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Journals European Journal of Gastroente...

European Journal of Gastroenterology & Hepatology

https://read.qxmd.com/read/38477857/time-trends-in-liver-cancer-mortality-rates-in-montenegro-from-1990-to-2018
#21
JOURNAL ARTICLE
Mirjana Nedović Vuković, Marina Jakšić, Danijela Stojanović, Brigita Smolović
OBJECTIVE: Liver cancer is the third most common cause of cancer-related deaths worldwide. Hepatitis B and C infections are the main factors affecting mortality. During recent years, Montenegro conducted activities on eradication of viral hepatitis according to the global strategy for the primary prevention of liver cancer mortality. The objective of this study was to assess the liver cancer mortality trend in Montenegro for the period of 1990-2018 using regression techniques. METHODS: liver cancer mortality data in Montenegro from 1990 to 2018 were collected...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477855/efficacy-and-safety-of-naldemedine-for-opioid-induced-constipation-in-older-patients-with-cancer-a-retrospective-study
#22
JOURNAL ARTICLE
Hisao Imai, Yukiyoshi Fujita, Eriko Hiruta, Takashi Masuno, Shigeki Yamazaki, Hajime Tanaka, Teruhiko Kamiya, Mitsuru Sandoh, Satoshi Takei, Kazuya Arai, Hiromi Nishiba, Junnosuke Mogi, Shiro Koizuka, Taeko Saito, Kyoko Obayashi, Kyoichi Kaira, Koichi Minato
BACKGROUND: Opioids are pain relievers that are often associated with opioid-induced constipation (OIC) that worsens with age. We performed a multicenter, retrospective analysis on the efficacy and safety of naldemedine, an opioid receptor antagonist, in treating OIC in patients with cancer (age >75 years). METHODS: The electronic medical records of cancer patients who received naldemedine at 10 Japanese institutions between 7 June 2017 and August 31, 2019, were retrieved...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477840/the-frequency-and-clinical-significance-of-antibodies-to-soluble-liver-antigen-liver-pancreas-in-autoimmune-hepatitis-a-prospective-single-center-study
#23
JOURNAL ARTICLE
Osman Yüksekyayla, Nabi Kina, Arjen Ulaba, Mehmet Emin Ergün, Ersin Batibay, Cem Şimşek, Fadile Yildiz Zeyrek, Staffan Wahlin, Cumali Efe
BACKGROUND AND AIMS: Soluble liver antigen/liver pancreas antibodies (anti-SLA/LP) are specific markers for autoimmune hepatitis (AIH) that have been associated with a distinct clinical phenotype and a more aggressive form of AIH. We prospectively evaluated the frequency and clinical significance of anti-SLA/LP in Turkish patients with AIH. MATERIAL AND METHODS: We prospectively included patients diagnosed with AIH between January 2018 and May 2023. Autoantibodies were detected using by immunofluorescence and immunoblot...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477856/iron-therapy-supplementation-in-inflammatory-bowel-disease-patients-with-iron-deficiency-anemia-findings-from-a-real-world-analysis-in-italy
#24
JOURNAL ARTICLE
Gionata Fiorino, Jean-Frederic Colombel, Kostas Katsanos, Fermín Mearin, Jürgen Stein, Margherita Andretta, Stefania Antonacci, Loredana Arenare, Rita Citraro, Stefania Dell'Orco, Luca Degli Esposti, Antonio Ramirez de Arellano Serna, Neige Teldja Morin, Ioannis E Koutroubakis
BACKGROUND: This real-world analysis evaluated iron therapy supplementation in inflammatory bowel disease patients with iron-deficiency anemia, considering disease progression and healthcare resource consumption. METHODS: A retrospective observational study was conducted using administrative databases of a pool of Italian healthcare entities, covering about 9.3 million beneficiaries. Between January 2010 and September 2017, adult patients were enrolled in the presence of either hospitalization or active exemption code for ulcerative colitis/Crohn's disease, or one vedolizumab prescription...
