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Oral and Maxillofacial Surgery Clinics of North America | Page 2

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https://read.qxmd.com/read/30454787/gene-therapy-in-head-and-neck-cancer
#21
REVIEW
Zachary L Farmer, Edward S Kim, Daniel R Carrizosa
Although overall cancer death rates are decreasing, comparative improvements in head and neck squamous cell cancer are modest. Although new advances targeting immune checkpoints may soon improve these numbers, additional research for new therapeutic options is vital. One potential treatment avenue is the use of gene therapy. This article provides insight into some gene therapy targets and varied techniques being evaluated for patients with head and neck cancer. Techniques include corrective gene therapy, cytoreductive gene therapy, and gene editing, in addition to a discussion on gene therapy vectors...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449529/the-head-and-neck-cancer-patient-neoplasm-management
#22
EDITORIAL
Zvonimir L Milas, Thomas D Shellenberger
No abstract text is available yet for this article.
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449528/immunotherapy-for-head-and-neck-cancer
#23
REVIEW
Felix Sim, Rom Leidner, Richard Bryan Bell
The immune system has a vital role in the development, establishment, and progression of head and neck squamous cell carcinoma (HNSCC). Immune evasion of cancer cells leads to progression of HNSCC. An understanding of this mechanism provides the basis for improved therapies and outcomes for patients. Through the tumor's influence on the microenvironment, the immune system can be exploited to promote metastasis, angiogenesis, and growth. This article provides an overview of the interaction between immune infiltrating cells in the tumor microenvironment, and the immunologic principles related to HNSCC...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449527/management-of-the-neck-in-oral-squamous-cell-carcinoma-background-classification-and-current-philosophy
#24
REVIEW
Payam Afzali, Brent Benson Ward
Nodal metastasis is the single most prognostic determinant in patients with oral squamous cell carcinoma (OSCC). Since its inception more than a century ago, the management of the neck has led to decreased surgical morbidity, with continued preservation of oncologic safety for OSCC. Nodal metastasis is the single most prognostic determinant in patients with OSCC. The decision for the extent of the neck dissection is tailored to tumor-specific characteristics, which dictate the probability and extent of nodal metastasis, including tumor size, location, histopathologic characteristics, and the presence or absence of clinical nodal disease...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449526/soft-tissue-reconstruction-for-head-and-neck-ablative-defects
#25
REVIEW
Stavan Y Patel, Andrew T Meram, Dongsoo D Kim
Soft tissue reconstruction of head and neck ablative defects is a broad, challenging, and subjective topic. The authors outline goals to keep in mind when deciding on a primary reconstructive option for defects created by oncologic resection. Factors considered in local, regional, and distant flap selection are discussed. Based on the goals of reconstruction and factors involved in flap selection, a defect-based reconstructive algorithm is developed to help choose the ideal reconstructive option. The authors also discuss indications, pearls, pitfalls, and challenges in the harvest and inset of commonly used soft tissue flaps for head and neck reconstructive surgery...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449525/current-concepts-in-chemotherapy-for-head-and-neck-cancer
#26
REVIEW
Simran K Sindhu, Julie E Bauman
This article highlights the evidence-based data to support systemic treatment options for patients with head and neck squamous cell carcinoma (HNSCC). The discovery of the human papillomavirus epidemic in HNSCC and its favorable prognosis has led to a major focus of research. Patients are stratified into clinical or pathologic risk categories and enrolled in trials comparing standard treatment paradigms with deintensification, in low-risk disease, or to intensification, in intermediate-risk or high-risk disease...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449524/salivary-gland-malignancies
#27
REVIEW
Eric R Carlson, Thomas Schlieve
Salivary gland tumors are rare pathologic entities that are derived from major and minor salivary gland tissue located throughout the head and neck region. These tumors are distinctly heterogenous, comprising numerous cell types, especially those deemed malignant. The incidence of malignant salivary gland tumors is widely distributed in both adult and pediatric patient populations. Accurate diagnosis and optimal treatment of these tumors pose challenges to both interpreting pathologists and ablative surgeons...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449523/contemporary-osseous-reconstruction-of-the-mandible-and-the-maxilla
#28
REVIEW
Ilya Likhterov, Ansley M Roche, Mark L Urken
Cancers of the oral cavity and paranasal sinuses often require ablative surgery with adjuvant therapy in most cases. Large, postablative defects of the mandible and the maxilla present several challenges to the reconstructive surgeon. Functional and cosmetically satisfactory restoration requires a thorough understanding of the underlying disease process, a firm grasp of the nuances of head and neck anatomy, and an ability to plan and execute a reconstruction with the most suitable tissue for each particular patient...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30449522/the-treatment-of-laryngeal-cancer
#29
REVIEW
Randa Obid, Magi Redlich, Chafeek Tomeh
Successful management of laryngeal cancer depends on careful pretreatment evaluation of patient and disease factors to arrive at accurate staging, leading to appropriate treatment selection for patients with this highly impacting disease. Surgical modalities, including transoral laser microsurgery, open partial laryngectomy, and total laryngectomy, offer options, alone or in combination with radiation and chemotherapy. Treatment strategy for laryngeal cancer should strive for cure while maintaining the best quality of life possible for the patient...
February 2019: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30266193/getting-it-right-from-the-start
#30
EDITORIAL
Zvonimir L Milas, Thomas D Shellenberger
No abstract text is available yet for this article.
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30266192/psychosocial-effects-of-head-and-neck-cancer
#31
REVIEW
Ali Alias, Melissa Henry
Head and neck cancer is known to be both physically and psychologically challenging. The present review summarizes the literature on the psychosocial effects of head and neck cancer by distinguishing features in the preoperative and postoperative periods. It outlines the importance of an integrated collaborative care approach in clinics as well as areas worthy of further program development.
