journal
https://read.qxmd.com/read/38527426/how-safe-are-proprotein-convertase-subtilisinekexin-type-9-inhibitors-in-diabetes
#1
JOURNAL ARTICLE
Tian Chen, Naifeng Liu
PURPOSE OF REVIEW: To examine the safety of proprotein convertase subtilisinekexin type 9 (PCSK9) inhibitors in patients with diabetes, specifically focusing on their impact on glucose metabolism. RECENT FINDINGS: Patients with diabetes often require intensified lipid-lowering therapy. PCSK9 inhibitors can reduce low-density lipoprotein cholesterol (LDL-C) concentrations by approximately 60%, and significantly reduce cardiovascular risk when added to statin therapy...
March 20, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38484227/altered-lipid-metabolism-and-the-development-of-metabolic-associated-fatty-liver-disease
#2
JOURNAL ARTICLE
Christy Foster, Charles A Gagnon, Ambika P Ashraf
PURPOSE OF REVIEW: An increasing amount of research has underscored the significant role of lipoproteins in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). This comprehensive review examines the intricate relationship between lipoprotein abnormalities and the development of MAFLD. RECENT FINDINGS: Atherogenic dyslipidemia seen in insulin resistance states play a significant role in initiating and exacerbating hepatic lipid accumulation. There are also specific genetic factors (PNPLA3, TM6SF2, MBOAT7, HSD17B13, GCKR-P446L) and transcription factors (SREBP-2, FXR, and LXR9) that increase susceptibility to both lipoprotein disorders and MAFLD...
March 15, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38465912/basic-and-translational-evidence-supporting-the-role-of-tm6sf2-in-vldl-metabolism
#3
JOURNAL ARTICLE
Jing Liu, Henry N Ginsberg, Gissette Reyes-Soffer
PURPOSE OF REVIEW: Transmembrane 6 superfamily member 2 (TM6SF2) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino acid position 167 (NM_001001524.3:c.499G> A) (p.Gln167Lys/p.E167K, rs58542926) was discovered (p.E167K) to be highly associated with increased hepatic fat content and reduced levels of plasma triglycerides and LDL cholesterol. In this review, we focus on the discovery of TM6SF2 and its role in VLDL secretion pathways...
March 11, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38465903/g-protein-coupled-receptor-146-new-insights-from-genetics-and-model-systems
#4
JOURNAL ARTICLE
Umesh Tharehalli, Antoine Rimbert
PURPOSE OF REVIEW: Atherosclerotic cardiovascular diseases continue to be a significant global cause of death. Despite the availability of efficient treatments, there is an ongoing need for innovative strategies to lower lipid levels, especially for individuals experiencing refractory dyslipidemias or intolerable adverse effects. Based on human genetic findings and on mouse studies, the G protein-coupled receptor 146 (GPR146) emerges as a promising target against hypercholesterolemia and atherosclerosis...
March 11, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38408035/newborn-screening-for-lipid-disorders
#5
JOURNAL ARTICLE
Xiangqiang Shao, Robert Steiner, Amy L Peterson
PURPOSE OF REVIEW: Newborn screening is one of the most successful public health programs of the last century and offers unparalleled access to universal screening for a variety of metabolic and other disorders. Interest in development of newborn screening for lipid disorders has intensified in recent years. Screening newborns for lipid disorders has important implications for the health of the newborn as well as their relatives, and in the case of more common lipid disorders like familial hypercholesterolemia, could have important public health implications...
February 27, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38408036/lipid-metabolism-during-pregnancy-consequences-for-mother-and-child
#6
JOURNAL ARTICLE
Janneke W C M Mulder, D Meeike Kusters, Jeanine E Roeters van Lennep, Barbara A Hutten
PURPOSE OF REVIEW: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of gestational hyperlipidemia on cardiovascular risk for mother and child. This review aims to provide a comprehensive overview of the current research on lipid profile alterations during pregnancy and its associated (cardiovascular) outcomes for mother and child from a clinical perspective...