March 1, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477843/myosteatosis-is-an-independent-risk-factor-for-overt-hepatic-encephalopathy-after-transjugular-intrahepatic-portosystemic-shunting
#25
JOURNAL ARTICLE
Wenfeng Shi, Hua Yin, Zhijian Yu, Yong Li, Xiao Bai, Sirui Fu, Chongyang Duan, Weiguo Xu, Yang Yang
OBJECTIVE: The relationship between skeletal muscle and adipose tissue compositions and risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) treatment needs to be investigated. METHODS: A total of 282 patients were collected from two medical centres. The median time of follow-up was 48.23 + 1.36 months and the first-year results of all patients after TIPS therapy were collected. The muscle and adipose tissue indices were quantified at the third lumbar vertebra level...
February 29, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407888/inflammatory-bowel-disease-is-associated-with-multiple-sclerosis-or-hodgkin-lymphoma
#26
JOURNAL ARTICLE
Karel Kostev, Christoph Roderburg, Sven H Loosen
No abstract text is available yet for this article.
February 26, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407842/prediction-and-evaluation-of-a-nomogram-model-for-recurrent-acute-pancreatitis
#27
JOURNAL ARTICLE
Yuan Chen, Shu Huang, Bei Luo, Jiao Jiang, Wensen Ren, Kang Zou, Xiaolin Zhong, Muhan Lü, Xiaowei Tang
OBJECTIVE: The purpose of this study was to investigate the influencing factors for recurrent acute pancreatitis and construct the nomogram model to predict the risk of recurrent acute pancreatitis. METHODS: Patients diagnosed with acute pancreatitis in the Affiliated Hospital of Southwest Medical University were enrolled. We collected these patients' basic information, laboratory data, imaging information. Using Logistic regression and least absolute shrinkage and selection operator regression to select risk factor for Cross-Validation Criterion...
February 26, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407856/impact-of-mafld-criteria-on-postoperative-recurrence-of-non-b-non-c-hcc
#28
JOURNAL ARTICLE
Yusuke Johira, Takashi Nakahara, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Shiro Oka
BACKGROUND: This study aimed to clarify the population in whom the presence of metabolic dysfunction-associated fatty liver disease (MAFLD) especially contributes to recurrence after liver resection for non-B, non-C hepatocellular carcinoma (NBNC-HCC). METHODS: Of the 199 patients who underwent liver resection for NBNC-HCC, those who exceeded Milan criteria and with pathologically proven vascular invasion, intrahepatic metastasis, and positive resection margins were excluded, and the remaining 94 were eligible for this study...
February 23, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407855/evaluation-of-chronic-hepatitis-b-patients-who-voluntarily-discontinued-oral-antiviral-therapy-is-there-an-answer-to-the-controversial-topic
#29
JOURNAL ARTICLE
Eyüp Arslan, Yeşim Yildiz, Ömer Karaşahin, Yakup Demir, Çiğdem Tümbül Mermutluoğlu, Gülten Ünlü, Ferit Kuşçu, Şafak Kaya, Fethiye Akgül, Tuba Damar Çakirca, Fatma Yilmaz Karadağ, Sibel Altunişik Toplu, Selçuk Nazik, İrem Akdemir, Şafak Özer Balin, Fatma Özlem Kandemir, Dilara İnan, Yaşar Bayindir, Yeşim Taşova, Mustafa Kemal Çelen
OBJECTIVE: The uncertain treatment duration for nucleos(t)ide analogues (NA) used in the treatment of chronic hepatitis B (CHB) is an important problem for both patients and physicians. The aim of this study was to evaluate the determinants of virologic relapse (VR) and the optimum time of treatment discontinuation in the follow-up of CHB patients who voluntarily discontinued treatment after virological suppression was achieved under NA use. METHODS: Data from 138 patients from 11 centers were included in this registry-based study...
February 23, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407839/optimizing-surveillance-of-low-risk-metabolic-dysfunction-associated-steatotic-liver-disease-using-transient-elastography
#30
JOURNAL ARTICLE
Harish Gopalakrishna, Gayatri B Nair, Roham Salman Roghani, Natarajan Ravendhran, Yaron Rotman
BACKGROUND: Most people with metabolic dysfunction-associated steatotic liver disease (MASLD) lack significant fibrosis and are considered low-risk. Surveillance strategy for low-risk MASLD remains uncertain. AIM: Identify which low-risk subjects can avoid follow-up vibration-controlled transient elastography (VCTE) within 1 year. METHODS: Retrospective analysis of two independent low-risk MASLD cohorts (baseline liver stiffness [LS] < 8kPa) with routine 6-12 months follow-up VCTE...
