journal
https://read.qxmd.com/read/36441130/effects-of-propofol-on-igf-1-activity-and-cell-behaviour-in-the-ges-1-mucosal-cell-model
#21
JOURNAL ARTICLE
Chai Hua, Peng Wenyong, Zhu Zhongquan, Xiong Chang, Jin Xiayun
Propofol is an important and widely used anaesthetic drug in the clinic. Many works have shown that propofol has important biological functions except as an anaesthetic. In the current study, we mainly explored the effect of propofol on the biological activity of IGF-1, which is an important growth factor involved in regulating the growth and development of the stomach. Here, we explored the effect of propofol on the biological activity of IGF-1 in a GES-1-cell model. We found that propofol affected the biological activity of IGF-1...
November 28, 2022: Growth Factors
https://read.qxmd.com/read/36373834/retinoic-acid-signaling-is-critical-for-generation-of-pancreatic-progenitors-from-human-embryonic-stem-cells
#22
JOURNAL ARTICLE
Niloufer P Dumasia, Aparna P Khanna, Prasad S Pethe
Retinoic acid (RA) is essential for gut endoderm development and has been extensively used for in vitro pancreatic differentiation from human pluripotent stem cells. However, the gene regulatory network triggered by RA signaling remains poorly addressed. Also, whether RA signals control histone modifiers such as the Polycomb group proteins during pancreatic specification remains to be explored. Here, we assess the role of RA on pancreas-specific genes during the differentiation of human embryonic stem cells (hESCs)...
November 14, 2022: Growth Factors
https://read.qxmd.com/read/36371694/the-polymethoxylated-flavone-hexamethylquercetagetin-suppresses-nf-%C3%AE%C2%BAb-signaling-and-inhibits-cell-survival-in-cervical-carcinoma
#23
JOURNAL ARTICLE
Yanan Sun, Nan Li, Yuru Cai, Xingnan Zhao, Hongyu Yang
Nuclear factor-κB (NF-κB) contributes to the development and progression of cervical carcinoma. To construct a xenograft model, Ca Ski cells were subcutaneously inoculated into BALB/c nude mice. The relative protein expression of NF-κB p65, p-p65, IκBα, and p-IκBα were detected in hexamethylquercetagetin (HTQC) treated cervical carcinoma cells with or without tumor necrosis factor (TNF)α stimulation, or representative tumors tissues in xenograft mice. HTQC could prohibit NF-κB-derived luciferase activity in Ca Ski and C-33 A cells and inhibit the relative NF-κB p-p65 and p-IκBα expression with or without TNFα stimulation...
November 13, 2022: Growth Factors
https://read.qxmd.com/read/36026559/platelet-lysate-and-tendon-healing-comparative-analysis-of-autologous-frozen-thawed-prp-and-ketorolac-tromethamine-in-the-treatment-of-patients-with-rotator-cuff-tendinopathy
#24
RANDOMIZED CONTROLLED TRIAL
Raha Markazi, Mohammad Sadegh Soltani-Zangbar, Majid Zamani, Shadi Eghbal-Fard, Roza Motavalli, Amin Kamrani, Sanam Dolati, Majid Ahmadi, Leili Aghebati-Maleki, Amir Mehdizadeh, Fariba Eslamian, Alireza Pishgahi, Mehdi Yousefi
Platelet-rich blood derivatives are being nowadays increasingly used in the treatment of tendon-related pathologies as a rich source of growth factors. We sought to ascertain if local application of platelet lysate (PL) to augment rotator cuff repair ameliorates patient outcomes compared to ketorolac tromethamine treated group. A total of forty patients, with clinical diagnosis of Rotator Cuff Tendinopathy were randomized to receive sub acromial injections of PL every week for a total of 3 injections and two injection of ketorolac tromethamine once every two weeks...
November 2022: Growth Factors
https://read.qxmd.com/read/36260520/matrine-induces-hepatocellular-carcinoma-apoptosis-and-represses-emt-and-stemness-through-microrna-299-3p-pgam1-axis
#25
JOURNAL ARTICLE
BaoLin Wang, HuiHai Wang, Qin Zhao, Fei Lu, ZhenZhuang Yan, Fang Zhou, QingLun Su
This study explored the impacts of matrine on hepatocellular carcinoma (HCC) cell growth, metastasis, epithelial-mesenchymal transition (EMT), and stemness through regulating the microRNA (miR)-299-3p / phosphoglycerate mutase 1 ( PGAM1 ) axis. The association between miR-299-3p expression with the prognosis of HCC patients was studied. miR-299-3p and PGAM1 sequences were transfected into matrine-treated HCC cells, and cell proliferation, invasion, apoptosis, and stemness were detected, as well as protein expression of EMT- and stemness-related makers...
