Journal of Biomaterials Science. Polymer Edition | Page 2

Ilyas Inci, Araz Norouz Dizaji, Ceren Ozel, Ugur Morali, Fatma Dogan Guzel, Huseyin Avci
Body membranes are thin sheets/layers of cells or tissues which cover the surface of internal organs, the outside of the body and lines various body cavities. These membranes are separated into two main groups which are epithelial membranes and connective tissue membranes. Decellularized forms of inner body membranes in the groups of epithelial membranes (amniotic membrane, mesentery, omentum, pericardium, peritoneum, pleura) and connective tissue membranes (fascia, periosteum, synovial membrane) have been used in tissue engineering studies for preparation and regeneration of various tissues such as bone, tendon, cartilage, skin, cornea, ocular surface, uterine, periodontium, vascular and cardiovascular structures...
April 6, 2020: Journal of Biomaterials Science. Polymer Edition
Samira Khaledi, Sevda Jafari, Samin Hamidi, Ommoleila Molavi, Soodabeh Davaran
Despite significant advances in cancer therapy, chemotherapeutic agents are still the main types of drugs used to treat cancer patients. 5-Fluorouracil (5-FU) is the first-line treatment in several types of human cancers, however, nonspecific function, low plasma half-life, and high doses toxicity are the important barrier to achieve efficient response in cancer patients. The use of polymeric nanoparticles (NPs) for tumor targeted delivery of 5-FU in combination with other potent anticancer agent is considered an important strategy to enhance the therapeutic efficacy of 5-FU...
April 5, 2020: Journal of Biomaterials Science. Polymer Edition
Erdoğan Özgür, Yeşeren Saylan, Nilay Bereli, Deniz Türkmen, Adil Denizli
A molecularly imprinted polymeric nanofilm was prepared for cocaine detection and applied to plasmonic nanosensor for real-time kinetic, selectivity and reusability analyses. The sensing polymeric surface was fabricated by synthesizing a selective and specific nanofilm on the gold plasmonic nanosensor surface. After characterization experiments with atomic force microscopy, ellipsometer, and contact angle measurements, the kinetic studies of cocaine detection in aqueous solutions in a wide concentration range between 0...
April 2, 2020: Journal of Biomaterials Science. Polymer Edition
Naoya Kinoshita, Yoshihiro Sasaki, Eriko Marukawa, Ryo Hirose, Shin-Ichi Sawada, Hiroyuki Harada, Kazunari Akiyoshi
Surgical resection in tongue cancer can impair speech and swallowing, reducing quality of life. There is a need for biomaterials that can regenerate tongue muscle tissue defects. Ideally, such a biomaterial would allow controlled release of therapeutic proteins, support the survival and differentiation of therapeutic cells, and promote tongue muscle regeneration in vivo . The aim of the current study was to assess these factors in an acryloyl group-modified crosslinked nanogel, consisting of cholesterol-bearing pullulan hydrogel nanoparticles, to determine its potential as a regenerative therapeutic following tongue resection...
March 25, 2020: Journal of Biomaterials Science. Polymer Edition
Weiwei Lan, Mengjie Xu, Xiumei Zhang, Liqin Zhao, Di Huang, Xiaochun Wei, Weiyi Chen
Type II collagen (Col-II) is one of the important organic components of the cartilage extracellular matrix (ECM). Such natural material is known for its good biocompatibility, but it could not provide a good supporting environment for seed cells due to its rapid degradation and poor strength. In the present work, different contents of Col-II were incorporated into porous polyvinyl alcohol (PVA) to fabricate porous PVA/Col-II composite hydrogels for cartilage tissue engineering. The results illustrate that, after incorporation of Col-II, the elasticity modulus of the composite hydrogels firstly increases, and then decreases (under moisture state)...
March 24, 2020: Journal of Biomaterials Science. Polymer Edition
Jinsong Du, Qiong Wu, Yanmei Li, Pengcheng Liu, Xiao Han, Lijuan Wang, Jiang Yuan, Xianwei Meng, Yinghong Xiao
Keratin-based drug carriers have attracted great interest due to their intrinsic biocompatibility and tumor micro-environmental responsiveness. In the study, keratin was first extracted from human hair with reduction method. The reduced keratin was successively conjugated with poly(ethylene glycol) (PEG) via thiol Michael addition reaction and iodoacetic acid (IAA) via substitution reaction to impart both physical stability and acidity responsiveness. Subsequently, the conjugated keratin was fabricated into micelles and loaded with doxorubicin (DOX) by self-assembly...
March 23, 2020: Journal of Biomaterials Science. Polymer Edition
Syed Saad Bin Qasim, Muhammad Sohail Zafar, Fayyez Hussain Niazi, Majid Alshahwan, Hanan Abdel Ks, Umer Daood
Design and development of novel therapeutic strategies to regenerate lost tissue structure and function is a serious clinical hurdle for researchers. Traditionally much of the research is dedicated in optimizing properties of scaffolds. Current synthetic biomaterials remain rudimentary in comparison to their natural counterparts. The ability to incorporate biologically inspired elements into the design of synthetic materials has advanced with time. Recent reports suggest that functionally graded material mimicking the natural tissue morphology can have a more exaggerated response on the targeted tissue...
