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Journal of Liposome Research

Qiying Shen, Yurun Shen, Feiyang Jin, Yongzhong Du, Xiaoying Ying
Multidrug resistance (MDR) is the largest obstacle to the success of chemotherapy. The development of innovative strategies and safe sensitizers are required to overcome MDR. Paclitaxel (PTX) is a widely used chemotherapeutic drug, the application of which has been learn to understand MDR. However, the application and use are severely restricted because of this MDR. Cyclodextrins (CDs) of many carriers, additionally have shown anti-cancer capability in MDR cancer cells. In this study, novel paclitaxel/hydroxypropyl-β-cyclodextrin complex-loaded liposomes (PTXCDL) have been developed in an attempt to overcome MDR in a PTX-resistant human lung adenocarcinoma (A549/T) cell line...
February 10, 2019: Journal of Liposome Research
Jinfang Zhu, Qiang Hu, Song Shen
The aim of this study was to evaluate whether lycopene-loaded liposomes (L-LYC) could interfere with the antitumor efficacy and cardiotoxicity of doxorubicin (DOX). L-LYC were prepared by a thin-film hydration method to overcome the instability, insolubility, and low bioavailability of lycopene. The mean diameter and morphology of the liposomes were determined by dynamic light scattering and transmission electron microscopy, respectively, and then, in vitro cytotoxicity and in vivo antitumor activity were determined to evaluate the effects of L-LYC and their combination with DOX...
February 10, 2019: Journal of Liposome Research
Haidy Abbas, Rabab Kamel
This study was aiming to improve the effect of the water insoluble drug, Resveratrol, by encapsulating it in surfactant-based elastic vesicles (SLs). SLs were prepared by thin film hydration method using different ratios of Span 60 (S60) and Edge activators (EAs). The prepared spanlastics (SLs) were subjected to full in-vitro evaluation. All the SLs showed improved properties compared to the drug suspension (P < 0.05). SL5 composed of S60: Brij 35 (7:3) attained the highest drug entrapment efficiency (79...
February 10, 2019: Journal of Liposome Research
Chandra Bhushan Tripathi, Poonam Parashar, Malti Arya, Mahendra Singh, Jovita Kanoujia, Gaurav Kaithwas, Shubhini A Saraf
Mammary gland tumor has the highest incidence rate and mortality in women, worldwide. The present study envisaged a molecularly targeted nanostructured lipid carrier (NLCs) for doxorubicin (Dox) delivery capable of inducing cellular apoptosis in mammary gland tumor. NLCs were prepared utilizing Perilla frutescens oil (54-69% ω3-fatty acid) as liquid lipid to enhance entrapment of Dox through molecular ion pairing. Biotin decorated NLCs (b-Dox-NLCs) were evaluated in vitro and in vivo. The b-Dox-NLCs showed particle size of 105...
February 10, 2019: Journal of Liposome Research
Dalia M N Abouhussein, Dina Bahaa El Din Mahmoud, Ebtehal Mohammad F
The increasing incidence of venous thromboembolism in paediatric population has stimulated the development of liquid anticoagulant formulations. Thus our goal is to formulate a liquid formulation of poorly-water soluble anticoagulant, Rivaroxaban, for paediatric use and to assess the possibility of its intravenous administration in emergencies. Self-nanoemulsifying drug delivery systems (SNEDDS) were developed and characterized. SNEDDS constituents were estimated from the saturated solubility study followed by plotting the corresponding ternary phase diagrams to determine the best self-emulsified systems...
February 5, 2019: Journal of Liposome Research
Rehab Nabil Shamma, Sinar Sayed, Nirmeen Ahmed Sabry, Solwan Ibrahim El-Samanoudy
Acne vulgaris is the most common dermatological disorder affecting millions of individuals. Acne therapeutic solutions include topical treatment with retinoic acid (RA) which showed a good efficacy in treatment of mild and moderate cases. However, the high prevalence of adverse events, such as skin dryness, shedding and skin irritation affects the patient convenience and obstruct the acne treatment. Thus, the objective of this paper was to produce Span 60 based elastic vesicles enriched with penetration enhancers, and study their influence on the delivery of RA and its skin irritation...
