Journals Journal of Molecular Neuroscie...

Journal of Molecular Neuroscience : MN
Satoshi Hirako, Nobuhiro Wada, Yuzuru Iizuka, Takahiro Hirabayashi, Haruaki Kageyama, Hyounju Kim, Naoko Kaibara, Naoko Yanagisawa, Fumiko Takenoya, Seiji Shioda
Galanin-like peptide (GALP) is a neuropeptide that was first isolated and identified from the porcine hypothalamus. Studies have described an anti-obesity effect of GALP. We previously found that intracerebroventricular administration of GALP in mice resulted in an increase in respiratory exchange rate 12 to 16 h later. GALP may also affect glucose metabolism, but the detailed mechanism has not been elucidated. In this study, we investigated the effects of GALP on glucose and lipid metabolism in the liver...
February 22, 2024: Journal of Molecular Neuroscience: MN
Li Lin, Xiao-Na Li, Zhen-Yan Xie, Yong-Zhen Hu, Qing-Shan Long, Yi-Qi Wen, Xiao-Bing Wei, Li-Yang Zhang, Xue-Song Li
Previous research has found that an adaptive response to ferroptosis involving glutathione peroxidase 4 (GPX4) is triggered after intracerebral hemorrhage. However, little is known about the mechanisms underlying adaptive responses to ferroptosis. To explore the mechanisms underlying adaptive responses to ferroptosis after intracerebral hemorrhage, we used hemin-treated HT22 cells to mimic brain injury after hemorrhagic stroke in vitro to evaluate the antioxidant enzymes and performed bioinformatics analysis based on the mRNA sequencing data...
February 22, 2024: Journal of Molecular Neuroscience: MN
Jina Jiang, Tingting Qi, Li Li, Yunzhi Pan, Lijuan Huang, Lijuan Zhu, Dongyang Zhang, Xiaoqing Ma, Yinghui Qin
Neuronal apoptosis is crucial in the pathophysiology of ischemic stroke (IS), albeit its underly24ing mechanism remaining elusive. Investigating the mechanism of neuronal apoptosis in the context of IS holds substantial clinical value for enhancing the prognosis of IS patients. Notably, the MRPS9 gene plays a pivotal role in regulating mitochondrial function and maintaining structural integrity. Utilizing bioinformatic tactics and the extant gene expression data related to IS, we conducted differential analysis and weighted correlation network analysis (WGCNA) to select important modules...
February 21, 2024: Journal of Molecular Neuroscience: MN
Hossam Tharwat Ali, Idris Sula, Abrar AbuHamdia, Sewar A Elejla, Ahmed Elrefaey, Hiba Hamdar, Mohamed Elfil
Neurotrauma is a significant cause of morbidity and mortality worldwide. For instance, traumatic brain injury (TBI) causes more than 30% of all injury-related deaths in the USA annually. The underlying cause and clinical sequela vary among cases. Patients are liable to both acute and chronic changes in the nervous system after such a type of injury. Cerebrovascular disruption has the most common and serious effect in such cases because cerebrovascular autoregulation, which is one of the main determinants of cerebral perfusion pressure, can be effaced in brain injuries even in the absence of evident vascular injury...
February 17, 2024: Journal of Molecular Neuroscience: MN
Megha Manoj, Siddarth Sowmyanarayan, Arjun V Kowshik, Jhinuk Chatterjee
The conventional method of one drug being used for one target has not yielded therapeutic solutions for Lewy body dementia (LBD), which is a leading progressive neurological disorder characterized by significant loss of neurons. The age-related disease is marked by memory loss, hallucinations, sleep disorder, mental health deterioration, palsy, and cognitive impairment, all of which have no known effective cure. The present study deploys a network medicine pipeline to repurpose drugs having considerable effect on the genes and proteins related to the diseases of interest...
February 16, 2024: Journal of Molecular Neuroscience: MN
Farzaneh Aghababaei, Majid Nejati, Hadi Karami, Maryam Darvish, Hamed Mirzaei
No abstract text is available yet for this article.
February 16, 2024: Journal of Molecular Neuroscience: MN
Yubao Fan, Shanshan Huang, Fugui Li, Xiyu Zhang, Xueying Huang, Weiqiang Li, Jixiao Zeng, Weijia Wang, Jia Liu
The sympathetic nervous system (SNS) is a crucial branch of the autonomic nervous system (ANS) that is responsible for regulating visceral function and various physiological processes. Dysfunction of the SNS can lead to various diseases, such as hypertension and metabolic disorders. However, obtaining sympathetic neurons from human tissues for research is challenging. The current research aimed at recapitulating the process of human sympathetic neuron development and achieved the successful establishment of a stepwise, highly efficient in vitro differentiation protocol...
