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Journal of Dermatological Treatment

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https://read.qxmd.com/read/30900514/risk-of-herpes-zoster-with-il-17-inhibitor-therapy-for-psoriasis-and-other-inflammatory-conditions
#1
Kevin K Wu, Michael P Lee, Erica B Lee, Jashin J Wu
Psoriasis is a chronic inflammatory skin disease that has been associated with a significantly higher risk of herpes zoster (HZ). Several newer biologics such as secukinumab, ixekizumab, and brodalumab inhibit IL-17 and have been highly effective for treatment of psoriasis. However, adverse events related to the immunosuppressive properties of these biologics have been observed. This review aims to synthesize and evaluate the literature investigating the risk of HZ in patients treated with IL-17 inhibitors, with a focus on psoriasis patients...
March 22, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30897016/the-real-world-impact-of-adalimumab-on-quality-of-life-and-the-physical-and-psychological-effects-of-moderate-to-severe-psoriasis-a-uk-prospective-multicenter-observational-study
#2
Joyce Leman, Shernaz Walton, Alison M Layton, Kathleen A Ward, Sandy McBride, Sandeep Cliff, Anthony Downs, Margarita Landeira, Anthony Bewley
Psoriasis can adversely affect quality of life (QoL) and emotional well-being. In this UK prospective observational study we evaluated the 'real-world' impact of adalimumab on QoL and the physical/psychological effects of moderate-to-severe psoriasis. 143 biologic-naïve patients with moderate-to-severe psoriasis, receiving adalimumab in clinical practice, were included. Patients completed a series of questionnaires at baseline (adalimumab initiation), 4 and 16-weeks and 6-months post-adalimumab initiation during routine visits...
March 21, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30897011/paclitaxel-as-first-or-second-line-treatment-for-hiv-negative-kaposi-s-sarcoma-a-retrospective-study-of-58-patients
#3
Athanasia Tourlaki, Francesca Germiniasi, Luisa Rossi, Stefano Veraldi, Lucia Brambilla
BACKGROUND: Paclitaxel has recently been approved for AIDS-related Kaposi's sarcoma (KS) and there is much interest also in HIV-negative KS. OBJECTIVE: To assess the safety and effectiveness of intravenous paclitaxel in the treatment of non-HIV associated KS. METHOD: A retrospective database analysis of our departmental database in histologically proven, HIV-negative KS. RESULTS: 58 patients treated with intravenous paclitaxel 100 mg weekly were identified...
March 21, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30897010/patient-experiences-of-using-chinese-herbal-medicine-for-psoriasis-vulgaris-and-chronic-urticaria-a-qualitative-study
#4
Meaghan E Coyle, Jason Jingjie Yu, Anthony Lin Zhang, Linda Jones, Charlie Changli Xue, Chuanjian Lu
BACKGROUND: Psoriasis vulgaris and chronic urticaria are common skin conditions with a significant health burden. Achieving long-term control remains a challenge, and some patients choose Chinese herbal medicine (CHM) to meet this need. Little is known about the motivators and experiences of using CHM for these skin conditions. OBJECTIVES: To determine the motivators for choosing CHM, and experience of using CHM for psoriasis vulgaris and chronic urticaria. METHODS: We conducted semi-structured interviews with participants who had previously used CHM for these conditions...
March 21, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30897009/finasteride-and-androgenic-alopecia-from-therapeutic-options-to-medical-implications
#5
Ion G Motofei, David L Rowland, Mircea Tampa, Maria-Isabela Sarbu, Madalina-Irina Mitran, Cristina-Iulia Mitran, Anca Pantea Stoian, Camelia C Diaconu, Stana Paunica, Simona R Georgescu
Androgenic alopecia (AGA) is an aesthetic condition with varying psycho-social implications, easily accepted by some patients and tolerated only with difficulty by others. Modern therapeutic options such as 5α-reductase inhibitors have significant outcomes, but also exert significant side effects in a subset of patients. The literature describes three distinct situations regarding finasteride administration, a compound largely used for AGA. Some studies show finasteride to be very safe with minimal or no side effects...
