journal
https://read.qxmd.com/read/38841827/pancreatic-and-cardiometabolic-complications-of-severe-hypertriglyceridaemia
#1
JOURNAL ARTICLE
Bilal Bashir, Maryam Ferdousi, Paul N Durrington, Handrean Soran
PURPOSE OF REVIEW: This review endeavours to explore the aetiopathogenesis and impact of severe hypertriglyceridemia (SHTG) and chylomicronaemia on cardiovascular, and pancreatic complications and summarizes the novel pharmacological options for management. RECENT FINDINGS: SHTG, although rare, presents significant diagnostic and therapeutic challenges. Familial chylomicronaemia syndrome (FCS), is the rare monogenic form of SHTG, associated with increased acute pancreatitis (AP) risk, whereas relatively common multifactorial chylomicronaemia syndrome (MCS) leans more towards cardiovascular complications...
June 7, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38640084/familial-hypercholesterolemia-plus-is-the-metabolic-syndrome-changing-the-clinical-picture-of-familial-hypercholesterolemia
#2
JOURNAL ARTICLE
Liam R Brunham
PURPOSE OF REVIEW: The purpose of this review article was to describe recent advances in our knowledge about how diabetes and metabolic syndrome are changing the face of familial hypercholesterolemia. RECENT FINDINGS: Heterozygous familial hypercholesterolemia, most commonly caused by disruption to LDL receptor function, leads to lifelong elevation of LDL cholesterol and increased risk of atherosclerotic cardiovascular disease. Familial hypercholesterolemia was originally described as a form of 'pure' hypercholesterolemia, in the sense that levels of LDL were uniquely affected...
April 22, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38640077/apoe-and-familial-hypercholesterolemia
#3
JOURNAL ARTICLE
Fernando Civeira, César Martín, Ana Cenarro
PURPOSE OF REVIEW: Autosomal dominant hypercholesterolemia is a common cause of cardiovascular disease. In addition to the classic genes that cause hypercholesterolemia, LDLR, APOB and PCSK9, a new locus has emerged as a candidate to be the cause of this hyperlipidemia, the p.(Leu167del) mutation in the APOE gene. RECENT FINDINGS: Various studies have demonstrated the involvement of the p.(Leu167del) mutation in the APOE gene in hypercholesterolemia: Studies of family segregation, lipoprotein composition by ultracentrifugation and proteomic techniques, and functional studies of VLDL-carrying p...
April 17, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38547336/proprotein-convertase-subtilisin-kexin-type-9-inhibition-across-different-patient-populations
#4
JOURNAL ARTICLE
Paulina Elena Stürzebecher, Ulrich Laufs
PURPOSE OF REVIEW: Monoclonal antibodies (mAb) targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have been established in cardiovascular risk prevention. The purpose of this review is to summarize the effects of PCSK9 inhibitors across different patient populations. RECENT FINDINGS: Long-term data on the use of evolocumab and alirocumab shows persisting low- density lipoprotein cholesterol (LDL-C) lowering and good tolerability. PCSK9 inhibitors are effective and safe in both sexes, in pediatric patients as well as in the elderly...
March 28, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38527426/how-safe-are-proprotein-convertase-subtilisinekexin-type-9-inhibitors-in-diabetes
#5
JOURNAL ARTICLE
Tian Chen, Naifeng Liu
PURPOSE OF REVIEW: To examine the safety of proprotein convertase subtilisinekexin type 9 (PCSK9) inhibitors in patients with diabetes, specifically focusing on their impact on glucose metabolism. RECENT FINDINGS: Patients with diabetes often require intensified lipid-lowering therapy. PCSK9 inhibitors can reduce low-density lipoprotein cholesterol (LDL-C) concentrations by approximately 60%, and significantly reduce cardiovascular risk when added to statin therapy...
March 20, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38484227/altered-lipid-metabolism-and-the-development-of-metabolic-associated-fatty-liver-disease
#6
JOURNAL ARTICLE
Christy Foster, Charles A Gagnon, Ambika P Ashraf
PURPOSE OF REVIEW: An increasing amount of research has underscored the significant role of lipoproteins in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). This comprehensive review examines the intricate relationship between lipoprotein abnormalities and the development of MAFLD. RECENT FINDINGS: Atherogenic dyslipidemia seen in insulin resistance states play a significant role in initiating and exacerbating hepatic lipid accumulation. There are also specific genetic factors (PNPLA3, TM6SF2, MBOAT7, HSD17B13, GCKR-P446L) and transcription factors (SREBP-2, FXR, and LXR9) that increase susceptibility to both lipoprotein disorders and MAFLD...
