journal
https://read.qxmd.com/read/38733469/encyclopedia-of-pathology-series-endocrine-pathology-by-stefano-la-rosa-and-silvia-uccella
#1
REVIEW
Vincenzo Guastafierro
No abstract text is available yet for this article.
May 11, 2024: Endocrine Pathology
https://read.qxmd.com/read/38642308/clinicopathologic-features-and-cytologic-correlation-of-alk-rearranged-papillary-thyroid-carcinoma-a-series-of-eight-cases
#2
JOURNAL ARTICLE
Kun-Ping Shih, Yu-Cheng Lee, Jia-Jiun Tsai, Shu-Hui Lin, Chih-Yi Liu, Wan-Shan Li, Chien-Feng Li, Jen-Fan Hang
Anaplastic lymphoma kinase (ALK) gene fusions are rare in papillary thyroid carcinoma (PTC) but may serve as a therapeutic target. This study aims to evaluate the preoperative cytologic findings and clinicopathologic features of a series of eight ALK-rearranged PTCs from our pathology archives and consultations. All cases were confirmed by ALK D5F3 immunohistochemistry and six with additional targeted RNA-based next-generation sequencing (NGS). The original fine-needle aspiration (FNA) cytology diagnosis included the Bethesda System (TBS) category II in three (37...
April 20, 2024: Endocrine Pathology
https://read.qxmd.com/read/38470548/molecular-classification-of-gastrointestinal-and-pancreatic-neuroendocrine-neoplasms-are-we-ready-for-that
#3
REVIEW
Silvia Uccella
In the last two decades, the increasing availability of technologies for molecular analyses has allowed an insight in the genomic alterations of neuroendocrine neoplasms (NEN) of the gastrointestinal tract and pancreas. This knowledge has confirmed, supported, and informed the pathological classification of NEN, clarifying the differences between neuroendocrine carcinomas (NEC) and neuroendocrine tumors (NET) and helping to define the G3 NET category. At the same time, the identification genomic alterations, in terms of gene mutation, structural abnormalities, and epigenetic changes differentially involved in the pathogenesis of NEC and NET has identified potential molecular targets for precision therapy...
March 12, 2024: Endocrine Pathology
https://read.qxmd.com/read/38438719/uncommon-mimicker-of-a-high-grade-thyroid-carcinoma-solitary-thyroid-metastasis-of-gastrointestinal-stromal-tumor-gist
#4
JOURNAL ARTICLE
Ozgur Mete, Mehmet Kefeli, Ralph Gilbert, Abha A Gupta
No abstract text is available yet for this article.
March 5, 2024: Endocrine Pathology
https://read.qxmd.com/read/38430335/primary-multiglandular-parathyroid-disease-in-the-setting-of-pompe-disease
#5
JOURNAL ARTICLE
Meryl Nath, Rumeal D Whaley, William Sukov, Lori A Erickson
No abstract text is available yet for this article.
March 2, 2024: Endocrine Pathology
https://read.qxmd.com/read/38416360/hand2-immunohistochemistry-in-the-diagnosis-of-paragangliomas-and-other-neuroendocrine-neoplasms
#6
JOURNAL ARTICLE
Jiri Soukup, Monika Manethova, Vaclav Stejskal, Marie Novakova, Jaroslava Duskova, Helena Hornychova, Maria Hacova, Iva Staniczkova-Zambo, Tomas Zelinka, Mikulas Kosak, Tomas Cesak, David Netuka, Ales Ryska, Filip Gabalec
Hand2 is a core transcription factor responsible for chromaffin cell differentiation. However, its potential utility in surgical pathology has not been studied. Thus, we aimed to investigate its expression in paragangliomas, other neuroendocrine neoplasms (NENs), and additional non-neuroendocrine tumors. We calibrated Hand2 immunohistochemistry on adrenal medulla cells and analyzed H-scores in 46 paragangliomas (PGs), 9 metastatic PGs, 21 cauda equina neuroendocrine tumors (CENETs), 48 neuroendocrine carcinomas (NECs), 8 olfactory neuroblastomas (ONBs), 110 well-differentiated NETs (WDNETs), 10 adrenal cortical carcinomas, 29 adrenal cortical adenomas, 8 melanomas, 41 different carcinomas, and 10 gastrointestinal stromal tumors (GISTs)...
February 28, 2024: Endocrine Pathology
https://read.qxmd.com/read/38403790/pancreatic-neuroendocrine-microtumors-who-2022-are-not-always-low-grade-neoplasms-a-case-with-a-highly-increased-proliferation-rate
#7
JOURNAL ARTICLE
Aziz Chouchane, Philipp Kirchner, Ilaria Marinoni, Eva Sticová, Tomáš Jirásek, Aurel Perren
Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5 mm, pancreatic (neuro)endocrine microadenomas are now classified as pancreatic neuroendocrine microtumors in the 2022 WHO classification of endocrine and neuroendocrine tumors. This case report discussed the features of an incidentally identified 4.7-mm glucagon-expressing pancreatic neuroendocrine microtumor with MEN1 mutation only, chromosomally stable and an epigenetic alpha-like phenotype...
