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Biosensors & Bioelectronics

Fuheng You, Mingyue Zhu, Lijun Ding, Yuhuan Xu, Kun Wang
Rational design and fabrication of Z-scheme visible-light-driven photoactive materials have drawn much attention owing to their great potential in handling environment and energy crisis. In this work, Z-scheme Bi2 S3 /nitrogen-doped graphene quantum dots (NGQDs) with superior photoelectric conversion efficiency were designed and fabricated, which demonstrated enhanced photoactivity compared with Bi2 S3 owing to the improved separation efficiency of photogenerated electron and hole pairs. The emphasis was put on designing Z-scheme Bi2 S3 /NGQDs, and then the mechanism of Z-scheme charge transfer mode was verified by the electron spin resonance (ESR) technique...
February 5, 2019: Biosensors & Bioelectronics
Yanxin Li, Xiaohua Li, Yuchan Meng, Xu Hun
In this work, a photoactive material, Graphdiyne (GDY) loaded with AuNPs (AuNPs-GDY), was successfully synthesized. The fabricated material made use of the natural band-gap structure of GDY, which could produce hole-electron pairs and the plasmon resonance effect of AuNPs to obtain a high photoelectrochemical (PEC) response. AuNPs-GDY PEC response changed with the mass ratio of GDY to tetrachloroauric acid. When the mass ratio of GDY to tetrachloroauric acid was 1:2.5, AuNPs-GDY exhibited the best PEC performance...
February 4, 2019: Biosensors & Bioelectronics
Fang Yang, Xia Zhong, Xinya Jiang, Ying Zhuo, Ruo Yuan, Shaping Wei
Gold nanoclusters (Au NCs) have been shown to be prospective nanoscale electrochemiluminescence (ECL) materials that are being extensively explored in bioanalysis. However, the low ECL efficiency of Au NCs has been a bottleneck barrier for their better bioapplications. To overcome this disadvantage, a low oxidation potential co-reactant N,N-diisopropylethylenediamine (DPEA) was first used to prepare self-enhanced Au NCs (Au-DPEA NCs) for drastically enhancing the ECL efficiency of Au NCs in this study. In addition, an efficient multi-site landing DNA walker with multidirectional motion track and rapid payloads release compared to directional DNA walker was constructed for converting target mucin 1 (MUC1) to intermediate DNA and achieving significant signal amplification...
February 1, 2019: Biosensors & Bioelectronics
J L D Nelis, A S Tsagkaris, Y Zhao, J Lou-Franco, P Nolan, H Zhou, C Cao, K Rafferty, J Hajslova, C T Elliott, K Campbell
Detailed knowledge regarding sensor based technologies for the detection of food contamination often remains concealed within scientific journals or divided between numerous commercial kits which prevents optimal connectivity between companies and end-users. To overcome this barrier The End user Sensor Tree (TEST) has been developed. TEST is a comprehensive, interactive platform including over 900 sensor based methods, retrieved from the scientific literature and commercial market, for aquatic-toxins, mycotoxins, pesticides and microorganism detection...
February 1, 2019: Biosensors & Bioelectronics
Jia Li, Junlin He, Chengli Zhang, Jun Chen, Weiran Mao, Chao Yu
In this study, a dual-type responsive electrochemical biosensor was developed for the quantitative detection of α2,6-sialylated glycans (α2,6-sial-Gs), a potential biomarker of tumors. The gold nanorods (AuNRs), which exhibited great specific surface area, as well as good biocompatibility, was synthesized by the way of seed growth method. Furthermore, a biotin-streptavidin (biotin-SA) system was introduced to improve the immunoreaction efficiency. Accordingly, a label-free biosensor was fabricated based on AuNRs-SA for the quick detection of α2,6-sial-Gs by recording the signal of differential pulse voltammetry (DPV)...
February 1, 2019: Biosensors & Bioelectronics
Abdullah Özkan, Necip Atar, Mehmet Lütfi Yola
An effective SPR nanosensor based on core-shell nanoparticles (Ag@AuNPs) incorporated hexagonal boron nitride (HBN) nanosheets and molecularly imprinted polymer (MIP) was presented for etoposide (ETO) detection. Scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD) method, cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), fourier transform infrared (FTIR) spectroscopy and atomic force microscopy (AFM) methods were utilized for all characterizations of nanomaterials and polymer surfaces...
January 31, 2019: Biosensors & Bioelectronics
Donglei Jiang, Panwei Ge, Lifeng Wang, Hui Jiang, Ming Yang, Limin Yuan, Qingfeng Ge, Weiming Fang, Xingrong Ju
Developing low-cost, portable and simple analysis tools is of vital importance for food safety point-of-care testing. Therefore, herein, a new low-cost, simple to fabricate, disposable, electrochemical mast cell-based paper sensor is proposed and developed to sensitively determine the major milk allergen casein. Then, a graphene (GN)/carbon nanofiber (CN)/ Gelatin methacryloyl (GelMA) composite material with high conductivity and good biocompatibility was modified on the cell-based paper sensor to improve the electrical conductivity and provide a sensing recognition interface for the immobilization of rat basophilic leukemia (RBL-2H3) mast cells...
