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Journal of Biomaterials Science. Polymer Edition

Dongni Li, Bo Gao, Qian Duan
Three aluminum alkyl complexes bearing porphyrin derivatives were synthesized by pyrrole derivatives and benzaldehyde derivatives. These complexes were characterized by NMR and elemental analysis. These complexes are used for racemic-lactide polymerization. In the ring-opening polymerization of racemic lactide, complex 3(2,3,7,8,12,13,17,18-octamethyl-5,10,15,20-tetraphenylporphyrin aluminum methyl, R1 =H, R2 =Me in Scheme 2) with isopropanol showed the highest stereoselectivity, and an isotactic polylactide with a Pm of 0...
April 8, 2019: Journal of Biomaterials Science. Polymer Edition
Chenzhi Lai, Guodong Song, Bo Zhao, Hongquan Wang, Bo Pan, Xiaoshuang Guo, Xiaolei Jin, Xianlei Zong
INTRODUCTION: Acellular dermal matrix (ADM) is commonly used to treat burn injuries and wounds. In this study, we aimed to analyze the structural and biomechanical characteristics of an ADM from human scars. METHODS: We randomly selected human mature scars, human proliferative scars, and human normal skin as experimental specimens. Split-thickness dermal grafts were obtained using a free-hand graft knife. Samples were subjected to cell lysis to obtain ADMs. Structural analysis was performed via light microscopy, fluorescence microplate reader and scanning electron microscopy...
April 5, 2019: Journal of Biomaterials Science. Polymer Edition
Yu Bai, Sidi Li, Xueping Li, Xing Han, Yang Li, Jin Zhao, Juntao Zhang, Xin Hou, Xubo Yuan
Proteins are ideal raw materials for preparing biomaterials with better biocompatibility and larger elastic range than synthetic polymers. Injectable hydrogels are highly desired for minimal invasive strategies. At present, preparation of injectable hydrogels with good comprehensive properties using natural materials receives more and more attention. In this paper, BSA was treated with urea and glutathione to prepare bovine serum albumin hydrogel controlled by two dynamic equilibrium bonds (disulfide and hydrogen bonds)...
April 5, 2019: Journal of Biomaterials Science. Polymer Edition
Yeyzon Cruz, Efrén Muñoz, E Y Gomez-Pachón, Juan Morales-Corona, Jesús Olayo-Lortia, R Olayo, Roberto Olayo-Valles
Polymeric scaffolds prepared from polycaprolactone (PCL), PCL-collagen and PCL-elastin were prepared by electrospinning. The scaffolds were coated by plasma polymerization of pyrrole doped with iodine, to improve cellular adhesion and fibroblast proliferation. The morphology, composition, and crystalline structure of the scaffolds were characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy, small- and wide-angle X-ray scattering, thermogravimetric analysis and differential scanning calorimetry...
April 4, 2019: Journal of Biomaterials Science. Polymer Edition
Xue-Na Zou, Xiao Han, Qian Zhang, Jun-Jiao Yin, Li-Qiang Chu
Herein, we report on a robust approach to fabricate antibacterial nanocomposite coating simply by immersing poly(oligo(ethylene glycol) methacrylate) (POEGMA) brush into a silver perchlorate solution without using any external reducing agents. The POEGMA brush of 48.3 nm in thickness is prepared via surface-initiated atom transfer radical polymerization method. Field-emission scanning electron microscope and Raman measurements indicate that silver nanoparticles of 14 ∼ 25 nm in diameter are successfully embedded into the POEGMA brush...
April 2, 2019: Journal of Biomaterials Science. Polymer Edition
Aimin Tang, Jing Li, Jiao Li, Shan Zhao, Wangyu Liu, Tingting Liu, Jufang Wang, Yingyao Liu
Three-dimensional (3D) porous scaffolds made of biopolymers have attracted significant attention in tissue engineering applications. In this study, cellulose-nanofibers/polyethylene glycol diacrylate (CNFs/PEGDA) mixture, a novelty 3D material, was prepared by physical mixing the CNFs with a waterborne photopolymerizable acrylic resin (PEGDA). Then the CNFs/PEGDA mixture was used to fabricate 3D cytocompatibility CNFs/PEGDA hydrogel scaffold by stereolithograph(SLA)process. The CNFs/PEGDA hydrogels were shaped by SLA, and then the aerogel scaffolds were prepared by the freeze-drying of hydrogels...
