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European Journal of Gastroenterology & Hepatology

https://read.qxmd.com/read/38526946/metabolic-dysfunction-associated-steatotic-liver-disease-related-hepatic-fibrosis-increases-risk-of-insulin-resistance-type-2-diabetes-and-chronic-kidney-disease
#1
JOURNAL ARTICLE
Weijing Zhang, Wen Jing Song, Weiyu Chen, Zoucheng Pan, Jiawei Zhang, Li Fan, Jie Li
Metabolic dysfunction-associated steatotic liver disease (MASLD) (previously called nonalcoholic fatty liver disease, NAFLD) is associated with cardiometabolic risk factors and chronic kidney disease (CKD). However, evidence is lacking regarding whether the severity of fibrosis is affected by these risk factors and diseases and to what degree. We aimed to determine the correlation between these factors and vibration-controlled transient elastography-determined liver stiffness measurements (LSMs) and controlled attenuation parameter (CAP) values in a sample of the US population...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526945/comparing-the-efficacy-of-vedolizumab-between-males-and-females-a-post-hoc-analysis-of-gemini-1-and-varsity
#2
JOURNAL ARTICLE
Tarun Chhibba, Emily C L Wong, Walter Reinisch, Laura Targownik, Neeraj Narula
Vedolizumab is a first-line treatment option for ulcerative colitis. There are differences in incidence of ulcerative colitis between males and females, but whether sex affects treatment outcomes is less clear. We examined sex-based differences in patients with ulcerative colitis initiated on vedolizumab from two major randomized controlled trials (RCTs). We conducted a post-hoc analysis on participants with ulcerative colitis from the VARSITY and GEMINI-1 RCTs who received vedolizumab. Outcomes of interest were rates of clinical improvement, clinical remission, and endoscopic improvement at weeks 6, 14, and 52 in male and female participants, as were differences in concentrations of trough vedolizumab and C-reactive protein; 1009 persons in GEMINI-1 and VARSITY trials were included...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526942/effectiveness-of-1-year-pemafibrate-treatment-on-steatotic-liver-disease-the-influence-of-alcohol-consumption
#3
JOURNAL ARTICLE
Motoh Iwasa, Ryosuke Sugimoto, Akiko Eguchi, Yasuyuki Tamai, Ryuta Shigefuku, Naoto Fujiwara, Hideaki Tanaka, Yoshinao Kobayashi, Jiro Ikoma, Masahiko Kaito, Hayato Nakagawa
BACKGROUND/AIMS: Pemafibrate is a selective peroxisome proliferator-activated receptor α modulator that improves serum alanine aminotransferase (ALT) in dyslipidemia patients. We previously reported that pemafibrate significantly improves liver function, serum triglyceride (TG) levels and liver stiffness in non-alcoholic fatty liver disease patients, however the influence of alcohol consumption was not considered. Therefore, we explored pemafibrate efficacy in patients with steatotic liver disease (SLD) and alcohol-associated liver disease (ALD)...
March 22, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526941/association-of-helicobacter-pylori-caga-seropositivity-with-gastric-precancerous-lesions-a-systematic-review-and-meta-analysis
#4
JOURNAL ARTICLE
Zengyun Qiao, Enbo Wang, Boyang Bao, Xiaodong Tan, Liu Yuan, Dong Wang
The objective of this meta-analysis is to delineate the association between H. pylori CagA serological status and the prevalence of gastric precancerous lesions (GPL). We searched peer-reviewed articles up to October 2023. The extraction of data from the included studies was carried out as well as the quality assessment. Pooled effect sizes were calculated using a random effect model. Thirteen studies met the inclusion criteria, comprising 2728 patients with GPL and 17 612 controls. The aggregate odds ratio (OR) for the association between serum CagA and GPL was 2...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526938/savings-in-social-expenditures-for-work-incapacity-in-patients-with-inflammatory-bowel-disease-depend-on-access-to-innovative-therapies-in-poland
#5
JOURNAL ARTICLE
Edyta Zagórowicz, Grzegorz Binowski, Dominik Strządała, Cezary Pruszko, Piotr Kucha, Jarosław Reguła
OBJECTIVES: Inflammatory bowel diseases (IBD) are an increasing burden for societies. We examined Polish Social Insurance Institution (ZUS) work incapacity expenditures for people with IBD compared with the general population. METHODS: Aggregate data were obtained on ZUS expenditures between 2012 and 2021 in Polish zlotys (PLN). Annual work incapacity benefit expenditures were analyzed and IBD benefit expenditures were examined relative to innovative IBD drug utilization in individual provinces...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526936/a-comparative-study-of-three-ultrasound-techniques-for-liver-fibrosis-staging