March 21, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30897007/aloe-polysaccharide-protects-skin-cells-from-uvb-irradiation-through-keap1-nrf2-are-signal-pathway
#6
Lingling Yuan, Xingwu Duan, Runtian Zhang, Yunbi Zhang, Muwen Qu
The aim of this study was to investigate if aloe polysaccharide (AP) has the repairing effect on ultraviolet b (UVB) injured nerve cells. The study applied BALB/c female mice as animal model, and NFG activated PC12 cells as cell model of skin nerve. The cell viability was detected by MTT assay, and cell apoptosis was detected by TUNEL (TdT-mediated dUTP nick-end labeling) and Annexin-/PI assay, and cell cycle status in different groups were observed via flow cytometry (FCM). Enzyme-linked immunosorbent assay (ELISA) was applied to analyze oxidative stress and anti-oxidative ability in each group...
March 21, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30893570/metformin-use-in-hidradenitis-suppurativa
#7
L Jennings, R Hambly, R Hughes, B Moriarty, B Kirby
BACKGROUND: Hidradenitis Suppurativa (HS) is a chronic debilitating inflammatory disease, associated with metabolic syndrome, obesity and insulin resistance. Metformin, an oral hypoglycaemic agent, may play an important role in delaying or preventing the onset of diabetes and metabolic syndrome. Metformin has been reported as having efficacy in HS. It may have a role in the treatment of HS and its associated co-morbidities. OBJECTIVE: To evaluate metformin use, response and tolerability in a HS population...
March 20, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30892982/real-world-use-of-extracorporeal-photopheresis-for-patients-with-cutaneous-t-cell-lymphoma-in-the-united-states-2010-2015
#8
You-Li Ling, Xingyue Huang, Ghaith Mitri, Belinda Lovelace, Pham, Robert Knobler, Xiaocong Li, Xin Gao
INTRODUCTION: The National Comprehensive Cancer Network and the European Organization for Research and Treatment of Cancer recommend extracorporeal photopheresis (ECP) as systemic therapy for cutaneous T-cell lymphoma (CTCL). OBJECTIVE: To investigate real-world use of ECP in CTCL patients in the US. METHODS: Data from the Truven MarketScan® database (2010-2015) were used to create a cohort of CTCL patients receiving systemic treatment. Multivariable regressions were performed to compare health care resource utilizations between ECP and propensity score-matched non-ECP patients...
March 20, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30892971/a-novel-treatment-for-retronychia-case-series
#9
M Vastarella, M C Annunziata, G Panariello, M Ferrillo, G Fabbrocini
The term retronychia describes the proximal ingrowth of the nail that occurs when the nail plate (NP) embeds backwards into the proximal nail fold (PNF). Proximal avulsion of the nail remains the treatment of choice however, permanent postsurgical nail dystrophy can occur. We report here a case series of retronychia treated through chemical avulsion with 50% urea and 10% salicylic acid in vaseline white petroleum, covered by occlusive dressing and kept for 1 week. Eight patients (median age 30, 5 females, 3 male) were referred to our dermatology outpatient because of pain and impaired walking...
March 20, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30892970/long-term-experience-with-radiotherapy-for-the-treatment-of-non-melanoma-skin-cancer
#10
Marjolein Birgitte Visch, Bas Kreike, Marie-Jeanne Pieternel Gerritsen
PURPOSE: In the Netherlands, the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin is increasing dramatically. Radiotherapy is one of the treatment options, especially for the high risk and the irradical excised tumours. METHODS: Retrospectively, the treatment outcome of all patients with BCC or SCC treated with radiotherapy in the period 2000-2013, were reviewed. Patients were divided into two groups, i.e. patients primarily treated with radiotherapy (n = 583) and patients with adjuvant radiation after irradical surgical excision (n = 140)...