March 15, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38447014/intracellular-lipase-and-regulation-of-the-lipid-droplet
#7
JOURNAL ARTICLE
Ainara G Cabodevilla, Ni Son, Ira J Goldberg
PURPOSE OF REVIEW: Lipid droplets are increasingly recognized as distinct intracellular organelles that have functions exclusive to the storage of energetic lipids. Lipid droplets modulate macrophage inflammatory phenotype, control the availability of energy for muscle function, store excess lipid, sequester toxic lipids, modulate mitochondrial activity, and allow transfer of fatty acids between tissues. RECENT FINDINGS: There have been several major advances in our understanding of the formation, dissolution, and function of this organelle during the past two years...
April 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38447013/editorial-introduction
#8
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38117614/genetic-variation-in-apolipoprotein-a-v-in-hypertriglyceridemia
#9
REVIEW
Shehan D Perera, Robert A Hegele
PURPOSE OF REVIEW: While biallelic rare APOA5 pathogenic loss-of-function (LOF) variants cause familial chylomicronemia syndrome, heterozygosity for such variants is associated with highly variable triglyceride phenotypes ranging from normal to severe hypertriglyceridemia, often in the same individual at different time points. Here we provide an updated overview of rare APOA5 variants in hypertriglyceridemia. RECENT FINDINGS: Currently, most variants in APOA5 that are considered to be pathogenic according to guidelines of the American College of Medical Genetics and Genomics are those resulting in premature termination codons...
April 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38465912/basic-and-translational-evidence-supporting-the-role-of-tm6sf2-in-vldl-metabolism
#10
JOURNAL ARTICLE
Jing Liu, Henry N Ginsberg, Gissette Reyes-Soffer
PURPOSE OF REVIEW: Transmembrane 6 superfamily member 2 (TM6SF2) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino acid position 167 (NM_001001524.3:c.499G> A) (p.Gln167Lys/p.E167K, rs58542926) was discovered (p.E167K) to be highly associated with increased hepatic fat content and reduced levels of plasma triglycerides and LDL cholesterol. In this review, we focus on the discovery of TM6SF2 and its role in VLDL secretion pathways...
March 11, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38465903/g-protein-coupled-receptor-146-new-insights-from-genetics-and-model-systems
#11
JOURNAL ARTICLE
Umesh Tharehalli, Antoine Rimbert
PURPOSE OF REVIEW: Atherosclerotic cardiovascular diseases continue to be a significant global cause of death. Despite the availability of efficient treatments, there is an ongoing need for innovative strategies to lower lipid levels, especially for individuals experiencing refractory dyslipidemias or intolerable adverse effects. Based on human genetic findings and on mouse studies, the G protein-coupled receptor 146 (GPR146) emerges as a promising target against hypercholesterolemia and atherosclerosis...
March 11, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38408035/newborn-screening-for-lipid-disorders
#12
JOURNAL ARTICLE
Xiangqiang Shao, Robert Steiner, Amy L Peterson
PURPOSE OF REVIEW: Newborn screening is one of the most successful public health programs of the last century and offers unparalleled access to universal screening for a variety of metabolic and other disorders. Interest in development of newborn screening for lipid disorders has intensified in recent years. Screening newborns for lipid disorders has important implications for the health of the newborn as well as their relatives, and in the case of more common lipid disorders like familial hypercholesterolemia, could have important public health implications...
February 27, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38408036/lipid-metabolism-during-pregnancy-consequences-for-mother-and-child
#13
JOURNAL ARTICLE
Janneke W C M Mulder, D Meeike Kusters, Jeanine E Roeters van Lennep, Barbara A Hutten
PURPOSE OF REVIEW: Accommodating fetal growth and development, women undergo multiple physiological changes during pregnancy. In recent years, several studies contributed to the accumulating evidence about the impact of gestational hyperlipidemia on cardiovascular risk for mother and child. This review aims to provide a comprehensive overview of the current research on lipid profile alterations during pregnancy and its associated (cardiovascular) outcomes for mother and child from a clinical perspective...