January 30, 2019: Biosensors & Bioelectronics
Rocío Cánovas, María Cuartero, Gastón A Crespo
The importance of knowing creatinine levels in the human body is related to the possible association with renal, muscular and thyroid dysfunction. Thus, the accurate detection of creatinine may indirectly provide information surrounding those functional processes, therefore contributing to the management of the health status of the individual and early diagnosis of acute diseases. The questions at this point are: to what extent is creatinine information clinically relevant?; and do modern creatinine (bio)sensing strategies fulfil the real needs of healthcare applications? The present review addresses these questions by means of a deep analysis of the creatinine sensors reported in the literature over the last five years...
January 30, 2019: Biosensors & Bioelectronics
Mallikarjunarao Ganesana, Elefterios Trikantzopoulos, Yash Maniar, Scott T Lee, B Jill Venton
L- Glutamate is the main excitatory neurotransmitter in the central nervous system and hyperglutamatergic signaling is implicated in neurological and neurodegenerative diseases. Monitoring glutamate with a glutamate oxidase-based amperometric biosensor offers advantages such as high spatial and high temporal resolution. However, commercially-available glutamate biosensors are expensive and larger in size. Here, we report the development of 50 µm diameter biosensor for real-time monitoring of L-glutamate in vivo...
January 30, 2019: Biosensors & Bioelectronics
Shujing Lin, Xiao Zhi, Di Chen, Fangfang Xia, Yihuan Shen, Jiaqi Niu, Shiyi Huang, Jie Song, Jianmin Miao, Daxiang Cui, Xianting Ding
White blood cells (WBCs) isolated from peripheral blood have been verified as important biomarkers for the diagnosis, treatment and prognosis of cancer. However, it's still under challenge to acquire high-purity WBCs, even by taking advantage of current microfluidic technology. Considering the universality of clinical magnetic activated cell sorting (MACS) method, new developments on microfluidic chip in combination of magnetic cells separation technologies may provide a fascinating approach for high-purity WBCs sorting and widely clinical application...
January 30, 2019: Biosensors & Bioelectronics
S Taniselass, M K Md Arshad, Subash C B Gopinath
Graphene is a 2-dimensional nanomaterial with an atomic thickness has attracted a strong scientific interest owing to their remarkable optical, electronic, thermal, mechanical and electrochemical properties. Graphene-based materials particularly graphene oxide and reduced graphene oxide are widely utilized in various applications ranging from food industry, environmental monitoring and biomedical fields as well as in the development of various types of biosensing devices. The richness in oxygen functional groups in the materials serves as a catalysis for the development of biosensors/electrochemical biosensors which promotes for an attachment of biological recognition elements, surface functionalization and compatible with micro- and nano- bio-environment...
January 29, 2019: Biosensors & Bioelectronics
Amogha Tadimety, Yichen Zhang, Kasia M Kready, Timothy J Palinski, Gregory J Tsongalis, John X J Zhang
Here we present a gold nanorod-based platform for the sequence-specific detection of circulating tumor DNA (ctDNA) point mutations without the need for amplification or fluorescence labeling. Peptide nucleic acid probes complimentary to the G12V mutation in the KRAS gene were conjugated to gold nanorods, and the localized surface plasmon resonance absorbance through the sample was measured after exposure to synthetic ctDNA at various concentrations. Each step of the reaction was thoroughly controlled, starting from reagent concentrations and including conjugation, sonication, and incubation time...
January 29, 2019: Biosensors & Bioelectronics
Xingcan Qian, Xu Zhou, Xin Ran, Hangcheng Ni, Zhi Li, Qing Qu, Jun Li, Guanben Du, Long Yang
In this work, a novel, facile, clean synthesis of monodisperse Au nanoparticles (AuNPs) with an average diameter of 5 nm was achieved by reducing HAuCl4 with dihydroxylatopillar[5]arene (2HP5) in basic solution without the use of harsh reagents and/or external energy. Accordingly, toluidine blue (TB), one electrochemcial indicator, could enter into the cavity of 2HP5 to fabricate host-guest complex through strong electrostatic interaction and charge-transfer interaction, which significantly enhanced the loading quantity of TB and effectively suppressed the leaking of TB resulting in an ultrasensitive and robust electrochemical response...
