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European Journal of Gastroenterology & Hepatology

Lasse L Langholm, Tina Manon-Jensen, Morten A Karsdal, Flemming Bendtsen, Diana J Leeming, Søren Møller
OBJECTIVES: Portal hypertension in cirrhosis is associated with endothelial dysfunction, impaired wound healing, and decreased platelet count. Increased von Willebrand factor (VWF) formation has been suggested as a compensatory mechanism, but the role of VWF processing has not been directly assessed. The aim was to measure the processing of activated VWF (VWF-A) in addition to VWF release (VWF-N) to investigate the association of primary hemostasis with disease activity and portal hypertension in liver cirrhosis...
February 12, 2019: European Journal of Gastroenterology & Hepatology
Mohammad Bilal, Obada Tayyem, Hamzeh Saraireh, Monica Chowdhry, Praveen Guturu, Marwan S Abougergi
OBJECTIVE: Acute cholangitis (AC) and upper gastrointestinal hemorrhage (UGIH) are common emergencies encountered by gastroenterologists. We aimed to evaluate the impact of UGIH on in-hospital mortality, morbidity and resource utilization among patients with AC. PATIENTS AND METHODS: Adult admissions with a principal diagnosis of AC were selected from the National Inpatient Sample 2010-2014. The exposure of interest was significant UGIH (requiring red blood cell transfusion)...
February 7, 2019: European Journal of Gastroenterology & Hepatology
Samar K Darweesh, Amal A Gad, Kafya Akroof, Zainab A ElLatif
BACKGROUND AND AIM: Although hepatitis B virus (HBV) recurrence after liver transplantation (LTx) has been reduced since the application of the combination of hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogs (NUCs), the optimum regimen to prevent HBV recurrence with LTx favorable outcome is still not clear. AIM: The aim was to evaluate the efficacy and safety of NUCs prophylaxis (±HBIG) against HBV recurrence after LTx. PATIENTS AND METHODS: This was a retrospective cohort-longitudinal study on 44 HBV-related post-LTx patients on anti-HBV prophylactic therapy...
February 4, 2019: European Journal of Gastroenterology & Hepatology
Waleed A Ismail, Ayman E Yousef
AIM: Until recently, clinicians caring for patients with psoriasis who were infected with hepatitis C virus (HCV) were concerned that treating one condition could exacerbate the other. We evaluated the outcome of treatment with direct-acting antiviral agents (DAAs) on patients with psoriasis having chronic hepatitis C (CHC) infection. PATIENTS AND METHODS: This was an observational prospective cross-sectional study. It included CHC-naive patients with plaque psoriasis...
January 29, 2019: European Journal of Gastroenterology & Hepatology
Jung Hwan Yu, Young Ju Suh, Young-Joo Jin, Nae-Yun Heo, Ji Woong Jang, Chan Ran You, Hyun Young An, Jin-Woo Lee
BACKGROUND/AIM: Accurate assessment of hepatocellular carcinoma (HCC) risk in chronic hepatitis B (CHB) patients receiving entecavir (ETV)/tenofovir disoproxil fumarate (TDF) is likely to play a pivotal role in post-treatment follow-up strategy. We aimed to develop a simple and reliable predictive model for HCC risk in these patients. PATIENTS AND METHODS: A database of 1242 consecutive treatment-naive CHB patients who initially underwent ETV/TDF between February 2007 and January 2017 at four referral hospitals in South Korea was analyzed...
January 28, 2019: European Journal of Gastroenterology & Hepatology
Parul Tandon, Vivian Huang, Nasir Jaffer, Richard Kirsch, Kenneth Croitoru
Whipple's disease is a rare, multisystem infection caused by the Gram-positive Tropheryma whippelii organism. In addition to neurological and rheumatological manifestations, this disease can result in significant gastrointestinal symptoms such as malabsorption, diarrhea, and weight loss. Given the diagnostic challenge and rare occurrence, a high index of suspicion is critical to prevent morbidity and mortality from this otherwise highly infectious disease transmitted via the fecal-oral route. We present a very rare but near-fatal case of hypovolemic shock secondary to protein-losing enteropathy and gastrointestinal bleeding from small bowel T...