April 2, 2019: Journal of Biomaterials Science. Polymer Edition
Shi Huan Han, Su Hyun Jung, Jae Hyup Lee
The specific objective of this study was to evaluate whether rhBMP-2-loaded bio-scaffolds can be used as effective rhBMP-2 carriers in the implantation of bone-defect sites or poor bone quality in host bone. The rhBMP-2 release pattern test showed slow results in both groups, and a 1:9 ratio composition with a high water-absorption rate was selected for in vivo study. All animals euthanized after 9 weeks. The new bone formation and bone quantity and quality of fibular samples were examined. The results showed that the rhBMP-2 powder gel composite improved the new bone formation in the cortical bone and the marrow space...
April 2, 2019: Journal of Biomaterials Science. Polymer Edition
Chengcheng Zhu, Haibo Yang, Liang Shen, Zhuoyuan Zheng, Zhao, Qingguo Li, Fengbin Yu, Lian Cen
The current study, inspired by the immunosuppressive property of rapamycin (Rapa) and the benefit of microspheres both as drug delivery system and cell carriers, was designed to develop an efficient Rapa delivery system with tunable controllability to facilitate its local administration. A capillary-based two-phase microfluidic device was designed to prepare monodisperse poly(lactide-co-glycolide) (PLGA) microspheres to load Rapa (PLGA-Rapa-M). The physical and chemical properties of PLGA-Rapa-M were characterized, and the Rapa loading capacity and release profile were explored...
April 1, 2019: Journal of Biomaterials Science. Polymer Edition
Meltem Koca Esentürk, Semra Akgönüllü, Fatma Yılmaz, Adil Denizli
Human serum albumin (HSA) is a major blood plasma protein also found in urine where its existence may be a marker of some types of liver or kidney dysfunction. Herein, we fabricated a novel surface plasmon resonance (SPR) nanosensor for selective, sensitive, and label-free microalbumin detection both in aqueous and urine sample solutions. Firstly, HSA-imprinted nanoparticles were synthesized, which consist of ethylene glycol dimethacrylate and N-methacryloyl-L-leucine as a cross-linker and functional monomer...
March 28, 2019: Journal of Biomaterials Science. Polymer Edition
Yanling Dai, Siyuan Dai, Xiaohui Xie, Jianping Ning
Systemic anticoagulation is not suitable for hemodialysis (HD) patients with a high risk of bleeding in the clinic. An HD membrane that provides a localized anticoagulation membrane surface may be a promising strategy to solve this intractable problem for HD patients. Herein, we modified a nonthrombogenic polyethersulfone (PES) dialyzer membrane by grafting argatroban (AG) and methoxy polyethylene glycol amine (mPEG-NH2 ) via a polydopamine (PDA) strategy. The PES substrates were immersed in an alkaline dopamine solution for 24 h, and then, AG and mPEG-NH2 were sequentially grafted covalently onto the resultant membrane...
March 25, 2019: Journal of Biomaterials Science. Polymer Edition
Yepeng Zhang, Jie Zhao, Guangmin Yang, Yu Zhou, Wentao Gao, Guangyan Wu, Xiaoqiang Li, Chun Mao, Tao Sheng, Min Zhou
Bioresorbable vascular scaffolds are expected to replace the traditional metal stent, avoiding the long-term complications of metal stents. However, it is hard for the traditional scaffold manufacturing process to meet the requirements of individualized treatment for vascular lesions, which requires different morphologies. Here, we used a new method of scaffold manufacturing, three-dimensional printing technology, to prepare bioresorbable vascular scaffolds. The fabricated scaffold was loaded with sirolimus mixed with scaffold preparation material for slow drug release...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Junying Li, Xiaoliang Li, Pengfei Yang, Qiuhong Mou, Mingyi Zhang, Yunqiao Ding, Jiachun Li
PSiQAEp-GH polymers were synthesized by the reaction of gelatin hydrolysate (GH) and polysiloxane quaternary ammonium salts containing epoxy group (PSiQAEp) with different molecular weight from 3147 to 12996. The results of FTIR, 1 H NMR and 13 C NMR showed that the reaction occurred between primary amino group of arginine in GH and epoxy of PSiQAEp. The XRD and DSC studies showed that the degree of short-range order of PSiQAEp-GH reduced and its glass transition temperature (Tg) lowered more than 10 °C compared with GH...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Nor Hazwan Ali, Mohd Cairul Iqbal Mohd Amin, Shiow-Fern Ng
Biofilms comprise bacteria attached to wound surfaces and are major contributors to non-healing wounds. It was found that the increased resistance of biofilms to antibiotics allows wound infections to persist chronically in spite of antibiotic therapy. In this study, the reduced form of graphene oxide (rGO) was explored as plausible antibiofilm agents. The rGO was synthesized via reducing the functional groups of GO. Then, rGO were characterized using zetasizer, X-ray photoelectron spectroscopy, UV-Vis spectroscopy and FESEM...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Yadong Wu, Fang Wang
Degradable hemostatic agents are the essential materials for controlling the hemorrhage. Hemostatic oxidized cellulose carboxylate sodium fiber (OCCSF) has been synthesized via a simple neutralization reaction between water-insoluble oxidized cellulose fiber (OCF) and NaOH. Importantly, the degradation mechanisms of OCCSF have been investigated in vitro assay. Chemical structure of the material is tested by using FT-IR and NMR, and no obvious change was detected before and after degradation. Degree of polymerization (DP) of OCCSF declines with prolonging the degradation period, accompanying with the decrease in carboxyl content (CC), so that it could be concluded that OCCSF may undergo decarboxylation degradation process...