February 23, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407895/osteonecrosis-in-patients-with-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#31
JOURNAL ARTICLE
Himanshu Bhayana, Tarun Kumar Sharma, Alka Sharma, Mehtab S Dhillon, Anuraag Jena, Deepak Kumar, Vishal Sharma
BACKGROUND: The relationship of inflammatory bowel disease (IBD) with osteonecrosis or avascular necrosis (AVN) is uncertain. METHODS: Systematic review to estimate the frequency of osteonecrosis in IBD was performed. Electronic databases were searched on 12 December 2022 to identify relevant studies. We planned to estimate the pooled prevalence of AVN in IBD, the risk in IBD when compared to the healthy population (without any chronic disease), and the impact of steroid use on osteonecrosis (IBD with and without steroid use)...
February 21, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407853/can-quantitative-surface-antigen-levels-and-systemic-immune-inflammation-index-be-predictive-as-a-new-indicator-for-the-initiation-of-treatment-in-chronic-hepatitis-b
#32
JOURNAL ARTICLE
Mehmet Koroglu, Muhammed Ali Ayvaz, Suat Baran Bakan, Abdullatif Sirin, Umit Akyuz
OBJECTIVES: The natural history of chronic HBV infection (CHB) is generally divided into four phases: HBeAg-positive chronic HBV infection (EPCI) and -hepatitis (EPCH), HBeAg-negative chronic HBV infection (ENCI) and -hepatitis (ENCH). This study aimed to investigate changes in serum quantitative surface antigen (qHBsAg), systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) in a large number of CHB patients. METHOD: Three hundred seventy-two CHB patients who underwent liver biopsy between January 2015 and February 2020 were evaluated...
February 21, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407849/performance-assessment-of-a-new-g12-a1-antibody-based-rapid-elisa-using-commercially-available-and-gluten-spiked-food-samples
#33
JOURNAL ARTICLE
Anil K Verma, Chiara Monachesi, Giulia N Catassi, Elisa Franceschini, Simona Gatti, Elena Lionetti, Carlo Catassi
OBJECTIVE: Food products with <20 mg/kg gluten can be labeled 'gluten-free' according to international regulations. Several antibodies-based ELISAs have been develop to track gluten traces in food products. Among them, R5 and G12 antibody-based ELISAs are the frequently used methods. However, these antibodies have certain limitations. We evaluated the accuracy of G12/A1 antibody-based 'Glutentox ELISA Rapid G12' and compared the results with the current reference method i.e...
February 21, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407887/the-role-of-donor-sex-on-the-post-liver-transplant-outcomes-in-patients-with-primary-sclerosing-cholangitis
#34
JOURNAL ARTICLE
David Uihwan Lee, Ashton Harmacinski, Sindhura Kolachana, Aneesh Bahadur, KeeSeok Lee, Ki Jung Lee, Alex Pu, Harrison Chou, Gregory Hongyuan Fan, Raza Malik
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) can result in hepatic decompensation and require liver transplantation (LT). This study investigates the effect of the sex of the donor and recipient as a prognostic risk factor for adverse outcomes after LT in patients with PSC. METHODS: UNOS registry was used to select LT patients with PSC from 1987 to 2019. The study cohort was stratified based on the sex of the recipient and further subdivided based on the sex of the donor...
February 16, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407882/renal-dysfunction-during-treatment-of-chronic-hepatitis-b-with-tenofovir-disoproxyl-fumarate-and-associated-risk-factors
#35
JOURNAL ARTICLE
Alessandra M de A Maciel, Maria Lucia C G Ferraz, Renata de M Perez, Carlos Eduardo Brandão-Mello
OBJECTIVES: To analyze the evolution of glomerular filtration rate (GFR) and the presence of renal tubular dysfunction during the treatment of chronic hepatitis B virus (HBV) infection with tenofovir disoproxil fumarate (TDF) and to determine the risk factors involved. METHODS: Retrospective cohort observational study of adults with chronic hepatitis B. Exclusion: hepatitis C virus-HBV coinfection, diabetes, baseline GFR less than 60 ml/min. Measurements of serum and urinary creatinine and phosphate; urinary albumin, retinol-binding protein (RBP) and neutrophil gelatinase-associated lipocalin (NGAL) were performed...
