journal
https://read.qxmd.com/read/38054895/the-current-state-of-apolipoprotein-e-in-dyslipidemia
#21
JOURNAL ARTICLE
Katrine L Rasmussen, Ruth Frikke-Schmidt
PURPOSE OF REVIEW: Apolipoprotein E (apoE) plays a pivotal role in lipid metabolism in the peripheral circulation and in the brain. This has been recognized for decades; however, the importance of the full spectrum of variation in the APOE gene has been less investigated. This review focusses on current progresses in this field with main focus on apoE in dyslipidemia and vascular disease. RECENT FINDINGS: Whereas ε4 is the risk increasing allele for Alzheimer disease, ε2 is associated with increased risk for age-related macular degeneration...
December 7, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37922089/editorial-introductions
#22
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37910076/editorial-introductions
#23
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37773930/triglyceride-rich-lipoprotein-cholesterol-and-cardiovascular-risk
#24
REVIEW
Selin Bilgic, Alan T Remaley, Allan D Sniderman
PURPOSE OF REVIEW: The triglyceride-rich apoB lipoprotein particles make up a minority of the apoB particles in plasma. They vary in size, in lipid, and in protein content. Most are small enough to enter the arterial wall and therefore most are atherogenic. But how important a contribution TRL particles make to the total risk created by the apoB lipoproteins remains controversial. A recent Mendelian randomization analysis determined that the cardiovascular risk related to the cholesterol within these apoB particles--the TRL cholesterol--was greater than--and independent of--the risk related to apoB...
December 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37732779/the-pathophysiology-of-excess-plasma-free-cholesterol
#25
REVIEW
Baiba K Gillard, Corina Rosales, Antonio M Gotto, Henry J Pownall
PURPOSE OF REVIEW: Several large studies have shown increased mortality due to all-causes and to atherosclerotic cardiovascular disease. In most clinical settings, plasma HDL-cholesterol is determined as a sum of free cholesterol and cholesteryl ester, two molecules with vastly different metabolic itineraries. We examine the evidence supporting the concept that the pathological effects of elevations of plasma HDL-cholesterol are due to high levels of the free cholesterol component of HDL-C...
December 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37606894/ups-and-downs-in-pcsk9-inhibition-in-the-cardiovascular-arena-a-review
#26
REVIEW
Daniel J McClintick, Robert P Giugliano
PURPOSE OF REVIEW: This article reviews PCSK9 inhibitors (PCSK9i) with a focus on clinically relevant studies published in the last 18 months. RECENT FINDINGS: Prespecified subgroup evaluations, secondary analyses, and open-label extension studies from the two landmark trials, FOURIER and ODYSSEY Outcomes, have provided new data on the safety and efficacy of the monoclonal PCSK9 antibodies evolocumab and alirocumab. Recent studies of PCSK9i early in ACS and post percutaneous coronary intervention have explored early effects on biomarkers and plaque morphology with various imaging modalities...
December 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37982290/pregnancy-cardiovascular-health-and-microchimerism
#27
JOURNAL ARTICLE
Sara Hallum Søndergaard, Mads Kamper-Jørgensen
PURPOSE OF REVIEW: To provide an updated review of scientific literature concerning associations between pregnancy and cardiovascular health among women, and to discuss a possible impact of microchimerism on the association. RECENT FINDINGS: In most studies, pregnancy and childbirth is associated with increased risk of cardiovascular disease in women. Some ascribe the association mainly to lifestyle, whereas others suggest that pregnancy itself negatively affects women's cardiovascular health...
November 21, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37962908/angiopoietin-like-protein-8-a-multifaceted-protein-instrumental-in-regulating-triglyceride-metabolism
#28
JOURNAL ARTICLE
Yi Wen, Yan Q Chen, Robert J Konrad
PURPOSE OF REVIEW: The angiopoietin-like (ANGPTL) proteins ANGPTL3 and ANGPTL4 are critical lipoprotein lipase (LPL) inhibitors. This review discusses the unique ability of the insulin-responsive protein ANGPTL8 to regulate triglyceride (TG) metabolism by forming ANGPTL3/8 and ANGPTL4/8 complexes that control tissue-specific LPL activities. RECENT FINDINGS: After feeding, ANGPTL4/8 acts locally in adipose tissue, has decreased LPL-inhibitory activity compared to ANGPTL4, and binds tissue plasminogen activator (tPA) and plasminogen to generate plasmin, which cleaves ANGPTL4/8 and other LPL inhibitors...