March 21, 2019: Journal of Biomaterials Science. Polymer Edition
Ashley Thomas
Macroporous composite scaffolds comprising of gelatin and glass ceramic has been fabricated and characterized for bone tissue engineering applications. Gelatin scaffold with varying glass-ceramic content was fabricated using lyophilization technique. The microstructure, compressive strength, bioactivity, biodegradation and biocompatibility of the fabricated scaffolds were evaluated. The scaffolds presented macroporous pore size with porosity varying from 79 to 84%. The compressive strength was enhanced by glass ceramic addition and the scaffolds exhibited strength in the range of 1...
February 25, 2019: Journal of Biomaterials Science. Polymer Edition
Janicy Arantes Carvalho, Alexandro da Silva Abreu, Antonio Claudio Tedesco, Milton Beltrame Junior, Andreza Ribeiro Simioni
In this study, zinc phthalocyanine (ZnPc) was loaded onto gelatin nanoparticles functionalized with polyelectrolytes (polystyrene sulfonate/polyallylamine hydrochloride) by layer-by-layer (LbL) assembly. The process yield and the encapsulation efficiency were 76.0% ± 2.5 and 86.0% ± 1.8, respectively. The functionalized photosensitive gelatin nanoparticles (FPGN) had a mean diameter of 396.5 ± 45.8 nm, narrow distribution size with a polydispersity index of 0.106. The obvious switching of zeta potential indicates successful alternating deposition of the polyanion PSS and polycation PAH directly on the gelatin nanoparticles...
February 19, 2019: Journal of Biomaterials Science. Polymer Edition
Juliana Martínez Rodríguez, Sandra J Renou, María B Guglielmotti, Daniel G Olmedo
High density polyethylene (HDPE) is a synthetic biomaterial used as a three-dimensional scaffold for bone defect reconstruction. Reports differ with regard to its biological response, particularly its osteoconductive capacity. The aim of the present work was to histologically and histomorphometrically evaluate tissue response to porous HDPE. An in vivo study was conducted in rat tibia to evaluate osteogenic capacity, angiogenesis, inflammatory response, and the presence of multinucleated giant cells 14 and 60 days post-biomaterial implantation...
February 19, 2019: Journal of Biomaterials Science. Polymer Edition
Irene Carmagnola, Valeria Chiono, Martina Abrigo, Elia Ranzato, Simona Martinotti, Gianluca Ciardelli
Poly(L-lactic) acid (PLLA) has been widely employed in tissue engineering due to its mechanical properties, biodegradability and biocompatibility. The layer-by-layer (LbL) technique was here proposed as a simple method to impart bioactivity to the surface of PLLA substrates. Aminolysis treatment was applied to introduce amino groups on the surface of PLLA solvent cast films. Then, PLLA films were coated with heparin (HE)/chitosan (CH) multilayer by the LbL technique. Each functionalization step was characterized through physico-chemical and morphological analyses...
February 18, 2019: Journal of Biomaterials Science. Polymer Edition
Emel Tamahkar, Monireh Bakhshpour, Adil Denizli
The aim of this work is to develop drug carrier system with high loading capacity and controlled drug release profile for antibiotic release. For this purpose, composite molecularly imprinted nanofibers were prepared via in-situ graft polymerization of methacrylic acid as a monomer, N,N'-methylene bisacrylamide as a crosslinker and gentamicin sulfate as a template molecule onto surface-modified bacterial cellulose nanofibers. Gentamicin imprinted microparticles were fabricated onto bacterial cellulose nanofibers resulting in the formation of composite BC nanofibers...
February 18, 2019: Journal of Biomaterials Science. Polymer Edition
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February 14, 2019: Journal of Biomaterials Science. Polymer Edition
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