Journals Journal of Molecular Neuroscie...

Journal of Molecular Neuroscience : MN
Nana Fukushima, Remina Shirai, Takanari Sato, Sayumi Nakamura, Arisa Ochiai, Yuki Miyamoto, Junji Yamauchi
In the central nervous system (CNS), insulative myelin sheaths are generated from the differentiated plasma membranes of oligodendrocytes (oligodendroglial cells) and surround neuronal axons to achieve saltatory conduction. Despite the functional involvement of myelin sheaths in the CNS, the molecular mechanism by which oligodendroglial cells themselves undergo differentiation of plasma membranes remains unclear. It also remains to be explored whether their signaling mechanisms can be applied to treating diseases of the oligodendroglial cells...
May 30, 2023: Journal of Molecular Neuroscience: MN
Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wang
The ventral tegmental area (VTA) is a heterogeneous midbrain area that plays a significant role in diverse neural processes such as reward, aversion, and motivation. The VTA contains three main neuronal populations, namely, dopamine (DA), γ-aminobutyric acid (GABA), and glutamate neurons, but some neurons exhibit combinatorial molecular characteristics of dopaminergic, GABAergic, or glutamatergic neurons. However, little information is available regarding detailed distribution of neurons with single, double, and triple molecular characteristics of glutamatergic, dopaminergic, or GABAergic neurons in mice...
May 27, 2023: Journal of Molecular Neuroscience: MN
Qiongni Zhu, Zhimin Zhu, Stephen James Renaud, Lei Hu, Ying Guo
Lower-grade gliomas (LGGs) are slow-growing, indolent tumors that usually affect younger patients and present a therapeutic challenge due to the heterogeneity of their clinical presentation. Dysregulation of cell cycle regulatory factors is implicated in the progression of many tumors, and drugs that target cell cycle machinery have shown efficacy as promising therapeutic approaches. To date, however, no comprehensive study has examined how cell cycle-related genes affect LGG outcomes. The cancer genome atlas (TCGA) data were used as the training set for differential analysis of gene expression and patient outcomes; the Chinese glioma genome atlas (CGGA) was used for validation...
May 24, 2023: Journal of Molecular Neuroscience: MN
Yi Sun, Xingdong Liu, Zhiqiang Wu, Xiefeng Wang, Yong Zhang, Wei Yan, Yongping You
Temozolomide (TMZ)-based chemotherapy plays a central part in glioma treatment. However, prominent resistance to TMZ is a major change by now. In this study, expression and prognosis of SRSF4 were analyzed using multiple public datasets. Therapeutic efficacy against TMZ resistance was determined by assessing colony formation, flow cytometry, and western blot assays. Bio-informational analysis, immunofluorescence (IF), and western blot assays were performed to evaluate double strand break repair. An orthotopic xenograft model was used to exam the functional role of SRSF4...
April 4, 2023: Journal of Molecular Neuroscience: MN
Aline Almeida Bentes, Walter Rebuite Dos Santos Junior, Natalia Lima Pessoa, Thais Alkifeles Costa, Gabriela Fernanda Garcia Oliveira, Lilian Martins Oliveira Diniz, Bruna Ribeiro Torres, Daniela Caldas Teixeira, Renata Barandas Mendes, Ana Beatriz Alvim Avelar, Marco Antônio Campos, Erna Geessien Kroon, Betania Paiva Drumond
This study evaluates the range of neurological manifestation in children with COVID-19 (neuro-COVID-19) both with and without the multisystem inflammatory syndrome (MIS-C) and the persistence of symptoms after hospital discharge. The study was conducted as a prospective study of children and adolescents under 18 years of age who were admitted to a children's hospital for infectious diseases from January 2021 to January 2022. The children had no previous neurological or psychiatric disorders. Out of the 3021 patients evaluated, 232 were confirmed to have COVID-19 and 21 of these patients (9%) showed neurological manifestations associated with the virus...
March 28, 2023: Journal of Molecular Neuroscience: MN
Pallabi Adak, Nilanjana Banerjee, Swagata Sinha, Apurba Kumar Bandyopadhyay
Despite several efforts to identify the causes of autism spectrum disorders (ASD), its etiology remains still unclear. Among other aspects, genes that encode neurotransmitter receptors are strong candidates for autism. Here, we wanted to study some genetic variants of gamma-aminobutyric acid (GABA) receptor subunit genes GABRB3, GABRG3, and GABRA5, located on chromosome 15q11-q13 that might contribute to the etiology of ASD in the affected children of West Bengal. rs7180158, rs2081648 (GABRB3); rs12910555 (GABRG3); rs35399885, rs35832850 (GABRA5) were analyzed in 316 children with ASD and 227 healthy controls...
