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Yi Chu, Jiwei Teng, Pin Feng, Hui Liu, Fangfang Wang, Xue Li
AIMS: Studies on the prognostic significance of circulating pentraxin-3 level in patients with coronary artery disease (CAD) have yielded conflicting results. The aim of this meta-analysis was to evaluate the prognostic value of circulating pentraxin-3 level in CAD patients. MATERIALS/METHODS: We made a systematic literature search in Pubmed, Embae, CNKI, Wanfang, and VIP database from their inception to January 10, 2019 for prospective cohort studies that investigated the association between pentraxin-3 level and adverse outcomes in patients with CAD...
April 4, 2019: Cytokine
Live Marie T Stokkeland, Guro F Giskeødegård, Solhild Stridsklev, Liv Ryan, Bjørg Steinkjer, Line H Tangerås, Eszter Vanky, Ann-Charlotte Iversen
INTRODUCTION: Human pregnancy is a state of elevated maternal systemic inflammation, and pregnancy complications are often associated with a dysfunctional immune response. The network of cytokines reflects this complex immune activity, and broad serum cytokine profiling provides a new tool to understand the changes in immune status during pregnancy. OBJECTIVE: This study aimed to determine how maternal serum cytokine patterns change during the first half of pregnancy...
April 3, 2019: Cytokine
Mao Mizuta, Masaki Shimizu, Natsumi Inoue, Yasuo Nakagishi, Akihiro Yachie
To clarify cytokines involved in the development of systemic juvenile idiopathic arthritis (s-JIA) associated macrophage activation syndrome (MAS) and to identify the serum biomarkers for the diagnosis of s-JIA associated MAS, we employed an antibody array that simultaneously detects 174 cytokines. Fifteen s-JIA patients including 5 patients receiving tocilizumab (TCZ) were analyzed. The levels of five cytokines were significantly elevated in MAS phase compared to those in the active phase of s-JIA. CXCL9 showed the most significant increase following the development of s-JIA associated MAS...
April 2, 2019: Cytokine
Ying Yu, Songfu Feng, Shiyu Wei, Yanyan Zhong, Guoguo Yi, Haiyan Chen, Lifang Liang, Hui Chen, Xiaohe Lu
The maturation state of dendritic cell (DC) plays an important role in immune activities. Previously we had found that NF-κB (p65) pathway could promote DC maturation and subsequent immune effects. But the upstream mechanism of this pathway was still unclear. Extracellular adenosine triphosphate (ATP) activating its receptor P2X7R has recently been considered as the fourth signal to activate T lymphocytes. Here we aimed to find out the connection between P2X7R and NF-κB (p65) pathway in DC maturation. Results showed that the expression of P2X7R and the intracellular ATP levels were increased along with the maturation of DC...
April 2, 2019: Cytokine
Bi Li, Jing Fang, Tingting He, Sirui Yin, Mingxian Yang, Hengmin Cui, Xiaoping Ma, Junliang Deng, Zhihua Ren, Yanchun Hu, Gang Ye, Ming Zhang, Yi Geng, Liping Gou, Zhicai Zuo
Resistin is a cysteine-rich cytokine, which has been indicated as a mediator of insulin resistance and inflammation. Previous studies demonstrated that lipoprotein lipase (LPL) was an important enzyme that could mediate lipid accumulation in macrophages. Additionally, the intracellular molecules phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (AKT)/peroxisome proliferator-activated receptor (PPARγ) were supposed to be involved in the lipid accumulation process in cells. However, it remains unclear whether resistin was correlated with the dysregulation of lipid metabolism in macrophages...
March 26, 2019: Cytokine
Yaju Duan, Yonghua Dong, Hua Hu, Qiumei Wang, Sheng Guo, Dandan Fu, Xiangfeng Song, Dhan V Kalvakolanu, Zhongwei Tian
Immune cells infiltrating the psoriatic skin secrete high amounts of pro-inflammatory cytokines IL-17, TNF-α, IL-21 and IL-36 resulting in chronic inflammation. However, the exact cellular and molecular mechanisms have not been fully understood. We report here elevation of IL-33 expression in psoriatic lesions. Studies in imiquimod (IMQ)-induced mice with psoriatic inflammation confirmed a critical role for IL-33 in driving the disease. IL-33 reduces the CD4+ and CD8+ cells, inhibits autophagy in IMQ-treated mouse skin, and promoted tyrosyl phosphorylation of STAT3...
March 22, 2019: Cytokine
Letizia Santinelli, Maura Statzu, Alessandra Pierangeli, Federica Frasca, Alessia Bressan, Claudia Pinacchio, Chiara Nonne, Ombretta Turriziani, Guido Antonelli, Gabriella d'Ettorre, Carolina Scagnolari
Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explore this hypothesis, transcript levels of IL-32 and IFN-γ were evaluated in PBMC from 139 virologically suppressed HIV-1-infected patients and from 63 healthy individuals by Real Time RT-PCR assays...
