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European Journal of Gastroenterology & Hepatology

https://read.qxmd.com/read/37724478/potential-missed-diagnoses-of-crohn-s-disease-in-tertiary-care-impact-on-drug-utilization-and-healthcare-facilities-use
#1
JOURNAL ARTICLE
Sara Ferraro, Emiliano Cappello, Claudia Bartolini, Irma Convertino, Lorenzo Bertani, Ersilia Lucenteforte, Francesco Costa, Olga Paoletti, Sabrina Giometto, Rosa Gini, Marco Tuccori
BACKGROUND: A missed diagnosis of Crohn's disease (CD) can delay treatment initiation with consequences on disease course. AIMS: To measure the possible impact of missed diagnoses on drug utilization and access to healthcare facilities in a real-world cohort of CD patients. METHODS: This retrospective observational study has been conducted on the regional administrative databases of Tuscany (Italy). We included patients with a first record of CD diagnosis between 06/11/2011 and 06/30/2016...
September 18, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37724477/therapeutic-effects-of-biological-treatments-on-aa-amyloidosis-associated-with-inflammatory-bowel-disease-a-case-report-and-literature-review
#2
JOURNAL ARTICLE
Marouf Alhalabi, Kamal Alaa Eddin, Ahmad Abbas
AA amyloidosis is a rare and significant complication of long-term inflammation that can be caused by a variety of disorders, including inflammatory bowel disease, and is linked to an increased risk of morbidity and mortality. To date, there has been no effective direct treatment, and treatment aims at treating the underlying condition with potent immunosuppression to limit inflammatory activity and, as a result, switch off amyloidogenesis. Theoretically, biological treatment can control AA amyloidosis by inducing and maintaining inflammatory bowel disease remission and inhibiting the synthesis of Serum Amyloid A, which is an acute phase reactant and precursor protein of AA amyloidosis that accumulates in the organs...
September 18, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37724476/epidemiology-of-liver-transplantation-and-post-lt-complications-in-germany-nationwide-study-2005-2018
#3
JOURNAL ARTICLE
Wenyi Gu, Louisa Schaaf, Hannah Hortlik, Yasmin Zeleke, Maximilian J Brol, Andreas A Schnitzbauer, Wolf O Bechstein, Stefan Zeuzem, Alexander Queck, Kai-Henrik Peiffer, Michael Tischendorf, Andreas Pascher, Wim Laleman, Michael Praktiknjo, Martin S Schulz, Frank E Uschner, Florian Rennebaum, Jonel Trebicka
BACKGROUND: To date, liver transplantation (LT) is the only curative treatment for cirrhosis and early-diagnosed progressive acute liver failure (ALF). However, LT results in morbidities and mortality even post-LT. Different comorbidities may follow and further increase mortality and morbidity. In this study, we investigated the outcomes and their trends over a period of 14 years among hospitalized patients evaluated for LT, transplant and post-LT in Germany. METHODS: This German nationwide study investigated the number of admissions of patients hospitalized for evaluation of LT and post-LT on related comorbidities and complications between 2005 and 2018 based on the DRG system with ICD-10/OPS codes...
September 18, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37724470/jak-inhibitors-for-the-treatment-of-inflammatory-bowel-disease-results-of-an-international-survey-of-perceptions-attitudes-and-clinical-practice
#4
JOURNAL ARTICLE
Sailish Honap, Peter M Irving, Mark A Samaan
BACKGROUND: Janus kinase inhibitors (JAKi) are small molecule drugs with demonstrated efficacy in inflammatory bowel disease (IBD). However, widespread utilisation may be hindered by safety concerns. AIMS: This is the first study assessing risk-benefit perceptions and clinical practices of those using JAKi for IBD. METHODS: A prospective, cross-sectional study was conducted using a 23-item survey distributed to IBD healthcare providers worldwide...
September 18, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37724454/vegetarian-diets-and-the-risk-of-gastrointestinal-cancers-a-meta-analysis-of-observational-studies
#5
JOURNAL ARTICLE
Tongtong Bai, Juanjuan Peng, Xinqi Zhu, Chengyu Wu
OBJECTIVE: The systematic review aimed to assess the association between vegetarian diet and the risk of gastrointestinal tumorigenesis. METHODS: PubMed, Embase, Cochrane Library, and Web of Science were searched from inception to August 2022 for observational studies on vegetarian diets and the risk of gastrointestinal tumorigenesis. The primary outcome was morbidity due to gastrointestinal cancer. The Newcastle-Ottawa Scale was used to assess the quality of included studies...
