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European Journal of Gastroenterology & Hepatology

https://read.qxmd.com/read/38477863/comparative-maintenance-performance-of-all-biologic-agents-and-small-molecules-in-ulcerative-colitis-a-network-meta-analysis
#1
JOURNAL ARTICLE
Theodore Rokkas, Javier P Gisbert, Konstantinos Ekmektzoglou, Themistocles Dassopoulos, Yaron Niv, Colm O'Morain
BACKGROUND AND AIMS: Βiologic agents and small molecules have expanded the therapeutic armamentarium of moderate to severe ulcerative colitis (UC). However, their comparative efficacy and safety performance as maintenance treatments have not been sufficiently explored. We performed a systematic review and network meta-analysis (NWM) to assess the comparative efficacy and safety of all approved and emerging treatments for maintenance in moderate to severe UC. METHODS: We searched Pubmed/Medline, EMBASE, and Cochrane Library databases for relevant RCTs through April 2023...
March 12, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477854/fatigue-depression-and-sleep-disorders-are-more-prevalent-in-patients-with-metabolic-associated-fatty-liver-diseases
#2
JOURNAL ARTICLE
Alaa M Mostafa, Shaimaa Moustafa Hafez, Noha M Abdullah, Yasser Fouad
AIM: To determine the prevalence and risk factors for depression, sleep disturbances, and exhaustion in MAFLD patients. METHODS: Two hundred twenty-four consecutive patients with MAFLD attending the outpatient clinic from April to October 2023; were subjected to clinical evaluation, laboratory testing including non-invasive laboratory markers, fibroscan (measuring steatosis and fibrosis), and different quantitative and qualitative fatigue scores. A control group including 342 patients without MAFLD was taken...
March 12, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477851/paraneoplastic-gastrointestinal-dysmotility-due-to-non-hodgkin-diffuse-large-b-cell-lymphoma-a-case-report
#3
JOURNAL ARTICLE
Emily Nash, John D Chetwood, Aravind G Tamilarasan, Emilia Prakoso
Paraneoplastic gastrointestinal dysmotility is a rare entity which occurs in association with malignancy. We present the second case associated with lymphoma, characterised by generalised gastrointestinal dysmotility with constipation, malnutrition, weight loss, and capsule endoscope retention. This case highlights the importance of maintaining a high index of suspicion for malignancy in patients with unexplained gastrointestinal dysmotility.
March 12, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38489662/relation-between-non-alcoholic-fatty-liver-disease-and-carotid-artery-intimal-media-thickness-as-a-surrogate-for-atherosclerosis-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Hazem Abosheaishaa, Mahmoud Nassar, Omar Abdelhalim, Ammar Ayman Bahbah, Sharif Abbas, Samah M Morsi, Muhammad Ghallab, Zakaria Alagha, Ahmed Omran, Khaled Elfert, Praneeth Bandaru, Arnold Nongmoh Forlemu, Madhavi Reddy
BACKGROUND AND OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis without heavy alcohol consumption or other chronic conditions, encompasses a spectrum from non-alcoholic fatty liver to non-alcoholic steatohepatitis leading to cirrhosis. This analysis aimed to investigate the correlation between NAFLD and carotid intimal media thickness (C-IMT), a non-invasive surrogate for atherosclerosis. METHODOLOGY: Database searches, including PubMed, EMBASE and Cochrane Library, yielded studies up to April 2023...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38489595/contemporary-perioperative-outcomes-after-total-abdominal-colectomy-for-ulcerative-colitis-in-a-tertiary-referral-centre
#5
JOURNAL ARTICLE
Ian J B Stephens, Brenda Murphy, Lucy Burns, Niamh McCawley, Deborah A McNamara, John P Burke
OBJECTIVE: Colectomy for ulcerative colitis (UC) is common despite therapeutic advances. Post-operative morbidity and mortality demonstrate an association between hospital volumes and outcomes. This single-centre retrospective study examines outcomes after emergency colectomy for UC. METHODS: Patient demographics, perioperative variables and outcomes were collected in Beaumont Hospital between 2010 and 2023. Univariant analysis was used to assess relationships between perioperative variables and morbidity and length of stay (LOS)...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477862/the-influence-of-carvedilol-posology-timing-on-clinically-significant-portal-hypertension-insights-from-elastography-measurements
