Kimberley A Stephenson, Mark G Rae, Dervla O'Malley
Interleukin-6 (IL-6) is a pro-inflammatory cytokine, classically associated with orchestrating an immune response to invading pathogens. However, IL-6 can also directly or indirectly modify central nervous system function, and thereby alter higher-order functions, such as learning and the consolidation of memories. IL-6 is chronically elevated in Duchenne Muscular Dystrophy (DMD), a neuromuscular disorder arising when a mutation causes the loss of the structural protein, dystrophin. Absence of dystrophin leads to progressive immobility, chronic inflammation and premature death...
May 23, 2020: Cytokine
Rezvan Noroozi, Wojciech Branicki, Krzysztof Pyrc, Paweł P Łabaj, Ewelina Pospiech, Mohammad Taheri, Soudeh Ghafouri-Fard
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic in early 2020. The infection has been associated with a wide range of clinical symptoms. In the severely affected patients, it has caused dysregulation of immune responses including over-secretion of inflammatory cytokines and imbalances in the proportion of naïve helper T cells, memory helper T cells and regulatory T cells. Identification of the underlying mechanism of such aberrant function of immune system would help in the prediction of disease course and selection of susceptible patients for more intensive cares...
May 21, 2020: Cytokine
Masamichi Komatsu, Hiroshi Yamamoto, Masanori Yasuo, Atsuhito Ushiki, Tomoyuki Nakajima, Takeshi Uehara, Satoshi Kawakami, Masayuki Hanaoka
We previously reported higher levels of C-C chemokine ligand (CCL) 1 in the bronchoalveolar lavage (BAL) fluid (BALF) of patients with sarcoidosis than in BALF of patients with immunoglobulin G4 (IgG4)-related disease (IgG4-RD), indicating that CCL1 might act as a marker of disease activity in sarcoidosis. Notably, less invasive sampling sources are desirable, as BAL cannot always be performed due to its inherent risk. In this study, we sought to decipher the correlation between serum levels of CCL1 and clinical characteristics of sarcoidosis...
May 21, 2020: Cytokine
Dong-Shi Liang, Ai-Rong Huang, Miao-Miao Lin, Xiao-Jiao Xia, Yi-Mei Jin
BACKGROUND: Acute exogenous lipoid pneumonia (AELP) is characterized by pulmonary inflammation. This mainly occur in children who have ingested sewing machine oil or other mineral oils accidentally. Despite emerging evidences revealing that inhibiting inflammation improves acute exogenous lipoid pneumonia, the actual process of inhibiting inflammation remains unknown. This study aimed to evaluate the effects of PDTC and dexamethasone on AELP to gain insight into the mechanism of AELP...
May 20, 2020: Cytokine
Christoph Grander, Nikolai Jaschke, Barbara Enrich, Felix Grabherr, Lisa Mayr, Julian Schwärzler, Maria Effenberger, Timon E Adolph, Herbert Tilg
Obesity has emerged as a substantial global healthcare issue that is frequently associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Tsukushi (TSK), a liver-derived molecule, was recently identified as a major driver of NAFLD. Laparoscopic adjustable gastric banding (LAGB) has proven effective in reducing body weight and improving NAFLD. We therefore aimed to investigate the relation between LAGB-induced weight loss and TSK expression. Twenty-six obese patients undergoing LAGB were included in the study and metabolic parameters were assessed before (t0) and six months after LAGB (t6)...
May 19, 2020: Cytokine
Beata Zelazowska-Rutkowska, Bozena Skotnicka, Bogdan Cylwik
OBJECTIVES: The study objective was to assess the levels of VEGF-A and TGF-β cytokines in the children with adenoid hypertrophy concomitant with exudative otitis media (OME) and in children with adenoid hypertrophy (HA) alone. METHODS: The study material consisted of hypertrophic adenoids removed during adenoidectomy from 39 children (20 girls and 19 boys), aged 2-7 years suffering from OME. The reference group included 41 children (19 girls and 22 boys), aged from 3 to 9 years with adenoid hypertrophy...
May 18, 2020: Cytokine
Enoch Appiah Adu-Gyamfi, Francis Tanam Djankpa, William Nelson, Armin Czika, Sanjay Kumar Sah, Jones Lamptey, Yu-Bin Ding, Ying-Xiong Wang
Activins and inhibins - comprising activin A, B, AB, C and E, and inhibin A and B isoforms - belong to the transforming growth factor beta (TGFβ) superfamily. They regulate several biological processes, including cellular proliferation, differentiation and invasiveness, to enhance the formation and functioning of many human tissues and organs. In this review, we have discussed the role of activin and inhibin signaling in the physiological and female-specific pathological events that occur in the female reproductive system...
