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Journals European Archives of Oto-rhino...

European Archives of Oto-rhino-laryngology

https://read.qxmd.com/read/38762844/efficacy-and-safety-of-dupilumab-in-the-treatment-of-crswnp-in-the-real-life-setting-a-review-of-the-literature
#1
REVIEW
Marella Reale, Giuseppe Licci, Pietro Orlando, Andrea Matucci, Franco Trabalzini, Giandomenico Maggiore, Oreste Gallo
INTRODUCTION: The recent approval of Dupilumab has profoundly revolutionized the management of patients affected by severe and recalcitrant Chronic Rhinosinusitis with Nasal Polyps (CRSwNP). However, a review that summarizes the results of real-life studies and compares them to phase 3 studies SINUS-24 and 52 is still lacking. MATERIALS AND METHODS: A search of all real-life studies published from 2019 to 2023 was performed. Patients characteristics at baseline and 6 and 12 months after starting Dupilumab were extracted and compared to those from phase 3 trials: age, sex, smoking habits, comorbid asthma and aspirin-exacerbated respiratory disease (AERD), previous endoscopic sinus surgery (ESS), hematic eosinophils and total IgE, NasalAQ2 Polyps Score (NPS), smell, SNOT-22, adverse events (AEs), and response to treatment...
May 19, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38761219/is-there-a-relationship-between-the-severity-of-obstructive-sleep-apnea-syndrome-and-the-systemic-immune-inflammation-index
#2
JOURNAL ARTICLE
Meltem Karacan Gölen, Şaziye Melike Işık, Veysel Arıkan
AIM: Vascular dysfunction, oxidative stress and systemic inflammation are considered responsible for the pathophysiology of Obstructive sleep apnea syndrome (OSAS). It is thought that desaturation due to apnea-hypopnea attacks in OSAS patients activates inflammatory pathways. In this study, we aimed to reveal the relationship between inflammation parameters Systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratios (PLR) severity of OSAS in patients who underwent polysomnography in our hospital's sleep laboratory...
May 18, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38761218/sinonasal-mucosal-melanoma-in-the-netherlands-between-2001-and-2021-a-clinical-and-epidemiological-overview-of-320-cases
#3
JOURNAL ARTICLE
W F Julius Scheurleer, Lise J van de Velde, Lot A Devriese, Mischa de Ridder, Marieke W J Louwman, Gerben E Breimer, Remco de Bree, Boukje A C van Dijk, Johannes A Rijken
PURPOSE: Sinonasal mucosal melanoma (SNMM) is a rare malignancy, characterised by high (local) recurrence rates and poor survival. Comprehensive understanding of tumour etiology is currently lacking, which complicates adequate tumour treatment. Besides examining trends in incidence, this study aims to assess the association between clinical characteristics, treatment practices and patient outcomes, with the objective of establishing a baseline from which SNMM management can be enhanced...
May 18, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38761217/outcomes-of-surgical-repair-of-type-iii-and-iv-laryngotracheoesophageal-clefts-with-posterior-cartilage-grafting
#4
JOURNAL ARTICLE
Letian Tan, Qi Li, Chao Chen
PURPOSE: To describe the clinical outcomes of patients who underwent surgical repair through an anterior approach that involved interposition a posterior cartilage for Type III or Type IV laryngotracheoesophageal cleft (LTEC). METHODS: A chart view was performed on patients with Type III or Type IV LTEC between May 2017 and May 2022. Demographic features and surgical outcomes were collected and analyzed. RESULTS: Seven patients were finally included...
May 18, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38758244/video-head-impulse-test-in-subacute-and-chronic-stroke-survivors-new-perspectives-for-implementation-of-assessment-in-rehabilitation
#5
JOURNAL ARTICLE
Marco Tramontano, Nicola Ferri, Andrea Turolla, Amaranta Soledad Orejel Bustos, Laura Casagrande Conti, Chiara Sorge, Paolo Pillastrini, Leonardo Manzari
INTRODUCTION: The Video Head Impulse Test (vHIT) is a safe and reliable assessment of peripheral vestibular function. Many studies tested its accuracy in clinical settings for differential diagnosis and quantification of the vestibulo-oculomotor reflex (VOR) in various disorders. However, the results of its application after lesions of the CNS are discordant and have never been studied in rehabilitation. This study aims to assess the VOR performance in a sample of stroke survivors. METHODS: This is a cross-sectional study on 36 subacute and chronic stroke survivors; only persons with first-ever stroke and able to walk independently, even with supervision, were included...
