Ying Wang, Yalan Sun, Mingjuan Tan, Xin Lin, Ping Tai, Xiaoqin Huang, Qing Jin, Dan Yuan, Tao Xu, Bangshun He
Breast cancer risk have been discussed to be associated with polymorphisms in genes as well as abnormal DNA damage repair function. This study aims to assess the relationship between genes single nucleotide polymorphisms (SNPs) related to DNA damage repair and female breast cancer risk in Chinese population. A case-control study containing 400 patients and 400 healthy controls was conducted. Genotype was identified using the sequence MassARRAY method and expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) in tumor tissues was analyzed by immunohistochemistry assay...
April 17, 2024: DNA and Cell Biology
Susanna Fang, Chi Kin Wong
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have shown efficacy in the treatment of metabolic disease-related complications, partially attributable to their anti-inflammatory properties. However, the specific cell types and pathways involved in these effects were not fully understood. A recent study by Wong et al. demonstrated the importance of the brain GLP-1R in mediating the anti-inflammatory effects of GLP-1RAs in Toll-like receptor and sepsis-mediated inflammation. In this discussion, we review the existing literature on the action of GLP-1RAs in inflammation and explore the implications of these recent findings...
April 5, 2024: DNA and Cell Biology
Chang Sun, Shanshan Zhao, Zimeng Pan, Jing Li, Yasong Wang, Hongying Kuang
Polycystic ovary syndrome (PCOS) refers to an endocrine disorder syndrome that are correlated with multiple organs and systems. PCOS has an effect on women at all stages of their lives, and it has an incidence nearly ranging from 6% to 20% worldwide. Mitochondrial dysfunctions (e.g., oxidative stress, dynamic imbalance, and abnormal quality control system) have been identified in patients and animal models of PCOS, and the above processes may play a certain role in the development of PCOS and its associated complications...
April 2024: DNA and Cell Biology
Chunli Cao, Xinxin Wu, Zhe Li, Yaoyao Xie, Shiyi Xu, Junming Guo, Weiliang Sun
Numerous studies have shown that circular RNAs are associated with the occurrence and development of various cancers, but the biological functions and mechanisms of hsa_circ_0006847 (circASPHD1) in gastric cancer (GC) remain unclear. The expression of hsa_circ_0006847 in GC cell lines, tissue, and plasma from GC patients was assayed by quantitative real-time reverse transcription-polymerase chain reaction. Hsa_circ_0006847 expression in cells was downregulated or upregulated by transfected small interfering RNA (siRNA) or overexpression plasmid...
March 22, 2024: DNA and Cell Biology
Lingna Ni, Qianqian Gao, Qiu Zhao, Kejun Dai, Mingming Jin, Cong Fu, Min Xiao, Wenyu Zhu, Yanzhi Bi
Hepatocellular carcinoma (HCC) is one of the most common malignant cancers globally. Circular RNAs (circRNAs) have been implicated in the development of HCC. Previous studies have confirmed that circ-EIF3I plays an important role in the progress of lung cancer. Nevertheless, the biological functions of circ-EIF3I and the underlying mechanisms by which they regulate HCC progression remain unclear. In this study, the regulatory mechanism and targets were studied with bioinformatics analysis, luciferase reporting analysis, transwell migration, Cell Counting Kit-8, and 5-Ethynyl-2'-deoxyuridine analysis...
March 22, 2024: DNA and Cell Biology
Xinming Hu, Desheng Li, Jiangtao Zhan, Changmin Yang, Pengfei Wang, Xusong Meng, Sheng Xu, Xianping Che, Lei Xu
Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of kidney epithelial cells, one of the most common tumors in the world. Transforming growth factor beta (TGFβ)1 is a crucial factor that induces epithelial-mesenchymal transition (EMT) in cancer cells. microRNA-141-3p (miR-141-3p) is a microRNA that is considered a tumor suppressor. However, the role and mechanism of miR-141-3p in TGFβ1-induced ccRCC cells are not fully understood. This study investigated the roles of miR-141-3p and its target gene in regulating EMT in ccRCC development...
March 15, 2024: DNA and Cell Biology
Yun Bai, Guanghua Cui, Xiaoke Sun, Meiqi Wei, Yanying Liu, Jialu Guo, Yu Yang
To investigate the functional differences of angiopoietin-related protein 4 ( ANGPTL4 ) transcripts in hepatocellular carcinoma (HCC) cells. By transfecting ANGPTL4 -Transcript 1 and ANGPTL4 -Transcript 3 overexpression vectors into HepG2 and Huh7 cell lines with ANGPTL4 knockdown, the effects of overexpression of two transcripts on cell viability, invasion, migration, and apoptosis were analyzed. The expression of two transcripts was compared in human liver cancer tissue, and their effects on tumor development were validated in vivo experiments in mice...
