Journal of Biomaterials Science. Polymer Edition

Jegadevswari Selvarajah, Mohd Fauzi Mh Busra, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus, Yogeswaran Lokanathan
Nasal injury following nasal surgery is an adverse consequence, and prompt treatment should be initiated. Nasal packing, either non-absorbable or absorbable, are commonly used after nasal surgery to prevent bleeding and promote wound healing. In the current study, a novel gelatine sponge crosslinked with genipin was evaluated for suitability to be used as nasal packing and compared to one of the frequently used commercial nasal packing made up of polyurethane. Gelatine at 7%, and 10% (w/v) concentration were crosslinked with varying concentrations of genipin, 0...
May 27, 2020: Journal of Biomaterials Science. Polymer Edition
Ruijuan Zu, Xiaocui Fang, Yuchen Lin, Shilin Xu, Jie Meng, Haiyan Xu, Yanlian Yang, Chen Wang
We report the efforts to construct active targeting quantum dots using receptor-binding peptide for enhanced detection and migration inhibition of cancer cells. Peptide E5 has specific binding with chemokine receptor 4 (CXCR4), which is a transmembrane G-coupled receptor involved in the metastasis of various types of cancers. E5 was introduced to the surface of CdSe/ZnS quantum dots via biotin-streptavidin interactions. The constructed CXCR4-targeting quantum dots (E5@QDs) was observed to display improved detection sensitivity and significantly enhanced binding affinity for CXCR4 over-expressed cancer cells, and the ability to inhibit cancer cells migration induced by CXCL12...
May 18, 2020: Journal of Biomaterials Science. Polymer Edition
Hua Jiao, Sen Song, Kang Zhao, Xinyuan Zhang, Yufei Tang
The biodegradable material poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffold has good biodegradability, but poor biocompatibility limits its application in the biological field. And it can effectively improve its biological activity by compounding with the bone conduction activity material of Barium titanate (BT). The PHBV and piezoelectric material BT were prepared into porous composite scaffolds with porosity of 45-50%. The mechanical properties and electrical properties of BT/PHBV scaffolds were systematically studied...
May 13, 2020: Journal of Biomaterials Science. Polymer Edition
Mohammad Zamanifard, Mohammad Taghi Khorasani, Morteza Daliri, Mahmoud Parvazinia
The reconstruction of the nerve tissue engineering scaffold is always of particular interest due to the inability to recover and repair neural tissues after being damaged by diseases or physical injuries. The primary purpose of this study was obtaining a model used to predict the diameter of the fibers of electrospun polyhydroxybutyrate (PHB) scaffolds. Accordingly, the range of operating parameters, namely the applied voltage, the distance between the nozzle to the collector, and solution concentration, was designed for the electrospinning process at three different levels, giving seventeen experiments...
May 13, 2020: Journal of Biomaterials Science. Polymer Edition
Gajanan Kashinathrao Arbade, Juhi Srivastava, Vidisha Tripathi, Nibedita Lenka, T Umasankar Patro
In this study, poly(ε-caprolactone) (PCL) has been blended with a more hydrophilic poly(ethylene glycol) (PEG) and with a biocompatible block-co-polymer: poly(L-lactide-co-ε-caprolactone-co-glycolide) (PLCG) in order to improve hydrophilicity, biocompatibility and biodegradability of PCL. PCL and the blend solutions were subjected to electrospinning to produce nanofiber scaffolds by the addition of only 1wt% of PEG and PLCG either singly or in combination in PCL to retain the mechanical properties of the scaffolds...
May 13, 2020: Journal of Biomaterials Science. Polymer Edition
Amjad Alagha, Abdulwahab Nourallah, Sahar Alhariri
BACKGROUND: This study aims to achieve the principles of tissue engineering using biopolymers to be applied in the field of vital endodontic treatment to stimulate stem cells and engineering and regeneration of dentin tissue. the polymer blend was loaded with the steroidal anti-inflammatory drug, dexamethasone, and the porous drug-loaded bio-sponge was produced by lyophilization. Bio-sponge, as a direct pulp capping agent, was histologically studied compared to calcium hydroxide Ca(OH)2 in an animal experiment...
May 13, 2020: Journal of Biomaterials Science. Polymer Edition
Emine Bulut
The main objective of this study was to develop an appropriate interpenetrating polymer network (IPN) particulate system from water-soluble polymers such as sodium alginate (NaAlg), poly (vinyl alcohol) (PVA) and methyl cellulose (MC) for the controlled release of flurbiprofen (FBP), a non-steroidal anti-inflammatory drug. Therefore, polymeric IPN beads containing FBP were prepared by crosslinking with glutaraldehyde (GA) as the crosslinking agent and by varying experimental variables such as polymer ratio, crosslinking time and drug/polymer ratio...