May 17, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38758243/the-risk-of-free-flap-revision-and-subsequent-medical-costs-in-patients-with-hypopharyngeal-cancer
#6
JOURNAL ARTICLE
Chun-Hsien Ho, Sheng-Dean Luo, Wei-Chih Chen, Tai-Jan Chiu, Yu-Ming Wang, Shao-Chun Wu, Yao-Hsu Yang, Shau-Hsuan Li, Spencer Chia-Hao Kuo, Ching-Nung Wu
BACKGROUND: Few studies have examined the preoperative risks and healthcare costs related to free flap revision in hypopharyngeal cancer (HPC) patients. METHODS: A 20-year retrospective case-control study was conducted using the Chang Gung Research Database, focusing on HPC patients who underwent tumor excision and free flap reconstruction from January 1, 2001, to December 31, 2019. The impacts of clinical variables on the need for re-exploration due to free flap complications were assessed using logistic regression...
May 17, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38758242/presence-of-herpesviruses-parvoviruses-and-polyomaviruses-in-sinonasal-lymphoma
#7
JOURNAL ARTICLE
Maria K Jauhiainen, Ushanandini Mohanraj, Maria F Perdomo, Jaana Hagström, Caj Haglund, Antti A Mäkitie, Maria Söderlund-Venermo, Saku T Sinkkonen
PURPOSE: Sinonasal lymphoma (SL) is a rare lymphatic neoplasm of the nasal cavities, paranasal sinuses and nasopharynx. Whereas some risk factors for SL subtypes have been identified, their aetiology is unknown. Along with other predisposing factors, the viral association of lymphomas, such as Epstein-Barr virus (EBV) and Burkitt and Hodgkin lymphomas, is well-established. Modern molecular biology techniques have enabled the discovery of novel human viruses, exemplified by the protoparvovirus cutavirus (CuV), associated with cutaneous T-cell lymphoma...
May 17, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38758241/cochlear-implantation-for-rare-streptococcus-suis-meningitis-with-hearing-loss
#8
JOURNAL ARTICLE
Shanshan Jiang, Xinyuan Tan, Fan Shu, Muqing Xu, Jieqing Cai, Hongzheng Zhang
OBJECTIVES: This study aimed to explore the diagnostic sensitivity of 3D heavily weighted T2-weighted MRI (T2MRI) and high-resolution computed tomography (HRCT) in patients with cochlear fibrosis associated with Streptococcus suis (S. suis) meningitis and the practicality of Cochlear implantation (CI) treatments. METHODS: Between January 2020 and December 2022, we enrolled four patients with rare cochlear S. suis meningitis with associated hearing loss despite aggressive or non-aggressive follow-up antibiotic treatment...
May 17, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38755508/language-profile-of-children-with-cochlear-implants-comparative-study-about-the-effect-of-age-of-cochlear-implantation-and-the-duration-of-rehabilitation
#9
JOURNAL ARTICLE
Heba Mahmoud Farag, Dalia Mostafa Osman, Rasha Farouk Safwat
PURPOSE: The analysis of different language domains and exploration of variables that affect the outcomes of cochlear implantation would help to document the efficacy of cochlear implantation and intervention programs. The aim of this work was to examine the language profile of children with Cochlear Implants (CI) and to assess the effect of age at the time of cochlear implantation and the impact of duration of rehabilitation on the development of linguistic abilities for cochlear implanted children...