October 19, 2022: Growth Factors
https://read.qxmd.com/read/36206173/embryonic-growth-retardation-and-altered-expression-of-igf-ii-is-reciprocal-induced-by-phytocompounds-during-early-gestation-in-mice
#26
JOURNAL ARTICLE
Khamhee Wangsa, Krishnakshi Misra, Upasa Gowala, Indira Sarma, Purba Jyoti Saikia, Hirendra Nath Sarma
Methanolic crude extract of Scoparia dulcis (CESD) was orally administered to female mice during the early gestation (day 4-day 8) at a dose of 500   mg/kg/day. It induces embryo resorption and morphological changes of fetal maternal tissue. Histomorphology was studied by routine hematoxylin eosin stain. In situ immunofluorescence localization of IGF-II using Texas red showed an ordered expression of the growth factor in the maternal decidual cells, trophoblast cells and the embryo. Western blot analysis showed a gradual increase of IGF-II from D4 to D8 of control females...
October 7, 2022: Growth Factors
https://read.qxmd.com/read/36165005/high-mobility-group-box-1-and-dickkopf-related-protein-1-as-biomarkers-of-glucose-toxicity-atherogenicity-and-lower-%C3%AE-cell-function-in-patients-with-type-2-diabetes-mellitus
#27
JOURNAL ARTICLE
Hussein Kadhem Al-Hakeim, Qasim Jasim Al-Kaabi, Michael Maes
Type 2 diabetes mellitus (T2DM) is associated with increased atherogenicity and inflammatory responses, which may be related to high mobility group box 1 (HMGB1) and Dickkopf-related protein 1 (DKK1). The role of HMGB1 and DKK1 in T2DM is examined in association with lipid and insulin profiles. Serum HMGB1 and DKK1 were measured in T2DM with and without hypertension and compared with controls. The results showed that HMGB1 and DKK1 are higher in T2DM irrespective of hypertension. A large part of the variance in the β-cell index and glucose toxicity was explained by the combined effects of HMGB1 and DKK1...
September 27, 2022: Growth Factors
https://read.qxmd.com/read/36129407/increased-circulating-tgf-%C3%AE-1-is-associated-with-impairment-in-nk-cell-effector-functions-in-metastatic-melanoma-patients
#28
JOURNAL ARTICLE
Katarina Mirjačić Martinović, Ana Vuletić, Emina Mališić, Tatjana Srdić-Rajić, Nevena Tišma Miletić, Nada Babović, Vladimir Jurišić
Transforming growth factor beta (TGF-β) plays a complex role in carcinogenesis. In 30 melanoma patients and 20 healthy controls (HC) we analysed functional and phenotypic characteristics of NK cells by Flow cytometry, gene expression of TGF-β1 in peripheral blood mononuclear cells by qPCR and serum and supernatant level of free TGF-β1 by ELISA. Melanoma patients had significantly higher serum level of circulatingTGF-β1 compared to HC, especially those with metastasis into the central nervous system (subclass M1d) and high LDH serum values...
September 21, 2022: Growth Factors
https://read.qxmd.com/read/36083236/effects-of-dual-gene-modification-on-biological-characteristics-of-vascular-endothelial-cells-and-their-significance-as-reserving-cells-for-chronic-wound-repair
#29
JOURNAL ARTICLE
Lingli Guo, Baohua Wei, Feng Pan, Hasi Wulan, Mi Cai
bFGF is a commonly used and reliable factor for improving chronic wound healing, and hSulf-1 expression is abundant in surrounding cells of chronic wound tissue and vascular endothelial cells, which can reverse the effect of bFGF and inhibit the signalling activity of cell proliferation. In this study, an adenovirus, Ad5F35ET1-bFGF-shSulf1, was designed for establishing the dual-gene modified vascular endothelial cells, which were used as the repair cells for skin chronic wound. Ad5F35ET1-bFGF-shSulf1 infected ECV304 cells in vitro and mediated the overexpression of bFGF and the knockdown of hSulf-1, which effectively activated the AKT and ERK signal transduction pathways, facilitate cell proliferation and migration, with the cell viability to 128...