September 18, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37695613/sensitivity-and-specificity-of-diagnostic-modalities-in-pouchitis-a-systematic-review-and-meta-analysis
#6
JOURNAL ARTICLE
Luis Miguel Nieto, Afia Iqbal, Danilo Vinci, Danujan Sriranganathan, Gianluca Pellino, Jonathan P Segal
Restorative proctocolectomy (RPC) is the most common surgical procedure to restore gastrointestinal continuity after surgical resection of the colon and rectum. Pouchitis is a common complication with several different modalities that can be used to aid diagnosis. This systematic review and meta-analysis aimed at exploring the sensitivity and specificity these diagnostic modalities. The medical literature was searched using MEDLINE, EMBASE and EMBASE classic and PubMed from 1978 to June 2022. We calculated descriptive statistics using sensitivity, specificity, and false-positive rate of the primary studies and also their positive and negative likelihood ratios, and their diagnostic odds ratios...
September 11, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37695599/impact-of-octreotide-on-sodium-level-in-cirrhotic-inpatients-with-hyponatremia-a-retrospective-study
#7
JOURNAL ARTICLE
Bahaaeldeen Ismail, Richard Charnigo, Syed Mohammad Ali, Baker Alkhairi, Karim Benrajab, Harjinder Singh, Fernando J Castro
OBJECTIVE: Octreotide could increase serum sodium in cirrhotics with hyponatremia by counteracting splanchnic vasodilation. Current supporting data is limited to case reports and series. The aim of the study is to assess the effect of octreotide on serum sodium in cirrhotic inpatients with hyponatremia compared with controls. METHODS: This is a retrospective study including adult inpatients with cirrhosis, admitted for ≥5 days with Na <133 at baseline...
September 11, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37695624/predictors-of-30-day-mortality-in-patients-diagnosed-with-hepatic-encephalopathy-on-admission-to-the-emergency-department
#8
JOURNAL ARTICLE
Ali Yuksek, Selen Acehan, Salim Satar, Muge Gulen, Muhammet Balcik, Sarper Sevdimbas, Cagdas Ince, Ahmet Naci Koca, Adnan Tas
BACKGROUND: The aim of this study is to compare the laboratory findings and disease severity scores of patients diagnosed with hepatic encephalopathy (HE) in the emergency department (ED) to predict 30-day mortality. METHOD: The patients over 18 years old and diagnosed HE in the ED of a tertiary hospital were included in the study. Demographic and clinical characteristics, laboratory parameters, predisposing causes and outcomes of the patients included in the study were recorded in the data form...
September 5, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37695595/multicenter-validation-of-fib-6-as-a-novel-machine-learning-non-invasive-score-to-rule-out-liver-cirrhosis-in-biopsy-proven-mafld
#9
JOURNAL ARTICLE
Amir Anushiravani, Khalid Alswat, George N Dalekos, Kalliopi Zachou, Necati Örmeci, Said Al-Busafi, Ayman Abdo, Faisal Sanai, Nabiel Nh Mikhail, Riham Soliman, Gamal Shiha
BACKGROUND AND AIMS: We previously developed and validated a non-invasive diagnostic index based on routine laboratory parameters for predicting the stage of hepatic fibrosis in patients with chronic hepatitis C (CHC) called FIB-6 through machine learning with random forests algorithm using retrospective data of 7238 biopsy-proven CHC patients. Our aim is to validate this novel score in patients with metabolic dysfunction-associated fatty liver disease (MAFLD). METHOD: Performance of the new score was externally validated in cohorts from one site in Egypt (n = 674) and in 5 different countries (n = 1798) in Iran, KSA, Greece, Turkey and Oman...
September 5, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37642661/external-validation-of-the-famish-predicting-score-for-early-gastric-cancer-with-endoscopic-submucosal-dissection
#10
JOURNAL ARTICLE
Zhennan Niu, Donghong Liang, Chaoyong Guan, Yang Zheng, Changjuan Meng, Xiaofang Sun, Zhuang Liu
OBJECTIVE: To externally validate the robustness of the FAMISH predicting score designed to estimate the risk of metachronous gastric lesions (MGLs) after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). METHODS: This multicenter, retrospective study included 618 patients with EGC who underwent curative ESD at two tertiary referral teaching hospitals between January 2014 and December 2019. FAMISH score was a composite indicator of age, sex, family history, corpus intestinal metaplasia, synchronous lesions, and H...
