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International Journal of Impotence Research

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https://read.qxmd.com/read/30755724/variation-in-collagenase-clostridium-histolyticum-practice-patterns-a-survey-of-issm-members
#1
T A Masterson, A Galante, M Butaney, A Pastuszak, H Sadeghi-Nejad, R Ramasamy
Collagenase clostridium histolyticum (CCH, Xiaflex, Xiapex) is the only FDA-approved medication for treatment of Peyronie's disease. It is unclear how practitioners actually use CCH in their own practices. The objectives of the study were: (1) to identify variability in practice patterns for CCH among practitioners, (2) to assess adherence to the package insert instructions, and (3) to evaluate whether provider satisfaction was associated with adherence to instructions. A 30-question online survey was distributed to 1270 members of the International Society for Sexual Medicine (ISSM) from the EU, USA, Canada and Australia...
February 12, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30745568/re-limited-success-with-clostridium-collagenase-histolyticum-following-fda-approval-for-the-treatment-of-peyronie-s-disease
#2
EDITORIAL
Thomas Masterson, Premal Patel, Ranjith Ramasamy
No abstract text is available yet for this article.
February 11, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30745567/postoperative-vacuum-therapy-following-ams%C3%A2-lgx-700%C3%A2-inflatable-penile-prosthesis-placement-penile-dimension-outcomes-and-overall-satisfaction
#3
Gabriele Antonini, Ettore De Berardinis, Gian Maria Busetto, Francesco Del Giudice, Benjamin I Chung, Simon L Conti, Matteo Ferro, Gennaro Musi, Ramiro Fragas, Ottavio De Cobelli, Isabella Sperduti, Martin S Gross, Paul E Perito
Penile shortening after inflatable penile prosthesis for erectile dysfunction is a common postoperative patient complaint and can reduce overall satisfaction with the procedure. In this prospective study we report our results regarding penile dimensions and patient satisfaction outcomes after 1 year of follow-up from AMS™LGX700® penile prosthesis implant with 6 months of vacuum erectile device therapy. Seventy-four selected patients with medically refractory erectile dysfunction underwent AMS™ LGX 700® IPP placement...
February 11, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30742045/which-psychosocial-variables-affect-drive-the-most-analysis-of-sexual-desire-in-a-group-of-italian-men
#4
Filippo Maria Nimbi, Francesca Tripodi, Roberta Rossi, Paolo Maria Michetti, Chiara Simonelli
Literature lacks wide studies on variables affecting sexual desire in men. Aim of this study was to explore the role of some psychosocial variables such as quality of life, sexual function, distress, sexual satisfaction, psychological symptoms, emotions, alexithymia, couple adjustment, sexism, dysfunctional beliefs, cognitive schemas, and modes. A self-administered survey reached 450 heterosexual Italian men (age 31.36 ± 10.73). Results showed "orgasmic function", "lack of erotic thoughts", "erection concerns thoughts", "hostile sexism", and "positive affect" as the main sexual desire predictors...
February 11, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30742044/controversies-in-low-intensity-extracorporeal-shockwave-therapy-for-erectile-dysfunction
#5
Hailiu Yang, Allen D Seftel
No abstract text is available yet for this article.
February 11, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30718828/current-practice-in-the-management-of-ischemic-priapism-an-anonymous-survey-of-issm-members
#6
Mohit Butaney, Nannan Thirumavalavan, Dayron Rodriguez, Martin S Gross, Ricardo Munarriz
Penile shunting is the standard of care in management of ischemic priapism refractory (IPR) to non-surgical interventions. Due to high rates of impotence, corporal fibrosis, and loss of penile length, recent literature suggests these patients benefit from immediate penile prosthesis (PP) placement. An IRB-exempt anonymous electronic survey of the 2168 members of the International Society for Sexual Medicine (ISSM) was conducted. The survey included demographic information, confidence, and experience-related management of IPR...
February 4, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30718827/correction-epalrestat-an-aldose-reductase-inhibitor-restores-erectile-function-in-streptozocin-induced-diabetic-rats
#7
Bai-Bing Yang, Zhi-Wei Hong, Zheng Zhang, Wen Yu, Tao Song, Lei-Lei Zhu, He-Song Jiang, Guo-Tao Chen, Yun Chen, Yu-Tian Dai
This Article was originally published under Nature Research's License to Publish, but has now been made available under a CC BY 4.0 license. The PDF and HTML versions of the Article have been modified accordingly.