September 9, 2022: Growth Factors
https://read.qxmd.com/read/36067091/mir-200c-regulates-invasion-proliferation-and-emt-of-anaplastic-thyroid-cancer-cells-by-targeting-parathyroid-hormone-like-hormone
#30
JOURNAL ARTICLE
Yan Zhang, Yuanyuan Duan, Chenguang Wu, Wen Peng, Wenyu Chen, Li Wang, Zhaoqun Deng
This study aimed to explore the specific effect of miR-200c in anaplastic thyroid cancer (ATC). Hth74 and ARO cell lines were used. Proliferation, invasion, and colony formation activities of Hth74 and ARO cell lines affected by miR-200c were studied. Expression of epithelial-to-mesenchymal transition (EMT) markers (E-cadherin, N-cadherin, Slug, and Snail) in the Hth74 and ARO cell lines were validated by western blot and qRT-PCR. In addition, the regulation of the parathyroid hormone-like hormone (PTHLH) by miR-200c was assessed...
September 6, 2022: Growth Factors
https://read.qxmd.com/read/36001478/halofuginone-inhibits-cell-proliferation-and-akt-mtorc1-signaling-in-uterine-leiomyoma-cells
#31
JOURNAL ARTICLE
Jing Lin, Xiaochun Wu
The present study aimed to explore the effects of antifibrotic agent halofuginone on uterine leiomyomas (ULs) cells. The survival of the uterine smooth muscle (UtSMC) cells and UL ELT3 cells were measured. Flow cytometry was used to assess the cell cycle distribution and apoptosis. Effects of halofuginone on the state of AKT/mTOR pathway were evaluated. Xenograft animal model was applied to explore the effects of halofuginone in vivo . Halofuginone inhibited the proliferation of ELT3 cells dose-dependently without obvious influence on UtSMC cells...
August 24, 2022: Growth Factors
https://read.qxmd.com/read/35984706/effects-of-penehyclidine-hydrochloride-on-myocardial-ischaemia-reperfusion-injury-in-rats-by-inhibiting-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway-via-mir-199a-3p
#32
JOURNAL ARTICLE
Ling Qiang Bai, Bin Zhe Wang, Qi Wei Liu, Wen Qiang Li, Hang Zhou, Xiao Yan Yang
This study was to probe the role of penehyclidine hydrochloride (PHC) mediating the impact of toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)/nuclear factor-kappa B (NF-κB) signalling pathway on myocardial ischaemia-reperfusion injury (MI/RI) in rats through miR-199a-3p. The rat MI/RI model was established through ligating left anterior descending (LAD) coronary artery. PHC was injected preoperatively into the model rats, and injected with miR-199a-3p lentiviral vector or TLR4 antagonist (TAK-242)...
August 19, 2022: Growth Factors
https://read.qxmd.com/read/35867635/the-expression-of-bmp-integrin-zeb2-in-ovarian-high-grade-serous-carcinoma-in-relation-with-lymph-node-metastasis
#33
JOURNAL ARTICLE
Elham Bahador Zırh, Elif Taşar Kapaklı, Anıl Dolgun, Alp Usubütün, Naciye Dilara Zeybek
Ovarian cancer (OC) is clinically important because it is diagnosed late and has metastasis when it is diagnosed. Mortality risk increases 2.75 times in the presence of lymph node (LN) metastasis. During metastasis, many molecules including BMPs originated from stroma, and tumor cells participate through transcription factors and integrins for cytoskeleton regulation during cell migration. We hypothesized an inverse correlation between BMP2 and BMP7 along with changes in ZEB2, and integrin α5β1 in high-grade OCs in relation to LN metastasis...
August 2022: Growth Factors
https://read.qxmd.com/read/35861197/the-cellular-and-molecular-mediators-of-metastasis-to-the-lung
#34
REVIEW
Oliver Cucanic, Rae H Farnsworth, Steven A Stacker
Organ-specific metastasis to secondary organs is dependent on the formation of a supportive pre-metastatic niche. This tissue-specific microenvironmental response is thought to be mediated by mutational and epigenetic changes to primary tumour cells resulting in altered cross-talk between cell types. This response is augmented through the release of tumour and stromal signalling mediators including cytokines, chemokines, exosomes and growth factors. Although researchers have elucidated some of the cancer-promoting features that are bespoke to organotropic metastasis to the lungs, it remains unclear if these are organ-specific or generic between organs...
July 21, 2022: Growth Factors
https://read.qxmd.com/read/35707986/transforming-growth-factor-%C3%AE-signalling-pathway-in-tendon-healing
#35
REVIEW
Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li
Transforming growth factor-β(TGF-β) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis. In the well-known canonical TGF-β signalling pathway, TGF-β activates Smad signalling through its two cell surface receptors, which leads to Smad-mediated transcriptional regulation and is also regulated by inhibitory Smads, forming a negative feedback regulatory pathway. In the context of the canonical TGF-β signalling mechanism mediated by Smad, the activated receptors also send signals through other signal transducers, which in the backdrop of TGF-β signaling are collectively known as non-Smad signalling pathways...