February 22, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38372218/angptl3-and-apoc-iii-inhibitors-for-treating-hypertriglyceridemia-in-context-horses-for-courses
#14
JOURNAL ARTICLE
Dick C Chan, Gerald F Watts
PURPOSE OF REVIEW: Hypertriglyceridemia (HTG) is an independent and casual risk factor for atherosclerotic cardiovascular disease (ASCVD). There is an unmet need for more effective treatments for patients with HTG. Angiopoietin-like protein 3 (ANGPTL3) and apolipoprotein C-III (apoC-III) are key regulators of triglyceride-rich lipoprotein (TRL) metabolism. We review recent clinical trials targeting ANGPTL3 and apoC-III with monoclonal antibody and nucleic acid therapies, including antisense oligonucleotides and small interfering RNA...
February 20, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38363694/familial-hypercholesterolemia-in-children-and-the-importance-of-early-treatment
#15
JOURNAL ARTICLE
Sibbeliene E van den Bosch, Barbara A Hutten, Willemijn E Corpeleijn, D Meeike Kusters
PURPOSE OF REVIEW: Familial hypercholesterolemia leads to elevated levels of low-density lipoprotein cholesterol (LDL-C) from birth onwards due to a pathogenetic variation in genes in cholesterol metabolism. Early screening to identify and subsequently treat children with familial hypercholesterolemia is crucial to reduce the risk of premature atherosclerotic cardiovascular disease (ASCVD). This review focuses on recent insights in the field of pediatric familial hypercholesterolemia...
February 15, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38299384/genetic-testing-for-familial-hypercholesterolemia
#16
JOURNAL ARTICLE
Yiyi Zhang, Sarah D de Ferranti, Andrew E Moran
PURPOSE OF REVIEW: Despite familial hypercholesterolemia (FH) being the most common genetic cause of cardiovascular disease (CVD), genetic testing is rarely utilized in the US. This review summarizes what is known about the clinical utility of genetic testing and its role in the diagnosis and screening of FH. RECENT FINDINGS: The presence of an FH-causative variant is associated with a substantially higher risk of CVD, even when low-density lipoprotein cholesterol (LDL-C) levels are only modestly elevated...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38112101/editorial-introductions
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38085172/bempedoic-acid-new-evidence-and-recommendations-on-use
#18
REVIEW
Kristina Paponja, Ivan Pećin, Željko Reiner, Maciej Banach
PURPOSES OF REVIEW: Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity worldwide. Recognizing the importance of dyslipidemia treatment in the prevention of cardiovascular events has become a part of standard clinical practice. Desired values of LDL cholesterol (LDL-C) have become lower and lower in the last few decades, as evidenced by the most recent guidelines. Therefore, efforts to lower LDL cholesterol concentrations with conventional therapies and combinations of lipid-lowering therapy may not be successful in a high proportion of patients...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38018863/dietary-fat-telomere-length-and-cognitive-function-unravelling-the-complex-relations
#19
REVIEW
Hamza Mostafa, Laia Gutierrez-Tordera, Javier Mateu-Fabregat, Christopher Papandreou, Mònica Bulló
PURPOSE OF REVIEW: The review aims to explore the recent evidence on the associations between different dietary fat intake and cognitive function, and to understand the role of telomere length in this relationship. RECENT FINDINGS: Clinical and preclinical studies included in this review suggest that dietary fat intake is associated with cognitive function and telomere length. High intake of saturated fats and trans fats, commonly found in ultra-processed foods, appears to have negative effects on cognitive function and telomere length, while other dietary fats, such as omega-3 polyunsaturated fatty acids and monounsaturated fatty acids are associated with improved cognitive performance and reduced telomere attrition...
February 1, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/37938937/lipidome-and-inflammation-interplay-the-role-of-diet-in-this-relationship
#20
REVIEW
Anacristina Rovayo, Estefanía Toledo, Cristina Razquin
PURPOSE OF REVIEW: The aim of this review was to provide an overview of the role of novel lipid biomarkers from the circulating lipidome in inflammatory processes and the impact that dietary patterns may have on the lipidome. RECENT FINDINGS: Inflammation is a process that underlies many acute and chronic diseases, contributing to their development and severity. Finding novel molecules which serve as biomarkers and which are involved in inflammation is very useful, since they offer us both preventive or therapeutic targets and reveal mechanisms of action...
February 1, 2024: Current Opinion in Lipidology
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