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Sabine Iberl, Anne-Louise Meyer, Gunnar Müller, Sebastian Peters, Siw Johannesen, Ines Kobor, Fabian Beier, Tim H Brümmendorf, Christina Hart, Roland Schelker, Wolfgang Herr, Ulrich Bogdahn, Jochen Grassinger
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of complex and still poorly understood etiology. Loss of upper and lower motoneurons results in death within few years after diagnosis. Recent studies have proposed neuroprotective and disease-slowing effects of granulocyte-colony stimulating factor (G-CSF) treatment in ALS mouse models as well as humans. In this study, six ALS patients were monitored up to 3.5 years during continuous high-dose G-CSF administration. Repetitive analyses were performed including blood count parameters, CD34+ hematopoietic stem and progenitor cell (HSPC) and colony forming cell (CFC) counts, serum cytokine levels and leukocyte telomere length...
May 14, 2019: Cytokine
Razieh Bidhendi Yarandi, Mohammad Hossein Panahi
The aim of this study was to mention some methodological issues in a study which investigate the effect of Granulocyte colony-stimulating factor on developing of aortitis.
May 14, 2019: Cytokine
Firouzeh Heidari, Soghra Rabizadeh, Mohammad Ali Mansournia, Hossein Mirmiranpoor, Salome Sadat Salehi, Setare Akhavan, Alireza Esteghamati, Manouchehr Nakhjavani
BACKGROUND: The role of chronic inflammation and oxidative stress in the development of diabetes and cancer has been established. In this study, we aimed to investigate inflammatory and oxidative stress markers in patients with diabetes (DM) and endometrial carcinoma (EC) separately and in combination. METHODS: In a case-control study design, a total of 88 participants were enrolled including: 37 patients with EC (19 with DM and 18 without DM), 29 with type2 diabetes and 22 healthy controls...
May 14, 2019: Cytokine
Chin-Chung Shu, Lawrence Shih-Hsin Wu, Ming-Fang Wu, Hsin-Chih Lai, Ping-Huai Wang, Shih-Lung Cheng, Jann-Yuan Wang, Chong-Jen Yu
AT A GLANCE: The diagnosis and progression of nontuberculous mycobacteria lung disease (NTN-LD) are important for clinical judgement but cannot easily be predicted. The immunological response of mono- and poly-functional T cells, a representative of host reactivity to NTM, could be a surrogate biomarker for disease and progression prediction. BACKGROUND: Mycobacterium avium complex (MAC) and M. abscessus (MAB) induced lung disease (LD) have become a clinical concern...
May 11, 2019: Cytokine
Weiguo Song, Juan Wang, Hanyuan Liu, Chenchen Zhu, Fei Xu, Lili Qian, Zhen Shen, Jing Zhu, Shuai Yin, Jiwei Qin, Liang Chen, Dabao Wu, Björn Nashan, Ge Shan, Weihua Xiao, Ying Zhou
This study explored the effect of LncRNA Lnc-LIF-AS on cell proliferation, migration and invasion in the human cervical cancer (HCC) cell line SiHa. SiHa cells had the lowest expression of Lnc-LIF-AS in the 4 human cervical cancer cell lines (SiHa, ME-180, C-33A and HeLa) and were transfected and divided into the SiHa/con (transfected with pMIGRI) cell group, SiHa/Lnc-LIF-AS (transfected with pMIGRI-Lnc-LIF-AS) cell group, and SiHa/Lnc-LIF-AS-DN (transfected with pMIGRI-Lnc-LIF-AS-DN, in which the sequences overlapping with LIF mRNA was deleted) cell group...
May 11, 2019: Cytokine
Dimiter Avtanski, Anabel Garcia, Beatriz Caraballo, Priyanthan Thangeswaran, Sela Marin, Julianna Bianco, Aaron Lavi, Leonid Poretsky
Breast cancer incidence and metastasis in postmenopausal women are known to associate with obesity, but the molecular mechanisms behind this association are largely unknown. We investigated the effect of adipokine resistin on epithelial to mesenchymal transition (EMT) and stemness in breast cancer cells in vitro. Previous reports demonstrated that the inflammatory actions of resistin are mediated by the adenylyl cyclase-associated protein 1 (CAP1), which serves as its receptor. As a model for our study, we used MCF-7 and MDA-MB-231 breast cancer and MCF-10A breast epithelial cells...
May 11, 2019: Cytokine
Nazmul Haque, Ilyas M Khan, Noor Hayaty Abu Kasim
The immunomodulatory properties of mesenchymal stem cells (MSCs) from autologous and allogeneic sources are useful in stimulating tissue regeneration and repair. To obtain a high number of MSCs for transplantation requires extensive in vitro expansion with culture media supplements that can cause xeno-contamination of cells potentially compromising function and clinical outcomes. In this study stem cells from human extracted deciduous teeth (SHED) were cultured in Knockout™ DMEM supplemented with either pooled human serum (pHS) or foetal bovine serum (FBS) to compare their suitability in maintaining immunomodulatory properties of cells during in vitro expansion...
