Marco Schiavo Lena, Stefano Partelli, Valentina Andreasi, Francesca Muffatti, Miriam Redegalli, Emanuela Brunetto, Beatrice Maghini, Monika Falke, Maria Giulia Cangi, Aurel Perren, Massimo Falconi, Claudio Doglioni
The incidence of well-differentiated non-functioning pancreatic neuroendocrine tumors (NF-PanNET) increased during the last decades. The risk of relapse after curative surgery, albeit low, is not negligible; moreover, adjuvant treatment is currently not an option and a reliable predictive model based on prognostic characteristics is urgently needed for tailoring a follow-up strategy. The histological classification of PanNET now relies only on the proliferative activity (mitosis and Ki67) and staging. In contrast to other endocrine neoplasms, the role of infiltrative growth pattern in NF-PanNET is not taken into consideration at present...
March 2023: Endocrine Pathology