#6
JOURNAL ARTICLE
Qianqian Shen, Jiaqi Zhang, Shangjie Yang, Liping Liu
The aim of this study is to assess the agreement and performance of visual transient elastography (ViTE), sound touch elastography (STE), and sound touch quantification (STQ) for liver fibrosis staging using transient elastography (TE) as a standard. We finally enrolled 252 subjects with chronic liver disease (CLD) who underwent ViTE, STE, STQ, and TE examinations simultaneously in our hospital from October 2022 to July 2023. We evaluated the correlation and agreement between various technologies. And also evaluated the performances and optimal cutoffs of ViTE, STE, and STQ ...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526935/association-of-left-ventricular-diastolic-dysfunction-with-inflammatory-activity-renal-dysfunction-and-liver-related-mortality-in-patients-with-cirrhosis-and-ascites
#7
JOURNAL ARTICLE
Georgios Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Lampros Lakkas, Spiridon Tsiouris, Xanthi Xourgia, Georgios S Markopoulos, Lefkothea Dova, Haralampos Milionis
Left ventricular diastolic dysfunction (LVDD) is the predominant cardiac abnormality in cirrhosis. We investigated the association of LVDD with systemic inflammation and its impact on renal function, occurrence of hepatorenal syndrome (HRS) and survival in patients with cirrhosis and ascites. We prospectively enrolled 215 patients with cirrhosis and ascites. We evaluated the diagnosis and grading of LVDD by Doppler echocardiography, inflammatory markers, systemic hemodynamics, vasoactive factors, radioisotope-assessed renal function and blood flow, HRS development and liver-related mortality...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526917/vonoprazan-amoxicillin-dual-therapy-with-different-amoxicillin-dosages-for-treatment-naive-patients-of-helicobacter-pylori-infection-in-china-a-prospective-randomized-controlled-study
#8
JOURNAL ARTICLE
Zhu Liu, Dongjie Sun, Luan Kou, Li Jia, Jiaorong Hao, Jihai Zhou, Wenwen Zheng, Fengyu Gao, Xin Chen
BACKGROUND: The vonoprazan (VPZ)-amoxicillin (AMO) dual therapy (VA) demonstrates a satisfactory eradication rate for Helicobacter pylori (H. pylori). However, the optimal dosage of AMO in this regimen remains uncertain. The objective of this study is to investigate the efficacy of different doses of AMO in the VA regimen for first-line treatment of H. pylori infection. METHODS: A total of 192 treatment-naive H. pylori-infected patients were randomly assigned to one of three groups: low-dose VA (LD-VA: VPZ 20 mg b...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477863/comparative-maintenance-performance-of-all-biologic-agents-and-small-molecules-in-ulcerative-colitis-a-network-meta-analysis
#9
JOURNAL ARTICLE
Theodore Rokkas, Javier P Gisbert, Konstantinos Ekmektzoglou, Themistocles Dassopoulos, Yaron Niv, Colm O'Morain
BACKGROUND AND AIMS: Βiologic agents and small molecules have expanded the therapeutic armamentarium of moderate to severe ulcerative colitis (UC). However, their comparative efficacy and safety performance as maintenance treatments have not been sufficiently explored. We performed a systematic review and network meta-analysis (NWM) to assess the comparative efficacy and safety of all approved and emerging treatments for maintenance in moderate to severe UC. METHODS: We searched Pubmed/Medline, EMBASE, and Cochrane Library databases for relevant RCTs through April 2023...
March 12, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477854/fatigue-depression-and-sleep-disorders-are-more-prevalent-in-patients-with-metabolic-associated-fatty-liver-diseases
#10
JOURNAL ARTICLE
Alaa M Mostafa, Shaimaa Moustafa Hafez, Noha M Abdullah, Yasser Fouad
AIM: To determine the prevalence and risk factors for depression, sleep disturbances, and exhaustion in MAFLD patients. METHODS: Two hundred twenty-four consecutive patients with MAFLD attending the outpatient clinic from April to October 2023; were subjected to clinical evaluation, laboratory testing including non-invasive laboratory markers, fibroscan (measuring steatosis and fibrosis), and different quantitative and qualitative fatigue scores. A control group including 342 patients without MAFLD was taken...
