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Endocrine Pathology

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https://read.qxmd.com/read/30953289/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-update-and-diagnostic-considerations-a-review
#1
Esther Diana Rossi, William C Faquin, Zubair Baloch, Guido Fadda, Lester Thompson, Luigi Maria Larocca, Liron Pantanowitz
Advances in our understanding of thyroid lesions, especially those entities with an indolent behavior, has led clinicians to question the most appropriate surgical management of such thyroid nodules. Several studies have shown that the non-invasive encapsulated follicular variant of papillary thyroid carcinomas (NI-EFVPC) exhibits poor histopathologic diagnostic reproducibility and have been over-treated as conventional thyroid cancer. In 2015, an international thyroid working group re-evaluated NI-EFVPC and its diagnostic criteria...
April 5, 2019: Endocrine Pathology
https://read.qxmd.com/read/30903445/pitx2-expression-in-non-functional-pituitary-neuroendocrine-tumor-with-cavernous-sinus-invasion
#2
Ryota Tamura, Kentaro Ohara, Yukina Morimoto, Kenzo Kosugi, Yumiko Oishi, Mizuto Sato, Kazunari Yoshida, Masahiro Toda
Although most pituitary neuroendocrine tumors (PitNETs) show benign behavior, a significant number of PitNETs exhibit an aggressive course including cavernous sinus (CS) invasion. To date, the cause of CS invasion has not been fully elucidated. In this study, we analyzed the relationship between CS invasion in PitNETs and the expression of PITX2 and SNAIL1, which are the transcription factors associated with the morphogenesis of pituitary gland. Sixty cases with non-functional PitNETs were classified into four types: type 1a, none of CS invasion and suprasellar expansion; type 1b, suprasellar expansion without CS invasion; type 2a, CS invasion without suprasellar expansion; and type 2b, CS invasion with suprasellar expansion...
March 22, 2019: Endocrine Pathology
https://read.qxmd.com/read/30903444/diagnostic-pitfall-parathyroid-carcinoma-expands-the-spectrum-of-calcitonin-and-calcitonin-gene-related-peptide-expressing-neuroendocrine-neoplasms
#3
Anjelica Hodgson, Sara Pakbaz, Farnoosh Tayyari, James Edward Massey Young, Ozgur Mete
No abstract text is available yet for this article.
March 22, 2019: Endocrine Pathology
https://read.qxmd.com/read/30825100/negative-results-on-thyroid-molecular-testing-decrease-rates-of-surgery-for-indeterminate-thyroid-nodules
#4
Rachel Jug, Shobha Parajuli, Sara Ahmadi, Xiaoyin Sara Jiang
Molecular tests and mutational panels such as Afirma Gene Expression Classifier (GEC) and ThyroSeq, respectively, have been used to help risk stratify cytologically indeterminate thyroid nodules with the aim to reduce unnecessary surgeries. We studied the effect of molecular testing on the rate of surgical resection in these nodules. Thyroid nodules with indeterminate (Bethesda III/IV) cytology that underwent molecular testing (GEC or ThyroSeq) at our institution between June 2012 and August 2016 were retrospectively reviewed...
March 1, 2019: Endocrine Pathology
https://read.qxmd.com/read/30772928/neuroendocrine-neoplasms-associated-with-germline-pathogenic-variants-in-the-homologous-recombination-pathway
#5
Marta Szybowska, Ozgur Mete, Evan Weber, Josh Silver, Raymond H Kim
No abstract text is available yet for this article.
February 16, 2019: Endocrine Pathology
https://read.qxmd.com/read/30767148/mirna-3653-is-a-potential-tissue-biomarker-for-increased-metastatic-risk-in-pancreatic-neuroendocrine-tumours
#6
Preetjote Gill, Edward Kim, Terence C Chua, Roderick J Clifton-Bligh, Christopher B Nahm, Anubhav Mittal, Anthony J Gill, Jaswinder S Samra
Pancreatic neuroendocrine tumours (PNETs) are relatively uncommon, accounting for 1-2% of all pancreatic neoplasms. Tumour grade (based on the Ki67 proliferative index and mitotic rate) is associated with metastatic risk across large cohorts; however, predicting the behaviour of individual tumours can be difficult. Therefore, any tool which could further stratify metastatic risk may be clinically beneficial. We sought to investigate microRNA (miRNA) expression as a marker of metastatic disease in PNETs. Tumours from 37 patients, comprising 23 with locoregional disease (L) and 14 with distant metastases (DM), underwent miRNA profiling...