January 28, 2019: European Journal of Gastroenterology & Hepatology
Ahmed Abdel-Razik, Nasser Mousa, Mahmoud Abdel-Aziz, Walid Elsherbiny, Sahar Zakaria, Walaa Shabana, Sally Abed, Rania Elhelaly, Rasha Elzehery, Waleed Eldars, Mahmoud El-Bendary
BACKGROUND AND OBJECTIVE: Spontaneous bacterial peritonitis (SBP) is a common bacterial infection with life-threatening sequelae in cirrhotic ascites. The purpose of this retrospective cohort study was to recognize the predictors of SBP to build up a noninvasive system to exclude or establish an episode of SBP. PATIENTS AND METHODS: Of 1194 consecutive patients with cirrhotic ascites, only 966 patients were enrolled in this study. SBP was diagnosed once polymorphonuclear count was at least 250 cells/mm and/or there was a positive ascitic fluid culture result...
January 28, 2019: European Journal of Gastroenterology & Hepatology
Mohamed M Abdelfatah, Mohamed Barakat, Dina Ahmad, Mariam Ibrahim, Yahia Ahmed, Yahia Kurdi, Ian S Grimm, Mohamed O Othman
Endoscopic submucosal dissection (ESD) and gastrectomy with lymph node dissection are considered acceptable treatment modalities for early gastric cancer (EGC). In the last decade, ESD has become more favorable than surgery as it offers faster recovery, lower costs, and a superior quality of life when compared to gastrectomy. The aim of this study is to compare the long-term outcome of ESD versus surgery in EGC. We performed a systematic and comprehensive search of major reference databases (Medline, Embase, CINHAL) for all studies that compared the outcome of EGC for patients underwent ESD or surgery in the same cohort...
January 28, 2019: European Journal of Gastroenterology & Hepatology
Mette Hald, Katrine Carlsen, Inge Nordgaard-Lassen, Vibeke Wewer
BACKGROUND: Adult and pediatric care have different views and ways of handling the patients and the parents, which may result in insufficient coordination and communication of transfer. The young patient, the parents, the pediatric, and the adult provider constitute four central actors in transition and transfer, and they have different roles, approaches, and needs. Our aim was to clarify the challenges and background for each actor. MATERIALS AND METHODS: Statements from semistructured interviews of adult gastroenterologists and nurses were analyzed and interpreted by social scientific principles...
January 25, 2019: European Journal of Gastroenterology & Hepatology
Hesham El-Khayat, Enas M Kamal, Mostafa Yakoot, Manal A Gawad, Naglaa Kamal, Mortada El Shabrawi, Yehia Sameh, Alaa Haseeb, Yasser Fouad, Dina Attia
BACKGROUND: The sustained virological response (SVR) rate for the 12-week sofosbuvir (SOF)/ledipasvir (LVD) treatment of adolescent genotype-4 patients is high. The aim of this study is to evaluate 8 versus 12-week treatment efficacy and safety in adolescent genotype-4 patients. PATIENTS AND METHODS: In total, 157 chronic hepatitis C-infected adolescent patients (mean age 14±2 years, 62% males) were included in this study. All patients received a morning dose of SOF (400 mg)/LVD (90 mg) as a single tablet for 8 and 12 weeks...
January 22, 2019: European Journal of Gastroenterology & Hepatology
Annalisa Schiepatti, Elisa Sprio, David S Sanders, Elisabetta Lovati, Federico Biagi
Coeliac disease (CD) is a chronic gluten-dependent enteropathy very common in the general population and characterized by an extremely heterogeneous clinical picture. Although its prevalence is growing worldwide, case-finding strategy remains the mainstay to diagnosis. Thus, correct identification of high-risk categories of patients who need to be tested for CD is an essential part of medical knowledge to a large number of specialists and primary care providers. In this regard, although CD might have a serious effect on women's reproductive health, a widespread consensus is lacking on which categories of obstetric and gynaecological disorders should be tested for CD...