March 22, 2019: Cytokine
Kiva Brennan, Bobby D O'Leary, Danielle Mc Laughlin, David Kinlen, Eleanor J Molloy, Declan Cody, Sri Paran, Fionnuala M McAuliffe, Andrew E Hogan, Sarah L Doyle
Almost a third of Irish children are now overweight and the country ranks 58th out of 200 countries for its proportion of overweight youths. With the rising obesity epidemic, and the impaired immune responses of this population, it is vital to understand the effects that obesity has on the immune system and to design future therapeutics, adjuvants and vaccines with overweight and obese populations in mind. Many current vaccines use adjuvants that have been found to be less effective at stimulating the immune response in children compared with adults and there is now substantial effort to design paediatric-focused adjuvants...
March 22, 2019: Cytokine
Nirali Rathwa, Roma Patel, Sayantani Pramanik Palit, Shahnawaz D Jadeja, Mahendra Narwaria, A V Ramachandran, Rasheedunnisa Begum
OBJECTIVE: Omentin-1, an anti-inflammatory protein, is secreted by the visceral adipose tissue. Altered levels of Omentin-1 are associated with obesity and Type 2 Diabetes (T2D). Although Omentin-1 is implicated in the insulin signaling pathway, the relationship between the genetic variants of Omentin-1 and T2D is not yet explored. The current study evaluates the association of Omentin-1 polymorphisms (rs2274907 A/T and rs1333062 G/T), its transcript and protein levels, and genotype-phenotype correlation with metabolic parameters and T2D susceptibility...
March 22, 2019: Cytokine
Vijayamahantesh, Vijayalaxmi
Nucleotides are one of the most primitive extracellular signalling molecules across all phyla and regulate a multitude of responses. The biological effects of extracellular nucleotides/sides are mediated via the specific purinergic receptors present on the cell surface. In mammalian system, adenine nucleotides are the predominant nucleotides found in the extracellular milieu and mediate a constellation of physiological functions. In the context of host-pathogen interaction, extracellular ATP is recognized as a danger signal and potentiates the release of pro-inflammatory mediators from activated immune cells, on the other hand, its breakdown product adenosine exerts potential anti-inflammatory and immunosuppressive actions...
March 22, 2019: Cytokine
Héloïse Débare, Jörg Schmidt, Nathalie Moiré, Céline Ducournau, Yoshuá D Acosta Paguay, Ralph T Schwarz, Isabelle Dimier-Poisson, Françoise Debierre-Grockiego
Neosporosis due to Neospora caninum causes abortions in farm animals such as cattle. No treatment and vaccine exist to fight this disease, responsible for considerable economic losses. It is thus important to better understand the immune responses occurring during the pathogenesis to control them in a global strategy against the parasite. In this context, we studied the roles of N. caninum glycosylphosphatidylinositols (GPIs), glycolipids defined as toxins in the related parasite Plasmodium falciparum. We demonstrated for the first time that GPIs could be excreted in the supernatant of N...
March 22, 2019: Cytokine
Divaker Choubey, Ravichandran Panchanathan
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that exhibits a strong female bias (female-to-male ratio 9:1) in patients. Further, 40-60% SLE patients develop lupus nephritis (LN), which significantly increases the mortality rates. The failure of current therapies to adequately treat LN in patients reflects an incomplete understanding of the disease pathogenesis. Notably, a chronic increase in serum interferon-α (IFN-α) activity is a heritable risk factor to develop SLE. Accordingly, blood cells from most SLE patients with an active disease exhibit an increase in the expression of the type I IFN (IFN-α/β)-stimulated genes (ISGs, also referred to as "IFN-signature"), a type I IFN response...
March 20, 2019: Cytokine
Silvia Méndez-Flores, Gabriela Hernández-Molina, Daniel Azamar-Llamas, Joaquín Zúñiga, Juanita Romero-Díaz, Janette Furuzawa-Carballeda
We compared the chemokine/receptor expression in skin biopsies of discoid (SLE/DLE) and subacute lupus (SLE/SCLE) and correlated it with tissue and circulating effector CD4 T cells/regulatory cells. Skin biopsies and peripheral blood from 9 active SLE/DLE patients, 9 SLE/SCLE patients, 5 control SLE patients without cutaneous lesions and 10 control healthy donors were included. Clinical skin activity was measured by Cutaneous Lupus Erythematosus Disease Area and Severity Index scoring, and systemic activity was measured by a modified SLEDAI-2K excluding the cutaneous items...
