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Journals European Journal of Gastroente...

European Journal of Gastroenterology & Hepatology

https://read.qxmd.com/read/38829959/clinicopathological-features-prognostic-factors-and-prognostic-survival-prediction-in-patients-with-extrahepatic-bile-duct-cancer-liver-metastasis
#1
JOURNAL ARTICLE
Xianyu Huang, Wenhui Chen, Jiaxin Liu, Yonghui Liao, Jia Cai, Dingwen Zhong
PURPOSE: Extrahepatic bile duct cancer (EBDC) is a compound malignant tumor mainly consisting of extrahepatic cholangiocarcinoma and gallbladder carcinoma. Most EBDC patients are diagnosed at an advanced stage characterized by distant metastases, and the liver is one of the common sites of metastasis. Hence, the purpose of this study is to investigate the clinicopathological features, identify prognostic risk factors, and assess the long-term prognosis of extrahepatic bile duct cancer liver metastasis (EBDCLM)...
May 31, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38829950/metabolic-dysfunction-associated-steatotic-liver-disease-related-cirrhosis-and-incidence-of-portal-vein-thrombosis
#2
JOURNAL ARTICLE
Waseem Amjad, Zhenghui G Jiang, Michelle Lai
BACKGROUND: There is heterogeneous data on whether metabolic-associated steatohepatitis is an independent risk factor for portal vein thrombosis (PVT). We aim to compare the incidence of PVT in patients with cirrhosis with and without metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: This is a single-center retrospective study of patients with cirrhosis seen between 1 January 2016 and 31 January 2021. Patients with a history of hepatocellular cancer, liver transplant, Budd-Chiari syndrome, and intra-abdominal malignancies were excluded...
May 31, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38829956/the-second-irish-helicobacter-pylori-working-group-consensus-for-the-diagnosis-and-treatment-of-helicobacter-pylori-infection-in-adult-patients-in-ireland
#3
JOURNAL ARTICLE
Sinéad M Smith, Breida Boyle, Martin Buckley, Conor Costigan, Maeve Doyle, Richard Farrell, M Syafiq Ismail, David Kevans, Sean Nugent, Anthony O'Connor, Colm O'Morain, Vikrant Parihar, Cristín Ryan, Deirdre McNamara
BACKGROUND: There has been an increase in resistance to many of the antimicrobials used to treat Helicobacter pylori (H. pylori) nationally and internationally. Primary clarithromycin resistance and dual clarithromycin and metronidazole resistance are high in Ireland. These trends call for an evaluation of best-practice management strategies. OBJECTIVE: The objective of this study was to revise the recommendations for the management of H. pylori infection in adult patients in the Irish healthcare setting...
May 30, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38829948/the-impact-of-meld-exception-points-for-hydrothorax-on-posttransplant-mortality-a-propensity-score-matched-analysis
#4
JOURNAL ARTICLE
Sawsan Fathma, Sarpong Boateng, Ayesha Amatya, Prince Ameyaw, Bubu A Banini
BACKGROUND: Hepatic hydrothorax is a challenging complication of end-stage liver disease, and.patients with this complication can receive model for end-stage liver disease (MELD) exception points if they meet specific criteria as defined by United Network for Organ Sharing (UNOS). This research aimed to analyze the effect of receiving MELD exception points for hepatic hydrothorax on posttransplant mortality, using a national transplant database. METHODS: Patients >18 years in the UNOS database awaiting liver transplant between 2012 and 2023 were identified based on their petition for MELD exception points...
May 30, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38808872/sarcopenia-is-an-independent-risk-factor-for-short-term-mortality-in-patients-undergoing-transjugular-intrahepatic-portosystemic-shunt
#5
JOURNAL ARTICLE
Elina Stoffel, Soo Young Hwang, Xia Qian, Brian Geller, Giuseppe Morelli, Wei Zhang
BACKGROUND: Sarcopenia is common in patients with cirrhosis and is a risk factor for increased mortality. Transjugular intrahepatic portosystemic shunt (TIPS) placement has been utilized in cirrhosis patients with decompensation. We investigated the role of sarcopenia in predicting mortality in patients undergoing TIPS. METHODS: We conducted a single-center retrospective study of 232 patients with cirrhosis who underwent TIPS between January 2010 and December 2015...
