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Journal of Biomaterials Science. Polymer Edition | Page 2

Meltem Koca Esentürk, Semra Akgönüllü, Fatma Yılmaz, Adil Denizli
Human serum albumin (HSA) is a major blood plasma protein also found in urine where its existence may be a marker of some types of liver or kidney dysfunction. Herein, we fabricated a novel surface plasmon resonance (SPR) nanosensor for selective, sensitive, and label-free microalbumin detection both in aqueous and urine sample solutions. Firstly, HSA-imprinted nanoparticles were synthesized, which consist of ethylene glycol dimethacrylate and N-methacryloyl-L-leucine as a cross-linker and functional monomer...
March 28, 2019: Journal of Biomaterials Science. Polymer Edition
Yepeng Zhang, Jie Zhao, Guangmin Yang, Yu Zhou, Wentao Gao, Guangyan Wu, Xiaoqiang Li, Chun Mao, Tao Sheng, Min Zhou
Bioresorbable vascular scaffolds are expected to replace the traditional metal stent, avoiding the long-term complications of metal stents. However, it is hard for the traditional scaffold manufacturing process to meet the requirements of individualized treatment for vascular lesions, which requires different morphologies. Here, we used a new method of scaffold manufacturing, three-dimensional printing technology, to prepare bioresorbable vascular scaffolds. The fabricated scaffold was loaded with sirolimus mixed with scaffold preparation material for slow drug release...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Junying Li, Xiaoliang Li, Pengfei Yang, Qiuhong Mou, Mingyi Zhang, Yunqiao Ding, Jiachun Li
PSiQAEp-GH polymers were synthesized by the reaction of gelatin hydrolysate (GH) and polysiloxane quaternary ammonium salts containing epoxy group (PSiQAEp) with different molecular weight from 3147 to 12996. The results of FTIR, 1 H NMR and 13 C NMR showed that the reaction occurred between primary amino group of arginine in GH and epoxy of PSiQAEp. The XRD and DSC studies showed that the degree of short-range order of PSiQAEp-GH reduced and its glass transition temperature (Tg) lowered more than 10 °C compared with GH...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Nor Hazwan Ali, Mohd Cairul Iqbal Mohd Amin, Shiow-Fern Ng
Biofilms comprise bacteria attached to wound surfaces and are major contributors to non-healing wounds. It was found that the increased resistance of biofilms to antibiotics allows wound infections to persist chronically in spite of antibiotic therapy. In this study, the reduced form of graphene oxide (rGO) was explored as plausible antibiofilm agents. The rGO was synthesized via reducing the functional groups of GO. Then, rGO were characterized using zetasizer, X-ray photoelectron spectroscopy, UV-Vis spectroscopy and FESEM...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Yadong Wu, Fang Wang
Degradable hemostatic agents are the essential materials for controlling the hemorrhage. Hemostatic oxidized cellulose carboxylate sodium fiber (OCCSF) has been synthesized via a simple neutralization reaction between water-insoluble oxidized cellulose fiber (OCF) and NaOH. Importantly, the degradation mechanisms of OCCSF have been investigated in vitro assay. Chemical structure of the material is tested by using FT-IR and NMR, and no obvious change was detected before and after degradation. Degree of polymerization (DP) of OCCSF declines with prolonging the degradation period, accompanying with the decrease in carboxyl content (CC), so that it could be concluded that OCCSF may undergo decarboxylation degradation process...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Ashley Thomas
Macroporous composite scaffolds comprising of gelatin and glass ceramic has been fabricated and characterized for bone tissue engineering applications. Gelatin scaffold with varying glass-ceramic content was fabricated using lyophilization technique. The microstructure, compressive strength, bioactivity, biodegradation and biocompatibility of the fabricated scaffolds were evaluated. The scaffolds presented macroporous pore size with porosity varying from 79 to 84%. The compressive strength was enhanced by glass ceramic addition and the scaffolds exhibited strength in the range of 1...
February 25, 2019: Journal of Biomaterials Science. Polymer Edition
Yanling Dai, Siyuan Dai, Xiaohui Xie, Jianping Ning
Systemic anticoagulation is not suitable for hemodialysis (HD) patients with a high risk of bleeding in the clinic. An HD membrane that provides a localized anticoagulation membrane surface may be a promising strategy to solve this intractable problem for HD patients. Herein, we modified a nonthrombogenic polyethersulfone (PES) dialyzer membrane by grafting argatroban (AG) and methoxy polyethylene glycol amine (mPEG-NH2 ) via a polydopamine (PDA) strategy. The PES substrates were immersed in an alkaline dopamine solution for 24 h, and then, AG and mPEG-NH2 were sequentially grafted covalently onto the resultant membrane...