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30266191/maxillofacial-prosthetics
#32
REVIEW
Kamolphob Phasuk, Steven P Haug
The treatment of head and neck cancers requires a team approach. Maxillofacial prosthetics and oncologic dentistry are involved in many phases of the treatment. After the cancer ablation surgery, if surgical reconstruction cannot not completely restore the surgical defect site, maxillofacial prostheses plays an important role to rehabilitate the patient's mastication, swallowing, and speech. For patients undergoing chemoradiation therapy, the outcome is enhanced by jaw positioning stent and fluoride carrier mouthpiece...
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30266190/head-and-neck-cancer-research-and-support-foundations
#33
REVIEW
Joshua E Lubek
Ongoing genetic and epigenetic research involving DNA methylation, salivary biomarkers, wild-type p53 tumor suppressor gene proteins, and HPV oncogenes are being directed at identification and treatment of dysplastic and malignant squamous cell mucosal lesions. Research is being conducted to improve immunotherapy drug response rates by increasing the amount of inflammation within the tumor microenvironment. Ongoing research is focused on the application of the antidiabetic drug metformin for the prevention and management of oral squamous cell dysplastic lesions...
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30266189/framework-for-speech-language-pathology-services-in-patients-with-oral-cavity-and-oropharyngeal-cancers
#34
REVIEW
Loni C Arrese, Katherine A Hutcheson
This article provides a framework speech-language pathology services to optimize functional outcomes of patients with oral cavity and oropharyngeal cancers. Key principles include (1) a proactive rehabilitation model that minimizes intervals of disuse or inactivity of speech and swallowing systems, (2) standardized evaluation paradigms that combine objective instrumental assessments with patient-reported outcome measures, and (3) systematic methods for surveillance and intensive rehabilitation for late dysphagia...
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30173902/nutrition-and-perioperative-care-for-the-patient-with-head-and-neck-cancer
#35
REVIEW
Amarbir Gill, Donald Gregory Farwell, Michael G Moore
Recovery after major head and neck cancer surgery is a complex process. In addition to perioperative sequelae such as pain, wound infections, venous thromboembolism (VTE), and pneumonia, these patients frequently suffer from malnutrition. We provide a contemporary evidence-based approach to common aspects of perioperative care to guide the clinician in the optimal management of patients. Particular emphasis is placed on the preoperative education of patients and the identification and management of malnutrition around the time of surgery...
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30173900/oral-assessment-and-management-of-the-patient-with-head-and-neck-cancer
#36
REVIEW
Herve Y Sroussi, Maryam Jessri, Joel Epstein
Patients undergoing treatment of head and neck cancer risk developing significant acute and chronic changes that affect the hard and soft tissue of the oral cavity and the head and neck region. This article discusses considerations and recommendations for patients before, during, and after treatment of head and neck cancer. The objective of these recommendations is to maintain oral health, compensate for treatment- and disease-associated morbidities, and improve quality of life. To achieve this objective, treatment of head and neck cancer must include an oral evaluation and management plan well-integrated within the overall oncologic treatment plan from the initiation of therapy...
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30143307/imaging-of-patients-with-head-and-neck-cancer-from-staging-to-surveillance
#37
REVIEW
Daniel P Seeburg, Aaron H Baer, Nafi Aygun
In this review, the authors summarize the latest imaging methods and recommendations for each of the various steps in managing patients with head and neck cancer, from staging of disease to posttreatment surveillance. Because staging of head and neck cancers is different for various subsites of the head and neck, imaging is discussed separately for each. A separate discussion of imaging of perineural spread, occult primary tumors, and lymph nodes is followed by a discussion of paradigms for surveillance imaging in the posttreatment neck...
November 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30173903/physical-rehabilitation-and-occupational-therapy
#38
REVIEW
Lauren C Capozzi, Naomi D Dolgoy, Margaret L McNeely
Head and neck cancer and associated treatments can have debilitating effects on patient physical function and quality of life. The American Cancer Society's Head and Neck Cancer Survivorship Care Guidelines recommend that all patients receive an assessment after their treatment to address complications that may impact long-term recovery and function. Evidence supports the role of physical activity, exercise, physical therapy, and occupational therapy to decrease symptom burden after treatment and improve strength, endurance, and function...
August 30, 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30173901/multidisciplinary-team-planning-for-patients-with-head-and-neck-cancer
#39
REVIEW
Thomas D Shellenberger, Randal S Weber
The multidisciplinary team planning conference is critical in the evaluation and management of patients with head and neck cancer. The management is complex and dictates the care of a multidisciplinary team for optimal results. First, the head and neck multidisciplinary team ensures the complete evaluation of patients before beginning treatment. Second, the team improves the accuracy of diagnosis and staging on which to base the most appropriate treatment. Third, the team improves the outcomes of treatment by appealing to the best available evidence, by following clinical practice guidelines and treatment algorithms, and by engaging in clinical research trials...
August 30, 2018: Oral and Maxillofacial Surgery Clinics of North America
https://read.qxmd.com/read/30078696/epidemiology-and-demographics-of-the-head-and-neck-cancer-population
#40
REVIEW
Natasha Cohen, Stacey Fedewa, Amy Y Chen
Head and neck malignancies comprise a heterogeneous group of malignancies that cause significant morbidity to those affected. These malignancies are associated with specific risk factors and exposures, some of which impact prognosis. The most common risk factors for developing head and neck cancers are tobacco and alcohol use. Marijuana and e-cigarettes, occupational exposures, and use of topical substances have also been linked to head and neck cancers. Human papilloma virus has been associated with oropharyngeal cancer...
August 2, 2018: Oral and Maxillofacial Surgery Clinics of North America
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