March 11, 2024: DNA and Cell Biology
Guijun Wang, Yanrong Li, Zhaokai Guo, Qiang He, Zhen Liu, Beibei Deng
Cisplatin (DDP) resistance frequently occurs in gastric cancer (GC) therapy. Tanshinone I is a liposoluble phenanthraquinone compound present in the roots of Salvia miltiorrhiza Bunge (Danshen). In this study, we aimed to explore the effects of tanshinone I on modulating DDP resistance of GC cells in vitro and in vivo . DDP-resistant GC cell models (BGC823/DDP and SGC7901/DDP) were established, and their viability, proliferation, migration, lactate dehydrogenase activity, reactive oxygen species (ROS) generation, and pyroptosis were assessed after DDP treatment with or without tanshinone I...
March 11, 2024: DNA and Cell Biology
Xibao Shi, Menglu Wei, Yuwen Feng, Yuanhao Yang, Xiaozhuan Zhang, Hao Chen, Yuqi Xing, Keqi Wang, Wensheng Wang, Li Wang, Aiping Wang, Gaiping Zhang
Previous studies have shown that interferon gene-stimulating protein (STING) is essential for IFN-γ-inducible protein 16 (IFI16) as the DNA sensor and RNA sensor to induce transcription of type I interferon (IFN-I) and is essential for IFI16 to synergize with DNA sensor GMP-AMP (cGAMP) synthase (cGAS) in induction of IFN-I transcription. While other and our previous studies have shown that IFI16 enhanced retinoic acid-inducible gene I (RIG-I)-, which was an RNA sensor, and mitochondrial antiviral signaling (MAVS)-, which was the adaptor protein of RIG-I, induced production of IFN-I, so we wonder whether IFI16 regulates the signal pathway of RNA-RIG-I-MAVS-IFN-I in a STING-dependent manner...
March 11, 2024: DNA and Cell Biology
Sedigheh Bahmyari, Seyyed Hossein Khatami, Sina Taghvimi, Sahar Rezaei Arablouydareh, Mortaza Taheri-Anganeh, Hojat Ghasemnejad-Berenji, Tooba Farazmand, Elahe Soltani Fard, Arezoo Solati, Ahmad Movahedpour, Hassan Ghasemi
Around 50% of all occurrences of infertility are attributable to the male factor, which is a significant global public health concern. There are numerous circumstances that might interfere with spermatogenesis and cause the body to produce abnormal sperm. While evaluating sperm, the count, the speed at which they migrate, and their appearance are the three primary characteristics that are analyzed. MicroRNAs, also known as miRNAs, are present in all physiological fluids and tissues. They participate in both physiological and pathological processes...
February 23, 2024: DNA and Cell Biology
Jong-Uk Lee, Hun Soo Chang, Ji-Su Shim, Min-Hye Kim, Young-Joo Cho, Min Kyung Kim, Seung-Lee Park, Sun Ju Lee, Jong-Sook Park, Choon-Sik Park
Genetic variation and epigenetic factors are thought to contribute to the development of hypersensitivity to aspirin. DNA methylation fluctuates dynamically throughout the day. To discover new CpG methylation in lymphocytes associated with aspirin-exacerbated respiratory disease (AERD), we evaluated changes in global CpG methylation profiles from before to after an oral aspirin challenge in patients with AERD and aspirin-tolerant asthma (ATA). Whole-genome CpG methylation levels of peripheral blood mononuclear cells were quantified with an Illumina 860K Infinium Methylation EPIC BeadChip array and then adjusted for inferred lymphocyte fraction (ILF) with GLINT and Tensor Composition Analysis...
February 22, 2024: DNA and Cell Biology
Jiaxi Chen, Xinjie Tan, Guangyang Guo, Panpan Wang, Hongxiao Zhang, Shufang Lv, Huawei Xu, Dianyun Hou
Cornus iridoid glycosides (CIGs), including loganin and morroniside, are the main active components of Cornus officinalis . As one of the key enzymes in the biosynthesis of CIGs, geranyl pyrophosphate synthase (GPPS) catalyzes the formation of geranyl pyrophosphate, which is the direct precursor of CIGs. In this study, the C. officinalis geranyl pyrophosphate synthase (CoGPPS) sequence was cloned from C. officinalis and analyzed. The cDNA sequence of the CoGPPS gene was 915 bp (GenBank No. OR725699)...
