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Journal of Biomaterials Science. Polymer Edition

M Ebtedaei, K Jalili, N Alizadeh, H Ghaleh, F Abbasi
In this work, well-defined poly(dimethylsiloxane)- b -poly(oligo (ethylene glycol) methacrylate) (PDMS- b -POEGMA) amphiphilic block copolymers were synthesized and their effect on human dermal fibroblast were investigated. Anionic ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) were used to synthesis the block copolymers. The molecular weight of synthesized copolymers ranged from 1000 to 2300 Da by changing the number of both PDMS and POEGMA units. It was found that the copolymer having low molecular weight decreased the fibroblast viability and proliferation by inducing apoptosis...
July 10, 2019: Journal of Biomaterials Science. Polymer Edition
Fernando Javier Aguilar-Pérez, Rossana Faride Vargas-Coronado, José Manuel Cervantes-Uc, Juan Valerio Cauich-Rodríguez, Raúl Rosales-Ibañez, José Antonio Rodríguez-Ortiz, Yadir Torres-Hernández
Polyurethanes (PU) foams with titanium particles (Ti) were prepared with castor oil (CO) and isophorone diisocyanate (IPDI) as polymeric matrix, and 1, 3 and 5 wt.% of Ti. Composites were physicochemically and mechanically characterized and their biocompatibility assessed using human dental pulp stem cells (HDPSC). PU synthesis was confirmed by FTIR, but the presence of Ti was detected by RAMAN, X-ray diffraction (peak at 2θ = 40.2º) and by EDX-mapping. Materials showed three decomposition temperatures between 300 °C and 500 ºC and their decomposition were not catalyzed by Ti particles...
June 24, 2019: Journal of Biomaterials Science. Polymer Edition
Debora Ferreira Laurito Friend, Maria Elena Leyva González, Mirta Mir Caraballo, Alvaro Antonio Alencar de Queiroz
Nowadays the development of sustainable technologies for the effective production of polymeric materials that can be used as biomaterials will be of importance. In this work, cellulose (CEL) was purified from potato peel waste (PPW) and used to produce electrospun nanofibers for tissue engineering applications. The purified CEL was solubilized in copper ethylenediamine (Cuen) and the electrospun nanofibers was produced through electrospinning technique in diameter range of 250-500 nm at electrical field strength of 20 kV...
June 24, 2019: Journal of Biomaterials Science. Polymer Edition
Zhen Yue, YuJu Che, Zhiwen Jin, Sisi Wang, Qinglin Ma, Qian Zhang, Yebang Tan, Fanjun Meng
A thermo- and pH-sensitive hydrogel was prepared by a facile free aqueous radical copolymerization of PEGMA and AAc without any crosslinkers for controlled drug delivery. The successful fabrication of hydrogels was confirmed by Fourier transform infrared spectroscopy (FT-IR) and thermo gravimetric analysis (TGA) measurements. The morphological, mechanical and swelling properties of the obtained hydrogels were studied systematically. The results showed that the morphological and mechanical behaviors of the resultant hydrogels were strongly affected by the content of AAc...
June 20, 2019: Journal of Biomaterials Science. Polymer Edition
Jéssica Aparecida Ribeiro Ambrosio, Bruna Cristina Dos Santos Pinto, Daniele da Silva Godoy, Janicy Arantes Carvalho, Alexandro da Silva Abreu, Bruna Graziele Marques da Silva, Leonardo de Carvalho Leonel, Maricilia Silva Costa, Milton Beltrame Junior, Andreza Ribeiro Simioni
Gelatin nanoparticles (GN) with an intrinsic antimicrobial activity maybe a good choice to improve the effectiveness of photodynamic antimicrobial chemotherapy (PACT). The aim of this study was to development gelatin nanoparticles loaded methylene blue (GN-MB) and investigate the effect of GN-MB in the Candida albicans growth by PACT protocols. The GN and GN-MB were prepared by two-step desolvation. The nanoparticulate systems were studied by scanning electron microscopy and steady-state techniques, the in vitro drug release was investigated, and we studied the effect of PACT on C...
June 19, 2019: Journal of Biomaterials Science. Polymer Edition
Joyce Pinto, Madiha Ahmad, Bharath Raja Guru
Fluocinolone acetonide (FA), a glucocorticoid is used to treat inflammation in the posterior segment of the eye. Due to short half-life and body clearance, it will not be able to give therapeutic effect for long time with a single injection. Formulating FA nanoparticles (NPs) or PEG conjugates can be an effective way to overcome these disadvantages. We prepared two formulations, FA loaded in PLGA nanoparticles (NPs-FA) and FA conjugated to linear PEG (PEG-FA). The NPs-FA were characterised for size and zeta potential using particle size analyser and shape and morphology by using scanning electron microscope (SEM)...