May 18, 2020: Cytokine
Mai A Abd-Elmawla, Mariam Hassan, Yumn A Elsabagh, Alshaimaa Rezk L R Alnaggar, Mahmoud A Senousy
Systemic sclerosis or systemic scleroderma (SSc) is an inflammatory autoimmune disease whose pathogenesis remains ambiguous; however, epigenetics, including long noncoding RNAs (lncRNAs) is an emerging paradigm. To date, the expression, role and clinical significance of most lncRNAs in SSc remain unelucidated. Herein, we investigated the plasma expression profiles of lncRNAs; ANCR, TINCR, HOTTIP, and SPRY4-IT1, which were linked to skin biology, in SSc patients and its subtypes, their potential as diagnostic tools and their correlations with autoantibodies and disease manifestations...
May 13, 2020: Cytokine
Junzheng Hu, Jun Lu, Xiao Zhang, Chen Wang, Ke Ren, Qing Chang, Mingliang Ji, Wei Pan, BinBin Ma, Weimin Fan
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune disease that leads to small joints irreversible destruction. Despite intense efforts, the pathophysiology of RA currently remains unclear. We aimed to gain insight into the pathophysiology process in peptidomic perspective and to identify bioactive peptides for RA treatment. METHODS: The endogenous peptides in synovial tissue between control and rheumatoid arthritis group were identified by liquid chromatography-mass spectrometry (LC-MS/MS)...
May 12, 2020: Cytokine
Oscar Illescas, Thalia Pacheco-Fernández, Juan P Laclette, Tonathiu Rodriguez, Miriam Rodriguez-Sosa
Human macrophage migration inhibition factor (MIF) is a protein with cytokine and chemokine properties that regulates a diverse range of physiological functions related to innate immunity and inflammation. Most research has focused on the role of MIF in different inflammatory diseases. D-dopachrome tautomerase (DDT), a different molecule with structural similarities to MIF, which shares receptors and biological functions, has recently been reported, but little is known about its roles and mechanisms. In this review, we sought to understand the similarities and differences between these molecules by summarizing what is known about their different structures, receptors and mechanisms regulating their expression and biological activities with an emphasis on immunological aspects...
May 11, 2020: Cytokine
Yanxia Chen, Jinlin Liu
No abstract text is available yet for this article.
May 10, 2020: Cytokine
Jeneen Panezai, Azra Ali, Ambereen Ghaffar, Daniel Benchimol, Mohammad Altamash, Bjӧrn Klinge, Per-Erik Engström, Anders Larsson
OBJECTIVES: Periodontal disease (PD) and rheumatoid arthritis (RA) are chronic immuno-inflammatory conditions with osteolysis being a hallmark feature. The influence of PD on RA's systemic inflammatory status and disease activity remains unclear. The objective of this study was to assess the systemic inflammation and disease activity of RA under the influence of PD. METHODS: In this case-control study, 38 RA patients (19 with PD and 19 without PD) were compared to 38 non-RA patients and 12 healthy controls...
May 8, 2020: Cytokine
Sandra Mara Witkowski, Eduardo Morais de Castro, Seigo Nagashima, Ana Paula Camargo Martins, Cristina Terumy Okamoto, Gustavo Takao Moreno Nakata, Mariana Collete, Cleber Machado-Souza, Lucia de Noronha
Bronchopulmonary dysplasia (BPD) is an abnormality that occurs in premature neonate lung development. The pathophysiology is uncertain, but the inflammatory response to lung injury may be the responsible pathway. The objective of this study is to evaluate the role of interleukins 6, 8, 10, and 17 through the anatomopathological and immunohistochemical study of the lungs of premature neonates with BPD. Thirty-two cases of neonatal autopsies from the Pathology Department of the Clinics Hospital of the Universidade Federal do Paraná, who presented between 1991 and 2005 were selected...
May 8, 2020: Cytokine
Daniela Berenice Torres-Pineda, María de Lourdes Mora-García, Rosario García-Rocha, Jorge Hernández-Montes, Benny Weiss-Steider, Juan José Montesinos-Montesinos, Christian Azucena Don-López, Luis Antonio Marín-Aquino, Ricardo Muñóz-Godínez, Luis Roberto Ávila Ibarra, Ricardo López Romero, Alberto Monroy-García
No abstract text is available yet for this article.