February 5, 2019: Journal of Liposome Research
Jaleh Varshosaz, Fatemeh Raghami, Mahboubeh Rostami, Ali Jahanian
The current study aimed to develop PEGylated trimethyl chitosan (TMC) coated emulsomes (EMs) conjugated with octreotide for targeted delivery of sorafenib to hepatocellular carcinoma cells (HCC) of HepG2. Sorafenib loaded TMC coated EMs were prepared by the emulsion evaporation method and characterized concerning particle size, zeta potential, drug encapsulation efficiency and in vitro drug release. Synthesized EMs were then conjugated to octreotide. The cytotoxicity of the targeted and non-targeted EMs was determined by cellular uptake and MTT assay on HepG2 cell...
January 22, 2019: Journal of Liposome Research
Maie S Tawfik, Khaled A Abdel-Ghaffar, Ahmed Y Gamal, Fatma H El-Demerdash, Heba A Gad
Lycopene, a naturally occurring carotenoid in red-colored fruits, especially tomatoes, has a pivotal role in counteracting the deleterious effect of oxidative stress on periodontal tissues. The aim of the present study is to prepare solid lipid microparticles (SLMs) encapsulating lycopene and to assess their biochemical and clinical effects in the management of chronic periodontitis. Optimization of SLMs was performed by assessing particle size and lycopene entrapment efficiency. Clinical study included 16 chronic periodontitis patients allocated into two groups, Group I was managed by scaling and root planing (SRP) and local delivery of lycopene loaded SLMs, while group II was managed by SRP only...
January 11, 2019: Journal of Liposome Research
Juliana F F Roncato, Daniela Camara, Thais Carla Brussulo Pereira, Caroline Brandão Quines, Letícia Marques Colomé, Cristiane Denardin, Sandra Haas, Daiana Silva Ávila
The ethanolic extract obtained from purple pitanga fruit (Eugenia uniflora- PPE) has been previously described by its potential to reduce lipid accumulation in vitro. In the present study, we aimed to study this potential in vivo using Caenorhabditis elegans as animal model. Considering the low pH of the extract, its hydrophilic characteristic, its absorption by the medium where the worms are cultivated and the need of a chronic exposure in the worms solid medium, we have loaded liposomes with PPE and investigated its potential for oral administration...
December 18, 2018: Journal of Liposome Research
Malleswara Rao Peram, Sunil S Jalalpure, Vijay M Kumbar, Sachin R Patil, Sumit A Joshi, Kishore G Bhat, Prakash V Diwan
Melanoma is the most deadly and life-threatening form of skin cancer with progressively higher rates of incidence worldwide. The objective of the present investigation is to develop and to statistically optimize and characterize curcumin (CUR) loaded ethosomes for treatment of melanoma. A two factor, three level (32 ) factorial design approach was employed for the optimization of ethosomes. The prepared ethosomes were evaluated for size, zeta potential, entrapment efficiency, in vitro skin permeation and deposition ability...
December 10, 2018: Journal of Liposome Research
Johan Unga, Daiki Omata, Nobuki Kudo, Soki Ueno, Lisa Munakata, Tadamitsu Shima, Ryo Suzuki, Kazuo Maruyama
It is known that Phosphatidyl choline-Phosphatidyl glycerol mixtures can be used for liposome formulations, making them less leaky than liposomes with only one lipid. We hypothesized that this might also be the case for bubbles, which can be used as ultrasound (US) contrast agents. Therefore, we have compared a series of mixed distearoyl phosphatidylcholine-distearoyl phosphatidylglycerol (DSPC-DPSG) bubbles and with bubbles containing either DSPC or DSPG (and distearoyl ethanolamine-polyethyleneglycol 2000, DSPE-PEG2k)...
December 10, 2018: Journal of Liposome Research
Susan Hua
Targeted delivery of therapeutics to the uterus is an important goal in the treatment of obstetric complications, such as preterm labor, postpartum hemorrhage and dysfunctional labor. Current treatment for these obstetric complications is challenging, as there are limited effective and safe therapeutic options available. We have developed a targeted drug delivery system for the uterus by conjugating anti-oxytocin receptor (OTR) antibodies to the surface of PEGylated liposomes (OTR-PEG-ILs). The functionality of the OTR-PEG-ILs have previously been evaluated on human and murine myometrial tissues as well as in vivo in a murine model of preterm labor...