May 6, 2019: Cytokine
Muhammed Yakin, Benedict Seo, Alison Rich
AIMS: Signal transducer and activator of transcription (STAT)-3 lies at the convergence point of key pathways involved in many malignancies including oral squamous cell carcinoma (OSCC). Endoplasmic reticulum stress (ERS) and the unfolded protein response have been shown to be involved in the pathogenesis and progression of different cancers by influencing key cellular processes such as apoptosis. We investigated the differential expression of STAT3 pathway-related genes and proteins under ERS in OSCC...
May 6, 2019: Cytokine
Hiroshi Yamamoto, Masanori Yasuo, Masamichi Komatsu, Atsuhito Ushiki, Hideaki Hamano, Atsushi Hori, Tomoyuki Nakajima, Takeshi Uehara, Yasunari Fujinaga, Shoko Matsui, Masayuki Hanaoka
BACKGROUND: We previously reported that the cytokine profiles in the bronchoalveolar lavage fluid (BALF) of IgG4-related respiratory disease (IgG4-RRD) more closely resemble the T-helper (Th) 2 response than sarcoidosis. The present study aimed to assess the chemokines in the BALF of IgG4-RRD and sarcoidosis in order to evaluate any possible associations between these chemokines and other markers. METHODS: We examined 12 chemokines using a MILLIPLEX® MAP Kit (Millipore, Darmstadt, Germany) in the same BALF samples of the same 44 patients (IgG4-RRD, n = 11; sarcoidosis, n = 33) in which we had previously evaluated the cytokines...
May 4, 2019: Cytokine
Junling Niu, Shuxian Wu, Mingkuan Chen, Ke Xu, Qiuhong Guo, Ailing Lu, Liping Zhao, Bing Sun, Guangxun Meng
Host innate immune system is critical for combating invading microbes including Influenza A virus (IAV). As an important arm of the innate immunity, the NLRP3 inflammasome has been found essential for protecting host against IAV challenge, while the mechanism remained elusive. Here we found that mice carrying a gain-of-function mutation in the Nlrp3 gene (Nlrp3R258W ) are strongly resistant to IAV infection. Upon H1N1 IAV infection, the Nlrp3R258W mice exhibited decreased weight loss, increased survival rate and attenuated lung damage compared with WT littermate controls...
May 2, 2019: Cytokine
Fahimeh Kazemi
The role of myostatin (MSTN) in the regulation of energy homeostasis has been known and that MSTN inhibition can attenuate the development of diabetes. However, the response of MSTN to exercise in type 1 diabetes (T1DM) is unknown. This study aimed to investigate the alteration of MSTN following aerobic exercise training in diabetic rats and its possible interaction with glycosylated hemoglobin (HbA1c) and inflammatory cytokines. Forty-eight male Wistar rats were divided into non-diabetic untrained, non-diabetic trained, diabetic untrained and diabetic trained groups...
May 1, 2019: Cytokine
Camila Mareti Bonin, Larissa Zatorre Almeida-Lugo, Andrielli Rodrigues Dos Santos, Cacilda Tezelli Junqueira Padovani, Ana Flávia Silva Pina, Alda Maria Teixeira Ferreira, Carlos Eurico Dos Santos Fernandes, Júlio César Possati Resende, Adriane Cristina Bovo, Inês Aparecida Tozetti
Persistent infection by high-risk oncogenic human papillomavirus (HR-HPV) is the main cause of cervical cancer and its precursor lesions, and both the systemic and local immunological responses play an important role in eliminating or maintenance this infection. Th17 cells, as well as interleukin (IL)-17, are related to tumor growth and persistence of viral infection. Thus, this study aimed to quantify IL-17 in the serum and exfoliated cervical cells of HR-HPV-infected patients and healthy patients as well as identify CD4+ IL17+ cells and IL-17 production in uterine cervix biopsies to better understand the behavior of this cytokine in HPV infections...
May 1, 2019: Cytokine
Felipe Vendrame, Leticia Olops, Sara Teresinha Olalla Saad, Fernando Ferreira Costa, Kleber Yotsumoto Fertrin
Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by vaso-occlusive crises and end-organ damage, which is curiously associated with hypocholesterolemia and a low incidence of atherosclerosis, whose underlying mechanisms are unclear. We hypothesized that ANGPTL3 and ANGPTL4 dysregulation is responsible for the hypolipidemic phenotype in SCA...