January 22, 2019: European Journal of Gastroenterology & Hepatology
Necati Örmeci, Orhan Sezgin, Ridvan Karaali, Bilgehan Aygen, Dilara Turan, Serkan Yaras, İlknur Erdem, Orhan Yildiz, Fatih Karakaya, Kenan Ateş, Özgün Ö Asiller
INTRODUCTION: Both hepatitis C virus infection (HCV) and chronic kidney disease (CKD) have been comorbid illnesses with increasing morbidity and mortality. The present study was conducted to present real-life experiences about treatment of HCV and CKD with a fixed-dose combination of paritaprevir 150 mg/day, ritonavir 100 mg/day as a booster, ombitasvir 25 mg/day, and dasabuvir 250 mg twice/day, the PROD regimen. PATIENTS AND METHODS: This was a multicenter, retrospective cohort study...
January 21, 2019: European Journal of Gastroenterology & Hepatology
Claire Liefferinckx, Charlotte Minsart, Anneline Cremer, Leila Amininejad, Vjola Tafciu, Eric Quertinmont, Sophie Tops, Jacques Devière, Ann Gils, André van Gossum, Denis Franchimont
BACKGROUND: Vedolizumab (VDZ) is effective as an induction and maintenance treatment for Crohn's disease and ulcerative colitis, but, as observed with antitumour necrosis factor-α (anti-TNFα) agents, some patients are nonetheless experiencing loss of response. OBJECTIVE: The aim of this study was to investigate the impact of the pharmacokinetics of VDZ during induction on long-term treatment response. PATIENTS AND METHODS: This study focused on a single cohort of 103 inflammatory bowel disease patients treated with VDZ...
January 21, 2019: European Journal of Gastroenterology & Hepatology
Erin L Symonds, Stephen R Cole, Su Yin Lau, Simon Steele, Rosie Meng, Richard J Woodman, Graeme P Young, Charles Cock, Robert Fraser, Peter Bampton
BACKGROUND: The international guidelines for surveillance following the finding of a small tubular adenoma vary between no surveillance or colonoscopy at 5 or 10 years, whereas surveillance after an advanced adenoma is 3 years. Optimization of surveillance reduces the risk of colorectal cancer (CRC) with efficient use of colonoscopy resources. We assessed the risks of advanced colorectal neoplasia following a baseline finding of a small adenoma compared with advanced adenoma. PATIENTS AND METHODS: A retrospective audit was undertaken of patients enrolled in a CRC surveillance program, wherein regular colonoscopies and screening with faecal immunochemical test (FIT) were provided...
January 21, 2019: European Journal of Gastroenterology & Hepatology
Jianhua Hu, Xiaoli Zhang, Jueqing Gu, Meifang Yang, Xuan Zhang, Hong Zhao, Lanjuan Li
BACKGROUND: Staging of liver fibrosis is critical in guiding the treatment of chronic hepatitis B (CHB) virus. Many efforts have been made toward the research of noninvasive techniques, mostly focusing on hepatitis B e-antigen (HBeAg)-positive [HBeAg(+)] CHB patients, whereas HBeAg(+) and HBeA-negative [HBeAg(-)] represent different stages of hepatitis B virus infection. Thus, in this study, we aimed to search for routinely available clinical noninvasive liver fibrosis markers and separately analysed the markers in HBeAg(+) and HBeAg(-) CHB patients...
