metabolic end products derived from fermentation of fiber. Our objective was to examine the effects of dietary fiber supplementation on gut microbiota and associated fecal and serum metabolites in relation to metabolic markers of obesity. We conducted a 12-week, single-center, double-blind, placebo-controlled trial with 53 adults with overweight or obesity...
November 26, 2018: Journal of Nutritional Biochemistry
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