June 19, 2019: Journal of Biomaterials Science. Polymer Edition
Mime Kobayashi, Ryosuke Honda, Tsuyoshi Ando, Masao Tanihara
We have developed biocompatible scaffolds that enable cell fate control with visible light. The scaffolds are based on synthetic collagen-like polypeptide, poly(prolyl-hydroxyprolyl-glycyl) {poly(Pro-Hyp-Gly)} which has been used for cosmetics and other healthcare applications. Bioactive peptides were conjugated to the scaffolds via photoactivation reaction utilizing 488 nm visible light. In addition, the use of a photocleavable crosslinker enables dissociation of chemical moieties by 405 nm laser irradiation...
June 14, 2019: Journal of Biomaterials Science. Polymer Edition
Sugandha Chahal, Anuj Kumar, Fathima Shahitha Jahir Hussian
Electrospinning is a promising and versatile technique that is used to fabricate polymeric nanofibrous scaffolds for bone tissue engineering. Ideal scaffolds should be biocompatible and bioactive with appropriate surface chemistry, good mechanical properties and should mimic the natural extracellular matrix (ECM) of bone. Selection of the most appropriate material to produce a scaffold is an important step towards the construction of a tissue engineered product. Bone tissue engineering is an interdisciplinary field, where the principles of engineering are applied on bone-related biochemical reactions...
June 11, 2019: Journal of Biomaterials Science. Polymer Edition
Tianyu Lan, Qianqian Guo, Xiangchun Shen
Bacterial infection has become a serious clinical concern due to the emergence of drug-resistance and biofilm formation. Therefore, it is in great demand to develop efficient antimicrobial agents to treat bacterial infection without using antibiotics. Herein, we successfully prepared four quaternized ammonium PEI (QPEI: PEI1200-C2, PEI1200-C4, PEI1200-C6 and PEI1200-C8) using the commercial available PEI1200. Both PEI and four QPEI presented broad-spectrum antimicrobial activity against Gram-negative bacteria (E...
June 10, 2019: Journal of Biomaterials Science. Polymer Edition
Bruna Leonel Carlos, Jéssica Suzuki Yamanaka, Gabriela Rezende Yanagihara, Ana Paula Macedo, Plauto Christopher Aranha Watanabe, João Paulo Mardegan Issa, Rondinelli Donizetti Herculano, Antônio Carlos Shimano
Natural latex extracted from Hevea brasiliensis is one of the materials pointed out as potential tissue regenerators. The use of latex-based membranes in bone regeneration might be an alternative to stimulate bone formation. The aim of this study was to evaluate the effects of latex membranes in guided bone regeneration of defects produced in long bones of rats. Sixty rats were equally divided into latex and control groups, and each group was subdivided into two subgroups according to treatment duration of one and four weeks...
June 10, 2019: Journal of Biomaterials Science. Polymer Edition
Xiaodong Xu, Jiping Zhou, Chen Feng, Yani Jiang, Qi Zhang, Hongcan Shi
Tissue scaffolds need to have anisotropic mechanical properties and a porous structure to meet the needs of different tissues and organs. This report presents results of a study on an especially-designed 3D printing method with oxidized nanocellulose and gelatin, analyzes the servo principle of pneumatic condensing extrusion 3D printer, and proposes a hexagonal algorithm. For the purpose of this study, a printing process file was written by G code, physical and mechanical performance of the 3D scaffolds was evaluated with Solidworks simulation, the porous structure and pressure-pull performance of the printed 3D scaffolds was observed by SEM, and experiments were conducted to measure their bio-compatibility...
June 5, 2019: Journal of Biomaterials Science. Polymer Edition
Fei Xu, Yinfang Wu, Yiyi Zhang, Ping Yin, Changyun Fang, Jiawei Wang
The aim of this study was to investigate the influence of the in vitro osteogenic differentiation status on the in vivo bone regeneration of cell/chitosan microspheres qualitatively and quantitatively. To this end, rat bone-marrow-derived mesenchymal stromal cells (BMSCs) were seeded onto apatite-coated chitosan microspheres. The constructs were osteogenically differentiated for 0, 7, 14, and 21 days followed by calvarial defect implantation in vivo for up to 8 weeks. In vitro studies showed that BMSCs in the constructs proliferated from day 0 to day 7...
June 4, 2019: Journal of Biomaterials Science. Polymer Edition
Xue Mi, Xingrui Wang, Chen Xu, Yuying Zhang, Xiaoyue Tan, Jianping Gao, Yu Liu
Modification of reduced graphene oxide nanosheets (MrGO) is an effective strategy to increase their dispersability and hydrophobicity in order to fabricate alginate microspheres via crosslingking stable Pickering alginate emulsions stabilized by MrGO, in where alginate aqueous solution is the dispersed phase and an organic solvent the continuous phase. The effects of MrGO concentration, water/oil ratio and salt concentration on the alginate spheres were investigated, and the results shows that MrGO could efficiently stabilize alginate spheres in suitable conditions and increasing the MrGO concentration or the oil/water ratio was favorable to the formation of alginate spheres...