February 14, 2019: Endocrine Pathology
https://read.qxmd.com/read/30734213/correction-to-evaluation-of-167-gene-expression-classifier-gec-and-thyroseq-v2-diagnostic-accuracy-in-the-preoperative-assessment-of-indeterminate-thyroid-nodules-bivariate-hroc-meta-analysis
#7
Martyna Borowczyk, Ewelina Szczepanek-Parulska, Michał Olejarz, Barbara Więckowska, Frederik A Verburg, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Katarzyna Ziemnicka, Marek Ruchała
The original version of the article unfortunately contained an error.
February 8, 2019: Endocrine Pathology
https://read.qxmd.com/read/30706322/an-institutional-experience-of-tumor-progression-to-pituitary-carcinoma-in-a-15-year-cohort-of-1055-consecutive-pituitary-neuroendocrine-tumors
#8
Omalkhaire M Alshaikh, Sylvia L Asa, Ozgur Mete, Shereen Ezzat
Pituitary carcinoma is a rare disease, defined by the presence of cerebrospinal or distant metastasis of a pituitary neuroendocrine tumor (PitNET). To review our institutional experience of pituitary carcinoma, we searched the database of the UHN Endocrine Oncology Site group and the University Health Network pathology laboratory information system from 2001 to 2016. Among 1055 PitNETs from 1169 transsphenoidal resections, we identified 4 cases of pituitary carcinoma, indicating that pituitary carcinoma represents around 0...
January 31, 2019: Endocrine Pathology
https://read.qxmd.com/read/30694510/revisiting-the-significance-of-prominent-c-cells-in-the-thyroid
#9
Talia L Fuchs, Stephen E Bell, A Chou, Anthony J Gill
C cell hyperplasia is considered a precursor lesion for hereditary forms of medullary thyroid carcinoma. It has therefore been suggested as a morphological marker to distinguish hereditary from sporadic medullary thyroid carcinoma and to triage genetic testing in resource poor settings. However, numerous definitions for C cell hyperplasia have been suggested, and there is surprisingly little data regarding the number of C cells present in thyroid glands removed for conditions other than medullary carcinoma...
January 29, 2019: Endocrine Pathology
https://read.qxmd.com/read/30661168/modified-transverse-vertical-gross-examination-a-better-method-for-the-detection-of-definite-capsular-invasion-in-encapsulated-follicular-patterned-thyroid-neoplasms
#10
Hye-Seon Oh, Sun Jae Kim, Eyun Song, Yu-Mi Lee, Tae-Yon Sung, Won Gu Kim, Tae Yong Kim, Dong Eun Song
The diagnosis of encapsulated follicular-patterned thyroid carcinoma (EFPTC) is challenging, and the detection of capsular invasion and/or vascular invasion is essential in distinguishing benign lesions from malignant lesions. In this study, we present a modified transverse-vertical gross examination method with additional vertical cuts at the upper and lower ends of thyroid nodules. In addition, we compared the clinicopathological characteristics of patients with EFPTC between conventional and modified methods...
January 19, 2019: Endocrine Pathology
https://read.qxmd.com/read/30565013/tall-cell-variant-of-papillary-thyroid-carcinoma-impact-of-change-in-who-definition-and-molecular-analysis
#11
Kristine S Wong, Sara E Higgins, Ellen Marqusee, Matthew A Nehs, Trevor Angell, Justine A Barletta
The morphologic criteria for tall cell variant (TCV) of papillary thyroid carcinoma (PTC) were modified in the 2017 WHO Classification of Tumors of Endocrine Organs, with a decrease in the requirements for both the height of cells and in the percentage of tumor demonstrating a tall cell morphology. The aim of this study was to determine if the change in criteria would result in a significant increase in the percentage of tumors that meet criteria for TCV. In addition, we evaluated the correlation between morphology, molecular alterations, and clinical behavior of TCV...