March 23, 2020: Journal of Biomaterials Science. Polymer Edition
Sandhya Singh, Dharam Dutt, Parminder Kaur, Hemant Singh, Narayan Chand Mishra
Cotton is cheap, easily available and widely used as surgical material. Therefore, cotton would be good raw material to design a scaffold for tissue engineering applications. In this work, the gelatin-coated microfibrous paper scaffold was fabricated successfully by a papermaking process. Microfibers-based scaffold could overcome the limitations of nanofibrous material-based scaffold for tissue engineering application. The physicochemical and mechanical properties of the scaffolds were characterized. The results revealed that the gelatin contributed to the enhanced cell attachment and proliferation over the scaffolds, whereas cellulose as a strong backbone in the scaffold to support it for keeping its appearance...
March 18, 2020: Journal of Biomaterials Science. Polymer Edition
Juan Wu, Xi Wang, Binglong Zhu, Qinting He, Fang Ren, Fei Tong, Wei Jiang, Xianghong He
Cancer is one of the biggest killers threat to human life and health and is still difficult to treat mainly due to the lack of targeted drug delivery stages and limitations associated with delivering drugs to targeted cancer tissues. The goal of this work was to develop a magnetic, pH-sensitive formulation for targeted delivery of chemotherapeutic agents to cancer cells. Then the functional drug delivery system (Fe3 O4 @CS/PEG-DOX) was synthesized by the layer-by-layer (LbL) self-assembly technique. And the drug loading content is calculated to be 19...
March 16, 2020: Journal of Biomaterials Science. Polymer Edition
Gülay Baysal, Faik Doğan
In this study, biodegradable starch-based nano films were developed by turmeric extract curcuma longa (CC), octaphenyl-polyhedral oligomeric silsesquioxane (POSS), garlic extract with antibacterial properties (GC) and clay nanoparticles. Ag+ -Mt-POSS-CC-CS, Mt-CC-CS and Mt-GC-CS nanofilms were synthesized as the final products. The antibacterial and surface-active corn starch-based nanofilms that were synthesized were analyzed by using the methods of X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and scanning electron microscopy (SEM)...
March 16, 2020: Journal of Biomaterials Science. Polymer Edition
Chaochen Zhao, Yang Li, Gongze Peng, Xiongxin Lei, Guifeng Zhang, Yi Gao
A bioreactor filled with functional hepatocytes is a crucial portion of the bio-artificial liver device. However, it is a difficult task to maintain sufficient cell quantity and active hepatocellular function. In this work, we developed a promising scaffold for hepatocyte culture by coating porcine liver extracellular matrix (ECM) on chitosan (CTS) fabrics. Porcine Liver was decellularized using 1% Triton X-100. Solubilized liver ECM was immobilized on CTS fibers surface through cross linking of ECM and CTS with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-Hydroxysuccinimide (NHS)...
March 12, 2020: Journal of Biomaterials Science. Polymer Edition
Kritika Nayak, Manju Misra
Dexamethasone (Dex) is one of the most commonly used anti-vascular endothelial growth factor (anti-VEGF) drug being used in ocular diseases whether it is associated with anterior segment or posterior segment. For diseases of posterior segment of eye, Dex is delivered as intravitreal implant but the route used for the same is very invasive and poses several hazards on long term use. Thus, topical formulation with ability to outreach retina from ocular surface was intended. Thus, polyethyleneglycolylated (PEGylated) microemulsion (ME) was attempted as it can cross the membranous barrier of eye (cornea, conjunctiva, and sclera) and remain afloat in fluidic barrier (aqueous humor, choroid etc) as well...
March 9, 2020: Journal of Biomaterials Science. Polymer Edition
Ji Li, Zhiwen Cai, Jin Cheng, Cong Wang, Zhiping Fang, Yonghao Xiao, Zeng-Guo Feng, Yongquan Gu
Decellularization is a promising approach in tissue engineering to generate small-diameter blood vessels. However, some challenges still exist. We performed two decellularization phases to develop an optimal decellularized scaffold and analyze the relationship between the extracellular matrix (ECM) composition and mechanical properties. In decellularization phase I, we tested sodium dodecylsulfate (SDS), Triton X-100 (TX100) and trypsin at different concentrations and exposure times. In decellularization phase II, we systematically compared five combined decellularization protocols based on the results of phase I to identify the optimal method...