May 1, 2019: Cytokine
Ruma G Singh, Ngoc Nhu Nguyen, Aya Cervantes, Gisselle C Alarcon Ramos, Jaelim Cho, Maxim S Petrov
While a plethora of studies have been conducted to investigate the associations between pro-inflammatory cytokines and obesity, the inter-relationship between pro-inflammatory cytokines and intra-pancreatic fat deposition (IPFD) has been poorly investigated. In the present study, circulating levels of C-C motif chemokine ligand 2 (CCL2), interleukin-6 (IL-6), leptin, and tumor necrosis factor-alpha (TNFα) were measured in 90 individuals after acute pancreatitis (AP) as well as 21 healthy non-obese individuals...
May 1, 2019: Cytokine
Pierre Peterlin, Joelle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Cherel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier
OBJECTIVE: This study was designed to assess the impact on outcomes of early soluble Fms-like tyrosine kinase 3 ligand concentrations (sFLc) in patients receiving an allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). METHODS: This was a prospective monocentric study including all allo-HSCT patients included in the previous FLAM/FLAL study (Peterlin et al., 2019). Blood samples collected before the start of conditioning then post-transplant were frozen, stored and tested by ELISA...
April 26, 2019: Cytokine
Shucheng Hua, Xiuhua Yu, Yucong Ma, Yanchun Li
Interleukin-23 (IL-23) is a cytokine that is composed of the subunits p19 and p40, while its receptor (IL-23R) consists of two subunits, that is, IL-23Rα and IL-12Rβ1. The interaction between IL-23 and IL-23R is necessary for exerting cardinal biological effects upon certain cell types, including promotion of memory T cell proliferation and Th17 cell-mediated IL-17 secretion. Accordingly, dendritic cells (DCs) are one of the main sources for IL-23 secretion. Interestingly, IL-23R is also present on the DC plasma membrane, suggesting that IL-23 potentially acts on DCs via an autocrine manner...
April 24, 2019: Cytokine
Yating Ma, Chen Chen, Ming Yang, Shang He, Kexin Zhang, Chengbin Wang
BACKGROUND: Bacterial bloodstream infection (BSI) remains an important cause of morbidity and mortality, which is a widespread and uncontrolled inflammatory response. There are some cytokines for the auxiliary diagnosis, such as procalcitonin (PCT), C reactive protein (CRP), and interleukin 6 (IL-6), which are not sufficient. This study was aimed to explore a new method of diagnosing bacterial BSI and to find some new biomarkers that could differentiate bloodstream infected patients from healthy people...
April 23, 2019: Cytokine
Wagner Silva Dantas, Willian das Neves, Saulo Gil, Cristiano Roberto Grimaldi Barcellos, Michele Patrocínio Rocha, Ana Lúcia de Sá-Pinto, Hamilton Roschel, Bruno Gualano
Polycystic ovary syndrome (PCOS) is characterized by exacerbated inflammation, which is implicated in cardiometabolic dysfunction. This study aimed to examine the potential effects of acute exercise on inflammatory responses in obese/overweight PCOS women and their controls. Participants underwent a single bout of moderate-intensity aerobic exercise (30 min at ∼65% of VO2peak ). Blood and muscle samples were collected immediately before (PRE) and 60 min after the exercise session. Cytokines (i.e., IL-1β, IL-6, IL-4, IL-10, TNF-α) were measured both in plasma and in skeletal muscle, and proteins related to inflammatory signaling (IKKα/β and JNK) were assessed in skeletal muscle...
April 18, 2019: Cytokine
Matteo Val, Girolamo Antonio Sidoti Pinto, Lorenzo Manini, Sergio Gandolfo, Monica Pentenero
Salivary biomarkers represent a promising diagnostic tool. Non-invasive and stress-free sampling results in objective parameters able to overcome the need of clinical expertise required for a correct interpretation of early oral squamous cell carcinoma (OSCC). The present study aims at evaluating potential variations in the salivary concentration of cytokines in presence of OSCC. Twenty patients who underwent surgical resection of OSCC were enrolled in order to assess the variation of the salivary concentration of cytokines and chemokines in a longitudinal prospective case-crossover setting...
April 18, 2019: Cytokine
Naoki Yoshimura, Yoko Yokoyama, Minako Sako, Nobuo Aoyama, Fumihito Hirai, Koji Sawada, Nobuhito Kashiwagi, Yasuo Suzuki
OBJECTIVE: Determination of antibodies to infliximab (ATI) is desirable for the management of patients with inflammatory bowel disease (IBD) who receive infliximab. Conventional ligand-binding ATI-assays detect only free-form of ATI, potentially increasing the proportion of patients with undetectable ATI, but with adequate trough infliximab (TRI) level who experience loss of response (LOR) to infliximab. We investigated this assertion using a novel ATI-Cim assay. METHODS: An ATI-Cim assay was developed by utilizing a C1q-immobilized plate, detecting free-form and ATI-infliximab complexes...
April 16, 2019: Cytokine
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