Jasna Metovic, Francesco Cabutti, Simona Osella-Abate, Giulia Orlando, Cristian Tampieri, Francesca Napoli, Francesca Maletta, Lorenzo Daniele, Marco Volante, Mauro Papotti
Papillary thyroid carcinoma (PTC) is considered an indolent neoplasm but it may demonstrate aggressive behavior. We aimed to identify clinical and pathological characteristics and molecular signatures associated with aggressive forms of PTCs. We selected 43 aggressive PTC cases based on the presence of metastases at the time of diagnosis, the development of distant metastasis during follow-up, and/or biochemical recurrence, and 43 PTC patients that were disease-free upon follow-up, matching them according to age, sex, pT, and pN parameters...
September 2023: Endocrine Pathology