May 13, 2020: Journal of Biomaterials Science. Polymer Edition
Saba Delir, Mohammad Sirousazar, Farshad Kheiri
The bionanocomposite hydrogels based on polyvinyl alcohol and egg white (as the matrix) and montmorillonite nanoclay (as reinforcement) were fabricated via the freezing-thawing technique. The prepared bionanocomposite hydrogels were loaded with clindamycin, as an effective antibiotic, to attain new potential wound dressings for healing the infected wounds. The microstructural properties of the bionanocomposite hydrogel wound dressings were characterized using the X-ray diffractometry, transmission electron microscopy, atomic force microscopy and gel fraction measurement...
May 3, 2020: Journal of Biomaterials Science. Polymer Edition
Ling Han, Yan Xu, Xianmin Guo, Chuanyu Yuan, Degong Mu, Ying Xiao
The long circulation time and targeting drug delivery at tumor sites are still the main challenges of nanodrug delivery systems for antitumor activity. Herein, a cancer cell membrane-coated biomimetic nanodrug delivery system was fabricated. The paclitaxel (PTX)-loaded poly(lactic acid) (PLA) nanoparticles (PPNs) were used as the inner cores and 4T1 cancer cell membranes were coated on the surface of PPNs as the outer shells. The biomimetic platform was noted as CPPNs. The CPPNs exhibited proper sizes for the enhanced permeability and retention (EPR) effect and could maintain stability in a simulated physiological environment...
May 2, 2020: Journal of Biomaterials Science. Polymer Edition
Yanchu Li, Chao Huang, Xiaolan Yang, Xin Zhang
Currently, conjunctivitis is treated using ofloxacin eye drop solution, which shows low bioavailability and patient non-compliance. Ofloxacin loaded contact lens can be used to overcome the issues related to eye drop solutions (i.e. low bioavailability and frequent instillation). However, the conventional soaking method shows poor ofloxacin uptake and significantly affect the swelling and optical properties of the contact lenses. The current research investigates the effect of microemulsion on the ofloxacin uptake and its effect on the physical properties of the contact lens along with ofloxacin-release kinetics...
April 30, 2020: Journal of Biomaterials Science. Polymer Edition
Yong Zhao, Jiazhen Li, Fan Leng, Siyao Lv, Wei Huang, Weiqing Sun, Xulin Jiang
Lethal hemorrhage could endanger lives. Although many hemostatic agents are commercially available with good clinical effect, it is necessary to develop novel hemostatic materials with high efficacy, biological safety, low cost, easily preparation and excellent biodegradability and biocompatibility. Here, novel biodegradable and uniform microspheres with regular spherical architecture and porous microstructure were prepared by thermosensitive carboxymethyl chitin (CMCH) with low substitution degree and low deacetylation through physical-crosslinking at high temperature without using any toxic crosslinkers...
April 29, 2020: Journal of Biomaterials Science. Polymer Edition
Jie Liu, Qin Zou, Bin Cai, Jiawei Wei, Chen Yuan, Yubao Li
A novel bilayer fibrous membrane for guided tissue regeneration (GTR) was prepared via two-step electrospinning process, subsequent crosslinking, and surface conjugation with heparin. The bilayer membrane consists of upper layer polycaprolactone/gelatin (PCL/Gel) membrane for soft tissue regeneration and lower layer PCL/Gel/nano-hydroxyapatite (PCL/Gel/n-HA) membrane for hard tissue regeneration. The results indicated that the physicochemical and biological properties of the membrane were strongly influenced by the crosslinking time and by the heparin conjugation...
April 29, 2020: Journal of Biomaterials Science. Polymer Edition
Qianqian Qi, Xianwu Zeng, Licong Peng, Hailiang Zhang, Miao Zhou, Jingping Fu, Jianchao Yuan
Herein, we construct a charge - switchable polymer nano micelles poly (2-(hexamethyl eneimino) ethyl methacrylate) - b - poly (ethylene glycol) monomethyl ether methacrylate) - b - poly (diethyl enetriaminepentaacetic acid methacrylate) - b - poly (1-vinyl imidazole) - b - poly (4-vinyl phenylboronic acid) (PC7A-PEG-DTPA-VI-PBA) in different pH solutions. DOX released faster from micelles in a weakly acidic environment (pH 5.0) than at pH 7.4. In order to enhance the anti-tumor effect, the imidazole functional groups in the polymer were used to coordinate CdSeTe quantum dots (QDs) for photodynamic treatment (PDT)...
April 29, 2020: Journal of Biomaterials Science. Polymer Edition
Wenwen Zhao, Zhiyun Du, Jiajin Fang, Lei Fu, Xin Zhang, Qing Cai, Xiaoping Yang
Electrospinning is a common and effective technology used for the fabrication of biomimetic nanofibers targeting tissue regeneration applications. As for cartilage regeneration, nanofibers containing natural components derived from cartilage extracellular matrix (ECM) are preferred. However, it is not easy an task to electrospin glycosaminoglycan (GAG) like hyaluronic acid (HA) and chondroitin sulfate (CS) by themselves. In this study, HA and/or CS were co-electrospun with poly(L-lactide) (PLLA) or PLLA/gelatin (1:1 in weight ratio) to obtain GAG-containing composite nanofibers...
