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Journal of Biomaterials Science. Polymer Edition | Page 2

Hsiu-Wen Chien, Chia-Jung Kuo
The present work proposes to investigate two series of silicone hydrogel materials for their characterization, water content, surface wettability, transmittance, mechanical property, oxygen permeability (Dk), and bacterial attachment as potential contact lens materials and discuss the relationships between water affinity and optical, mechanical, oxygen permeable and biological properties. One of the series of silicone hydrogels is presented on the basis of 3-(methacryloyloxy)propyltris(trimethylsiloxy)silane (TRIS), 3-(3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane (BIS) and 2-hydroxyethyl methacrylate (HEMA) with different silicone monomers/HEMA ratios...
May 18, 2019: Journal of Biomaterials Science. Polymer Edition
Thalles Canton Trevisol, Rayane Kunert Langbehn, Suellen Battiston, Ana Paula Serafini Immich
Scaffold-type biomaterials are crucial for application in tissue engineering. Among them, the use of a nonwoven scaffold has grown in recent years and has been widely investigated for the regeneration of different types of tissues. Several polymers, whether they are synthetic, biopolymers or both, have been used to produce a scaffold that can mimic the natural tissue to which it will be applied to. The scaffolds used in tissue engineering must be biocompatible and allow cell adhesion and proliferation to be applied in tissue engineering...
May 18, 2019: Journal of Biomaterials Science. Polymer Edition
Sha Liu, Changmei Niu, Ziqi Xu, Yingyu Wang, Yunyun Liang, Ying Zhao, Yahong Zhao, Yumin Yang
Remyelination is a major therapeutic goal in peripheral nerve regeneration, serving to restore function of demyelinated axons and provide neuroprotection. In order to apply myelin biogenesis strategies to peripheral nerve defects, the tissue engineered substitutes might be amenable to the promotion of this repair process. Electrospun nanofibers are considered as promising scaffolds for tissue engineering due to extracellular matrix mimicking factor and enhanced electrostatic interaction resulting in a controllable 3D nanofibrous membrane...
May 18, 2019: Journal of Biomaterials Science. Polymer Edition
Yufan Zhang, Xian Li, Nan Zhong, Yuanlin Huang, Kewen He, Xu Ye
A series of injectable in situ dual-crosslinking hydrogels (HA/ALG) based on oxidized sodium alginate (oxi-ALG) and hyaluronic acid modified with thiol and hydrazide (HA-SH/CDH) were prepared via hydrazone bonds and disulfide bonds. The chemical structures, morphologies, rheological properties, gelling time, swelling ratio, degradation rate and drug release behavior of hydrogels were investigated. HA/ALG hydrogels exhibited tunable gelling time, rheological properties, swelling ratio, and degradation rate with varying precursor concentrations...
May 14, 2019: Journal of Biomaterials Science. Polymer Edition
Hiroko Nagai, Wataru Hatanaka, Masayoshi Matsuda, Akihiro Kishimura, Yoshiki Katayama, Takeshi Mori
We report here a folate-modified membrane anchor for cell surface modification to induce cell adhesion to target cells. The membrane anchor region, which was consisted of cationic lysine residues and palmitoyl group-modified residues, was modified with folate through an oligoethlene glycol linker. The peptide anchor was modified on to the cell membrane via by using β-cyclodextrin as a solubilizer of the peptide anchor. After modification, the peptide anchor disappeared from the cell membrane via endocytotic uptake or dissociation from the cell membrane...
May 8, 2019: Journal of Biomaterials Science. Polymer Edition
Qianqian Guo, Xinge Zhang
We reported on the fabrication of sugar-responsive nanogels covalently incorporated with 3-acrylamidophenylboronic acid (AAPBA) as glucose-recognizing moiety, 2-(acrylamido)glucopyranose (AGA) as biocompatible moiety, and boron dipyrromethene (BODIPYMA) as fluorescence donor molecule. The p(AAPBA-AGA-BODIPYMA) nanogels were synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization in the mixture solvents of H2 O/ethanol. Nanogels could respond to glucose and size of nanogels increased after treating with 3 mg/mL glucose medium...
May 2, 2019: Journal of Biomaterials Science. Polymer Edition
Ivana Postic, Heather Sheardown
Delivery of drugs from contact lens materials is attractive for a number of reasons. However, the controlled delivery of hydrophilic drugs can be difficult to achieve due to the burst release of drug that is associated with materials of high water content, such as hydrogels. Silicone hydrogels have significant potential for drug delivery due to their increased hydrophobicity and the tortuous nature of the pores, overcoming some of the limitations associated with conventional hydrogel materials. The aim of this study was to examine the potential of model poly(ethylene glycol) (PEG) containing silicone hydrogels for delivery of the hydrophilicaminoglycoside antibiotics...