August 28, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37642669/granulocyte-colony-stimulating-factor-in-decompensated-liver-cirrhosis-a-meta-analysis-of-four-randomized-controlled-trials
#11
JOURNAL ARTICLE
Reem Dimachkie, Rachelle Hamadi, Zakaria Alameddine, Hussam Aridi, Fouad Sakr, Samer Asmar, Liliane Deeb
BACKGROUND: Decompensated liver cirrhosis (DC) has high mortality, but liver transplantation is limited due to organ scarcity and contraindications for transplantation. Granulocyte-colony stimulating factor (GCSF) shows potential for liver disease treatment with its regenerative and immunomodulatory properties. To assess the controversial use of GCSF in DC, a meta-analysis of randomized controlled trials (RCTs) compared survival benefits in patients receiving GCSF plus standard medical therapy (SMT) versus SMT alone...
August 23, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37642651/association-of-nonalcoholic-fatty-liver-disease-with-colorectal-adenomatous-polyps-and-non-adenomatous-polyps-a-cross-sectional-study
#12
JOURNAL ARTICLE
Yingxue Yang, Yajie Teng, Jiayi Shi, Jianhao Xu, Jie Bao, Xia Zhang, Qinghua Wang
AIM: This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non-adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD. METHODS: A retrospective, cross-sectional study was conducted at the First People's Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who underwent abdominal ultrasonography and colonoscopy over a 5 year period...
August 23, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577819/real-time-assessment-of-h-pylori-during-the-endoscopic-assessment-of-individuals-with-gastric-intestinal-metaplasia-a-possible-way-to-reduce-the-burden-of-care
#13
JOURNAL ARTICLE
Gianluca Esposito, Diogo Libânio, Irene Ligato, Diana Ramos Silva, Emanuele Dilaghi, Raquel Ortigão, Marilia Carabotti, Jéssica Chaves, Bruno Annibale, Mário Dinis-Ribeiro
OBJECTIVES: The management of individuals with gastric intestinal metaplasia (GIM) includes biopsies for its staging and to diagnose Helicobacter pylori (Hp). Advanced-stage GIM can be estimated by endoscopy through EGGIM, and a new device permits the real-time assessment of ammonia for the identification of Hp infection. The aim of this study was to assess the simultaneous use of EGGIM and real-time assessment of ammonia to avoid biopsies and reduce the burden of care in clinical practice...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577805/unresectable-hepatocellular-carcinoma-at-dawn-of-immunotherapy-era-real-world-data-from-the-french-prospective-chief-cohort
#14
JOURNAL ARTICLE
Eric Nguyen-Khac, Pierre Nahon, Olivier Ganry, Hajer Ben Khadhra, Philippe Merle, Giuliana Amaddeo, Nathalie Ganne-Carrie, Christine Silvain, Jean-Marie Peron, Philippe Mathurin, Rodolphe Anty, Thomas Uguen, Thomas Decaens, Ghassan Riachi, Mohamed Bouattour, Aurore Baron, Jean-Pierre Bronowicki, Georges-Philippe Pageaux, Olivier Rosmorduc, Gérard Ducournau, Mélina Gilberg, Alexandre Tanang, Julien Dupin, Anika Gilbert-Marceau, Jean-Frédéric Blanc
BACKGROUND AND OBJECTIVES: Hepatocellular carcinoma epidemiological data are limited in France. The Epidemio Liver Immunotherapy Tecentriq outcome research (ELITor) retrospective study, based on real-world data from the Carcinome HépatocellulaIrE en France (CHIEF) French cohort of hepatocellular carcinoma patients, aimed to get insight into the treatment patterns, the sociodemographic, clinical, biological, and etiological characteristics, and the quality of life of patients with unresectable hepatocellular carcinoma...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577802/clinical-course-and-prognosis-of-patients-with-hepatocellular-carcinoma-and-haemophilia
#15
JOURNAL ARTICLE
Noritaka Matsuda, Norihiro Imai, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Shuichi Okamoto, Takeshi Kanematsu, Nobuaki Suzuki, Tadashi Matsushita, Masatoshi Ishigami, Hiroki Kawashima
INTRODUCTION: Although patients with haemophilia are known to develop hepatocellular carcinoma (HCC) at a lower age than patients without, there are few reports on the clinical course and prognosis of HCC. AIM: We aimed to investigate the clinical course and prognosis of patients with HCC and haemophilia. METHODS: Twenty-two patients with haemophilia, who were initially diagnosed with HCC between 2003 and 2021, were included. Their clinical courses and prognoses were retrospectively analysed...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577793/the-number-of-hepatocellular-carcinoma-foci-as-predictor-of-poor-response-to-tumor-directed-therapies-in-patients-awaiting-liver-transplantation-a-prospective-cohort-study