April 29, 2020: Journal of Biomaterials Science. Polymer Edition
Yuichi Ohya, Kazuki Nishimura, Hiromichi Sumida, Yuta Yoshizaki, Akinori Kuzuya, Atsushi Mahara, Tetsuji Yamaoka
Small-caliber artificial blood vessels with inner diameters of smaller than 4 mm have not been put into practical use because of early thrombus formation and graft occlusion. To realize small-caliber artificial blood vessels with anti-thrombus property and long-term patency, one of the promising approaches is endothelialization of the lumen by tissue engineering approaches. Integrin α4β1 on the endothelial cell membrane is known to act as a receptor for Arg-Glu-Asp-Val (REDV) tetra-peptide, and this peptide can be used as a specific ligand to introduce endothelial cell attachment onto the surfaces of polymer scaffold...
April 27, 2020: Journal of Biomaterials Science. Polymer Edition
Mariana Ribeiro Farah Mazzilli, Jéssica Aparecida Ribeiro Ambrósio, Daniele da Silva Godoy, Alexandro da Silva Abreu, Janicy Arantes Carvalho, Milton Beltrame Junior, Andreza Ribeiro Simioni
Recently several scientific-technological advances in the health area have developed. Among them, we can highlight research addressing nanoscience and nanotechnology focusing on the development of formulations for the cancer treatment. This work describes the synthesis and characterization of bovine serum albumin (BSA) polyelectrolytic nanoparticles for controlled release using silicon dihydroxide phthalocyanine [SiPc (OH)2 ] as a photosensitizer model for application in Photodynamic Therapy (PDT). BSA nanoparticles were prepared by the one-step desolvation process and the nanoparticulate system was coated with polyelectrolytes using poly-(4-styrene sulfonate - PSS) as a strong polyanion and polyallylamine hydrochloride (PAH) as a weak polycation by the technique self-assembling layer-by-layer (LbL)...
April 23, 2020: Journal of Biomaterials Science. Polymer Edition
M A Kaplan, K V Sergienko, A A Kolmakova, S V Konushkin, A S Baikin, A G Kolmakov, M A Sevostyanov, A V Kulikov, V E Ivanov, K N Belosludtsev, S S Antipov, M Yu Volkov, N N Shusharina, E V Karaduleva, V A Kozlov, A V Simakin, S V Gudkov
The novelty of the work lies in the creation and study of the physical and biological properties of biodegradable polymer coatings for stents based on poly (lactic-co-glycolic acid) (PLGA). Polymer coatings are capable of prolonged and directed release of molecules with a high molecular weight, in particular protein molecules of prourokinase (m.w. 54 kDa). A technology has been developed to create coatings having a relative elongation of 40 to 165% and a tensile strength of 25 to 65 MPa. Coatings are biodegradable, the rate of degradation of the polymer in an isotonic solution varies in the range of 0...
April 23, 2020: Journal of Biomaterials Science. Polymer Edition
Haiying Gao, Chenghui Huang, Youqi Zhu, Xilan Ma, Chuanbao Cao
Silk fibroin (SF) porous scaffolds provide mechanical support and biochemical signals to encourage cell attachment and modify biological performance. The available methods for the preparation of SF scaffolds are still required. The crosslinkers used are likely to impact the biocompatibility. Herein, water-insoluble SF scaffolds were prepared by physical methods. The phosphate solution promoted SF molecules aggregate from SF/heparin mixed solution. Then SF scaffolds were prepared in centrifuge tubes under different centrifugal speed...
April 18, 2020: Journal of Biomaterials Science. Polymer Edition
Yunchao Wang, Qing Liu, Tongyi Men, Ye Liang, Haitao Niu, Jianning Wang
Circulating bladder tumor cells provide significant information for cancer diagnosis, tumor staging and personalized cancer therapy. Previous studies have reported various methods for capturing circulating tumor cells; however, capturing circulating tumor cells remain a challenge. Here, we present a microfluidic chip with high specificity and capture yields that we refer to as a bladder cancer diagnosis chip. We show that this chip can be used to effectively capture circulating bladder cancer cells based on antibody-BCMab1, a monoclonal antibody that binds to aberrantly glycosylated integrin a3b1...
April 10, 2020: Journal of Biomaterials Science. Polymer Edition
Tingxiao Li, Lei Wang, Yifan Huang, Binjie Xin, Shuang Liu
Beaded nanofiber is a promising fibrous structure could act as drug delivery system with sustained drug release for regulating cell behaviors used in tissue engineering. Poly (L-lactic acid-co-ε-caprolactone) (PLCL) beaded nanofiber with core-shell structure (130 ± 30 nm) was fabricated and bovine serum albumin (BSA) was encapsulated into the inner layer. The surface morphology and characteristic were evaluated by scanning electron microscopy (SEM), inverted fluorescence microscopy and water contact angle test...
April 8, 2020: Journal of Biomaterials Science. Polymer Edition
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