May 8, 2020: Cytokine
Su Ui Lee, Eun Sol Oh, Hyung Won Ryu, Mun-Ock Kim, Myung-Ji Kang, Yu Na Song, Ro Woon Lee, Doo-Young Kim, Hyunju Ro, Sunin Jung, Sung-Tae Hong, Sei-Ryang Oh
Longifolioside A is an iridoid glucoside compound isolated from Pseudolysimachion rotundum var. subintegrum, which has been used in traditional herbal medicines to treat respiratory inflammatory diseases. Logifolioside A is a potent antioxidant; however, its underlying pharmacological mechanisms of action in inflammatory diseases are unknown. Here, we investigated the inhibitory effects of longifolioside A in lipopolysaccharide (LPS)-stimulated toll-like receptor 4 (TLR4) signal transduction systems using human THP-1 macrophages and HEK293 cells stably expressing human TLR4 protein (293/HA-hTLR4)...
May 7, 2020: Cytokine
Papiya Chakraborty, Nibedita Dalpati, Chandra Bhan, Shiba Prasad Dash, Puneet Kumar, Pranita P Sarangi
Accumulation of hyperactive neutrophils in the visceral organs was shown to be associated with sepsis-induced multi-organ failure. Recently, a C-terminal fragment of secreted glycoprotein Fibulin7 (Fbln7-C) was shown to inhibit angiogenesis and regulate monocyte functions in inflammatory conditions. However, its effects on neutrophil functions and systemic inflammation induced lethality remain unknown. In this study, we show that human peripheral blood neutrophils adhered to Fbln7-C in a dose-dependent manner via integrin β1...
May 6, 2020: Cytokine
Eun Jung Lee, Sandra Lilja, Xinxiu Li, Samuel Schäfer, Huan Zhang, Mikael Benson
No abstract text is available yet for this article.
May 4, 2020: Cytokine
Narges Marefati, Farimah Beheshti, Sara Memarpour, Reza Bayat, Mohammad Naser Shafei, Hamid Reza Sadeghnia, Hamed Ghazavi, Mahmoud Hosseini
The therapeutic effects of the olibanum, the resin of Boswellia serrata on inflammatory diseases have been reported. There are more than 200 active ingredients in this resin including acetyl-11-keto-β-boswellic acid (AKBA). We proposed that AKBA can improve memory impairment induced by cerebral inflammation following the administration of lipopolysaccharide (LPS). Forty male rats were grouped and received the following treatments: Control (diluted DMSO + saline), LPS (diluted DMSO + 1 mg/kg LPS), LPS- AKBA 5 and LPS- AKBA 10 (5 or 10 mg/ kg AKBA before LPS)...
May 4, 2020: Cytokine
Ferrin Antony, Yoya Vashi, Sudhir Morla, Vandna, Hari Mohan, Sachin Kumar
Newcastle disease (ND) is prevalent among the domesticated and the wild birds and is caused by the avian paramyxovirus serotype-I (APMV-I). It is commonly known to affect chicken, pheasant, ostrich, pigeon and waterfowl. Depending on the virulence, the velogenic NDV strains cause severe respiratory and nervous disorders with a high mortality rate. The live and killed vaccines are available for the prevention of infection in the market, but the drug for the treatment is not available. Nitazoxanide (NTZ), a member of thiazolides, is an antiparasitic drug...
May 3, 2020: Cytokine
Pengzhi Li, Yawei Li, Yuliang Dai, Bing Wang, Lei Li, Bin Jiang, Pengfei Wu, Jietao Xu
Reactive astrocyte proliferation post SCI (spinal cord injury) leads to the formation of glial scars, thus hindering axon regeneration and SCI repair, during which the activation of astrocytes plays a central role. This study attempted to identify the lncRNA-miRNA-mRNA network which exerts a critical effect on normal human astrocyte (NHA) activation and proliferation during SCI inflammation. Herein, lncRNA H19 expression was increased by LPS in NHAs, and H19 was positively correlated with CCL2. H19 silencing in NHAs significantly attenuated the promoting effects of LPS stimulation on NHA proliferation and activation as manifested by inhibited cell viability and DNA synthesis capacity, reduced NHA activation markers, and reduced inflammatory factor concentrations (CCL2, IL-6, and TNF-α)...
May 1, 2020: Cytokine
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