March 20, 2019: Cytokine
Dan Wen, Ping Jia, Xin Du, Jian-Zeng Dong, Chang-Sheng Ma
OBJECTIVE: To determine the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and aortic diameter in predicting in-hospital mortality in acute aortic dissection (AD). METHODS: A single-center prospective study was designed in the setting of University hospital in China. 122 patients with acute AD were enrolled. Admission plasma NT-proBNP levels and aortic diameter were measured. RESULTS: Plasma NT-proBNP concentrations (P < 0...
March 20, 2019: Cytokine
Siqi Peng, Yutong Chen, Yihang Gong, Zizi Li, Rongzhi Xie, Yujing Lin, Baojia Zou, Jian Li, Linjuan Zeng
Hepatocellular carcinoma (HCC) is always accompanied by persistent inflammation of liver tissues, which is considered to exert protumourigenic effects by promoting cancer growth, progression, and metastasis. However, the tumour-promoting roles and predictive value of intratumoural inflammatory cytokines remain unclear. In the present study, we used database analysis, clinical pathological studies, and in vitro biological experiments on human hepatic cancer cell lines to assess the prognostic potential of the primary tumour cytokine mRNA levels and underlying mechanisms in HCC...
March 20, 2019: Cytokine
Tiego A Diniz, Jefferson Comin Jonco Aquino Júnior, Francielle Caroline Mosele, Carolina Cabral-Santos, Edson Alves de Lima Junior, Alexandre Abilio de Souza Teixeira, Fábio Santos Lira, José Cesar Rosa Neto
BACKGROUND: Adiponectin exhibits anti-inflammatory actions and is mainly expressed in adipose tissue. However, recent studies have shown that adiponectin can also be secreted by skeletal muscle fibers with autocrine and paracrine effects. OBJECTIVES: To analyze the role of adiponectin in the metabolic and inflammatory response of skeletal muscle after acute exhaustive aerobic exercise. METHODS: C57BL/6 (WT) and adiponectin knockout (AdKO) mice underwent four days of treadmill running adaptation and at the fifth day, they performed an incremental maximum test to determine the maximum speed (Vmax)...
March 20, 2019: Cytokine
Jin-Mei Chen, Qing-Wei Li, Guo-Xin Jiang, Jian-Sheng Liu, Qi Cheng
Recent studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathogenesis of Alzheimer's diseases (AD). The potential involvement of pro-inflammatory cytokines interleukin (IL)-18, IL-23 and IL-17 on amyloid (Aβ) clearance is still unclear. In this study, we addressed that there might be a net relationship among IL-18, IL-23, and IL-17 and they can affect Aβ clearance in cultured macrophage/microglia cells. In human macrophage cell line THP-1, Aβ42 incubation could increase the expression of IL-18, IL-23 and IL-17 in a concentration dependent manner...
March 20, 2019: Cytokine
Irene Karampela, Gerasimos Socrates Christodoulatos, Evangelia Kandri, Georgios Antonakos, Evaggelos Vogiatzakis, George Dimopoulos, Apostolos Armaganidis, Maria Dalamaga
BACKGROUND: The adipocytokines eNampt and resistin are involved in the regulation of inflammation exerting pro-inflammatory actions. Our aim was to jointly investigate whether circulating eNampt and resistin, and their kinetics predict 28-day mortality of sepsis. METHODS: In a prospective study, serum eNampt and resistin were determined in 102 critically ill patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age, gender and month of diagnosis...
March 15, 2019: Cytokine
Alisson L da Rocha, Ana P Pinto, Eike B Kohama, José R Pauli, Leandro P de Moura, Dennys E Cintra, Eduardo R Ropelle, Adelino S R da Silva
Chronic moderate-intensity exercise is an efficient non-pharmacological strategy to prevent and treat several diseases such as type 2 diabetes mellitus, cardiovascular and chronic obstructive pulmonary diseases, cancers, and Parkinson's disease. On the other hand, improving an athlete's performance requires completing high-intensity and volume exercise sessions. When the delicate balance between high-load exercise sessions and adequate recovery periods is disrupted, excessive training (known as overtraining) can lead to performance decline...
March 15, 2019: Cytokine
Asumi Jinkawa, Masaki Shimizu, Keigo Nishida, Shuya Kaneko, Masaaki Usami, Naoto Sakumura, Hitoshi Irabu, Maiko Takakuwa, Natsumi Inoue, Mao Mizuta, Yasuhiro Ikawa, Shuhei Fujita, Akihiro Yachie
The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sTNFR-II levels were determined using enzyme-linked immunosorbent assay in 78 patients with KD, including five with MAS. Results were compared to the clinical features of MAS. Serum neopterin, IL-18, sTNFR-II levels and sTNFR-II/I ratio were significantly elevated in KD patients with MAS compared to those in the acute phase...
March 13, 2019: Cytokine
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