March 20, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30889998/assessing-factors-affecting-sunscreen-use-and-barriers-to-compliance-a-cross-sectional-survey-based-study
#11
Emily A Weig, Rechelle Tull, Jina Chung, Zoe O Brown-Joel, Rumbidzai Majee, Nkanyezi N Ferguson
While sunscreen is effective prevention for skin cancer, public sunscreen use and compliance are low. Identifying factors affecting sunscreen use and barriers to compliance are important to understand in order to increase sunscreen use, especially among high-risk individuals. We conducted a single institution survey of 429 dermatology clinic patients to better understand patients' barriers to sunscreen use. Overall several personal barriers to sunscreen use included dislike of feel or appearance of sunscreen (33...
March 19, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30889369/effectiveness-of-subcision-using-carboxytherapy-plus-fractional-carbon-dioxide-laser-resurfacing-in-the-treatment-of-atrophic-acne-scars-comparative-split-face-study
#12
Ibrahim Mohamed Abdel Kareem, Mohamed Ahmed Fouad, Mohamed Kotb Ibrahim
INTRODUCTION: fractional carbon dioxide laser resurfacing is the gold standard treatment for atrophic acne scars but when combined with subcision to the depressed scars it provides rapid improvement. Carboxytherapy is considered a tool for subcision via injecting the gas under pressure plus its well-known effect in rejuvenating scars. AIM OF THE WORK: is to evaluate the effectiveness of combined subcision using carboxytherapy plus fractional carbon dioxide laser resurfacing in the treatment of atrophic acne scars...
March 19, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30888880/drug-survival-of-conventional-systemic-and-biologic-therapies-for-moderate-to-severe-psoriasis-in-clinical-practice-in-spain-prospective-results-from-the-sahara-study
#13
L Puig, J M Carrascosa, E Daudén, S Sulleiro, C Guisado
BACKGROUND: A better understanding of determinants for drug survival of anti-psoriatic agents may guide dermatologists in the right therapeutic choice. OBJECTIVES: To describe 2-year drug survival of conventional and biologic antipsoriatic treatments. METHODS: SAHARA was a prospective study in patients with moderate-to severe psoriasis who initiated a conventional or biologic drug. Kaplan-Meier analysis estimated the drug survival and Cox-regression the predictors of treatment persistence at two years...
March 19, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30887876/efficacy-and-safety-of-guselkumab-administered-with-a-novel-patient-controlled-injector-one-press-for-moderate-to-severe-psoriasis-results-from-the-phase-3-orion-study
#14
Laura K Ferris, Elyssa Ott, Jingzhi Jiang, H Chih-Ho Hong, Shu Li, Chenglong Han, Wojciech Baran
OBJECTIVES: Guselkumab, an interleukin-23 antagonist, is approved for self-administration with the UltraSafe Plus™ syringe to treat moderate-to-severe plaque-type psoriasis. We evaluated the efficacy, safety, pharmacokinetics, and acceptability of guselkumab administered using a novel patient-controlled injector (One-Press) in psoriasis patients. MATERIALS AND METHODS: This Phase 3, multicentre, double-blind, placebo-controlled study (ORION, Clinicaltrials.gov identifier-NCT02905331) randomized adults with moderate-to-severe psoriasis (4:1) to guselkumab 100 mg at Weeks 0/4/12/20/28 or placebo at Weeks 0/4/12 with crossover to guselkumab 100 mg at Weeks 16/20/28...
March 19, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30885022/a-cross-sectional-study-of-youtube-videos-as-a-source-of-patient-information-for-topical-psoriasis-therapies
#15
Deeti J Pithadia, Kelly A Reynolds, Erica B Lee, Jashin J Wu
YouTube is becoming an increasingly popular resource for patients seeking knowledge regarding treatment options for dermatologic conditions. This study assessed the quality of content on YouTube regarding topical treatment for psoriasis. A cross-sectional analysis of YouTube videos was conducted using search terms related to psoriasis topical therapies. Of the 400 videos screened, 199 met inclusion criteria. One hundred ten (55.3%) videos discussed natural treatments, 56 (28.1%) discussed therapies with grade A recommendations by the American Academy of Dermatology, 22 (8...