February 4, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30710107/low-intensity-extracorporeal-shockwave-therapy-in-the-treatment-of-erectile-dysfunction-following-radical-prostatectomy-a-critical-review
#8
Mustafa F Usta, Andrew T Gabrielson, Trinity J Bivalacqua
Low-intensity extracorporeal shockwave therapy (LI-ESWT) to the penis has recently emerged as novel therapeutic option in the treatment of erectile dysfunction (ED). Randomized-controlled studies investigating the effect of this new treatment modality revealed promising results in men with vasculogenic ED. However, the efficacy of LI-ESWT in men who develop ED following radical prostatectomy (RP) remains obscure due to the exclusion of this group in nearly all clinical trials. In this review, the authors synthesize the findings from available preclinical and clinical studies that examine the potential utility of LI-ESWT in men with post-RP ED...
February 1, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30705437/efficacy-and-safety-of-dapoxetine-sildenafil-combination-tablets-in-the-treatment-of-men-with-premature-ejaculation-and-concomitant-erectile-dysfunction-dap-speed-study
#9
Murat Tuken, Mehmet Gokhan Culha, Ege Can Serefoglu
Premature ejaculation (PE) and erectile dysfunction (ED) are the most prevalent sexual disorders in men. ED is commonly reported among patients with PE. Although recent guidelines recommend to treat ED first in men with both PE and ED, this recommendation is not based on evidence and there are limited data about the efficacy and safety of dapoxetine/sildenafil combination therapy for these patients. The aim of this study is to evaluate the clinical efficacy and safety of the dapoxetine/sildenafil combination (Dapoxil® 30/50 mg film-coated tablet) in the treatment of patients with PE and concomitant ED...
January 31, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30705436/early-improvement-in-shim-scores-with-revactin-%C3%A2
#10
Sabine Nguyen, Magda Shaheen, Youngju Pak, Jacob Rajfer
No abstract text is available yet for this article.
January 31, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30705435/additional-procedures-performed-at-time-of-penile-prosthesis-implantation-a-review-of-current-literature
#11
REVIEW
Patrick Whelan, Laurence A Levine
Penile prosthesis implantation for treatment of medical refractory erectile dysfunction remains the gold standard. However, some men have additional pathology present such as Peyronie's Disease, penile shortening, penoscrotal webbing, buried penis or other penoscrotal anatomical abnormalities that may be addressed at the time of prosthesis implantation. Although several techniques are described, there remains a lack of data regarding the outcomes. We sought to identify the results of available literature regarding the additional procedures performed at the time of penile prosthesis implantation that provide defined surgical outcomes rather than merely describe surgical techniques...
January 31, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30705434/proximal-corporal-reconstruction-adjunct-of-penile-prosthesis-revision-surgery
#12
Emad Rajih, Arthur L Burnett
Proximal corporal deformities may account for failed inflatable penile prosthesis (IPP) surgery. No contemporary series has focused solely on describing the natural history and management of isolated proximal corporal deformities in patients after IPP surgery. The aim of the current report is to present the clinical courses and surgical management with outcomes of proximal corporal deformities in the context of prior IPP implantation surgery. We conducted a retrospective analysis of the Johns Hopkins Hospital institutional database of IPP surgeries from May 2006 to March 2017 consisted of 198 patients who had undergone IPP revisions...
January 31, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30696978/carotid-artery-intima-media-thickness-can-predict-the-response-of-patients-with-erectile-dysfunction-to-phosphodiesterase-5-inhibitors
#13
Eyyup Sabri Pelit, Dilek Şen Dokumacı, Bülent Kati, İsmail Yağmur, Erkan Arslan, Adem Tunçtekin, Atakan Kırteke, Halil Çiftçi, Ercan Yeni
This study investigated the role of carotid artery intima-media thickness (IMT) as a morphological marker of the response of vasculogenic erectile dysfunction (ED) patients to tadalafil, one of the phosphodiesterase 5 inhibitor (PDE5-I). Through March-December 2016, 51 men with vasculogenic ED aged over 30 years were enrolled in this prospective study. Vasculogenic ED was accepted as a normal testosterone level, with penile colour Doppler ultrasonography showing arteriogenic ED, venogenic ED or mixed arteriogenic and venogenic ED...
January 29, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30679768/a-comparative-study-of-white-matter-volume-between-postoperative-female-to-male-transsexuals-and-healthy-female
#14
Gwang-Won Kim, Yun-Hyeon Kim, Kwangsung Park, Gwang-Woo Jeong
Cross-sex hormones in female-to-male (FtM) transsexuals play a crucial role in brain plasticity. Morphological study associated with white matter (WM) volume in postoperative FtM transsexuals receiving cross-sex hormones has not been published yet. This study was performed to discriminate the regional WM volume differences between postoperative FtM transsexuals and female controls using voxel-based morphometry (VBM) and further to assess the correlations between regional volume variations and cross-sex hormones...