February 22, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38372218/angptl3-and-apoc-iii-inhibitors-for-treating-hypertriglyceridemia-in-context-horses-for-courses
#7
JOURNAL ARTICLE
Dick C Chan, Gerald F Watts
PURPOSE OF REVIEW: Hypertriglyceridemia (HTG) is an independent and casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more effective treatments for patients with HTG. Angiopoietin-like protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III) are key regulators of triglyceride-rich lipoprotein (TRL) metabolism. We review recent clinical trials targeting ANGPTL3 and apoC-III with monoclonal antibody and nucleic acid therapies, including antisense oligonucleotides and small interfering RNA...
February 20, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38363694/familial-hypercholesterolemia-in-children-and-the-importance-of-early-treatment
#8
JOURNAL ARTICLE
Sibbeliene E van den Bosch, Barbara A Hutten, Willemijn E Corpeleijn, D Meeike Kusters
PURPOSE OF REVIEW: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia...
February 15, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38299384/genetic-testing-for-familial-hypercholesterolemia
#9
JOURNAL ARTICLE
Yiyi Zhang, Sarah D de Ferranti, Andrew E Moran
PURPOSE OF REVIEW: Despite familial hypercholesterolemia (FH) being the most common genetic cause of cardiovascular disease (CVD), genetic testing is rarely utilized in the US. This review summarizes what is known about the clinical utility of genetic testing and its role in the diagnosis and screening of FH. RECENT FINDINGS: The presence of an FH-causative variant is associated with a substantially higher risk of CVD, even when low-density lipoprotein cholesterol (LDL-C) levels are only modestly elevated...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38277208/c-reactive-protein-pharmacological-treatments-and-diet-how-to-target-your-inflammatory-burden
#10
JOURNAL ARTICLE
Benjamin Bay, Natalie Arnold, Christoph Waldeyer
PURPOSE OF REVIEW: This article focuses on pharmacological agents as well as dietary changes aimed at the reduction of the inflammatory burden measured by circulating C-reactive protein concentrations. RECENT FINDINGS: Over the last years, repurposed as well as new anti-inflammatory agents have been investigated in outcome trials in the cardiovascular field. Currently, a specific inhibition of the inflammatory cascade via the interleukin-6 ligand antibody ziltivekimab is being explored in large-scale outcome trials, after the efficacy of this agent with regard to the reduction of inflammatory biomarkers was proven recently...
January 26, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38276967/remnant-cholesterol-as-a-new-lipid-lowering-target-to-reduce-cardiovascular-events
#11
JOURNAL ARTICLE
Paolo Raggi, Maria Laura Becciu, Eliano Navarese
PURPOSE OF REVIEW: Remnant cholesterol has become increasingly recognized as a direct contributor to the development of atherosclerosis and as an additional marker of cardiovascular risk. This review aims to summarize the pathophysiological mechanisms, and the current evidence base from epidemiological investigations and genetic studies that support a causal link between remnant cholesterol and atherosclerotic cardiovascular disease. Current and novel therapeutic approaches to target remnant cholesterol are discussed...
January 24, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38277255/pcsk9-directed-therapies-an-update
#12
JOURNAL ARTICLE
Julius L Katzmann, Ulrich Laufs
PURPOSE OF REVIEW: Two large cardiovascular outcomes trials of monoclonal antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9) demonstrated that therapeutic inhibition of extracellular PCSK9 markedly reduces LDL cholesterol concentration and cardiovascular risk. Several novel strategies to inhibit PCSK9 function are in development. Different mechanisms of action may determine specific properties with potential relevance for patient care. RECENT FINDINGS: For the monoclonal antibodies evolocumab und alirocumab as first-generation PCSK9 inhibitors, follow-up data of up to 8 years of exposure complement the information on efficacy and safety available from outcome trials...