March 6, 2020: Journal of Biomaterials Science. Polymer Edition
Akira Mochizuki, Yuko Miwa, Chie Yahata, Dai Ono, Tsubasa Kawaguchi
Poly(2-methoxyethyl acrylate) (PMEA) is well known to show excellent blood compatibility. The reason for its performance has been attributed to the existence of cold crystallizable water in PMEA observed using differential scanning calorimetry (DSC). However, there is little known about the property of water in PMEA over 0 °C, especially at ambient temperature including body temperature, because blood compatibility is observed at 37 °C. The present study was performed to clarify the state of water at the temperature ranging from 15 to 45 °C using a solution nuclear magnetic resonance spectroscopy (NMR)...
March 5, 2020: Journal of Biomaterials Science. Polymer Edition
Xiuju Zhang, Xiuzhen Cao, Ping Qi
Eye drop solutions are widely used by the ophthalmologist to treat the anterior segment eye diseases. However, eye drop solutions have many limitations including low bioavailability, high dose requirements, and poor patient compliance. Contact lenses are used to deliver the ocular drugs with high ocular bioavailability due to its immediate location to cornea. To attend controlled and prolonged drug release from the contact lenses, scientists are working on various systems including polymeric nanoparticles, molecular imprinting, microemulsion, micelles, liposomes, implantation, supercritical fluids, and use of vitamin E...
March 2020: Journal of Biomaterials Science. Polymer Edition
Wenwei Gao, Liying Sun, Zetian Zhang, Zhengjun Li
Simulating components, precise porous three-dimensional structure and physico-mechanical properties of natural bone have become a vital direction in the development of bone tissue regeneration. This work focused on enhancing mechanical strength of scaffold materials for bone regeneration, a subject of serious attention in its fabrication. Hence, cellulose nanocrystals (CNC), possessing favorable biocompatibility and impressive mechanical properties, was selected to reinforce the nanocomposite scaffolds of gelatin / bioactive glass (BG-Gel) system...
February 26, 2020: Journal of Biomaterials Science. Polymer Edition
Xiaojuan Wang, Rongxin Wan, Hanqing Gu, Guoqi Fu, Huiqin Tang, Guoying Hu
Fe3 O4 nanoparticles, used as peroxidase mimetics, exhibit splendid future in the biomedical field. However, the functionalization on Fe3 O4 nanoparticles always goes with the loss of superparamagnetism and decrease in peroxidase-activity. Here, we synthesized green polyethylene glycol (PEG)-functionalized magnetic/N-trimethyl chitosan (CS) hybrid nanoparticles (Fe3 O4 @PAA/TMC/PEG NPs) with improved water dispersibility, superparamagnetism, high saturation magnetization and well peroxidase-like activity. The functionalized coating was divided in two steps, one involved a cross-linked PEG/PAA/CS middle layer to protect the nanocrystal Fe3 O4 from oxidization, the other was a hydrophilic PEG/TMC outer layer improving the water dispersion, biocompatibility, as well as supplying positive quaternary ammonium groups for a potential increase of cell binding efficiency...
February 21, 2020: Journal of Biomaterials Science. Polymer Edition
Shuo Li, Yulun Tao, Pakeeza Maryum, Qingping Wang, Jinbo Zhu, Fanfei Min, Hao Cheng, Shuai Zhao, Chengjun Wang
In this paper, bi-functional polyaniline/polyacrylamide (PANI/PAAm)-hydrogel is fabricated. The hydrogel has capacitive performance and can be used for monitoring human motions. The effect of polyaniline doped with two different acids on the properties of hydrogels was researched. The first type of PANI-hydrogel is doped with hydrochloric (HCL) and the second one with p-toluenesulfonic acid (PTSA). One application of these two kinds of hydrogels were prepared to serve as solid electrolytes in supercapacitors with sandwich structure...
February 19, 2020: Journal of Biomaterials Science. Polymer Edition
Babitha Sumathy, Prabha D Nair
Generation of full thickness skin equivalent models is of increasing interest in tissue engineering because of the limitations inherent to current models. In recent years, considerable interest has been given to electrospun hybrid nanofibers prepared using natural and synthetic combinations of polymers. By blending two polymers, gelatin and PEG methacrylate we created a novel functional hydrogel-named GelMet. By adjusting the concentration of GelMet between 14 and 20wt%, three types of electrospun membranes were fabricated...
February 19, 2020: Journal of Biomaterials Science. Polymer Edition
Xujia Hu, Yanli Chen, Zenghui Xie, Lanyun Zhang
Cyfluthrin is a widely used pesticide. In this study, a sensitive and efficient magnetic molecularly imprinted polymer (MMIP) was prepared by surface molecular imprinting, which used functionalized Fe3 O4 particles as magnetic cores. Cyfluthrin was extracted and enriched using magnetic molecularly polymer for analyzing pesticide residue of Chinese herbal medicines. The crystal type, microstructure, particle size, saturation magnetization, and characteristic functional groups of the synthesized MMIPs were analyzed by analysis equipment...
February 18, 2020: Journal of Biomaterials Science. Polymer Edition
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