#6
JOURNAL ARTICLE
Bruno Besteiro, Manuel Marques da Cruz, Cláudia Alves, Fátima Costa, Mariana Nunes, Daniel Martinho Dias, Ana Barreira, Joana Calvão, Mónica Mesquita, Sónia Carvalho, Inês Pinho, Paulo Carrola, José Presa Ramos
BACKGROUND AND AIMS: Carvedilol has emerged as the preferred β-blocker for treating portal hypertension. However, there is still a debate in dosing regimen, with a potential lower bioavailability in once-daily regimens. The aim of this study is to assess the acute effects of carvedilol posology in patients with clinically significant portal hypertension (CSPH), as a surrogate marker of bioavailability. METHODS: In this experimental study, 34 patients with CSPH receiving carvedilol twice daily were asked to suppress the night dose of carvedilol, creating a standardized 24-hour dose interval...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477858/prevalence-trends-and-characteristics-of-metabolic-dysfunction-associated-steatotic-liver-disease-among-the-us-population-aged-12-79-years
#7
JOURNAL ARTICLE
Tsung-Hua Shen, Chung-Hsuen Wu, Yuan-Wen Lee, Chun-Chao Chang
BACKGROUND AND AIMS: Clinical observation revealed an increase in metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence among adults and adolescents and young adults (AYA). However, its prevalence trend in specific subgroups and its characteristics are unclear. APPROACH AND RESULTS: This cross-sectional study included adults and AYA aged 20-79 and 12-19 years, respectively, from the National Health and Nutrition Examination Survey from 1999 to 2018...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477850/idiopathic-chronic-intestinal-pseudo-obstruction-syndrome-is-strongly-associated-with-low-serum-levels-of-vitamin-d
#8
JOURNAL ARTICLE
Alba Panarese, Elton Dajti, Leonardo Henry Eusebi, Amanda Vestito, Rocco Maurizio Zagari
Idiopathic chronic intestinal pseudo-obstruction (CIPO) is associated with intestinal inflammation and malabsorption and may cause serum vitamin D deficiency. We aimed to assess whether there is an association between idiopathic CIPO and serum levels of 25-hydroxy-vitamin D. Consecutive patients with confirmed diagnosis of idiopathic CIPO were prospectively enrolled and matched with healthy controls by gender, age, and BMI. Median serum level of 25-hydroxy-vitamin D of patients with CIPO was compared with that of healthy subjects using the Wilcoxon signed-rank test for matched samples...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477849/sugar-sweetened-beverage-intake-and-long-term-mortality-in-individuals-with-metabolic-dysfunction-associated-steatotic-liver-disease-a-longitudinal-analysis-of-the-national-health-and-nutrition-examination-survey-database
#9
JOURNAL ARTICLE
Ji Zhou, Chu Liu, Lili Liu, Lei Li
BACKGROUND: Consuming sugar-sweetened beverages (SSBs) has been linked to the development of various adverse health conditions, including metabolic dysfunction-associated steatotic liver disease (MASLD). This study evaluated associations between SSB intake and long-term mortality among individuals with MASLD using a nationally representative database. METHODS: This population-based, longitudinal study extracted data of adults aged 20-79 years with MASLD from the USA (US) National Health and Nutrition Examination Survey database 2003-2014...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477847/high-antibiotic-resistance-rates-in-helicobacter-pylori-strains-in-turkey-over-20-years-implications-for-gastric-disease-treatment
#10
JOURNAL ARTICLE
Burak Sarikaya, Riza Aytaç Çetinkaya, Derya Özyiğitoğlu, Sinem Akkaya Işik, Mustafa Kaplan, Duygu Kirkik, Levent Görenek
OBJECTIVE: Helicobacter pylori (Hp) eradication therapy is crucial for preventing the development of gastritis, peptic ulcers, and gastric cancer. An increase in resistance against antibiotics used in the eradication of Hp is remarkable. This meta-analysis aims to examine the resistance rates of Hp strains isolated in Turkey over the last 20 years against clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LVX), tetracycline (TET), and amoxicillin (AMX) antibiotics. BASIC METHODS: Literature search was carried out in electronic databases, by searching articles published in Turkish and English with the keywords 'helicobacter pylori' or 'Hp' and 'antibiotic resistance' and 'Turkey'...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477839/clinical-outcomes-with-metformin-use-in-diabetic-patients-with-compensated-cirrhosis-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Spyros Peppas, Stavros Doumas, Advait Suvarnakar, Jiling Chou, Ayah Arafat, Akram I Ahmad, James H Lewis