June 2019: Journal of Biomaterials Science. Polymer Edition
Janicy Arantes Carvalho, Alexandro da Silva Abreu, Antonio Claudio Tedesco, Milton Beltrame Junior, Andreza Ribeiro Simioni
In this study, zinc phthalocyanine (ZnPc) was loaded onto gelatin nanoparticles functionalized with polyelectrolytes (polystyrene sulfonate/polyallylamine hydrochloride) by layer-by-layer (LbL) assembly. The process yield and the encapsulation efficiency were 76.0% ± 2.5 and 86.0% ± 1.8, respectively. The functionalized photosensitive gelatin nanoparticles (FPGN) had a mean diameter of 396.5 ± 45.8 nm, narrow distribution size with a polydispersity index of 0.106. The obvious switching of zeta potential indicates successful alternating deposition of the polyanion PSS and polycation PAH directly on the gelatin nanoparticles...
February 19, 2019: Journal of Biomaterials Science. Polymer Edition
Juliana Martínez Rodríguez, Sandra J Renou, María B Guglielmotti, Daniel G Olmedo
High density polyethylene (HDPE) is a synthetic biomaterial used as a three-dimensional scaffold for bone defect reconstruction. Reports differ with regard to its biological response, particularly its osteoconductive capacity. The aim of the present work was to histologically and histomorphometrically evaluate tissue response to porous HDPE. An in vivo study was conducted in rat tibia to evaluate osteogenic capacity, angiogenesis, inflammatory response, and the presence of multinucleated giant cells 14 and 60 days post-biomaterial implantation...
February 19, 2019: Journal of Biomaterials Science. Polymer Edition
Irene Carmagnola, Valeria Chiono, Martina Abrigo, Elia Ranzato, Simona Martinotti, Gianluca Ciardelli
Poly(L-lactic) acid (PLLA) has been widely employed in tissue engineering due to its mechanical properties, biodegradability and biocompatibility. The layer-by-layer (LbL) technique was here proposed as a simple method to impart bioactivity to the surface of PLLA substrates. Aminolysis treatment was applied to introduce amino groups on the surface of PLLA solvent cast films. Then, PLLA films were coated with heparin (HE)/chitosan (CH) multilayer by the LbL technique. Each functionalization step was characterized through physico-chemical and morphological analyses...
February 18, 2019: Journal of Biomaterials Science. Polymer Edition
Emel Tamahkar, Monireh Bakhshpour, Adil Denizli
The aim of this work is to develop drug carrier system with high loading capacity and controlled drug release profile for antibiotic release. For this purpose, composite molecularly imprinted nanofibers were prepared via in-situ graft polymerization of methacrylic acid as a monomer, N,N'-methylene bisacrylamide as a crosslinker and gentamicin sulfate as a template molecule onto surface-modified bacterial cellulose nanofibers. Gentamicin imprinted microparticles were fabricated onto bacterial cellulose nanofibers resulting in the formation of composite BC nanofibers...
February 18, 2019: Journal of Biomaterials Science. Polymer Edition
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February 14, 2019: Journal of Biomaterials Science. Polymer Edition
Qianxin Wang, Zhiyong Qian, Bo Liu, Jinglong Liu, Liang Zhang, Juan Xu
In this study, a solution chitosan fibroin emulsion with added Silver Nanoparticles (AgNPs) was freeze-dried to be the scaffold, and an asymmetric coating was formed on one side. PRP was loaded onto the composite scaffold using a secondary lyophilization technology to prepare the tissue engineering dressings. AgNPs were characterized using a transmission electron microscope. The morphologies of the composite dressing were examined under a scanning electron microscope. The silver content of the dressing was measured by inductively coupled plasma mass spectrometry...
February 12, 2019: Journal of Biomaterials Science. Polymer Edition
Balaji Ramachandran, Vignesh Muthuvijayan
Poor haemocompatibility of material surfaces is a serious limitation that can lead to failure of blood-contact devices and implants. In this work, we have improved the haemocompatibility of polyethylene terephthalate (PET) surfaces by immobilizing apyrase/ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) on to the carboxylated PET. NTPDase immobilized PET surfaces scavenge the ADP released by activated platelets, which prevents further platelet activation and aggregation. The surface properties of the modified PET were characterized by scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDAX), and contact angle measurement...