March 2019: Endocrine Pathology
https://read.qxmd.com/read/30610567/plurihormonal-pituitary-tumor-of-pit-1-and-sf-1-lineages-with-synchronous-collision-corticotroph-tumor-a-possible-stem-cell-phenomenon
#12
Karen M Tordjman, Yona Greenman, Zvi Ram, Dov Hershkovitz, Orna Aizenstein, Ofra Ariel, Sylvia L Asa
Thyrotropin (TSH)-secreting pituitary tumors are the rarest functioning pituitary tumors. Nonetheless, they are not infrequently plurihormonal, as they may express/secrete hormones made by other pituitary cells derived from the Pit-1 lineage such as growth hormone (GH), prolactin (PRL), and α-subunit (αSU). However, adrenocorticotropin (ACTH) or gonadotropin secretion by such a tumor is exceptional. Although double pituitary tumors are rare, they often combine ACTH and GH secretion. A 41-year-old presented almost 2 years after delivering her 10th child; she had thyrotoxicosis (goiter and palpitations) masquerading as autoimmune postpartum thyroiditis...
January 4, 2019: Endocrine Pathology
https://read.qxmd.com/read/30610566/the-prognostic-roles-of-the-ki-67-proliferation-index-p53-expression-mitotic-index-and-radiological-tumor-invasion-in-pituitary-adenomas
#13
Rovshan Hasanov, Berna İmge Aydoğan, Saba Kiremitçi, Esra Erden, Sevim Güllü
The fourth edition of the World Health Organization (WHO) classification of pituitary tumors recommended evaluation of tumor proliferation and invasion to identify aggressiveness. We aimed to assess the prognostic roles of the Ki-67 proliferation index, mitotic index, P53 expression, and cavernous sinus invasion in pituitary adenomas (PAs). Among the 601 patients who underwent transnasal/transsphenoidal adenomectomy from 2001 to 2016, 101 patients (16.8%) who had tumors with a high (≥ 3%) Ki-67 index (group A) and a control group consisting of 43 patients with a low (< 3%) Ki 67 index who were matched for age, gender, and tumor type were included...
January 4, 2019: Endocrine Pathology
https://read.qxmd.com/read/30600442/in-situ-hybridization-analysis-of-long-non-coding-rnas-malat1-and-hotair-in-gastroenteropancreatic-neuroendocrine-neoplasms
#14
Ying-Hsia Chu, Heather Hardin, Jens Eickhoff, Ricardo V Lloyd
Recent studies suggest onco-regulatory roles for two long non-coding RNAs (lncRNAs), MALAT1 and HOTAIR, in various malignancies; however, these lncRNAs have not been previously examined in neuroendocrine neoplasms (NENs) of gastroenteropancreatic origins (GEP-NENs). In this study, we evaluated the expressions and prognostic significance of MALAT1 and HOTAIR in 83 cases of GEP-NENs (60 grade 1, 17 grade 2, and 6 grade 3 tumors) diagnosed during the years 2005-2017. Expression levels of MALAT1 and HOTAIR were digitally quantitated in assembled tissue microarray slides labeled by chromogenic in situ hybridization (ISH) using InForm 1...
January 2, 2019: Endocrine Pathology
https://read.qxmd.com/read/30591992/evaluation-of-167-gene-expression-classifier-gec-and-thyroseq-v2-diagnostic-accuracy-in-the-preoperative-assessment-of-indeterminate-thyroid-nodules-bivariate-hroc-meta-analysis
#15
Martyna Borowczyk, Ewelina Szczepanek-Parulska, Michał Olejarz, Barbara Więckowska, Frederik A Verburg, Szymon Dębicki, Bartłomiej Budny, Małgorzata Janicka-Jedyńska, Katarzyna Ziemnicka, Marek Ruchała
The objective of this meta-analysis was to evaluate the performance of the Gene Expression Classifier (GEC) and ThyroSeq v2 (ThyroSeq) in the preoperative diagnosis of thyroid nodules with indeterminate fine-needle aspiration biopsy results. We searched literature databases from January 2001 to April 2018. The bivariate model analysis was performed to estimate pooled sensitivity, specificity, positive likelihood ratio (LR+), negative likelihood ratio (LR-), positive predictive value (PPV), and negative predictive value (NPV)...