BACKGROUND: Previous studies have demonstrated a beneficial effect of metformin in patients with cirrhosis, but no improvement in liver histology. AIM: To investigate the impact of metformin on mortality and hepatic decompensation in people with diabetes with compensated cirrhosis. METHODS: Medline, Embase and Cochrane databases were searched from inception to February 2023 for studies reporting results regarding the impact of metformin on all-cause mortality and hepatic decompensation in people with diabetes with compensated cirrhosis...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477864/referral-for-liver-transplant-following-acute-variceal-bleeding-a-multicenter-cohort-study
#12
JOURNAL ARTICLE
Sofia Bragança, Marta Ramos, Sara Lopes, Gonçalo Alexandrino, Milena Mendes, Rui Perdigoto, João Coimbra, Hugo P Marques, Filipe S Cardoso
OBJECTIVES: Referral for liver transplant (LT) following acute variceal bleeding (AVB) varies widely. We aimed to characterize and assess its impact on clinical outcomes. METHODS: Observational retrospective cohort including cirrhosis patients with AVB from 3 hospitals in Lisbon, Portugal, from 2018 to 2019. Primary exposure was referral for LT and primary endpoint was all-cause mortality within 2 years of index hospital admission. RESULTS: Among 143 patients, median (IQR) age was 59 (52-72) years and 90 (62...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477857/time-trends-in-liver-cancer-mortality-rates-in-montenegro-from-1990-to-2018
#13
JOURNAL ARTICLE
Mirjana Nedović Vuković, Marina Jakšić, Danijela Stojanović, Brigita Smolović
OBJECTIVE: Liver cancer is the third most common cause of cancer-related deaths worldwide. Hepatitis B and C infections are the main factors affecting mortality. During recent years, Montenegro conducted activities on eradication of viral hepatitis according to the global strategy for the primary prevention of liver cancer mortality. The objective of this study was to assess the liver cancer mortality trend in Montenegro for the period of 1990-2018 using regression techniques. METHODS: liver cancer mortality data in Montenegro from 1990 to 2018 were collected...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477855/efficacy-and-safety-of-naldemedine-for-opioid-induced-constipation-in-older-patients-with-cancer-a-retrospective-study
#14
JOURNAL ARTICLE
Hisao Imai, Yukiyoshi Fujita, Eriko Hiruta, Takashi Masuno, Shigeki Yamazaki, Hajime Tanaka, Teruhiko Kamiya, Mitsuru Sandoh, Satoshi Takei, Kazuya Arai, Hiromi Nishiba, Junnosuke Mogi, Shiro Koizuka, Taeko Saito, Kyoko Obayashi, Kyoichi Kaira, Koichi Minato
BACKGROUND: Opioids are pain relievers that are often associated with opioid-induced constipation (OIC) that worsens with age. We performed a multicenter, retrospective analysis on the efficacy and safety of naldemedine, an opioid receptor antagonist, in treating OIC in patients with cancer (age >75 years). METHODS: The electronic medical records of cancer patients who received naldemedine at 10 Japanese institutions between 7 June 2017 and August 31, 2019, were retrieved...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477840/the-frequency-and-clinical-significance-of-antibodies-to-soluble-liver-antigen-liver-pancreas-in-autoimmune-hepatitis-a-prospective-single-center-study
#15
JOURNAL ARTICLE
Osman Yüksekyayla, Nabi Kina, Arjen Ulaba, Mehmet Emin Ergün, Ersin Batibay, Cem Şimşek, Fadile Yildiz Zeyrek, Staffan Wahlin, Cumali Efe
BACKGROUND AND AIMS: Soluble liver antigen/liver pancreas antibodies (anti-SLA/LP) are specific markers for autoimmune hepatitis (AIH) that have been associated with a distinct clinical phenotype and a more aggressive form of AIH. We prospectively evaluated the frequency and clinical significance of anti-SLA/LP in Turkish patients with AIH. MATERIAL AND METHODS: We prospectively included patients diagnosed with AIH between January 2018 and May 2023. Autoantibodies were detected using by immunofluorescence and immunoblot...