January 19, 2019: European Journal of Gastroenterology & Hepatology
Masaaki Natsui, Yohei Aoki, Hiromitsu Oka, Kiyotaka Tsuboi, Shunsuke Tsubata, Kazumi Yoko, Toshifumi Sato
OBJECTIVE: This study aimed to investigate whether a novel method including prophylactic pancreatic stent (PS) placement prevents postendoscopic papillary balloon dilation pancreatitis. PATIENTS AND METHODS: This study enrolled 200 consecutive patients with bile duct stones measuring up to 8 mm in diameter and retrospectively recruited 113 patients undergoing ordinary endoscopic papillary balloon dilation (EPBD) without PS placement from our previous study. In the novel method, EPBD and PS placement was attempted with a guidewire left in the main pancreatic duct for patients in whom stable guidewire placement in the main pancreatic duct was possible...
January 17, 2019: European Journal of Gastroenterology & Hepatology
Wouter B van der Sluis, Mark-Bram Bouman, Margriet G Mullender, Malieka C Degen, Paul H M Savelkoul, Wilhelmus J H J Meijerink, Nanne K H de Boer, Adriaan A van Bodegraven, Andries E Budding
OBJECTIVES: The intestinal microbiota plays an important role in intestinal health. After colonic diversion from the fecal stream, luminal nutrients for bacteria are expected to be depleted, inducing changes in microbial composition. In this study, we describe microbial changes in the healthy colon following surgical fecal stream diversion, studied in the surgically constructed sigmoid-derived neovagina. METHODS: At various postoperative times after sigmoid vaginoplasty, rectal, neovaginal, and skin microbial swabs were obtained for microbial analysis by interspacer profiling, a PCR-based bacterial profiling technique...
January 17, 2019: European Journal of Gastroenterology & Hepatology
Ashraf O Abdelaziz, Hanan Abdelhalim, Aisha M Elsharkawy, Hend I Shousha, Ahmed H Abdelmaksoud, Zeinab A Soliman, Mohamed I Seif, Dina B Sayed, Mohamed H Farouk, Tamer M Elbaz, Mohamed M Nabeel
BACKGROUND: Liver stiffness increases after the development of hepatocellular carcinoma (HCC). Transient elastography for liver stiffness measurement (LSM) using fibroscan is a simple noninvasive method of proven efficacy. This study aims to assess the changes in LSM following HCC treatment. PATIENTS AND METHODS: This study included 150 patients with hepatitis C virus related HCC attending the multidisciplinary HCC clinic, Kasr Al-Ainy Hospital between March 2014 and October 2015 who underwent either transarterial chemoembolization (TACE) or microwave ablation (MWA)...
January 11, 2019: European Journal of Gastroenterology & Hepatology
Xiafei Leng, Feng Zhang, Ming Zhang, Huiwen Guo, Xiaochun Yin, Jiangqiang Xiao, Yi Wang, Xiaoping Zou, Yuzheng Zhuge
BACKGROUND AND AIMS: Transjugular intrahepatic portosystemic shunt (TIPS) is an effective intervention for portal hypertensive complications in cirrhosis. Spontaneous portosystemic shunts (SPSSs) may increase the risk of post-TIPS complications and mortality. This study was done to evaluate the safety and efficacy of TIPS for treating variceal bleeding between patients with and without SPSSs. PATIENTS AND METHODS: The clinical data of 467 consecutive patients with cirrhosis who received TIPS for variceal bleeding from January 2012 to January 2018 were screened...
January 9, 2019: European Journal of Gastroenterology & Hepatology
Aimen Al Mahjoub, Véronique Bouvier, Benjamin Menahem, Céline Bazille, Audrey Fohlen, Arnaud Alves, Andrea Mulliri, Guy Launoy, Jean Lubrano
OBJECTIVES: The objective of this study was to investigate the differences between cholangiocarcinoma (CC) subtypes in terms of incidence rate, clinical presentation, management and survival by applying a stable anatomical classification in a population-based study. PATIENTS AND METHODS: Cancer data for the period 2000-2012 were obtained from a specialized digestive cancer registry in the Department of Calvados, France. Patients' files were checked, and the diagnosis was verified by two hepatobiliary surgeons...
January 9, 2019: European Journal of Gastroenterology & Hepatology
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