May 27, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38652516/nomogram-predicting-survival-in-patients-with-lymph-node-negative-hepatocellular-carcinoma-based-on-the-seer-database-and-external-validation
#6
JOURNAL ARTICLE
Ziqiang Li, Qingyong Hong, Kun Li
BACKGROUND: The relationship between lymph node (LN) status and survival outcome in hepatocellular carcinoma (HCC) is a highly controversial topic. The aim of this study was to investigate the prognostic factors in patients without LN metastasis (LNM) and to construct a nomogram to predict cancer-specific survival (CSS) in this group of patients. METHODS: We screened 6840 eligible HCC patients in the Surveillance, Epidemiology and End Results(SEER)database between 2010 and 2019 and randomized them into a training cohort and an internal validation cohort, and recruited 160 patients from Zhongnan Hospital of Wuhan University as an external validation cohort...
April 24, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38652529/the-cost-implications-of-wilson-disease-among-hospitalized-patients-analysis-of-usa-hospitals
#7
JOURNAL ARTICLE
David Uihwan Lee, Ashton Harmacinski, Aneesh Bahadur, Ki Jung Lee, Hannah Chou, Mohammed Rifat Shaik, Harrison Chou, Gregory Hongyuan Fan, Jean Kwon, Reid Ponder, Kevin Chang, KeeSeok Lee, Zurabi Lominadze
BACKGROUND AND AIM: In this study, we used a national cohort of patients with Wilson's disease (WD) to investigate the admissions, mortality rates, and costs over the captured period to assess specific subpopulations at higher burden. METHODS: Patients with WD were selected using 2016-2019 National Inpatient Sample (NIS). The weighted estimates and patient data were stratified using demographics and medical characteristics. Regression curves were graphed to derive goodness-of-fit for each trend from which R2 and P values were calculated...
April 23, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38652524/intestinal-ultrasound-scan-predicts-corticosteroid-failure-and-colectomy-risk-in-patients-with-ulcerative-colitis
#8
JOURNAL ARTICLE
Baisi Yuan, Pengfei Huang, Miaofang Yang, Guoxing Tang, Fangyu Wang
OBJECTIVE: Intestinal ultrasound (IUS) is an emerging modality for assessing disease activity, extent, and treatment response in ulcerative colitis. This study aimed to evaluate the potential of IUS in predicting severe flares, the need for rescue therapy (corticosteroid failure), and colectomy in patients with ulcerative colitis. METHODS: We conducted a retrospective review of medical records, collecting clinical and IUS data. The Milan Ultrasound Criteria (MUC) score was used to assess ulcerative colitis severity...
April 17, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38652507/association-between-nonalcoholic-fatty-liver-disease-and-gallstone-risk-in-nonobese-and-lean-individuals
#9
JOURNAL ARTICLE
Nam Hee Kim, Ji Hun Kang, Hong Joo Kim
PURPOSE: The association between nonobese/lean nonalcoholic fatty liver disease (NAFLD) and gallstone formation remains unclear. We aimed to assess whether NAFLD is an independent risk factor for gallstones, even in nonobese or lean individuals. METHODS: We analyzed 265 353 asymptomatic adults who underwent abdominal ultrasonography. The risk of gallstone was assessed on the basis of obesity and NAFLD status. RESULTS: The overall prevalence rates of NAFLD and gallstones were 27...
April 17, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625821/appraisal-of-a-newly-developed-albi-sarcopenia-score-as-a-prognostic-marker-in-patients-with-hepatocellular-carcinoma
#10
JOURNAL ARTICLE
Maha Elsabaawy, Hanaa Badran, Amr Ragab, Rasha Abdelwahab, Eman Sayed, Sameh Afify, Warda Othman
OBJECTIVE: This study aimed to evaluate the impact of the combined Albumin-bilirubin (ALBI)/sarcopenia score as a newly developed prognostic model for hepatocellular carcinoma (HCC), with a focus on its utility in predicting mortality. METHODS: This prospective study was conducted on HCC patients who were followed for 1 year or until death. Sarcopenia was assessed radiologically by computed tomography at the level of L3. The study consisted of two sets: a development set in which the new ALBI-sarcopenia score was created, comprising 262 HCC patients, followed by an internal validation set with 100 patients...
April 17, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625824/causal-effect-between-gut-microbiota-and-gastroesophageal-reflux-disease-a-bidirectional-two-sample-mendelian-randomization-study
#11
JOURNAL ARTICLE
Jingyu Liu, Tongxin Zhang, Xiao Liu, Qian Wang, Huawei Zhang
Previous observational studies have found that the gut microbiota is closely related to the pathogenesis of gastroesophageal reflux disease (GERD), while their causal relationship is unclear. A two-sample multivariate Mendelian randomization analysis was implemented to estimate the causal effect of gut microbiota on GERD. The gut microbiota aggregated statistics were derived from a meta-analysis of the largest available genome-wide association studies (GWAS) conducted by the MiBioGen alliance (n = 13 266)...