December 27, 2018: Endocrine Pathology
https://read.qxmd.com/read/30523500/expression-of-insulinoma-associated-protein-1-insm1-and-orthopedia-homeobox-otp-in-tumors-with-neuroendocrine-differentiation-at-rare-sites
#16
Madhuchhanda Roy, Darya G Buehler, Ranran Zhang, Michael L Schwalbe, Rebecca M Baus, M Shahriar Salamat, Ricardo V Lloyd, Jason N Rosenbaum
Insulinoma-associated protein 1 (INSM1) and orthopedia homeobox (OTP) are transcription factors that play a critical role in neuroendocrine (NE) and neuroepithelial cell development. INSM1 has been identified in multiple tumors of NE or neuroepithelial origin, whereas OTP expression has been mainly studied in NE tumors of pulmonary origin. Expression of OTP appears to correlate with poorer prognosis in pulmonary carcinoids; however, its expression patterns in other NE/neuroepithelial tumors need further investigation...
December 6, 2018: Endocrine Pathology
https://read.qxmd.com/read/30361844/a-young-male-with-parafibromin-deficient-parathyroid-carcinoma-due-to-a-rare-germline-hrpt2-cdc73-mutation
#17
Alisha Kapur, Narendra Singh, Ozgur Mete, Robert A Hegele, I George Fantus
Hyperparathyroidism, commonly observed in asymptomatic middle-aged women, with mild hypercalcemia, is usually caused by a benign adenoma. Some cases present with more severe manifestation and greater hypercalcemia. Within this spectrum, several familial/genetic associations have been discovered. While the majority are caused by benign disease, adenomas, or hyperplasia, a small proportion (< 1%) are associated with malignant tumors and present with more severe symptoms. Although usually sporadic, recent reports document various gene mutations that strongly predispose to the development of parathyroid carcinoma...
December 2018: Endocrine Pathology
https://read.qxmd.com/read/30315491/cytomorphological-analysis-of-thyroid-nodules-diagnosed-as-follicular-variant-of-papillary-thyroid-carcinoma-a-fine-needle-aspiration-study-of-diagnostic-clues-in-42-cases-and-the-impact-of-using-bethesda-system-in-reporting-an-institutional-experience
#18
Levent Trabzonlu, Nadir Paksoy
Follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common subtype of papillary thyroid carcinoma (PTC) after classical PTC (cPTC). Follicular thyroid lesions such as follicular adenomas/carcinomas, FVPTC, and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) pose some diagnostic challenges for FNAC. In this study, we aimed to explore whether FNAC can demonstrate diagnostic clues by re-evaluating cytology slides from histopathologically diagnosed FVPTC cases...
December 2018: Endocrine Pathology
https://read.qxmd.com/read/30306386/tert-immunohistochemistry-is-a-poor-predictor-of-tert-promoter-mutations-and-gene-expression-in-follicular-thyroid-carcinoma
#19
LETTER
Johan O Paulsson, Anton Olander, Felix Haglund, Jan Zedenius, C Christofer Juhlin
No abstract text is available yet for this article.
December 2018: Endocrine Pathology
https://read.qxmd.com/read/30251060/tekt4-promotes-papillary-thyroid-cancer-cell-proliferation-colony-formation-and-metastasis-through-activating-pi3k-akt-pathway
#20
Zhouci Zheng, Xiaofen Zhou, Yefeng Cai, Endong Chen, Xiaohua Zhang, Ouchen Wang, Qingxuan Wang, Haiguang Liu
Thyroid carcinoma is the most common malignancy of the endocrine system worldwide, but its molecular mechanisms remain unclear. Some diseases are associated with TEKT4 gene. However, its role in thyroid carcinoma has yet to be fully examined. This study was designed to investigate the function of TEKT4 in papillary thyroid cancer (PTC). The effect of TEKT4 on aggressive behavior of PTC cell lines, namely, TPC1 and BCPAP, transfected with small interfering RNA was identified through cell proliferation, colony formation, migration, and invasion...
December 2018: Endocrine Pathology
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