February 15, 2024: Journal of Molecular Neuroscience: MN
Kun Zhang, Tianrui Yang, Yu Xia, Xiaopeng Guo, Wenlin Chen, Lijun Wang, Junlin Li, Jiaming Wu, Zhiyuan Xiao, Xin Zhang, Wenwen Jiang, Dongrui Xu, Siying Guo, Yaning Wang, Yixin Shi, Delin Liu, Yilin Li, Yuekun Wang, Hao Xing, Tingyu Liang, Pei Niu, Hai Wang, Qianshu Liu, Shanmu Jin, Tian Qu, Huanzhang Li, Yi Zhang, Wenbin Ma, Yu Wang
Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study is to investigate the relationship between preoperative cognitive function and clinical as well as molecular factors, firstly based on the new 2021 World Health Organization's updated classification of central nervous system tumors. A total of 110 diffuse glioma patients enrolled underwent preoperative cognitive assessments using the Mini-Mental State Examination and Montreal Cognitive Assessment. Clinical information was collected from medical records, and gene sequencing was performed to analyze the 18 most influenced genes...
February 5, 2024: Journal of Molecular Neuroscience: MN
Vinitha Narayan, Munish Kumar, Shalvi Mahajan, Venkata Ganesh, Ankur Luthra, Tulika Gupta, Amit Rawat, Apinderpreet Singh, Sameer Vyas, Vidhya Narayanan, Aparna Depuru, Kirandeep Kaur, Nidhi Panda, Hemant Bhagat
Delayed cerebral ischemia (DCI) is one of the major causes of a poor neurological outcome following aneurysmal subarachnoid hemorrhage (aSAH). Several biomarkers, including matrix metalloproteinase-9 (MMP-9), have been evaluated to predict the development of DCI for timely management. This prospective cohort study was done on 98 patients with aSAH presenting within 72 h of the ictus. Serum samples were collected preoperatively, 7 days after ictus, 10 days after ictus, or when the patient developed DCI, whichever was earlier...
February 5, 2024: Journal of Molecular Neuroscience: MN
Tianyu Liu, Chao Xu, Jiaqi Guo, Zile He, Yunpeng Zhang, Yi Feng
Trigeminal neuralgia (TN) brings a huge burden to patients, without long-term effective treatment. This study aimed to explore the differentially expressed genes (DEGs) and related enrichment pathways in patients with TN. This was a study of transcriptome sequencing and bioinformatics analysis of human samples. Whole blood samples were collected from the TN patients and pain-free controls. RNA was extracted to conduct the RNA-sequencing and the subsequent bioinformatics analysis. DEGs between the two groups were derived...
February 1, 2024: Journal of Molecular Neuroscience: MN
Jospeh Levine, Alexandra Lobyntseva, Shula Shazman, Fahed Hakim, Illana Gozes
Activity-dependent neuroprotective protein (ADNP) is essential for neurodevelopment and de novo mutations in ADNP cause the ADNP syndrome. From brain pathologies point of view, tauopathy has been demonstrated at a young age, implying stunted development coupled with early/accelerated neurodegeneration. Given potential genotype-phenotype differences and age-dependency, we have assessed here a cohort of 15 individuals (1-27-year-old), using 1-3 longitudinal parent (caretaker) interview/s (Vineland 3 questionnaire) over several years...
January 29, 2024: Journal of Molecular Neuroscience: MN
Sandhini Lockman, Matthew Genung, Kimia Sheikholeslami, Annan Ali Sher, Daniel Kroft, Marjorie Buist, Carl O Olson, Brian Toor, Mojgan Rastegar
The epigenetic factor Methyl-CpG-Binding Protein 2 (MeCP2) is a nuclear protein that binds methylated DNA molecules (both 5-methylcytosine and 5-hydroxymethylcytosine) and controls gene transcription. MeCP2 is an important transcription factor that acts in a dose-dependent manner in the brain; thus, its optimal expression level in brain cells is important. As such, its deregulated expression, as well as gain- or loss-of-function mutation, lead to impaired neurodevelopment, and compromised structure and function of brain cells, particularly in neurons...
January 26, 2024: Journal of Molecular Neuroscience: MN
Shruti Subhash Shiromwar, Vijay R Chidrawar, Sudarshan Singh, Havagiray R Chitme, Rahul Maheshwari, Shabnam Sultana
Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors (NMDAR) on hypothalamic neurons and their interaction with GABAA and serotoninergic neuronal circuits. However, the precise mechanisms governing energy homeostasis remain elusive. Notably, in females, the consumption of progesterone-containing preparations, such as hormonal replacement therapy and birth control pills, has been associated with hyperphagia and obesity-effects mediated through the hypothalamus...