March 4, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477856/iron-therapy-supplementation-in-inflammatory-bowel-disease-patients-with-iron-deficiency-anemia-findings-from-a-real-world-analysis-in-italy
#16
JOURNAL ARTICLE
Gionata Fiorino, Jean-Frederic Colombel, Kostas Katsanos, Fermín Mearin, Jürgen Stein, Margherita Andretta, Stefania Antonacci, Loredana Arenare, Rita Citraro, Stefania Dell'Orco, Luca Degli Esposti, Antonio Ramirez de Arellano Serna, Neige Teldja Morin, Ioannis E Koutroubakis
BACKGROUND: This real-world analysis evaluated iron therapy supplementation in inflammatory bowel disease patients with iron-deficiency anemia, considering disease progression and healthcare resource consumption. METHODS: A retrospective observational study was conducted using administrative databases of a pool of Italian healthcare entities, covering about 9.3 million beneficiaries. Between January 2010 and September 2017, adult patients were enrolled in the presence of either hospitalization or active exemption code for ulcerative colitis/Crohn's disease, or one vedolizumab prescription...
March 1, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477843/myosteatosis-is-an-independent-risk-factor-for-overt-hepatic-encephalopathy-after-transjugular-intrahepatic-portosystemic-shunting
#17
JOURNAL ARTICLE
Wenfeng Shi, Hua Yin, Zhijian Yu, Yong Li, Xiao Bai, Sirui Fu, Chongyang Duan, Weiguo Xu, Yang Yang
OBJECTIVE: The relationship between skeletal muscle and adipose tissue compositions and risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) treatment needs to be investigated. METHODS: A total of 282 patients were collected from two medical centres. The median time of follow-up was 48.23 + 1.36 months and the first-year results of all patients after TIPS therapy were collected. The muscle and adipose tissue indices were quantified at the third lumbar vertebra level...
February 29, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407888/inflammatory-bowel-disease-is-associated-with-multiple-sclerosis-or-hodgkin-lymphoma
#18
JOURNAL ARTICLE
Karel Kostev, Christoph Roderburg, Sven H Loosen
No abstract text is available yet for this article.
February 26, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407842/prediction-and-evaluation-of-a-nomogram-model-for-recurrent-acute-pancreatitis
#19
JOURNAL ARTICLE
Yuan Chen, Shu Huang, Bei Luo, Jiao Jiang, Wensen Ren, Kang Zou, Xiaolin Zhong, Muhan Lü, Xiaowei Tang
OBJECTIVE: The purpose of this study was to investigate the influencing factors for recurrent acute pancreatitis and construct the nomogram model to predict the risk of recurrent acute pancreatitis. METHODS: Patients diagnosed with acute pancreatitis in the Affiliated Hospital of Southwest Medical University were enrolled. We collected these patients' basic information, laboratory data, imaging information. Using Logistic regression and least absolute shrinkage and selection operator regression to select risk factor for Cross-Validation Criterion...
February 26, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38407856/impact-of-mafld-criteria-on-postoperative-recurrence-of-non-b-non-c-hcc
#20
JOURNAL ARTICLE
Yusuke Johira, Takashi Nakahara, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Eisuke Murakami, Tomokazu Kawaoka, Daiki Miki, Masataka Tsuge, Shiro Oka
BACKGROUND: This study aimed to clarify the population in whom the presence of metabolic dysfunction-associated fatty liver disease (MAFLD) especially contributes to recurrence after liver resection for non-B, non-C hepatocellular carcinoma (NBNC-HCC). METHODS: Of the 199 patients who underwent liver resection for NBNC-HCC, those who exceeded Milan criteria and with pathologically proven vascular invasion, intrahepatic metastasis, and positive resection margins were excluded, and the remaining 94 were eligible for this study...
February 23, 2024: European Journal of Gastroenterology & Hepatology
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