March 21, 2023: Journal of Molecular Neuroscience: MN
Tingting Gu, Chang Xu, Xiaozhou Meng, Dapeng Gao, Guanghao Jiang, Anqi Yin, Qingzhen Liu, Lidong Zhang
Posttraumatic stress disorder (PTSD) is a persistent and severe psychological and mental disorder resulting from experiences of serious trauma or stress and is suffered by many individuals. Previous studies have shown that pretreatment with sevoflurane is efficient in reducing the incidence of PTSD. However, we require a more comprehensive understanding of the specific mechanisms by which sevoflurane works. Enhancer of zeste homolog 2 (EZH2) has been reported to be regulated by sevoflurane, and to improve patient cognition...
March 17, 2023: Journal of Molecular Neuroscience: MN
Balachandar Vellingiri, Dhivya Venkatesan, Mahalaxmi Iyer, Gomathi Mohan, Padmavathi Krishnan, Krothapalli Sai Krishna, Sangeetha R, Arul Narayanasamy, Abilash Valsala Gopalakrishnan, Nachimuthu Senthil Kumar, Mohana Devi Subramaniam
Autism spectrum disorder (ASD) is a neurodevelopmental disability that causes social impairment, debilitated verbal or nonverbal conversation, and restricted/repeated behavior. Recent research reveals that mitochondrial dysfunction and oxidative stress might play a pivotal role in ASD condition. The goal of this case-control study was to investigate oxidative stress and related alterations in ASD patients. In addition, the impact of mitochondrial DNA (mtDNA) mutations, particularly MT-ATP6, and its link with oxidative stress in ASD was studied...
March 17, 2023: Journal of Molecular Neuroscience: MN
Lanxiao Cao, Luyan Gu, Jiali Pu, Dayao Lv, Jun Tian, Xinzhen Yin, Ting Gao, Zhe Song, Jinyu Lu, Gaohua Zhao, Baorong Zhang, Yaping Yan, Guohua Zhao
Genetic factors play a major role in essential tremor (ET) pathogenesis. This study aimed to assess variant burden in ET-associated genes in a relatively large Chinese population cohort. We genotyped 27 single nucleotide polymorphisms (SNPs) previously reported to be associated with ET by multiplex PCR amplicon sequencing assay in 488 familial and sporadic ET patients and 514 healthy controls (HCs). Then, we performed allelic and genotypic association test by Pearson chi-square test or Fisher's exact test. A total of 1002 samples were included in our analysis, consisting of 488 ET patients and 514 sex and age-matched HCs...
March 16, 2023: Journal of Molecular Neuroscience: MN
Shaotian Zhang, Huihui Zou, Xiaopei Zou, Jiaqia Ke, Bofang Zheng, Xinrun Chen, Xianju Zhou, Jiana Wei
It is shown that great progress was recently made in the treatment of repetitive transcranial magnetic stimulation (rTMS) for neurological and psychiatric diseases. This study aimed to address how rTMS exerted it therapeutic effects by regulating competitive endogenous RNAs (ceRNAs) of lncRNA-miRNA-mRNA. The distinction of lncRNA, miRNA and mRNA expression in male status epilepticus (SE) mice treated by two different ways, low-frequency rTMS (LF-rTMS) vs. sham rTMS, was analyzed by high-throughput sequencing...
May 2023: Journal of Molecular Neuroscience: MN
Tammy B Pham, Ely Cheikh Boussaty, Antonio Currais, Pamela Maher, David R Schubert, Uri Manor, Rick A Friedman
In the senescence-accelerated mouse prone 8 (SAMP8) mouse model, oxidative stress leads to premature senescence and age-related hearing impairment (ARHI). CMS121 inhibits oxytosis/ferroptosis by targeting fatty acid synthase. The aim of our study was to determine whether CMS121 is protective against ARHI in SAMP8 mice. Auditory brainstem responses (ABRs) were used to assess baseline hearing in sixteen 4-week-old female SAMP8 mice, which were divided into two cohorts. The control group was fed a vehicle diet, while the experimental group was fed a diet containing CMS121...
May 2023: Journal of Molecular Neuroscience: MN
Yan Wu, Yin Wu, Liuxi Chu, Haoran Yang, Wei Wang, Huihua Deng
In recent decades, testosterone challenge research examining the effects of testosterone on human neuropsychological behaviors has rapidly grown with the development of a single-dose transdermal testosterone administration paradigm. However, the optimal time-lag between testosterone administration and behavioral measurement is not unified, partly hindering causal understanding of the "testosterone effect". The present study aimed to investigate the optimal time-lag through LC-MS/MS-based salivary profiles of ten biomarkers among healthy males following administration of different doses of transdermal testosterone (i...
May 2023: Journal of Molecular Neuroscience: MN
Baoqi Yin, Honglei Li, Pengju Zhao, Yonghong Zhao, Ruijuan Zheng, Pengya Feng, Cuixiang Xu, Enyao Li, Liguo Li
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that cannot be cured. The ASD rat model was developed in this study to demonstrate the role and mechanism of ganglioside GM1 (GM1). Rats were given valproic acid (VPA) to create the ASD rat model. The rats' behaviors were assessed using the Y-maze test, open-field test, three-chamber social interaction test, and Morris water maze test. Relative levels of glutathione (GSH), malondialdehyde (MDA), catalase (CAT), reactive oxygen species (ROS), and superoxide dismutase (SOD) were quantitated using relative kits...