January 19, 2024: Journal of Molecular Neuroscience: MN
Wenyan Huang, Zhenni Liu, Ziling Li, Si Meng, Yuhang Huang, Min Gao, Ning Zhong, Sujuan Zeng, Lijing Wang, Wanghong Zhao
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a broad spectrum of symptoms and prognoses. Effective therapy requires understanding this variability. ASD children's cognitive and immunological development may depend on iron homoeostasis. This study employs a machine learning model that focuses on iron metabolism hub genes to identify ASD subgroups and describe immune infiltration patterns. A total of 97 control and 148 ASD samples were obtained from the GEO database. Differentially expressed genes (DEGs) and an iron metabolism gene collection achieved the intersection of 25 genes...
January 18, 2024: Journal of Molecular Neuroscience: MN
Eskandar Qaed, Eman Alyafeai, Ahmed Al-Maamari, Mohamed Y Zaky, Marwan Almoiliqy, Bandar Al-Hamyari, Abdullah Qaid, Saeed Yafei, Waleed Aldahmash, Mueataz A Mahyoub, Fuhan Wang, Le Kang, Zeyao Tang, Jianbin Zhang
Diabetic retinopathy (DR) stands as a prevalent complication of diabetes mellitus, causing damage to the delicate retinal capillaries and potentially leading to visual impairment. While the exact underlying cause of DR remains elusive, compelling research suggests that mitochondrial energy deficiency and the excessive generation of reactive oxygen species (ROS) play pivotal roles in its pathogenesis. Recognizing that controlling hyperglycemia alone fails to reverse the defects in retinal mitochondria induced by diabetes, current strategies seek to restore mitochondrial function as a means of safeguarding against DR...
January 17, 2024: Journal of Molecular Neuroscience: MN
Jian Li, Zhaoming Song, Zhouqing Chen, Jingyu Gu, Yifan Cai, Li Zhang, Zhong Wang
Glioblastoma (GBM) is the most invasive type of glioma and is difficult to treat. Diverse programmed cell death (PCD) patterns have a significant association with tumor initiation and progression. A novel prognostic model based on PCD genes may serve as an effective tool to predict the prognosis of GBM. The study incorporated 11 PCD patterns, namely apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, entotic cell death, netotic cell death, parthanatos, lysosome-dependent cell death, autophagy-dependent cell death, alkaliptosis, and oxeiptosis, to develop the model...
January 12, 2024: Journal of Molecular Neuroscience: MN
Madeleine Morelli, Jamie Adcock, Tsz Wing Yim, Jerri Rook, J Mocco, Colleen Brophy, Joyce Cheung-Flynn
Subarachnoid hemorrhage (SAH) due to the rupture of an intracranial aneurysm leads to delayed vasospasm and neuroischemia, which can result in profound neurologic deficit and death. Therapeutic options after SAH are currently limited to hemodynamic optimization and nimodipine, which have limited clinical efficacy. Experimental SAH results in cerebral vasospasm have demonstrated the downregulation of nitric oxide (NO)-protein kinase G (PKG) signaling elements. VP3 is a novel cell permeant phosphopeptide mimetic of VASP, a substrate of PKG and an actin-associated protein that modulates vasorelaxation in vascular smooth muscle cells...
January 12, 2024: Journal of Molecular Neuroscience: MN
Shirin Jalili, Hadi Shirzad, Seyed Amin Mousavi Nezhad
Major depressive disorder (MDD) is generally among the most prevalent psychiatric illnesses. Significant advances have occurred in comprehension of the MDD biology. However, it is still essential to recognize new biomarkers for potential targeted treatment of patients with MDD. The present work deals with in-depth comparative computational analyses to obtain new insights, such as gene ontology and pathway enrichment analyses and weighted gene co-expression network analysis (WGCNA) through gene expression dataset...
January 10, 2024: Journal of Molecular Neuroscience: MN
Farzaneh Aghababaei, Majid Nejati, Hadi Karami, Maryam Darvish, Hamed Mirzaei
Glioblastoma multiforme (GBM) is the most common as well as the most fatal primary malignant tumor of the central nervous system (CNS), which still lacks a definitive cure. 5-FU is an anti-metabolite anti-cancer agent which has shown promising results for GBM treatment. Resveratrol (Res) is a phytochemical anti-oxidant that has also been effective in suppressing the progression of GBM. The combination of 5-FU and Res has been studied in a variety of cancers, but no study has assessed this combination in GBM...
January 9, 2024: Journal of Molecular Neuroscience: MN
Jiecong Wu, Wenqi Wu, Ping Jiang, Yuhao Xu, Ming Yu
The objective of this study is to investigate the potential biomarkers and therapeutic target genes for Parkinson's disease (PD). We analyzed four datasets (GSE8397, GSE20292, GSE20163, GSE20164) from the Gene Expression Omnibus database. We employed weighted gene co-expression network analysis and differential expression analysis to select genes and perform functional analysis. We applied three algorithms, namely, random forest, support vector machine recursive feature elimination, and least absolute shrinkage and selection operator, to identify hub genes, perform functional analysis, and assess their clinical diagnostic potential using receiver operating characteristic (ROC) curve analysis...
January 8, 2024: Journal of Molecular Neuroscience: MN
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