January 29, 2019: Biosensors & Bioelectronics
Kai Zhang, Ning Gan, Zhipeng Shen, Jinxuan Cao, Futao Hu, Tianhua Li
Microchip electrophoresis (MCE) was a good available method for high-throughput and rapid detecting chemical pollutants in food samples. However, many of the reported MCE assays involve complex design of microchip, laborious operation and poor universality which limited its promotion in multiple antibiotics' detection. Herein, a multiplexed aptasensor was developed based on a universal double-T type microchip to one-step and simultaneously detect several antibiotics within 3 min using chloramphenicol (CAP) and kanamycin (Kana) as representatives...
January 29, 2019: Biosensors & Bioelectronics
Iswary Letchumanan, M K Md Arshad, S R Balakrishnan, Subash C B Gopinath
This paper primarily demonstrates the approach to enhance the sensing performance on antigen C-reactive protein (CRP) and anti-CRP antibody binding event. A nanogapped electrode structure with the gap of ~100 nm was modified by the anti-CRP antibody (Probe) to capture the available CRP. In order to increase the amount of antigen to be captured, a gold nanorod with 119 nm in length and 25 nm in width was integrated, to increase the surface area. A comparative study between the existence and non-existence of gold nanorod utilization was evaluated...
January 29, 2019: Biosensors & Bioelectronics
Yuanfeng Pang, Chaoguang Wang, LuChun Lu, Chongwen Wang, Zhiwei Sun, Rui Xiao
MicroRNAs have been proved to be the biomarker for early detection of pancreatic cancer and the precisely quantitation of the MicroRNA-10b in the blood samples even can distinguish pancreatic cancer from chronic pancreatitis (CP) and normal controls (NC). In this study, we developed a DSN-assisted dual-SERS biosensor for microRNA-10b in exosome and residual plasma of blood samples detection based on the Fe3 O4 @Ag-DNA-Au@Ag@DTNB (SERS tag) conjugates. In presence of target microRNA, it can hybridized with the complementary DNA probes...
January 25, 2019: Biosensors & Bioelectronics
Alisha Prasad, Junseo Choi, Zheng Jia, Sunggook Park, Manas Ranjan Gartia
Point-of-care (POC) applications have expanded hugely in recent years and is likely to continue, with an aim to deliver cheap, portable, and reliable devices to meet the demands of healthcare industry. POC devices are designed, prototyped, and assembled using numerous strategies but the key essential features that biosensing devices require are: (1) sensitivity, (2) selectivity, (3) specificity, (4) repeatability, and (5) good limit of detection. Overall the fabrication and commercialization of the nanohole array (NHA) setup to the outside world still remains a challenge...
January 24, 2019: Biosensors & Bioelectronics
Ruchita Shandilya, Arpit Bhargava, Neha Bunkar, Rajnarayan Tiwari, Irina Yu Goryacheva, Pradyumna Kumar Mishra
Early cancer diagnosis is of prime importance as it paves the way for effective treatment and possible patient survival. The recent advancements in the field of biosensorics have facilitated the development of functionalized nanobiosensors which have the potential to provide a cost-effective, reliable and rapid diagnostic strategy for cancers. These nanoscaled sensing systems utilize electrochemical, optical, mass and calorimetric sensing mechanisms to specifically identify the disease-specific biomarkers. Because of clinical translational utility, the present review aims to describe the recent developments and status of the nanobiosensors as a point-of-care approach for cancer diagnosis...
January 22, 2019: Biosensors & Bioelectronics
Zeqian Xu, Luisa Coriand, Ronny Loeffler, Juergen Geis-Gerstorfer, Yi Zhou, Lutz Scheideler, Monika Fleischer, Frank K Gehring, Frank Rupp
Bacteria adhering to implanted medical devices can cause invasive microbial infections, of e.g. skin, lung or blood. In dentistry, Streptococcus gordonii is an early oral colonizer initiating dental biofilm formation and also being involved in life-threatening infective endocarditis. To treat oral biofilms, antibacterial mouth rinses are commonly used. Such initial biomaterial-bacteria interactions and the influence of antibacterial treatments are poorly understood and investigated here in situ by quartz crystal microbalance with dissipation monitoring (QCM-D)...
January 22, 2019: Biosensors & Bioelectronics
Xueting Liu, Huijun Zhang, Zhiping Song, Liangqia Guo, Fengfu Fu, Yongning Wu
The integrating of high fluorescent quenching capability of two-dimensional nanomaterials with dye-labelled ssDNA as nanoprobes has attracted increasing interest for biosensing applications. However, this absolute intensity-dependent single fluorescent signal may be influenced by target concentration-independent factors. To overcome this challenge, a ratiometric nanoprobe was developed by utilizing green fluorescent phenyl-doped carbon nitride (PDCN) nanosheets as an internal reference and quenching platform...
January 22, 2019: Biosensors & Bioelectronics
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