March 18, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30883242/effectiveness-and-safety-of-ustekinumab-90-mg-in-patients-weighing-100-kg-or-less-a-retrospective-observational-multicenter-study
#16
Elena Del Alcázar, Marta Ferran, Anna López-Ferrer, Jaime Notario, Vidal David, José Riera, Gloria Aparicio, Fernando Gallardo, Eva Vilarrasa, Mercè Alsina, Lluís Puig, Carlos Ferrándiz, José Manuel Carrascosa
BACKGROUND: Scant information from clinical practice is available on the effectiveness and safety of ustekinumab (UST) 90mg in patients with psoriasis weighing 100kg or less. OBJECTIVES: To assess the effectiveness and safety at weeks 16 and 24 of UST 90 mg in patients with psoriasis weighing ≤100kg, and to study the impact on clinical outcomes of body mass index and prior exposure to UST 45mg. METHODS: A retrospective, observational, multicenter study of 74 adult patients who were treated with UST 90mg at least 24 weeks...
March 18, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30843746/a-patient-with-squamous-cell-carcinoma-in-situ-successfully-treated-with-intralesional-5-fluorouracil-and-topical-trichloroacetic-acid
#17
Thomas Vazquez, Mercedes Florez-White
BACKGROUND: The current gold standard and the first line of treatment for non-melanoma skin cancer is surgical excision. Nevertheless, some patients are not good candidates for surgery when wound healing may be impaired. METHODS: A 96-year-old male presented with 1.2 cm by 1.5 cm tumoral lesion with an ill-infiltrated border and central ulceration located on the mid right lower leg. Biopsy confirmed the diagnosis of squamous cell carcinoma (SCC) in situ. The primary lesion was treated centrally to peripherally with multiple intralesional injections of 1...
March 7, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30843444/iontophoretic-delivery-of-lidocaine-hydrochloride-through-ex-vivo-human-skin
#18
Roopa G Manjunatha, Rachna Prasad, Sunil Sharma, R P Narayan, Veena Koul
BACKGROUND: Iontophoresis is one of the widely used noninvasive and painless transdermal drug delivery technique. OBJECTIVE: Transdermal delivery of Lidocaine Hydrochloride using continuous and modulated iontophoresis were evaluated across human skin ex-vivo and further assessed for skin tolerance in-vivo in the Swiss albino mice. METHODS: Continuous DC was modified into modulated DC by introducing ON-OFF time in continuous DC. Iontophoresis studies were conducted on human skin samples for 60 min...
March 7, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30836808/minimise-the-regular-laboratory-monitoring-during-the-systemic-isotretinoin-treatment-data-of-704-patients-with-acne-vulgaris
#19
Ayşe Öktem, Yıldız Hayran, Esra Arı, Başak Yalçın
Backround: Despite extensive usage of systemic isotretinoin in patients with acne for many years, laboratory monitoring protocols for adverse effects depend on the centers and there is no standardized practice for frequency and type of laboratory testing. We aimed to decrease unnecessary monitoring and to standardize our general clinical practice of our department as well as to provide patient comfort and cost saving. MATERIAL AND METHOD: The medical charts of 704 acne patients treated with systemic isotretinoin were reviewed retrospectively...
March 6, 2019: Journal of Dermatological Treatment
https://read.qxmd.com/read/30836026/efficacy-of-topical-imiquimod-3-75-in-the-treatment-of-actinic-keratosis-of-the-scalp-in-immunosuppressed-patients-our-case-series
#20
E Zavattaro, F Veronese, G Landucci, V Tarantino, P Savoia
BACKGROUND: Actinic keratoses (AK) represent common cutaneous lesions, appearing in "Field cancerization areas" and potentially evolving towards invasive neoplasm. Immunosuppressed patients frequently develop numerous and aggressive AKs. AIM: In this observational study, we report our experience with topical Imiquimod 3.75% as "Field-directed therapy" in a cohort of immunosuppressed patients. METHODS: A group of 13 immunosuppressed patients presenting multiple AKs of the balding scalp was treated with topical Imiquimod 3...
March 5, 2019: Journal of Dermatological Treatment
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