November 15, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37938937/lipidome-and-inflammation-interplay-the-role-of-diet-in-this-relationship
#29
JOURNAL ARTICLE
Anacristina Rovayo, Estefanía Toledo, Cristina Razquin
PURPOSE: The aim of this review was to provide an overview of the role of novel lipid biomarkers from the circulating lipidome in inflammatory processes and the impact that dietary patterns may have on the lipidome. RECENT FINDINGS: Inflammation is a process that underlies many acute and chronic diseases, contributing to their development and severity. Finding novel molecules which serve as biomarkers and which are involved in inflammation is very useful, since they offer us both preventive or therapeutic targets and reveal mechanisms of action...
November 9, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37820081/angiopoietin-like-3-inhibition-and-the-liver-less-is-more
#30
JOURNAL ARTICLE
Reindert F Oostveen, G Kees Hovingh, Erik S G Stroes
PURPOSE OF REVIEW: The aim of this study was to discuss the potential mechanisms and implications of the opposing liver safety results from recent angiopoietin-like 3 (ANGPTL3) inhibition studies. RECENT FINDINGS: The clinical development of vupanorsen, a N-acetylgalactosamine (GalNAc) antisense targeting hepatic ANGPTL3, was recently discontinued due to a significant signal of liver transaminase increase. Vupanorsen elicited a dose-dependent increase in hepatic fat fraction up to 75%, whereas the small interfering RNA (siRNA) ARO-ANG3, has reported preliminary evidence of a dose-dependent decrease in hepatic fat fraction up to 30%...
October 12, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37800671/circulating-cell-free-dna-and-its-association-with-cardiovascular-disease-what-we-know-and-future-perspectives
#31
JOURNAL ARTICLE
Steffen Ullitz Thorsen, Kristine Frøsig Moseholm, Frederik Banch Clausen
PURPOSE OF REVIEW: The aim of this review is to explore a possible link between cell-free DNA (cfDNA) and cardiovascular disease (CVD), which may hold valuable potential for future diagnostics. RECENT FINDINGS: cfDNA has become topic of high interest across several medical fields. cfDNA is used as a diagnostic biomarker in cancer, prenatal care, and transplantation. In addition, cfDNA may play an unrecognized role in biological processes that are involved in or underlying various disease states, for example, inflammation...
October 7, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37797204/sweet-swell-of-burning-fat-emerging-role-of-high-density-lipoprotein-in-energy-homeostasis
#32
JOURNAL ARTICLE
Anatol Kontush, Maximiliano Martin, Fernando Brites
PURPOSE OF REVIEW: Metabolism of lipids and lipoproteins, including high-density lipoprotein (HDL), plays a central role in energy homeostasis. Mechanisms underlying the relationship between energy homeostasis and HDL however remain poorly studied. RECENT FINDINGS: Available evidence reveals that HDL is implicated in energy homeostasis. Circulating high-density lipoprotein-cholesterol (HDL-C) levels are affected by energy production, raising with increasing resting metabolic rate...
October 6, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37788374/high-density-lipoprotein-functionality-cardiovascular-health-and-patterns-of-alcohol-consumption-new-insights-and-future-perspectives
#33
JOURNAL ARTICLE
Marta Trius-Soler, Kenneth J Mukamal, Marta Guasch-Ferré
PURPOSE OF REVIEW: Cardiovascular diseases (CVD) pose a significant public health challenge, contributing to 422 million disability-adjusted life years in 2021. The role of high-density lipoproteins (HDL) and alcohol consumption, one of their major modifiable determinants, remains controversial. The objective of this review is to provide a comprehensive narrative overview of HDL functionality and its predictive value for CVD in relation to patterns of alcohol consumption. RECENT FINDINGS: HDL phenotypes beyond HDL-cholesterol (HDL-c) such as distribution of HDL subspecies, HDL particle abundance, and reverse cholesterol transport capacity are promising indicators of atherosclerotic CVD risk...