#16
JOURNAL ARTICLE
Yucel Aydin, Ali R Koksal, Paul Thevenot, Kelley Nunez, Mohamed Elgamal, Ulkuhan I Koksal, Tyler Sandow, Martin Moehlen, Frederic Regenstein, Veysel Tahan, Ari Cohen
BACKGROUND AND AIMS: Tumor-directed therapies (TDTs) are a constitutive part of hepatocellular carcinoma (HCC) treatment in patients awaiting liver transplantation (LT). While most patients benefit from TDTs as a bridge to LT, some patients drop out from the waiting list due to tumor progression. The study aimed to determine the risk factors for poor treatment outcome following TDTs among patients with HCC awaiting LT. METHODS: A total of 123 patients with HCC were evaluated with 92 patients meeting Milan Criteria enrolled in the prospective cohort study...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577787/is-histological-healing-more-clinically-valuable-than-endoscopic-healing-in-crohn-s-disease
#17
JOURNAL ARTICLE
Ting Zhang, Qi-De Zhang, Tian Jin, Wen-Jie Li, Han-Ying Wang, Xiao-Yun Lu, Xiu-Qing Li, Shi-Jia Liu, Bo-Lin Yang
OBJECTIVES: Small bowel (SB) endoscopic healing has not been well explored in patients with Crohn's disease (CD). This study aimed to assess the clinical utility of SB endoscopic mucosal and histological healing in patients with CD. METHODS: In total, 99 patients with CD in clinical-serological remission were retrospectively followed after they underwent colonoscopy and double-balloon enteroscopy. Time until clinical relapse (CD activity index of >150 with an increase of >70 points) and serological relapse (abnormal elevation of C-reactive protein levels) constituted the primary endpoints...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577784/vibration-controlled-transient-elastography-in-screening-for-silent-liver-diseases
#18
JOURNAL ARTICLE
Ebada Said, Muhammad Abdel-Gawad, Eman Abdelsameea, Eman Elsayed Elshemy, Nermeen Abdeen, Mohamed Elbasiony, Dalia Omran, Yasser Elesnawy, Alshaimaa Eid, Sameh A Lashen, Osama Elbahr, Gina Gamal Naguib, Shimaa Afify, Eshak I Bahbah, Mohamed Alboraie
OBJECTIVES: The objective of this study was to screen for significant hepatic fibrosis or steatosis in asymptomatic, apparently healthy subjects by using Vibration-controlled transient elastography and controlled attenuation parameter (CAP). METHODS: Prospectively, 433 asymptomatic apparently healthy adults were included. Fibroscan/CAP examination was performed for all of them. Subjects with liver stiffness measurement > 6 kPa or CAP >248 dB/m were further evaluated to assess underlying chronic liver disease...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577778/cultivation-based-characterization-of-biliary-microbiota-in-bile-samples-collected-during-routine-endoscopic-retrograde-cholangiography-10-years-of-experience-at-a-tertiary-center
#19
JOURNAL ARTICLE
Kilian Forster, Friederike Klein, Nicolas Simon, Patrick Chhatwal, Stefan Ziesing, Benjamin Heidrich, Philipp Solbach
INTRODUCTION: Bile has long been considered sterile. Recent studies show that bacteria can frequently be detected in bile and certain bacterial species are associated with bile duct-associated liver disease. OBJECTIVES: To detect bacterial species and antibiotic resistance in bile in bile duct-associated liver disease. METHODOLOGY: To evaluate microbiological findings of bile samples obtained during ERCP at a tertiary center from 2009 to 2019...
August 14, 2023: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37577844/dual-x-ray-absorptiometry-derived-bone-status-indexes-and-videocapsule-intestinal-aspects-in-celiac-disease
#20
JOURNAL ARTICLE
Luca Elli, Elisabetta Filippi, Luca Ciceri, Fabio Massimo Ulivieri, Matilde Topa, Nicoletta Nandi, Luca Piodi, Bruno Cesana, Leda Roncoroni, Vincenza Lombardo, Alice Scricciolo, Lucia Scaramella, Maurizio Vecchi
BACKGROUND AND AIM: Celiac disease is a risk factor for osteopenia and osteoporosis. Our aim was to evaluate the possible correlation between villous atrophy extension and dual-energy X-ray absorptiometry (DXA)-derived parameters of bone status. METHODS: We have retrospectively analyzed data of 47 celiac patients (36 women, 52 ± 14 years of age) who underwent video capsule endoscopy and DXA scans within 1 year of interval from 2006 to 2019...
July 31, 2023: European Journal of Gastroenterology & Hepatology
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