January 30, 2019: Journal of Biomaterials Science. Polymer Edition
Xin Wen, Rashed Almousa, Gregory Anderson, Sungsoo Na, Dong Xie
Antifouling surfaces are specifically crucial to cardiovascular applications. In this study, a polyvinylchloride (PVC) surface was modified by coating a biocompatible and hydrophilic polymer by a mild coating technique. The PVC surface was first activated and then functionalized, followed by coating with the polymer. Results show that the coated hydrophilic polymer significantly reduced 3T3 fibroblast cell adhesion as well as bacteria adhesion. The 3T3 cell adhesion to the polymer-coated surface was reduced to 52-66% as compared to the original PVC surface...
January 27, 2019: Journal of Biomaterials Science. Polymer Edition
Aybüke Garipcan, Petek Korkusuz, Elif Bilgic, Halil M Aydin, Eda Ozturk, Ilyas Inci, Asya Ozkizilcik, K Kamile Ozturk, Erhan Piskin, Ibrahim Vargel
In the present study a combination of Transforming Growth Factor Beta 3 (TGF-β3) and Bone Morphogenetic Protein-2 (BMP-2) loaded gelatin films sandwiched between poly (L-lactide) (PLLA)/poly (ε-caprolactone) (PCL) matrices were produced to enhance bone formation in alveolar bone defects. Osteogenic properties of tissue constructs were tested in alveolar bone defect model in rats. Bone healing was assessed by osteogenic gene expression levels of bone sialoprotein (BSP), alkaline phosphatase (ALP), osteonectin (ON, SPARC), osteocalcin (OC), runt-related transcription factor 2 (RUNX2), bone specific alkaline phosphatase (BALP) activity, histomorphometry and microtomography...
January 27, 2019: Journal of Biomaterials Science. Polymer Edition
Jiesheng Xv, Haoying Li, Wenrui Zhang, Guichao Lai, Haoyu Xue, Jianhao Zhao, Mei Tu, Rong Zeng
Zwitterionic polymer is a new generation of anti-fouling materials with its good resistance to protein and bacterial adhesion. Constructing the anti-fouling surfaces with zwitterionic polymer has been regarded as an effective approach for improving the biocompatibility and biofunctionality of clinic devices. Herein, we reported a facile approach to construct a biodegradable anti-biofouling and functionalizable hydrogel coating via photo-immobilization using commercial polyethylene terephthalate (PET) films as the substrate, based on zwitterionic glycidyl methacrylate-phosphorylcholine-chitosan (PCCs-GMA)...
January 27, 2019: Journal of Biomaterials Science. Polymer Edition
Agata Kurzyk, Tomasz Dębski, Wojciech Święszkowski, Zygmunt Pojda
Adipose tissue yields adult adipose stem cells (ASCs) in large quantities via less-invasive methods. These cells are of interest owing to their modulating properties and paracrine activities, which can be harnessed in regenerative medicine. Many studies on the use of rat fat tissue in an autologous animal model have been conducted; however, the different locations to obtain stromal vascular fraction of rat fat depots have not been fully characterized. The purpose of the current study was to identify optimal source of ASC from various locations of rat body...
January 27, 2019: Journal of Biomaterials Science. Polymer Edition
Libing Huang, Kuan Cao, Ping Hu, Yong Liu
How to improve the bioavailability of the Sanguis Draconis (SD) is an important problem in the potential clinical applications. The aim of this study was to develop a drug delivery system to achieve high bioavailability of SD, a drug with poor water solubility. It will promote the research about new formulations of the SD and the other insoluble drugs. In this study, a highly biocompatible hydrophilic polymer, polyvinylpyrrolidone (PVP), was selected as a carrier, mixed with different proportions of SD to produce SD-PVP microfibers by solution electrospinning...
January 27, 2019: Journal of Biomaterials Science. Polymer Edition
Paula Christina Mattos Dos Santos, Paulo Emilio Feuser, Priscilla Barreto Cardoso, Bethina Trevisol Steiner, Emily da Silva Córneo, Rahisa Scussel, Alexandre da Cas Viegas, Ricardo Andrez Machado-de-Ávila, Claudia Sayer, Pedro Henrique Hermes de Araújo
Magnetic nanoparticles encapsulated in biocompatible and biodegradable polymeric matrices are promising materials for biomedical applications, such as transport of antitumoral drugs and cancer treatment by hyperthermia. In this study, biobased poly(thioether-ester), PTEe, was obtained by thiol-ene polymerization and superparamagnetic nanoparticles, MNPs, were successfully incorporated in PTEe nanoparticles by miniemulsification followed by solvent evaporation. MNPs-PTEe nanoparticles with average diameter around 150 nm presented superparamagnetic behavior as confirmed by magnetization curves analysis...
January 4, 2019: Journal of Biomaterials Science. Polymer Edition
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