May 2, 2019: Journal of Biomaterials Science. Polymer Edition
Nadda Chiaoprakobkij, Sutasinee Seetabhawang, Neeracha Sanchavanakit, Muenduen Phisalaphong
Hydrogels from bacterial, algal, and animal cells-bacterial cellulose (BC), alginate, and gelatin, respectively-were combined to fabricate a biocomposite film (BCAGG) via an eco-friendly casting technique. In addition, glycerol was added as a plasticizer to improve the elasticity and water absorption capacity of the film. In this study, BC pellicles were simply deconstructed into fibrils suspension and then reconstructed into films with a supplement of alginate, gelatin and glycerol. The physical appearance of fabricated films resembled native BC but possessed improved ductility, enhanced flexibility, higher water uptake ability and better biocompatibility...
May 2, 2019: Journal of Biomaterials Science. Polymer Edition
Haley H Barnett, Abitha M Heimbuck, India Pursell, Rachel A Hegab, Benjamin J Sawyer, Jamie J Newman, Mary E Caldorera-Moore
Three-dimensional (3D) hydrogel scaffolds are an attractive option for tissue regeneration applications because they allow for cell migration, fluid exchange, and can be synthesized to closely mimic the physical properties of the extracellular matrix environment. The material properties of hydrogels play a vital role in cellular migration and differentiation. In light of this, in-depth understanding of material properties is required before such scaffolds can be used to study their influence on cells. Herein, various blends and thicknesses of poly (ethylene glycol) dimethacrylate (PEGDMA) hydrogels were synthesized, flash frozen, and dried by lyophilization to create scaffolds with multiscale porosity...
April 30, 2019: Journal of Biomaterials Science. Polymer Edition
Ceren Türkcan, Burcu Somtürk, Nalan Özdemir, Merve Özel, Rıfat Çatalkaya, Deniz Aktaş Uygun, Murat Uygun, Sinan Akgöl
In this study, molecularly imprinted polymer membranes were synthesized for the recognition and adsorption of quercetin. For this, quercetin imprinted polymeric membranes [p(HEMA-MAH)] (Poly(2-hydroxyethyl methacrylate-co-N-methacryloly-l-histidinemethylester) were synthesized by UV polymerization technique using HEMA and MAH as monomers. Synthesized polymeric membranes were characterized with SEM, FTIR and swelling test. Characterized membranes were used for the direct adsorption of quercetin in a batch system...
April 30, 2019: Journal of Biomaterials Science. Polymer Edition
Dan Peng, Huijie Gao, Pingsheng Huang, Xiaoguang Shi, Junhui Zhou, Jianhua Zhang, Anjie Dong, Hua Tang, Weiwei Wang, Liandong Deng
Synergistic therapy that combines drug/siRNA for the solid tumor treatment is becoming more and more popular to reduce the side effects and enhance the antitumor efficiency. Given that, a novel injectable supramolecular hydrogel mPECT(D)/GDDC-4(R)/α-CDgel (mPECT(D) represents DOX-loaded methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-1,4,8-trioxa[4.6]spiro-9-un-decanone) (mPECT) nanoparticles, GDDC-4(R) represents siBcl-2-loaded PG-P(DPAx-co-DMAEMAy)-PCB (GDDC-4) complexes nanoparticles (NPs)) was prepared via the incorporation of GDDC-4/siRNA complexes NPs into the DOX-loaded mPECT NPs/α-CDgel formed by the host-guest interaction between mPEG and α-CD...
April 26, 2019: Journal of Biomaterials Science. Polymer Edition
Rongrong Wang, Zhaoyue Wang, Yayuan Guo, Hongmin Li, Zhuoyue Chen
RADA16 (RADARADARADARADA) is an amphiphilic polypeptide composed of 16 amino acids, which is composed of alternating positively charged arginine (R), hydrophobic alanine (A) and negatively charged aspartic acid (D) that repeat periodically throughout the composition. This structure allows RADA16 to form an extremely stable and highly ordered β-sheet structure by noncovalent bonding (ionic bonds, hydrogen bonds, hydrophobic action, π-π bonds, etc.). Moreover, it can form a three-dimensional (3D) nanofiber hydrogel scaffold in neutral pH with water content higher than 99% and with a physiological saline solution, having excellent biocompatibility and low immunogenicity, etc...
April 24, 2019: Journal of Biomaterials Science. Polymer Edition
Zuhra Tayyab, Sher Zaman Safi, Abdur Rahim, Amir Sada Khan, Faiza Sharif, Zia Ul Haq Khan, Fozia Rehman, Zahoor Ullah, Jibran Iqbal, Nawshad Muhammad
Cellulose-based nanocomposites have gained much attention due to their remarkable biological properties such as biodegradability, biocompatibility, and low toxicity. In this research work, 1-h-3-methylimidazolium hydrogen sulfate ionic liquid was employed as an efficient solvent for preparation of cellulosic Ag-nanocomposites (CRC/AgNPs composite) from Neem plant. Ionic liquid plays a dual role in obtaining cellulose-rich compound (CRC; removing lignin and hemicellulose components) and plant's extract (phenolic compounds such as flavonoids, tannins, etc...