March 12, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477851/paraneoplastic-gastrointestinal-dysmotility-due-to-non-hodgkin-diffuse-large-b-cell-lymphoma-a-case-report
#11
JOURNAL ARTICLE
Emily Nash, John D Chetwood, Aravind G Tamilarasan, Emilia Prakoso
Paraneoplastic gastrointestinal dysmotility is a rare entity which occurs in association with malignancy. We present the second case associated with lymphoma, characterised by generalised gastrointestinal dysmotility with constipation, malnutrition, weight loss, and capsule endoscope retention. This case highlights the importance of maintaining a high index of suspicion for malignancy in patients with unexplained gastrointestinal dysmotility.
March 12, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38489662/relation-between-non-alcoholic-fatty-liver-disease-and-carotid-artery-intimal-media-thickness-as-a-surrogate-for-atherosclerosis-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Hazem Abosheaishaa, Mahmoud Nassar, Omar Abdelhalim, Ammar Ayman Bahbah, Sharif Abbas, Samah M Morsi, Muhammad Ghallab, Zakaria Alagha, Ahmed Omran, Khaled Elfert, Praneeth Bandaru, Arnold Nongmoh Forlemu, Madhavi Reddy
BACKGROUND AND OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis without heavy alcohol consumption or other chronic conditions, encompasses a spectrum from non-alcoholic fatty liver to non-alcoholic steatohepatitis leading to cirrhosis. This analysis aimed to investigate the correlation between NAFLD and carotid intimal media thickness (C-IMT), a non-invasive surrogate for atherosclerosis. METHODOLOGY: Database searches, including PubMed, EMBASE and Cochrane Library, yielded studies up to April 2023...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38489595/contemporary-perioperative-outcomes-after-total-abdominal-colectomy-for-ulcerative-colitis-in-a-tertiary-referral-centre
#13
JOURNAL ARTICLE
Ian J B Stephens, Brenda Murphy, Lucy Burns, Niamh McCawley, Deborah A McNamara, John P Burke
OBJECTIVE: Colectomy for ulcerative colitis (UC) is common despite therapeutic advances. Post-operative morbidity and mortality demonstrate an association between hospital volumes and outcomes. This single-centre retrospective study examines outcomes after emergency colectomy for UC. METHODS: Patient demographics, perioperative variables and outcomes were collected in Beaumont Hospital between 2010 and 2023. Univariant analysis was used to assess relationships between perioperative variables and morbidity and length of stay (LOS)...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477862/the-influence-of-carvedilol-posology-timing-on-clinically-significant-portal-hypertension-insights-from-elastography-measurements
#14
JOURNAL ARTICLE
Bruno Besteiro, Manuel Marques da Cruz, Cláudia Alves, Fátima Costa, Mariana Nunes, Daniel Martinho Dias, Ana Barreira, Joana Calvão, Mónica Mesquita, Sónia Carvalho, Inês Pinho, Paulo Carrola, José Presa Ramos
BACKGROUND AND AIMS: Carvedilol has emerged as the preferred β-blocker for treating portal hypertension. However, there is still a debate in dosing regimen, with a potential lower bioavailability in once-daily regimens. The aim of this study is to assess the acute effects of carvedilol posology in patients with clinically significant portal hypertension (CSPH), as a surrogate marker of bioavailability. METHODS: In this experimental study, 34 patients with CSPH receiving carvedilol twice daily were asked to suppress the night dose of carvedilol, creating a standardized 24-hour dose interval...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477858/prevalence-trends-and-characteristics-of-metabolic-dysfunction-associated-steatotic-liver-disease-among-the-us-population-aged-12-79-years
#15
JOURNAL ARTICLE
Tsung-Hua Shen, Chung-Hsuen Wu, Yuan-Wen Lee, Chun-Chao Chang
BACKGROUND AND AIMS: Clinical observation revealed an increase in metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence among adults and adolescents and young adults (AYA). However, its prevalence trend in specific subgroups and its characteristics are unclear. APPROACH AND RESULTS: This cross-sectional study included adults and AYA aged 20-79 and 12-19 years, respectively, from the National Health and Nutrition Examination Survey from 1999 to 2018...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477850/idiopathic-chronic-intestinal-pseudo-obstruction-syndrome-is-strongly-associated-with-low-serum-levels-of-vitamin-d