February 16, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38251444/late-presentation-for-hepatitis-c-treatment-prevalence-and-risk-factors-in-the-swiss-hepatitis-c-cohort
#36
JOURNAL ARTICLE
Nathalie Brunner, Thomas Grischott, Philip Bruggmann
OBJECTIVE: Patients with 'late presentation' (LP) of chronic hepatitis C infection (HCV) have already developed advanced liver disease before receiving direct-acting antiviral (DAA) treatment. Even after successful treatment, the risk of morbidity and premature death remains elevated, leading to an unnecessary disease burden. This study aimed to assess the prevalence of LP within the prospective observational Swiss Hepatitis C Cohort (SCCS) and evaluate risk factors as determinants of LP...
January 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38251441/unraveling-the-blood-microbiome-novel-insights-into-inflammasome-responses-in-crohn-s-disease
#37
JOURNAL ARTICLE
Duygu Kirkik, Sevgi Kalkanli Tas, Alpaslan Tanoglu
OBJECTIVE: Crohn's disease (CD), an inflammatory bowel disease with unknown etiology, is influenced by genetic, environmental, and immunological factors. This study aimed to analyze the blood microbiome and inflammasome responses, emphasizing NLRP3 protein expression and IL-1β and IL-18 plasma levels, between Crohn's patients and healthy subjects. METHODS: A total of 40 volunteers were included in this study. The 16S rRNA technique was used to sequence the V3-V4 regions of the blood sample...
January 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38251437/variation-in-proliferative-and-cell-cycle-markers-in-barrett-s-esophagus-in-relation-to-circumferential-and-axial-location-in-the-esophagus
#38
JOURNAL ARTICLE
Nosheen Umar, Lance Alleyne, Danny Cheung, James Rees, Caitlin Trudgill, Ulises Zanetto, Suhail Muzaffar, Nigel Trudgill
BACKGROUND: Adenocarcinoma in Barrett's esophagus (BE) occurs more frequently between 12 and 3 o'clock at the gastroesophageal junction (GEJ). METHODS: BE patients were prospectively recruited from December 2013 to July 2016. Expression of p53, Ki-67, cyclin-D1, COX-2 and p21 was assessed in quadrantic biopsies from the proximal and distal margins of the BE segments. Cell cycle marker association with current or subsequent dysplasia or adenocarcinoma was examined...
January 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38251433/endoscopy-in-pediatric-polyposis-syndromes-why-when-and-how
#39
JOURNAL ARTICLE
Shlomi Cohen, Warren Hyer, Thomas Attard
Single or multiple polyps are frequently encountered during colonoscopy among children and adolescents and may be indicative of hereditary polyposis syndrome (HPS). The management of children with single or multiple polyps is guided by the number of polyps, their distribution and the histological findings. Children with HPS carry a high risk of complications, including intestinal and extra-intestinal malignancies. The goals of surveillance in pediatric HPS are to treat symptoms, monitor the burden of polyps and prevent short- and long-term complications...
January 10, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38417062/neither-hepatic-steatosis-nor-fibrosis-is-associated-with-clinical-outcomes-in-patients-with-intestinal-beh%C3%A3-et-s-disease
#40
JOURNAL ARTICLE
Hye Kyung Hyun, Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Seung Lee, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Seung Up Kim, Jae Hee Cheon
BACKGROUND: Behçet's disease (BD) and nonalcoholic fatty liver disease (NAFLD) are chronic inflammatory diseases that share pathogenetic mechanisms. In this study, we investigated whether NAFLD influences the clinical outcomes in patients with intestinal BD. METHODS: Patients with intestinal BD and available hepatic steatosis index (HSI) and fibrosis-4 (FIB-4) scores were recruited between 2005 and 2022. An HSI of ≥30 and FIB-4 of ≥1.45 were used to diagnose hepatic steatosis and significant liver fibrosis, respectively...
April 1, 2024: European Journal of Gastroenterology & Hepatology
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