Evgenia V Dueva, Ksenia K Tuchynskaya, Liubov I Kozlovskaya, Dmitry I Osolodkin, Kseniya N Sedenkova, Elena B Averina, Vladimir A Palyulin, Galina G Karganova
Tick-borne encephalitis is an important human arbovirus neuroinfection spread across the Northern Eurasia. Inhibitors of tick-borne encephalitis virus (TBEV) strain Absettarov, presumably targeting E protein n -octyl-β-d-glucoside (β-OG) pocket, were reported earlier. In this work, these inhibitors were tested in vitro against seven strains representing three main TBEV subtypes. The most potent compound, 2-[(2-methyl-1-oxido-5,6,7,8-tetrahydroquinazolin-4-yl)amino]-phenol, showed EC50 values lower than 22 µM against all the tested strains...
January 2020: Antiviral Chemistry & Chemotherapy