October 4, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37694755/editorial-introductions
#34
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
October 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37527183/aspirin-and-lipoprotein-a-in-primary-prevention
#35
REVIEW
Harpreet S Bhatia
PURPOSE OF REVIEW: Lipoprotein(a) [Lp(a)] is causally associated with cardiovascular diseases, and elevated levels are highly prevalent. However, there is a lack of available therapies to address Lp(a)-mediated risk. Though aspirin has progressively fallen out of favor for primary prevention, individuals with high Lp(a) may represent a high-risk group that derives a net benefit. RECENT FINDINGS: Aspirin has been demonstrated to have a clear benefit in secondary prevention of cardiovascular disease, but recent primary prevention trials have at best demonstrated a small benefit...
October 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37527160/macrophage-inflammarafts-in-atherosclerosis
#36
REVIEW
Shenglin Li, Juliana M Navia-Pelaez, Soo-Ho Choi, Yury I Miller
PURPOSE OF REVIEW: Advances in single cell techniques revealed a remarkable diversity in macrophage gene expression profiles in atherosclerosis. However, the diversity of functional processes at the macrophage plasma membrane remains less studied. This review summarizes recent advances in characterization of lipid rafts, where inflammatory receptors assemble, in macrophages that undergo reprogramming in atherosclerotic lesions and in vitro under conditions relevant to the development of atherosclerosis...
October 1, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37769168/predictors-of-cardiovascular-risk-in-familial-hypercolesterolemia
#37
JOURNAL ARTICLE
Manuel Jesús Romero-Jiménez, María Elena Mansilla-Rodríguez, Eva Nadiejda Gutiérrez-Cortizo
PURPOSE OF REVIEW: Familial hypercholesterolemia is associated with an increased risk of cardiovascular disease. The current international guidelines of the main scientific societies consider that, all people with Familial Hypercholesterolemia have a high or very high cardiovascular risk. However, the occurrence of atherosclerotic cardiovascular disease is very heterogeneous in this population. Stratifying risk within people with familial hypercholesterolemia is essential to identify individuals who require intensive cholesterol-lowering therapies...
September 29, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37560987/established-and-potential-cardiovascular-risk-factors-in-metabolic-syndrome-effect-of-bariatric-surgery
#38
JOURNAL ARTICLE
Bilal Bashir, Safwaan Adam, Jan H Ho, Zara Linn, Paul N Durrington, Handrean Soran
PURPOSE OF REVIEW: The aim of this review was to provide an overview of the role of novel biomarkers in metabolic syndrome, their association with cardiovascular risk and the impact of bariatric surgery on these biomarkers. RECENT FINDINGS: Metabolic syndrome encompasses an intricate network of health problems, and its constituents extend beyond the components of its operational definition. Obesity-related dyslipidaemia not only leads to quantitative changes in lipoprotein concentration but also alteration in qualitative composition of various lipoprotein subfractions, including HDL particles, rendering them proatherogenic...
August 28, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37594008/strategies-of-improving-adherence-to-lipid-lowering-therapy-in-patients-with-atherosclerotic-cardiovascular-disease
#39
JOURNAL ARTICLE
Dean G Karalis
PURPOSE OF REVIEW: Lowering LDL-C has been shown to reduce ASCVD events, yet many ASCVD patients do not achieve their guideline-directed LDL-C goals leaving patients at increased risk of another ASCVD event. This review discusses implementation strategies to improve guideline-directed lipid management in patients with ASCVD focusing on the provider, patient, and system level. RECENT FINDINGS: At a provider level, under-prescribing of statin intensity due most often to statin intolerance, clinical inertia, insufficient monitoring of LDL-C levels, and the difficulty and cost of prescribing other lipid-lowering therapies such as the PCSK9 inhibitors leads to suboptimal cholesterol management in ASCVD patients...
August 21, 2023: Current Opinion in Lipidology
https://read.qxmd.com/read/37548415/phospholipid-transport-by-abca1-the-extracellular-translocase-or-alternating-access-model
#40
JOURNAL ARTICLE
Jere P Segrest, W Sean Davidson, Jay W Heinecke
PURPOSE OF REVIEW: ATP-binding cassette transporter A1 (ABCA1) plays a key role in high-density lipoprotein (HDL) biogenesis and cholesterol export from artery wall cells. Recent evidence challenges the generally accepted model for lipid transport by ABCA1, termed the alternating access mechanism, which proposes that phospholipid moves from the inner leaflet to the outer leaflet of the plasma membrane. RECENT FINDINGS: In contrast to the standard model, our computer simulations of ABCA1 indicate that ABCA1 extracts phospholipid from the plasma membrane's outer leaflet...
August 4, 2023: Current Opinion in Lipidology
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