February 26, 2024: Endocrine Pathology
https://read.qxmd.com/read/38363524/not-all-parafibromin-deficiency-relates-to-parathyroid-carcinoma-the-role-of-morphological-assessment
#8
JOURNAL ARTICLE
C Christofer Juhlin
No abstract text is available yet for this article.
March 2024: Endocrine Pathology
https://read.qxmd.com/read/38324206/focal-tall-cell-change-in-papillary-thyroid-carcinoma-lessons-learned-from-practices-adopting-rigid-criteria-height-to-width-ratio-of-3
#9
LETTER
Esther Diana Rossi, Liron Pantanowitz
No abstract text is available yet for this article.
March 2024: Endocrine Pathology
https://read.qxmd.com/read/38280141/a-comprehensive-approach-to-the-thyroid-bethesda-category-iii-aus-in-the-transition-zone-between-2nd-edition-and-3rd-edition-of-the-bethesda-system-for-reporting-thyroid-cytopathology-subcategorization-nuclear-scoring-and-more
#10
JOURNAL ARTICLE
Merve Bagıs, Nuray Can, Necdet Sut, Ebru Tastekin, Ezgi Genc Erdogan, Buket Yilmaz Bulbul, Yavuz Atakan Sezer, Osman Kula, Elif Mercan Demirtas, Inci Usta
Significant interobserver variabilities exist for Bethesda category III: atypia of undetermined significance (AUS) of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Thus, subcategorization of AUS including AUS "nuclear" and AUS "other" is proposed in the recent 3rd edition of TBSRTC. This study investigated the impact of the nuclear features/architectural features/nuclear score (NS) (3-tiered)/subcategories and subgroups on risk of malignancy (ROM) in thyroid fine-needle aspirations (FNA)...
March 2024: Endocrine Pathology
https://read.qxmd.com/read/38032439/the-3-rd-edition-of-bethesda-system-for-reporting-thyroid-cytopathology-highlights-and-comments
#11
LETTER
C Christofer Juhlin, Zubair W Baloch
No abstract text is available yet for this article.
March 2024: Endocrine Pathology
https://read.qxmd.com/read/38285158/the-role-of-5-hydroxymethylcytosine-as-a-potential-epigenetic-biomarker-in-a-large-series-of-thyroid-neoplasms
#12
JOURNAL ARTICLE
Sule Canberk, João Gonçalves, Elisabete Rios, Antónia A Povoa, Ebru Tastekin, Manuel Sobrinho-Simões, Aysun Uguz, Ozlem Aydin, Umit Ince, Paula Soares, Valdemar Máximo
Cytosine modifications at the 5-carbon position play a critical role in gene expression regulation and have been implicated in cancer development. 5-Hydroxymethylcytosine (5hmC), arising from 5-methylcytosine (5-mC) oxidation, has shown promise as a potential malignancy marker due to its depletion in various human cancers. However, its significance in thyroid tumors remains underexplored, primarily due to limited data. In our study, we evaluated 5hmC expression levels by immunohistochemistry in a cohort of 318 thyroid tumors...
January 29, 2024: Endocrine Pathology
https://read.qxmd.com/read/38280140/spatial-transcriptomics-in-a-case-of-follicular-thyroid-carcinoma-reveals-clone-specific-dysregulation-of-genes-regulating-extracellular-matrix-in-the-invading-front
#13
JOURNAL ARTICLE
Vincenzo Condello, Johan O Paulsson, Jan Zedenius, Anders Näsman, C Christofer Juhlin
Follicular thyroid carcinoma (FTC) is recognized by its ability to invade the tumor capsule and blood vessels, although the exact molecular signals orchestrating this phenotype remain elusive. In this study, the spatial transcriptional landscape of an FTC is detailed with comparisons between the invasive front and histologically indolent central core tumor areas. The Visium spatial gene expression platform allowed us to interrogate and visualize the whole transcriptome in 2D across formalin-fixated paraffin-embedded (FFPE) tissue sections...
January 27, 2024: Endocrine Pathology
https://read.qxmd.com/read/38252340/thyroid-gland-blastomycosis
#14
JOURNAL ARTICLE
Rumeal D Whaley, Lori A Erickson
No abstract text is available yet for this article.