May 2023: Journal of Molecular Neuroscience: MN
Aierpati Maimaiti, Yanwen Liu, Aimitaji Abulaiti, Xixian Wang, Zhaohai Feng, Jiaming Wang, Maimaitili Mijiti, Mirzat Turhon, Nilipaer Alimu, Yongxin Wang, Wenbao Liang, Lei Jiang, Yinan Pei
Lower WHO grade II and III gliomas (LGGs) exhibit significant genetic and transcriptional heterogeneity, and the heterogeneity of DNA damage repair (DDR) and its relationship to tumor biology, transcriptome, and tumor microenvironment (TME) remains poorly understood. In this study, we conducted multi-omics data integration to investigate DDR alterations in LGG. Based on clinical parameters and molecular characteristics, LGG patients were categorized into distinct DDR subtypes, namely, DDR-activated and DDR-suppressed subtypes...
May 2023: Journal of Molecular Neuroscience: MN
Fengzhen Xiong, Chenglong Li, Qingbo Wang, Xin Geng, Zhengbo Yuan, Zefu Li
Alzheimer's disease is one of the common neurodegenerative diseases in the elderly, which mainly manifests as progressively severe cognitive impairment, which seriously affects the quality of life of patients. Chromatin regulators have been shown to be associated with a variety of biological processes, and we mainly explore the relationship between chromatin regulators and Alzheimer's disease. Eight hundred seventy chromatin regulators were collected from previous studies, and data related to Alzheimer's disease patients were downloaded from the GEO database...
February 24, 2023: Journal of Molecular Neuroscience: MN
Yan-Li Wang, Yang Du, Lei Chen, Qing-Shan Liu, Yong Cheng
Fibroblast growth factor 2 (FGF2) plays an essential role in neurogenesis, oxidative stress, and emotional behavior. However, the evidence regarding the role of FGF2 in the pathophysiology of depression remains limited and inconclusive. We conducted a systematic review and meta-analysis to investigate peripheral blood FGF2 levels in patients with depression and healthy controls. The PubMed and Web of Science databases were used to identify relevant articles for systematic retrieval. Eight studies involving 310 patients with depression and 268 healthy controls were included in this meta-analysis...
February 20, 2023: Journal of Molecular Neuroscience: MN
Yiming Guan, Bing Xu, Yi Sui, Hui Li, Zhezhou Chen, Yu Luan, Ruijia Yang, Wanshun Qi, Qi Guan
Cytohesin-4 (CYTH4) is a member of the PSCD family. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. In previous studies, CYTH4 has been linked with multiple brain diseases, but not glioma, the most common type of brain tumor. We utilized multiple glioma single-cell RNA sequencing datasets and bulk data from the TCGA and CGGA and conducted GSEA and KEGG and GO analyses. Biomarker potential was tested via ROC curve analysis. Radar plots were used to study TMB and MSI correlations...
February 7, 2023: Journal of Molecular Neuroscience: MN
Olesya A Shchepina, Petr N Menshanov
Regardless of shifts in levels of individual transcripts, it remains elusive whether natural variability in cell-specific transcriptomes within the cerebral cortex is limited in aggregate. It is also unclear whether cortical cell-specific transcriptomes might change dynamically in absence of cell number changes. Total variation in neuron- and glia-specific in-aggregate transcriptomes could be identified in a model-free way via glia-neuron ratio approach, by univariate median-to-median ratios comparing integral levels of cell-specific transcripts within a tissue sample...
February 6, 2023: Journal of Molecular Neuroscience: MN
Shuaishuai Wu, Augustine K Ballah, Wenqiang Che, Xiangyu Wang
Cuprotosis is a novel and different cell death mechanism from the existing known ones that can be used to explore new approaches to treating cancer. Just like ferroptosis and pyroptosis, cuprotosis-related genes regulate various types of tumorigenesis, invasion, and metastasis. However, the relationship between cuprotosis-related long non-coding RNA (cuprotosis-related lncRNA) in glioma development and prognosis has not been investigated. We obtained relevant data from the Genotype-Tissue Expression (GTEx), Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and published articles...
January 27, 2023: Journal of Molecular Neuroscience: MN
Ke Ying, Juan Chen, Zhenhui Fu, Bo Ren
New data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in cerebral infarction (CI). This study aims to illustrate the GEO database-based identification of a circRNA-miRNA-mRNA crosstalk network underlying immune cell infiltration in CI. The differential analysis suggested that 1696 circRNAs, 1989 miRNAs, and 5550 mRNAs that were differentially expressed in CI samples were retrieved from GEO database. GO and KEGG functional enrichment analyses showed that the differentially expressed mRNAs were mainly associated with common risk factors of CI, such as immune and inflammatory response...
January 19, 2023: Journal of Molecular Neuroscience: MN
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