February 13, 2024: DNA and Cell Biology
Sanjaya K Sahu, Rahul K Maurya, Hrishikesh S Kulkarni
The complement system is a family of proteins that facilitate immune resistance by attacking microbes to decrease pathogen burden. As a result, deficiencies of certain complement proteins result in recurrent bacterial infections, and can also result in acute lung injury (ALI). We and others have shown that C3 is present in both immune and nonimmune cells, and modulates cellular functions such as metabolism, differentiation, cytokine production, and survival. Although the emerging roles of the complement system have implications for host responses to ALI, key questions remain vis-a-vis the lung epithelium...
February 6, 2024: DNA and Cell Biology
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No abstract text is available yet for this article.
February 2024: DNA and Cell Biology
Jacob G Malone, Catriona M A Thompson
No abstract text is available yet for this article.
January 30, 2024: DNA and Cell Biology
Shiyu Dong, Genrong Xu, Xiaoliang Li, Shengjun Guo, Jing Bai, Jiyang Zhao, Liming Chen
Osteoarthritis (OA) is a chronic disease characterized by the progressive loss of cartilage and failure of the diarrheal joint. Quercetin has been reported to attenuate the development of OA. Bone marrow derived mesenchymal stem cell (BMSC)-derived exosomes are involved in OA progression. However, the role of BMSC-derived exosomes in quercetin-mediated progression of OA remains unclear. Western blotting and RT-qPCR were used to assess protein and mRNA levels, respectively. CCK8 assay was performed to assess cell viability, and cell apoptosis was assessed using flow cytometry...
January 19, 2024: DNA and Cell Biology
Lianshun Li, Huiming Zhao, Zhengyang Li, Wengui Shi, Zuoyi Jiao
Primary cilia are microtubule-based organelles that mediate various biological processes. Pancreatic cells are typically ciliated; however, the role of primary cilia in acute pancreatitis (AP) is largely unknown. Here, we report that the loss of primary cilia, mediated by SHCBP1 (SHC1 binding protein), exerted a provocative effect on AP. Primary cilia are extensively lost in inflamed pancreatic cells in vitro and in mouse tissues with AP in vivo . Abrogation of primary cilia aggravated lipopolysaccharide (LPS)-induced inflammation in pancreatic cells...
January 12, 2024: DNA and Cell Biology
Deepali Pathak, Arka Baksi, S S Vasan, Rajan R Dighe
The male sex-determining gene, sex-determining region on the Y chromosome ( SRY ), is expressed in adult testicular germ cells; however, its role in regulating spermatogenesis remains unclear. The role of SRY in the postmeiotic gene expression was investigated by determining the effect of SRY on the promoter of the haploid-specific Protamine 1 ( PRM1 ) gene, which harbors five distinct SRY -binding motifs. In a luciferase reporter assay system, SRY upregulates PRM1 promoter activity in vitro in a dose-dependent manner...
January 3, 2024: DNA and Cell Biology
Lyu-Ye Liu, Si-Jia He, Zhao Chen, Man Ge, Chun-Yi Lyu, Dandan Gao, Ji-Peng Yu, Meng-Han Cai, Jin-Xiang Yuan, Jun-Ling Zhang
Vitiligo is one of the common chronic autoimmune skin diseases in clinic, which is characterized by localized or generalized depigmentation and seriously affects the physical and mental health of patients. At present, the pathogenesis of vitiligo is not clear; mainly, heredity, autoimmunity, oxidative stress, melanocyte (MC) self-destruction, and the destruction, death, or dysfunction of MCs caused by various reasons are always the core of vitiligo. Regulatory cell death (RCD) is an active and orderly death mode of cells regulated by genes, which widely exists in various life activities, plays a pivotal role in maintaining the homeostasis of the organism, and is closely related to the occurrence and development of many diseases...
December 28, 2023: DNA and Cell Biology
Mohammad Rasouli, Fatemeh Safari, Navid Sobhani, Mana Alavi, Raheleh Roudi
The effector proteins of several pathogenic bacteria contain the Glu-Pro-Ile-<u>Tyr</u>-Ala (EPI<u>Y</u>A) motif or other similar motifs. The EPIYA motif is delivered into the host cells by type III and IV secretion systems, through which its tyrosine residue undergoes phosphorylation by host kinases. These motifs atypically interact with a wide range of Src homology 2 (SH2) domain-containing mammalian proteins through tyrosine phosphorylation, which leads to the perturbation of multiple signaling cascades, the spread of infection, and improved bacterial colonization...
December 28, 2023: DNA and Cell Biology
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