June 4, 2019: Journal of Biomaterials Science. Polymer Edition
Gizem Uzunoğlu, Duygu Çimen, Nilay Bereli, Kemal Çetin, Adil Denizli
In this study, low molecular weight heparin immobilized P(HEMA) cryogels, were fabricated for the removal of LDL-C in hypercholesterolemic human plasma. After characterization studies for P(HEMA) cryogels, effects of the parameters including medium pH, CNBr concentration, heparin concentration and contact time on heparin immobilization were investigated. Blood compatibility and cell adhesion tests were also performed, and platelet and leucocyte loss for P(HEMA)-Hp cryogels were found to be 2.95% and 4.91%, respectively...
June 3, 2019: Journal of Biomaterials Science. Polymer Edition
Cijun Shuai, Yong Xu, Pei Feng, Liang Xu, Shuping Peng, Youwen Deng
Mesoporous silica Santa Barbara Amorphous-15 (SBA15) and nano-hydroxyapatite (nHA) were introduced in poly-l-lactic acid (PLLA) scaffold fabricated by selective laser sintering to co-enhance the bioactivity. On the one hand, the active elements silicon and calcium released respectively by the degradation of SBA15 and nHA were favorable for stimulating cell response. On the other hand, the hydrated silica gel layer derived from SBA15 could adsorb calcium ions released from nHA, thereby co-promoting apatite nucleation and growth...
June 3, 2019: Journal of Biomaterials Science. Polymer Edition
Xiang Fu, AhmedM Al-Jumaily, Maximiano Ramos, Ata Meshkinzar, Xiyong Huang
With the rapid development of wearable devices in recent years, stretchable strain sensors based on electrically conductive composites have attracted a great deal of attention owing to their good stretchability and piezoresistivity. However, due to the intrinsic restriction of these types of composites, the conventional stretchable strain sensors cannot do well in all aspect of sensing performance. A stretchable strain sensor based on carbon nanotubes/poly(dimethylsiloxane) composite with the serpentine shape was devised and fabricated...
June 3, 2019: Journal of Biomaterials Science. Polymer Edition
Li Zhang, Chunxia Zhang, Wenwen Zhang, Honghong Zhang, Zhaosheng Hou
In this paper, a series of medical poly(ester-urethane)s (PEUs) with varying uniform-size hard segment content were prepared via one-step chain extension of poly( ε -caprolactone)s with aliphatic urethane diisocyanate, and the corresponding films were obtained by solvent evaporation technique. The chemical structures of polymers were confirmed by 1 H NMR, FT-IR and GPC. The effect of uniform-size hard segment content on the physicochemical properties of PEU films, including thermal properties, mechanical properties, crystallization behavior, water-swelling behavior and in vitro degradability, was extensively researched...
May 29, 2019: Journal of Biomaterials Science. Polymer Edition
Xuan-Qi Zheng, Jin-Feng Huang, Jia-Liang Lin, De-Jun Yang, Tian-Zhen Xu, Dong Chen, Xin-Jie Zan, Ai-Min Wu
The repair of critical-size bone defect remains a challenge for orthopedic surgeons. With the advent of an aging society and their accompanying chronic diseases, it is becoming more difficult to treat bone defects, especially large segmental bone defects that are caused by trauma, tumors, infections, and congenital malformations. New materials and technologies need to be developed to address these conditions. 3D bioprinting is a novel technology that bridges the biomaterial and living cells and is an important method in tissue engineering projects...
May 24, 2019: Journal of Biomaterials Science. Polymer Edition
Jie Wang, Xin Liu, Tao Jin, Haifeng He, Lei Liu
Cellulose is a kind of natural polymer material, which is composed of bundle-like fibrils. By peeling the fibrils layer by layer, the size of cellulose can be nanocrystallized, and nanofibers and nanocrystals with unique and potentially useful features can be prepared. As an emerging functional polymer material, nanocellulose has become a research hotspot in the field of technology. This review discusses the preparation of nanocellulose, including the commonly used hydrolysis, oxidation, physical and environmentally friendly ionic liquid methods...
May 24, 2019: Journal of Biomaterials Science. Polymer Edition
Namita Ojah, Jyotishikha Deka, Saurav Haloi, Raghuram Kandimalla, Dolly Gogoi, Tapas Medhi, Manabendra Mandal, Gazi Ameen Ahmed, Arup Jyoti Choudhury
The current study is designed to develop mechanically strong chitosan (Cs) coated silk based drug delivery system loaded with amoxicillin trihydrate (AMOX). For this purpose, surface modification of Antherarea assama silk fibroin (AASF) yarn is carried out using dielectric barrier discharge (DBD) oxygen (O2 ) plasma at atmospheric pressure followed by coating with drug incorporated Cs (AASF/O2 /Cs-AMOX). It is observed that O2 plasma treatment results in altering surface chemistry and morphology of silk fibroin surface which subsequently improves mechanical properties of AASF/O2 /Cs-AMOX yarn...
May 21, 2019: Journal of Biomaterials Science. Polymer Edition
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