May 16, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38750174/apnoeic-oxygenation-with-high-flow-nasal-oxygen-for-interventional-surgery-of-the-larynx-and-pharynx
#10
JOURNAL ARTICLE
Christine Langer, Claus Wittekindt, Christoph Arens, Sonja Käbisch
BACKGROUND: Highflow nasal cannula oxygen (HFNO) is known to be used for noninvasive oxygenation in intensive care patients but it has rarely been used in airway management for elective surgery of the upper aerodigestive tract. OBJECTIVES: HFNO offers opportunities of a tubeless oxygenation system which is easy to handle and not limited only on surgery of the endolarynx. METHODS: We evaluated this method for oxygenation during brief interventional procedures of the larynx and pharynx in 92 adult patients for safety and intraoperative complications...
May 16, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38748311/epistaxis-first-aid-a-multi-center-knowledge-assessment-study-among-medical-workers
#11
JOURNAL ARTICLE
Tomer Boldes, Nabil Zahalka, Firas Kassem, Benny Nageris, Leigh J Sowerby, Ameen Biadsee
PURPOSE: To assess the knowledge and confidence level regarding the basic first-aid for treating epistaxis among medical staff, including nurses and physicians across various medical disciplines. The study focused three aspects of first aid management: location of digital pressure, head position and duration of pressure. METHODS: The study involved 597 participants, categorized into five groups according to their specialties: emergency medicine, internal medicine, surgery, pediatrics, and community-based healthcare...
May 15, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38743080/heated-humidified-high-flow-nasal-cannula-a-new-conservative-approach-for-neonatal-nasal-stenosis
#12
JOURNAL ARTICLE
Shany Havazelet, Patrick Stafler, Ihab Zarzur, Tara Coreanu, Roy Hod, Keren Armoni-Domany, Dror Gilony
PURPOSE: The aim of this study is to evaluate the efficacy of heated humidified high flow nasal cannula (HFNC) therapy as a conservative treatment option for newborns suffering from nasal stenosis, a condition that often leads to respiratory distress and feeding difficulties. Given the increasing utilization of HFNC in various upper and lower respiratory tract indications, characterized by its flow-based mechanism and minimal mucosal damage, we seek to investigate its potential benefits in this specific patient population...
May 14, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38743079/clinical-evaluation-of-a-machine-learning-based-dysphagia-risk-prediction-tool
#13
JOURNAL ARTICLE
Markus Gugatschka, Nina Maria Egger, K Haspl, David Hortobagyi, Stefanie Jauk, Marlies Feiner, Diether Kramer
PURPOSE: The rise of digitization promotes the development of screening and decision support tools. We sought to validate the results from a machine learning based dysphagia risk prediction tool with clinical evaluation. METHODS: 149 inpatients in the ENT department were evaluated in real time by the risk prediction tool, as well as clinically over a 3-week period. Patients were classified by both as patients at risk/no risk. RESULTS: The AUROC, reflecting the discrimination capability of the algorithm, was 0...
May 14, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38740579/increase-in-acute-mastoiditis-at-the-end-of-the-covid-19-pandemic
#14
JOURNAL ARTICLE
Eva Goldberg-Bockhorn, Clara Hurzlmeier, Julius M Vahl, Franziska Stupp, Aleš Janda, Heike von Baum, Thomas K Hoffmann
PURPOSE: Common respiratory infections were significantly reduced during the COVID-19 pandemic due to general protective and hygiene measures. The gradual withdrawal of these non-pharmaceutical interventions (NPI) was associated with a notable increase in these infections, particularly in pediatric and adult otorhinolaryngology. The aim of this retrospective monocentric study was to evaluate the impact of NPI during the COVID-19 pandemic on the incidence and severity of acute mastoiditis (AM)...
May 14, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38740578/rhinitis-medicomentosa-and-substance-addiction
#15
JOURNAL ARTICLE
Mehmet Birinci, Dogukan Ozdemir, Meltem Pusuroglu, Ömer Sevim, Tuğba Yemiş, Seda Nur Cihan, Esra Yılmaz, Metin Çeliker, Özlem Çelebi Erdivanlı
BACKGROUND: Rhinitis medicomentosa (RM) is a form of non-allergic rhinitis caused by the use of nasal decongestants for longer than the recommended duration. Because of this problem of use, addiction to the drug occurs in individuals. In our study, we aimed to evaluate the susceptibility of RM patients to substance addiction. METHODS: The study was planned as a prospective, multicentric study between September 2022 and September 2023. Patients diagnosed with RM were included in the study...