January 22, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38236937/novel-functions-of-tribbles-homolog-1-in-liver-adipocytes-and-atherosclerosis
#13
JOURNAL ARTICLE
Ileana Hernandez-Resendiz, Ralph Burkhardt
PURPOSE OF REVIEW: Human genetics studies have sparked great interest in the pseudokinase Tribbles homolog 1, as variant at the TRIB1 gene locus were robustly linked to several cardiometabolic traits, including plasma lipids and coronary artery disease. In this review, we summarize recent findings from mouse models that investigated the function of hepatic and adipocyte Trib1 in lipid metabolism and its role in atherosclerosis. RECENT FINDINGS: Studies in atherosclerosis prone low-density lipoprotein (LDL)-receptor knockout mice suggested that systemic Trib1-deficiency promotes atherosclerotic lesion formation through the modulation of plasma lipids and inflammation...
January 18, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38447014/intracellular-lipase-and-regulation-of-the-lipid-droplet
#14
JOURNAL ARTICLE
Ainara G Cabodevilla, Ni Son, Ira J Goldberg
PURPOSE OF REVIEW: Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotype, control the availability of energy for muscle function, store excess lipid, sequester toxic lipids, modulate mitochondrial activity, and allow transfer of fatty acids between tissues. RECENT FINDINGS: There have been several major advances in our understanding of the formation, dissolution, and function of this organelle during the past two years...
April 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38447013/editorial-introduction
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38112101/editorial-introductions
#16
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38085172/bempedoic-acid-new-evidence-and-recommendations-on-use
#17
REVIEW
Kristina Paponja, Ivan Pećin, Željko Reiner, Maciej Banach
PURPOSES OF REVIEW: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide. Recognizing the importance of dyslipidemia treatment in the prevention of cardiovascular events has become a part of standard clinical practice. Desired values of LDL cholesterol (LDL-C) have become lower and lower in the last few decades, as evidenced by the most recent guidelines. Therefore, efforts to lower LDL cholesterol concentrations with conventional therapies and combinations of lipid-lowering therapy may not be successful in a high proportion of patients...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38018863/dietary-fat-telomere-length-and-cognitive-function-unravelling-the-complex-relations
#18
REVIEW
Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló
PURPOSE OF REVIEW: The review aims to explore the recent evidence on the associations between different dietary fat intake and cognitive function, and to understand the role of telomere length in this relationship. RECENT FINDINGS: Clinical and preclinical studies included in this review suggest that dietary fat intake is associated with cognitive function and telomere length. High intake of saturated fats and trans fats, commonly found in ultra-processed foods, appears to have negative effects on cognitive function and telomere length, while other dietary fats, such as omega-3 polyunsaturated fatty acids and monounsaturated fatty acids are associated with improved cognitive performance and reduced telomere attrition...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/37910156/cardiovascular-disease-prevention-in-heterozygous-familial-hypercholesterolemia-how-important-is-a-healthy-diet-in-the-era-of-long-lasting-cholesterol-lowering-drug-therapies
#19
REVIEW
Gabrielle Roy, Jean-Philippe Drouin-Chartier
PURPOSE OF REVIEW: This review aims to provide an in-depth perspective on the importance of diet for cardiovascular disease (CVD) prevention in heterozygous familial hypercholesterolemia (HeFH). RECENT FINDINGS: Even though data on diet and CVD prevention in HeFH are limited, the currently available evidence supports its cholesterol-lowering effect and its favorable association with CVD risk on the long-term. However, qualitative evidence from individuals with HeFH suggests that there is a common perception that diet is useless compared to medication, and this misconception serves as a barrier to healthy eating...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38117614/genetic-variation-in-apolipoprotein-a-v-in-hypertriglyceridemia
#20
JOURNAL ARTICLE
Shehan D Perera, Robert A Hegele
PURPOSE OF REVIEW: While biallelic rare APOA5 pathogenic loss-of-function (LOF) variants cause familial chylomicronemia syndrome, heterozygosity for such variants is associated with highly variable triglyceride phenotypes ranging from normal to severe hypertriglyceridemia, often in the same individual at different time points. Here we provide an updated overview of rare APOA5 variants in hypertriglyceridemia. RECENT FINDINGS: Currently, most variants in APOA5 that are considered to be pathogenic according to guidelines of the American College of Medical Genetics and Genomics are those resulting in premature termination codons...
December 21, 2023: Current Opinion in Lipidology
journal
journal
30481
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.