January 24, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30670840/clinical-trial-update-on-shockwave-therapy-and-future-of-erectile-function-restoration
#15
Premal Patel, Chun Huang, Manuel Molina, Ranjith Ramasamy
Our interim analysis of a phase II clinical trial on low-intensity extracorporeal shockwave therapy (Li-ESWT) for men with erectile dysfunction (ED) has demonstrated it is safe with no reported adverse outcomes. Interim analysis has demonstrated Sexual Encounter Profile 3 (ability to maintain erection till completion) was achieved in 60% of men prior to Li-ESWT, which increased to 90% after treatment. Nevertheless, limitations of our clinical trial include the lack of a sham arm and our inability to exclude men with psychogenic ED...
January 22, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30670839/therapeutic-areas-of-li-eswt-in-sexual-medicine-other-than-erectile-dysfunction
#16
REVIEW
Mikkel Fode, Giorgio I Russo, Paolo Verze
Low intensity extracorporal shock wave therapy (Li-ESWT) may induce tissue regeneration, neo-angiogenesis and improve endothelial function. This has shown promise in the treatment of erectile dysfunction (ED). The aim of this narrative review was to describe potential therapeutic areas of Li-ESWT in sexual medicine other than ED. An extensive literature search and review of the most recent guidelines revealed that Li-ESWT has been used in the treatment of Peyronie's disease (PD) and is being investigated as a method of improving stem cell therapy...
January 22, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30670838/association-of-low-testosterone-with-changes-in-non-cardiovascular-biomarkers-in-adult-men
#17
Michael Samoszuk, Abraham Morgentaler, Mark de Groot, Wouter van Solinge, Yu Li, Fiona Adair, Imo Hoefer, Saskia Haitjema
Testosterone has effects on many organs and systems. The purpose of this study was to test the hypothesis that low testosterone is associated with changes in various non-cardiovascular biomarkers in men older than 40 who were tested for possible hypogonadism. We extracted data from 9939 outpatient men who were over 40 years old (median age 56) and who also had concurrent laboratory measurements of total testosterone and one or more biomarkers of interest: estradiol, uric acid, prostate-specific antigen (PSA), sex-hormone binding globulin (SHBG), luteinizing hormone, creatinine, bone alkaline phosphatase (BAP), creatine kinase, hemoglobin A1c, and 25-hydroxy-vitamin D, and body mass index (BMI)...
January 22, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30670837/cellular-signaling-pathways-modulated-by-low-intensity-extracorporeal-shock-wave-therapy
#18
REVIEW
Tianshu Liu, Alan W Shindel, Guiting Lin, Tom F Lue
Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a form of energy transfer that is of lower intensity (<0.2mJ/mm2 ) relative to traditional Extracorporeal Shock Wave Lithotripsy (ESWL) used for management of urinary stones. At this intensity and at appropriate dosing energy transfer is thought to induce beneficial effects in human tissues. The proposed therapeutic mechanisms of action for Li-ESWT include neovascularization, tissue regeneration, and reduction of inflammation. These effects are thought to be mediated by enhanced expression of vascular endothelial growth factor, endothelial nitric oxide synthase, and proliferating cell nuclear antigen...
January 22, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30664671/clinical-studies-on-low-intensity-extracorporeal-shockwave-therapy-for-erectile-dysfunction-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#19
REVIEW
Ioannis Sokolakis, Georgios Hatzichristodoulou
The efficacy of low intensity extracorporeal shock wave therapy (LI-ESWT) for erectile dysfunction (ED) has received hard criticism and recently published meta-analyses were not able to provide further insights, nor specific recommendations. The aim of this systematic review and meta-analysis is to evaluate the efficacy of LI-ESWT for ED, identify the ideal treatment population and treatment protocol, and provide recommendations for future research in the field. A systematic research for relevant clinical studies published from January 2010 to September 2018 was performed, using the following databases: Medline, Embase, The Cochrane Library, Scopus, and Web of Science...
January 21, 2019: International Journal of Impotence Research
https://read.qxmd.com/read/30659293/pre-and-post-radical-prostatectomy-testosterone-levels-in-prostate-cancer-patients
#20
Supanut Lumbiganon, Suthep Patcharatrakul, Wisoot Khongcharoensombat, Premsant Sangkum
Radical prostatectomy is one of the treatment of choices for localized prostate cancer. Published data show that radical prostatectomy is associated with both an increase and decrease in testosterone levels. This study aimed to document the changes in pre- and postoperative serum testosterone levels after radical prostatectomy along with the associations between serum testosterone levels and prostate cancer profiles in Thai population. Localized and locally advanced prostate cancer patients who elected to have radical prostatectomy without prior androgen deprivation therapy were included in the study...
January 18, 2019: International Journal of Impotence Research
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