June 16, 2022: Growth Factors
https://read.qxmd.com/read/35658773/impact-of-methionine-restriction-on-muscle-aerobic-metabolism-and-hypertrophy-in-young-and-old-mice-on-an-obesogenic-diet
#36
JOURNAL ARTICLE
Anandini Swaminathan, Leonardo Cesanelli, Tomas Venckunas, Hans Degens
Methionine restriction (MR) reduces inflammation and increases longevity. We studied the effects of MR (0.17% kCal methionine, 10% kCal fat) and MR + high-fat diet (HFD) (0.17% methionine, 45% kCal fat) and overload-induced hypertrophy on inflammation, angiogenesis and mitochondrial activity in the hind-limb muscle in 10- and 26-month-old male C57BL/6J mice. Plasma IL-6 concentrations were higher in old compared to young mice. M. plantaris hypertrophy was accompanied by increased p-Akt, without a significant change in Akt and VEGF levels...
June 5, 2022: Growth Factors
https://read.qxmd.com/read/35442129/the-effects-of-chf6467-a-new-mutated-form-of-ngf-on-cell-models-of-human-glioblastoma-a-comparison-with-wild-type-ngf
#37
JOURNAL ARTICLE
Lucia Lisi, Gabriella Maria Pia Ciotti, Marta Chiavari, Maria Martire, Pierluigi Navarra
CHF6467 is a mutated form of human recombinant nerve growth factor (NGF). The mutation selectively disrupts the binding of NGF to its p75NTR receptor while maintaining the affinity toward TrkA receptor. Because of such different profile of receptor interaction, CHF6467 maintains unaltered the neurotrophic and neuroprotective properties of wild-type NGF but shows reduced algogenic activity.In this study, we investigated the effects of CHF6467 on mortality, proliferation, cell-damage and migration in three human glioblastoma cell lines (U87MG, T98G, LN18), and in the rat astrocytoma C6 cells...
June 2022: Growth Factors
https://read.qxmd.com/read/35605149/mir-146a-suppresses-the-expression-of-vascular-endothelial-growth-factor-and-inflammatory-responses-in-diabetic-retinopathy
#38
JOURNAL ARTICLE
Shichao Sun, Fujun Wang, Yao Sun, Lei Bai
This study was designed to explore the role of miR-146a in diabetic retinopathy (DR). 30 healthy control (HC), 50 patients with type 2 diabetes mellitus, and 48 DR patients were enrolled. Blood was collected and levels of miR-146a expression, vascular endothelial growth factor (VEGF), and three inflammatory cytokines (NF-κB, IL-1β, and TNF-α) were detected. Moreover, ARPE-19 cells were treated with miR-146a mimic or inhibitor in the presence of high glucose to evaluate its effect in vitro . DR patients had the lowest level of miR-146a and the highest level of VEGF as well as the most severe inflammation among the three groups...
May 23, 2022: Growth Factors
https://read.qxmd.com/read/35584274/an-appraisal-of-vascular-endothelial-growth-factor-vegf-the-dynamic-molecule-of-wound-healing-and-its-current-clinical-applications
#39
REVIEW
Aakansha Giri Goswami, Somprakas Basu, Farhanul Huda, Jayanti Pant, Amrita Ghosh Kar, Tuhina Banerjee, Vijay Kumar Shukla
Angiogenesis is a critical step of wound healing, and its failure leads to chronic wounds. The idea of restoring blood flow to the damaged tissues by promoting neo-angiogenesis is lucrative and has been researched extensively. Vascular endothelial growth factor (VEGF), a key dynamic molecule of angiogenesis has been investigated for its functions. In this review, we aim to appraise its biology, the comprehensive role of this dynamic molecule in the wound healing process, and how this knowledge has been translated in clinical application in various types of wounds...
May 18, 2022: Growth Factors
https://read.qxmd.com/read/35439043/the-roles-of-epidermal-growth-factor-receptor-in-viral-infections
#40
REVIEW
Kah Man Lai, Wai Leng Lee
Viruses are intracellular pathogen that exploit host cellular machinery for their propagation. Extensive research on virus-host interaction have shed light on an alternative antiviral strategy that targets host cell factors. Epidermal growth factor receptor (EGFR) is a versatile signal transducer that is involved in a range of cellular processes. Numerous studies have revealed how viruses exploit the function of EGFR in different stages of viral life cycle. In general, viruses attach onto the host cell surface and interacts with EGFR to facilitate viral entry, viral replication and spread as well as evasion from host immunosurveillance...
April 19, 2022: Growth Factors
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