January 22, 2024: Endocrine Pathology
https://read.qxmd.com/read/38165630/artificial-intelligence-detected-the-relationship-between-nuclear-morphological-features-and-molecular-abnormalities-of-papillary-thyroid-carcinoma
#15
JOURNAL ARTICLE
Toui Nishikawa, Ibu Matsuzaki, Ayata Takahashi, Iwamoto Ryuta, Fidele Yambayamba Musangile, Kanako Sagan, Mizuki Nishikawa, Yurina Mikasa, Yuichi Takahashi, Fumiyoshi Kojima, Shin-Ichi Murata
Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma and has characteristic nuclear features. Genetic abnormalities of PTC affect recent molecular target therapeutic strategy towards RET-altered cases, and they affect clinical prognosis and progression. However, there has been insufficient objective analysis of the correlation between genetic abnormalities and nuclear features. Using our newly developed methods, we studied the correlation between nuclear morphology and molecular abnormalities of PTC with the aim of predicting genetic abnormalities of PTC...
January 2, 2024: Endocrine Pathology
https://read.qxmd.com/read/38095839/clinical-and-molecular-characteristics-of-gonadotroph-pituitary-tumors-according-to-the-who-classification
#16
JOURNAL ARTICLE
Francesca Carbonara, Tiziana Feola, Francesca Gianno, Michela Anna Polidoro, Rosa Maria Di Crescenzo, Antonietta Arcella, Michelangelo De Angelis, Roberta Morace, Dario de Alcubierre, Vincenzo Esposito, Felice Giangaspero, Marie-Lise Jaffrain-Rea
Since 2017, hormone-negative pituitary neuroendocrine tumors expressing the steroidogenic factor SF1 have been recognized as gonadotroph tumors (GnPT) but have been poorly studied. To further characterize their bio-clinical spectrum, 54 GnPT defined by immunostaining for FSH and/or LH (group 1, n = 41) or SF1 only (group 2, n = 13) were compared and studied for SF1, βFSH, βLH, CCNA2, CCNB1, CCND1, caspase 3, D2R, and AIP gene expression by qRT-PCR. Immunohistochemistry for AIP and/or D2R was performed in representative cases...
December 14, 2023: Endocrine Pathology
https://read.qxmd.com/read/38064165/morphometric-analysis-of-lateral-cervical-lymph-node-metastasis-in-papillary-thyroid-carcinoma-using-digital-pathology
#17
JOURNAL ARTICLE
Chae A Kim, Hyeong Rok An, Jungmin Yoo, Yu-Mi Lee, Tae-Yon Sung, Won Gu Kim, Dong Eun Song
Digital pathology uses digitized images for cancer research. We aimed to assess morphometric parameters using digital pathology for predicting recurrence in patients with papillary thyroid carcinoma (PTC) and lateral cervical lymph node (LN) metastasis. We analyzed 316 PTC patients and assessed the longest diameter and largest area of metastatic focus in LNs using a whole slide imaging scanner. In digital pathology assessment, the longest diameters and largest areas of metastatic foci in LNs were positively correlated with traditional optically measured diameters (R = 0...
December 8, 2023: Endocrine Pathology
https://read.qxmd.com/read/37999888/fundamentals-of-endocrine-pathology-part-i
#18
EDITORIAL
Ozgur Mete
No abstract text is available yet for this article.
December 2023: Endocrine Pathology
https://read.qxmd.com/read/37792156/glomangiosarcoma-like-anaplastic-transformation-in-papillary-thyroid-carcinoma-a-novel-form-of-heterologous-differentiation-and-a-systematic-review-of-heterologous-element-prevalence
#19
JOURNAL ARTICLE
Rayan Rammal, Jason K Wasserman, Aatur D Singhi, Christopher C Griffith, Raja R Seethala
Anaplastic thyroid carcinoma (ATC) demonstrates a wide variety of morphologies and is characteristically associated with a differentiated thyroid carcinoma component. Heterologous differentiation is a rare, potentially challenging phenomenon in ATC, mostly observed as osteosarcomatous or chondrosarcomatous differentiation. We now describe a novel 'glomangiosarcoma-like' differentiation, review our archival experience from two institutions (UPMC, CC), and perform a systematic review for the prevalence of heterologous elements in ATC...
December 2023: Endocrine Pathology
https://read.qxmd.com/read/37209390/inflammatory-and-infectious-disorders-in-endocrine-pathology
#20
REVIEW
Silvia Uccella, Matthias Dottermusch, Lori Erickson, Julia Warmbier, Kathleen Montone, Wolfgang Saeger
A variety of inflammatory conditions may directly involve the endocrine glands, leading to endocrine dysfunction that can cause severe consequences on patients' health, if left untreated. Inflammation of the endocrine system may be caused by either infectious agents or other mechanisms, including autoimmune and other immune-mediated processes. Not infrequently, inflammatory and infectious diseases may appear as tumor-like lesions of endocrine organs and simulate neoplastic processes. These diseases may be clinically under-recognized and not infrequently the diagnosis is suggested on pathological samples...
December 2023: Endocrine Pathology
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