December 10, 2018: Journal of Liposome Research
Mohamed S El-Ridy, Soad A Yehia, Ibrahim El-Sayed, Mostafa M Younis, Rehab Fawzy Abdel Rahman, Menna Ahmed El-Gamil
Niosomes as drug delivery systems have the ability to decrease drugs' side effects and increase their therapeutic effectiveness. Metformin HCl is an oral anti-hyperglycemic agent belonging to biguanides. It is the most commonly chosen drug as a start-up therapy for patients newly diagnosed with type 2 diabetes. This study aims to encapsulate metformin HCl inside niosomes to be used as a transdermal formulation helping to prolong its anti-diabetic effect and investigate its ability to enhance wound healing in diabetic patients...
December 10, 2018: Journal of Liposome Research
Rahul P Patil, Devlya D Pawara, Chetan S Gudewar, Avinash R Tekade
The purpose of this research was to develop cubosomal mucoadhesive in situ nasal gel to enhance the donepezil HCl delivery to the brain. Glycerol mono-oleate (GMO) and surfactant poloxamer 407 were used to prepare cubosomes. The developed formulations were characterized for particle size (PS), poly dispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), transmission electron microscopy (TEM), in vitro drug release and in vivo bio-distribution study in blood and brain tissue. Central composite design was used for the optimization purpose and the selected formulation (containing GMO 2g and poloxamer 1...
December 2, 2018: Journal of Liposome Research
Poonam Parashar, Preeti Rana, Monika Dwivedi, Shubhini A Saraf
Hepatic carcinoma (HC) is one of the most prevalent cancers, ranked as the second most common cause of cancer related deaths worldwide. Silymarin (SYL) has been reported for its anticarcinogenic activity against various types of cancer such as prostate, breast, ovary, colon, lung, bladder and liver. Due to poor solubility and low bioavailability SYL lacks satisfactory therapeutic value thus designing a suitable and effective delivery system of SYL can led to improved therapeutic potential. The present study was aimed to develop SYL loaded dextrose (DEX) modified bilosomes for targeted delivery to HC cells...
December 2, 2018: Journal of Liposome Research
Ghada A Abdelbary, Maha M Amin, Mohamed Y Zakaria, Sally A El Awdan
The present study aimed to prepare proliposomal formulae for improving the oral bioavailability of adefovir dipivoxil (AD), a nucleoside reverse transcriptase inhibitor effective against hepatitis B virus (HBV). The prepared proliposomal formulae were characterized for entrapment efficiency (E.E.%), vesicle size and in vitro drug release after reconstitution to conventional liposomes. The optimized formula (F9) with a maximum desirability value of 0.858 was selected having E.E.% of 71 ± 3.3% with an average vesicle size of 164...
December 2018: Journal of Liposome Research
Pushpendra Singh, Zoltan Beck, Gary R Matyas, Carl R Alving
Liposomes containing cholesterol and monophosphoryl lipid A (such as ALFQ and AS01B) are vaccine adjuvants. During construction of the formulations, addition of QS21 to nano-size (50-100 nm) liposomes resulted in extremely large (up to ∼30 micron) liposomes in ALFQ, but AS01B liposomes remained small nano-vesicles. Here, we show that saturation of phospholipid chains is essential for production of large liposomes by QS21.
October 23, 2018: Journal of Liposome Research
Mariia Nesterkina, Sergii Smola, Iryna Kravchenko
The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy. We report here, that inclusion of monocyclic terpenoid esters in phospholipid liposomes leads to growth of excimer to monomer ratio (IE /IM ) indicating a decrease of membrane microviscosity...
October 23, 2018: Journal of Liposome Research
Sandip Honmane, Ashok Hajare, Harinath More, Riyaz Ali M Osmani, Sachin Salunkhe
The motive behind present work was to discover a solution for overcoming the problems allied with deprived oral bioavailability of salbutamol sulphate (SS) due to its first pass hepatic metabolism, shorter half life and systemic toxicity at high doses. Pulmonary delivery provides alternative route of administration to avoid hepatic metabolism of SS, moreover facilitated diffusion and prolonged retention can be achieved by incorporation into liposomes. Liposomes were prepared by thin film hydration technique using 32 full factorial design and formulation was optimized based on the vesicle size and percent drug entrapment (PDE) of liposomes...
October 8, 2018: Journal of Liposome Research
Mohammad A Obeid, Christine Dufès, Sukrut Somani, Alexander B Mullen, Rothwelle J Tate, Valerie A Ferro
RNA interference (RNAi) is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeutics is limited by the development of an effective delivery system, as naked siRNA is unstable and cannot penetrate the cell membrane. In this study, we investigated the use of cationic niosomes (CN) prepared by microfluidic mixing for siRNA delivery...
October 8, 2018: Journal of Liposome Research
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