#16
JOURNAL ARTICLE
Alba Panarese, Elton Dajti, Leonardo Henry Eusebi, Amanda Vestito, Rocco Maurizio Zagari
Idiopathic chronic intestinal pseudo-obstruction (CIPO) is associated with intestinal inflammation and malabsorption and may cause serum vitamin D deficiency. We aimed to assess whether there is an association between idiopathic CIPO and serum levels of 25-hydroxy-vitamin D. Consecutive patients with confirmed diagnosis of idiopathic CIPO were prospectively enrolled and matched with healthy controls by gender, age, and BMI. Median serum level of 25-hydroxy-vitamin D of patients with CIPO was compared with that of healthy subjects using the Wilcoxon signed-rank test for matched samples...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477849/sugar-sweetened-beverage-intake-and-long-term-mortality-in-individuals-with-metabolic-dysfunction-associated-steatotic-liver-disease-a-longitudinal-analysis-of-the-national-health-and-nutrition-examination-survey-database
#17
JOURNAL ARTICLE
Ji Zhou, Chu Liu, Lili Liu, Lei Li
BACKGROUND: Consuming sugar-sweetened beverages (SSBs) has been linked to the development of various adverse health conditions, including metabolic dysfunction-associated steatotic liver disease (MASLD). This study evaluated associations between SSB intake and long-term mortality among individuals with MASLD using a nationally representative database. METHODS: This population-based, longitudinal study extracted data of adults aged 20-79 years with MASLD from the USA (US) National Health and Nutrition Examination Survey database 2003-2014...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477847/high-antibiotic-resistance-rates-in-helicobacter-pylori-strains-in-turkey-over-20-years-implications-for-gastric-disease-treatment
#18
JOURNAL ARTICLE
Burak Sarikaya, Riza Aytaç Çetinkaya, Derya Özyiğitoğlu, Sinem Akkaya Işik, Mustafa Kaplan, Duygu Kirkik, Levent Görenek
OBJECTIVE: Helicobacter pylori (Hp) eradication therapy is crucial for preventing the development of gastritis, peptic ulcers, and gastric cancer. An increase in resistance against antibiotics used in the eradication of Hp is remarkable. This meta-analysis aims to examine the resistance rates of Hp strains isolated in Turkey over the last 20 years against clarithromycin (CLR), metronidazole (MTZ), levofloxacin (LVX), tetracycline (TET), and amoxicillin (AMX) antibiotics. BASIC METHODS: Literature search was carried out in electronic databases, by searching articles published in Turkish and English with the keywords 'helicobacter pylori' or 'Hp' and 'antibiotic resistance' and 'Turkey'...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477839/clinical-outcomes-with-metformin-use-in-diabetic-patients-with-compensated-cirrhosis-a-systematic-review-and-meta-analysis
#19
JOURNAL ARTICLE
Spyros Peppas, Stavros Doumas, Advait Suvarnakar, Jiling Chou, Ayah Arafat, Akram I Ahmad, James H Lewis
BACKGROUND: Previous studies have demonstrated a beneficial effect of metformin in patients with cirrhosis, but no improvement in liver histology. AIM: To investigate the impact of metformin on mortality and hepatic decompensation in people with diabetes with compensated cirrhosis. METHODS: Medline, Embase and Cochrane databases were searched from inception to February 2023 for studies reporting results regarding the impact of metformin on all-cause mortality and hepatic decompensation in people with diabetes with compensated cirrhosis...
March 11, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38477864/referral-for-liver-transplant-following-acute-variceal-bleeding-a-multicenter-cohort-study
#20
JOURNAL ARTICLE
Sofia Bragança, Marta Ramos, Sara Lopes, Gonçalo Alexandrino, Milena Mendes, Rui Perdigoto, João Coimbra, Hugo P Marques, Filipe S Cardoso
OBJECTIVES: Referral for liver transplant (LT) following acute variceal bleeding (AVB) varies widely. We aimed to characterize and assess its impact on clinical outcomes. METHODS: Observational retrospective cohort including cirrhosis patients with AVB from 3 hospitals in Lisbon, Portugal, from 2018 to 2019. Primary exposure was referral for LT and primary endpoint was all-cause mortality within 2 years of index hospital admission. RESULTS: Among 143 patients, median (IQR) age was 59 (52-72) years and 90 (62...
March 4, 2024: European Journal of Gastroenterology & Hepatology
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