May 14, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38740577/retrospective-analysis-of-radiological-investigation-of-surgically-excised-head-and-neck-lipomas
#16
JOURNAL ARTICLE
Amy L Schranz, Fiona Riordan, Roisin Dolan, Catriona Lawlor, Colin Morrison, Gary O'Toole, Ronan Killeen, Graeme McNeill, Rory O'Donohoe, Tom Moran, Fergal O'Duffy
PURPOSE: Differentiating benign lipomas from malignant causes is challenging and preoperative investigative guidelines are not well-defined. The purpose of this study was to retrospectively identify cases of head and neck lipomas that were surgically resected over a 5-year period and to identify the radiological modality chosen and features discussed in the final report. Multidisciplinary outcomes and pathology reports were examined with a view to identifying high risk features of a lipoma to aid in future risk stratification...
May 13, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38739186/recreational-music-exposure-and-hearing-health-in-young-adults
#17
JOURNAL ARTICLE
Onur Ergun, Eda Cakmak, Asuman Alniacik
OBJECTIVE: This study aimed to compare daily and total recreational music exposure levels and extended-spectrum audiogram results in young adults without pre-existing hearing problems. DESIGN: The study included healthy volunteers aged 18-25 with no known ear disease or hearing loss. Participants completed a questionnaire, underwent otoscopic and tympanometric examinations, and determined preferred music volumes in an audiometry booth using calibrated music samples of their preferred genres...
May 13, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38739185/keep-calm-does-parental-preoperative-anxiety-affect-post-tonsillectomy-pain-scores-in-children
#18
JOURNAL ARTICLE
Clara Serdoura Alves, Joana Dias, Sara Azevedo, Francisco Sousa, Mariline Santos, Joao Lino, Luis Meireles
PURPOSE: To understand if high parental anxiety leads to increased post-tonsillectomy pain in children. METHODS: Prospective study including parents of children aged 3-10 years old submitted to tonsillectomy with or without adenoidectomy. To evaluate anxiety, parents were asked to fill the State-Trait Anxiety Inventory form-Y, with postoperative pain being evaluated with the Wong-Baker FACES pain scale at postoperative days 1, 3 and 7. Parents were also asked to register the number of days during which children took analgesic and the number of analgesic intakes needed...
May 13, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38739184/stapler-versus-conventional-pharyngeal-repair-after-total-laryngectomy-a-randomized-clinical-trial
#19
JOURNAL ARTICLE
Elsaeed Ahmed Mandor, Hisham Atef Ebada, Ahmed Musaad Abd El-Fattah, Elsharawy Kamal, Hemmat Baz, Ali Tawfik
OBJECTIVES: The aim of the current study was to evaluate the functional outcomes of stapler pharyngeal closure after total laryngectomy by the incidence of PCT and assessment of swallowing after surgery. In addition, the study aimed to evaluate the oncological outcomes in terms of patients' survival rates. METHODS: This randomized clinical trial was conducted on 58 patients with advanced laryngeal carcinoma who underwent total laryngectomy. Patients were randomly assigned to two groups according to the method of pharyngeal repair after laryngectomy: manual closure group (n = 28), and stapler group (n = 30)...
May 13, 2024: European Archives of Oto-rhino-laryngology
https://read.qxmd.com/read/38733533/circulating-tumor-cells-a-valuable-indicator-for-locally-advanced-nasopharyngeal-carcinoma
#20
JOURNAL ARTICLE
Ting Liu, Jing Liu, Guimei Wang, Chunmei Chen, Lihe He, Rensheng Wang, Chunli Ouyang
BACKGROUND: Advancements in nasopharyngeal carcinoma (NPC) treatment have led to a focus on personalized treatment. Circulating tumor cells (CTCs) are important for liquid biopsies and personalized treatment but are not being fully utilized. This study examined how pre- and post-treatment CTC counts, EMT subtypes, clinical characteristics, and patient prognosis are related in order to support the use of liquid biopsy in managing NPC. METHODS: This retrospective study included 141 patients with locally advanced NPC...
May 11, 2024: European Archives of Oto-rhino-laryngology
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