April 24, 2019: Journal of Biomaterials Science. Polymer Edition
Shun Kunomura, Yasuhiko Iwasaki
Poly(ether ether ketone) (PEEK) is an alternative material to metals for orthopedic applications. However, the compatibility of PEEK with hard tissues needs to be improved. To address this issue, this study proposes a novel technique for PEEK surface modifications. A polyphosphodiester macromonomer (PEPMA·Na) was synthesized via the demethylation of polyphosphotriester macromonomer obtained via the ring-opening polymerization of cyclic phosphoesters using 2-hydroxypropyl methacrylamide as the initiator. PEPMA·Na was grafted onto PEEK via photoinduced and self-initiated graft polymerization without using any photoinitiators...
April 23, 2019: Journal of Biomaterials Science. Polymer Edition
Mădălina Elena Grigore, Ramona Marina Grigorescu, Lorena Iancu, Rodica-Mariana Ion, Cătălin Zaharia, Elena Ramona Andrei
This study aims to provide an overview of the main polyhydroxyalkanoates (PHAs) used in medical applications. In this review, it has been demonstrated that the properties of PHAs can be controlled both by varying the concentration of units in the copolymer and the substrate for PHA production. Another way of controlling the mechanical properties of PHAs is varying the 3HV content, such as the case of P(3HB-co-3HV). A higher 3HV content in the structure of this polyester will lead to a lower cristallinity and, therefore, to greater flexibility, strength and elongation at break...
April 23, 2019: Journal of Biomaterials Science. Polymer Edition
Yanling Dai, Siyuan Dai, Xiaohui Xie, Jianping Ning
Systemic anticoagulation is not suitable for hemodialysis (HD) patients with a high risk of bleeding in the clinic. An HD membrane that provides a localized anticoagulation membrane surface may be a promising strategy to solve this intractable problem for HD patients. Herein, we modified a nonthrombogenic polyethersulfone (PES) dialyzer membrane by grafting argatroban (AG) and methoxy polyethylene glycol amine (mPEG-NH2 ) via a polydopamine (PDA) strategy. The PES substrates were immersed in an alkaline dopamine solution for 24 h, and then, AG and mPEG-NH2 were sequentially grafted covalently onto the resultant membrane...
June 2019: Journal of Biomaterials Science. Polymer Edition
Dongni Li, Bo Gao, Qian Duan
Three aluminum alkyl complexes bearing porphyrin derivatives were synthesized by pyrrole derivatives and benzaldehyde derivatives. These complexes were characterized by NMR and elemental analysis. These complexes are used for racemic-lactide polymerization. In the ring-opening polymerization of racemic lactide, complex 3(2,3,7,8,12,13,17,18-octamethyl-5,10,15,20-tetraphenylporphyrin aluminum methyl, R1 =H, R2 =Me in Scheme 2) with isopropanol showed the highest stereoselectivity, and an isotactic polylactide with a Pm of 0...
April 8, 2019: Journal of Biomaterials Science. Polymer Edition
Chenzhi Lai, Guodong Song, Bo Zhao, Hongquan Wang, Bo Pan, Xiaoshuang Guo, Xiaolei Jin, Xianlei Zong
INTRODUCTION: Acellular dermal matrix (ADM) is commonly used to treat burn injuries and wounds. In this study, we aimed to analyze the structural and biomechanical characteristics of an ADM from human scars. METHODS: We randomly selected human mature scars, human proliferative scars, and human normal skin as experimental specimens. Split-thickness dermal grafts were obtained using a free-hand graft knife. Samples were subjected to cell lysis to obtain ADMs. Structural analysis was performed via light microscopy, fluorescence microplate reader and scanning electron microscopy...
April 5, 2019: Journal of Biomaterials Science. Polymer Edition
Yu Bai, Sidi Li, Xueping Li, Xing Han, Yang Li, Jin Zhao, Juntao Zhang, Xin Hou, Xubo Yuan
Proteins are ideal raw materials for preparing biomaterials with better biocompatibility and larger elastic range than synthetic polymers. Injectable hydrogels are highly desired for minimal invasive strategies. At present, preparation of injectable hydrogels with good comprehensive properties using natural materials receives more and more attention. In this paper, BSA was treated with urea and glutathione to prepare bovine serum albumin hydrogel controlled by two dynamic equilibrium bonds (disulfide and hydrogen bonds)...
April 5, 2019: Journal of Biomaterials Science. Polymer Edition
Yeyzon Cruz, Efrén Muñoz, E Y Gomez-Pachón, Juan Morales-Corona, Jesús Olayo-Lortia, R Olayo, Roberto Olayo-Valles
Polymeric scaffolds prepared from polycaprolactone (PCL), PCL-collagen and PCL-elastin were prepared by electrospinning. The scaffolds were coated by plasma polymerization of pyrrole doped with iodine, to improve cellular adhesion and fibroblast proliferation. The morphology, composition, and crystalline structure of the scaffolds were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy, small- and wide-angle X-ray scattering, thermogravimetric analysis and differential scanning calorimetry...
April 4, 2019: Journal of Biomaterials Science. Polymer Edition
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