April 15, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625820/improvement-of-quality-of-care-provided-to-outpatients-with-hepatic-cirrhosis-after-an-educational-intervention
#12
JOURNAL ARTICLE
Alberto Amador, Silvia Salord, Xavier Xiol, Marta Garcia-Guix, Alba Cachero, Rosa Rota, Nerea Hernandez Aretxabaleta, Carme Baliellas, Jose Castellote
OBJECTIVE: A set of indicators has been reported to measure the quality of care for cirrhotic patients, and previously published studies report variable adherence rates to these indicators. This study aimed to assess the quality of care provided to cirrhotic outpatients before and after an educational intervention by determining its impact on adherence to quality indicators. METHODS: We conducted a quasi-experimental, cross-sectional study including 324 cirrhotic patients seen in 2017 and 2019 at a tertiary teaching hospital in Spain...
April 15, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625827/antidepressant-treatment-in-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#13
JOURNAL ARTICLE
Frances Weston, Ben Carter, Nick Powell, Allan H Young, Calum D Moulton
Around 25% of patients with inflammatory bowel disease (IBD) have depressive symptoms, yet antidepressants have been poorly studied in IBD. We systematically searched IBD studies testing antidepressants in four databases. Outcomes were depressive symptoms, anxiety, IBD disease activity, quality of life (QoL) and adverse events. For randomized controlled trials (RCTs), we performed random-effects meta-analysis of the standardized mean difference (SMD) in posttreatment scores between antidepressant and placebo groups...
April 5, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625823/the-effect-of-implementing-a-transanal-minimally-invasive-surgical-programme-for-the-local-excision-of-early-rectal-neoplasia-on-outcomes-in-a-tertiary-referral-rectal-cancer-centre
#14
JOURNAL ARTICLE
William P Duggan, John Lenihan, Cillian Clancy, Deborah A McNamara, John P Burke
Transanal minimally invasive surgery (TAMIS) is a surgical alternative to proctectomy in the management of complex rectal polyps and early rectal cancers. In 2016, our institution introduced a TAMIS programme. The purpose of this study was to evaluate changes in practice and outcomes in our institution in the 3 years before and after the implementation of TAMIS. We conducted a retrospective analysis of a prospective database of patients who underwent proctectomy or TAMIS for the management of complex rectal polyps or early rectal cancers at our institution between 2013 and 2018...
April 5, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625818/long-term-outcomes-of-intestinal-penetrating-crohn-s-disease-following-successful-nonoperative-management
#15
JOURNAL ARTICLE
Zhenya Sun, Lei Cao, Yusheng Chen, Weiming Zhu, Yi Li
There is a paucity of data on the surgical or medical treatment for abscess/fistula complicating Crohn's disease after successful nonsurgical management. We conducted a cohort study to investigate the long-term outcomes and the risk factors for the requirement of subsequent surgical intervention in Crohn's disease patients with complicating fistulas/abscess following successful nonsurgical management. Data were collected on penetrating Crohn's disease experiencing successful nonsurgical treatment between December 2012 and December 2021...
April 5, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625832/histopathological-staging-and-differential-diagnosis-of-marginal-zone-lymphoma-of-gastric-mucosa-associated-lymphoid-tissue
#16
JOURNAL ARTICLE
Dong-Feng Ge, Yang-Kun Wang, Shen-Lin Li, Xiong-Fei Zou, Ling-Chao Kong, Wei-Yi Deng, Su-Nan Wang
The purpose of this study was to explore the histopathological staging and differential diagnosis of marginal zone lymphoma in gastric mucosa-associated lymphoid tissue (MALT lymphoma). We performed detailed histomorphology and immunohistochemistry investigations as well as genetic testing on endoscopic biopsy and endoscopic mucosal resection specimens from 18 patients with gastric MALT lymphoma. We found that gastric MALT lymphoma typically begins as a small, isolated area outside the lymphoid follicular mantle zone or proliferates in a multifocal, patchy manner, gradually spreads to the interfollicular zone, forming diffuse proliferation, invades the gastric mucosal glands, and infiltrates or proliferates into the center of peripheral reactive lymphoid follicles...
April 2, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38625825/biological-treatment-approach-to-inflammatory-bowel-disease-is-similar-in-academic-and-nonacademic-centres-prime-time-for-decentralisation-of-inflammatory-bowel-disease-care
#17
JOURNAL ARTICLE
Katja Tepeš, Jurij Hanžel, David Štubljar, Karin Strmšek, Luka Erjavec, Eva Supovec, Zala Jagodic, Mirjam Končan, Jan Grosek, Jurij Aleš Košir, Aleš Tomažič, Urška Kogovšek, Gregor Norčič, Renata Šibli, Marija Žnidaršič, Tadeja Pačnik Vižintin, Barbara Sodin, Janez Breznik, Vanesa Anderle Hribar, Andreja Ocepek, Cvetka Pernat Drobež, Nejc Bukovnik, Andrej Zafošnik, Tamara Marušič, Nataša Jurečič Brglez, Maja Denkovski, Nataša Smrekar, Gregor Novak, Matic Koželj, Tina Kurent, Jože Simonič, Špela Pintar, Borut Štabuc, David Drobne
BACKGROUND: With the increasing number of inflammatory bowel disease (IBD) patients, it is difficult to manage them within specialised IBD teams in academic medical centres: many are therefore treated in nonacademic IBD centres. It is unclear whether the time to introducing biologics is the same in both settings. AIM: We aimed to compare treatment approach with biologics in academic vs. nonacademic centres. METHODS: We analysed Slovenian national IBD registry data (UR-CARE Registry, supported by the European Crohn's and Colitis Organisation), which included 2 academic (2319 patients) and 4 nonacademic IBD (429 patients) centres...
April 2, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38555605/efficacy-of-radiofrequency-ablation-vs-transcatheter-arterial-embolization-for-hepatic-hemangiomas
#18
JOURNAL ARTICLE
Jushang Li, Shuaiguo Zhang, Chunmin Ning, Guoming Li, Shigang Guo
OBJECTIVE: The objective of this study was to evaluate the safety and effectiveness of radiofrequency ablation (RFA) and transcatheter arterial chemoembolization (TACE) in the treatment of large hepatic hemangiomas (LHH) (5-9.9 cm in diameter). METHODS AND MATERIALS: This study retrospectively collected data from 82 patients with LHH treated at Chaoyang Central Hospital. The study analyzed the differences in postoperative efficacy, operative time, blood routine, liver and kidney function on the first day after surgery, postoperative hospitalization time and postoperative complications...
March 28, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526946/metabolic-dysfunction-associated-steatotic-liver-disease-related-hepatic-fibrosis-increases-risk-of-insulin-resistance-type-2-diabetes-and-chronic-kidney-disease
#19
JOURNAL ARTICLE
Weijing Zhang, Wen Jing Song, Weiyu Chen, Zoucheng Pan, Jiawei Zhang, Li Fan, Jie Li
Metabolic dysfunction-associated steatotic liver disease (MASLD) (previously called nonalcoholic fatty liver disease, NAFLD) is associated with cardiometabolic risk factors and chronic kidney disease (CKD). However, evidence is lacking regarding whether the severity of fibrosis is affected by these risk factors and diseases and to what degree. We aimed to determine the correlation between these factors and vibration-controlled transient elastography-determined liver stiffness measurements (LSMs) and controlled attenuation parameter (CAP) values in a sample of the US population...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526945/comparing-the-efficacy-of-vedolizumab-between-males-and-females-a-post-hoc-analysis-of-gemini-1-and-varsity
#20
JOURNAL ARTICLE
Tarun Chhibba, Emily C L Wong, Walter Reinisch, Laura Targownik, Neeraj Narula
Vedolizumab is a first-line treatment option for ulcerative colitis. There are differences in incidence of ulcerative colitis between males and females, but whether sex affects treatment outcomes is less clear. We examined sex-based differences in patients with ulcerative colitis initiated on vedolizumab from two major randomized controlled trials (RCTs). We conducted a post-hoc analysis on participants with ulcerative colitis from the VARSITY and GEMINI-1 RCTs who received vedolizumab. Outcomes of interest were rates of clinical improvement, clinical remission, and endoscopic improvement at weeks 6, 14, and 52 in male and female participants, as were differences in concentrations of trough vedolizumab and C-reactive protein; 1009 persons in GEMINI-1 and VARSITY trials were included...
March 22, 2024: European Journal of Gastroenterology & Hepatology
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