journal
Journals Journal of Dermatological Trea...

Journal of Dermatological Treatment

https://read.qxmd.com/read/38632977/efficacy-of-risankizumab-across-subgroups-in-patients-with-active-psoriatic-arthritis-a-post-hoc-integrated-analysis-of-the-phase-3-keepsake-1-and-keepsake-2-randomized-controlled-trials
#1
JOURNAL ARTICLE
Joseph F Merola, April Armstrong, Saakshi Khattri, So Yeon Paek, Byron Padilla, Cuiyong Yue, Huzefa Photowala, Blair Kaplan, Lars Erik Kristensen
In the KEEPsAKE 1 (NCT03675308) and KEEPsAKE 2 (NCT03671148) phase 3 trials, risankizumab demonstrated greater efficacy compared with placebo in patients with active psoriatic arthritis (PsA). This post hoc integrated analysis evaluated achieving the following efficacy outcomes at weeks 24 and 52 by baseline demographics and clinical characteristics: ≥20%/50%/70% improvement in American College of Rheumatology response criteria (ACR20/50/70), ≥90% improvement in Psoriasis Area and Severity Index, minimal disease activity status, Low Disease Activity status (Disease Activity in Psoriatic Arthritis), and minimal clinically important difference in pain...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38632962/tofacitinib-for-managing-granuloma-formation-after-dermal-filler-injection-three-case-reports-and-literature-review
#2
JOURNAL ARTICLE
Jieyi Wang, Zhuoxuan Chen, Lin Wu, Yan Liao, Bo Yu
BACKGROUND: Granuloma formation is an uncommon and persistent skin inflammatory condition caused by the injection of dermal fillers. The exact cause of this reaction is not well understood, but it may be associated with irritating components or abnormal immune function. Treating granulomas can be difficult. However, recent research has shown that Janus kinase (JAK) inhibitors hold promise as a potential therapy for refractory granulomatous diseases. OBJECTIVES: The aim was to evaluate the efficacy and safety of tofacitinib as a treatment for granulomas secondary to filler injection and the possible mechanisms were discussed and summarized...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38626923/methodological-quality-of-systematic-reviews-on-atopic-dermatitis-treatments-a-cross-sectional-study
#3
REVIEW
Leonard Ho, Yolenda Man Kei Cheung, Cyrus Chung Ching Choi, Irene Xinyin Wu, Chen Mao, Vincent Chi Ho Chung
BACKGROUND: Systematic reviews (SRs) could offer the best evidence supporting interventions, but methodological flaws limit their trustworthiness in decision-making. This cross-sectional study appraised the methodological quality of SRs on atopic dermatitis (AD) treatments. METHODS: We searched MEDLINE, EMBASE, PsycINFO, and Cochrane Database for SRs on AD treatments published in 2019-2022. We extracted SRs' bibliographical data and appraised SRs' methodological quality with AMSTAR (A MeaSurement Tool to Assess systematic Reviews) 2...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38616301/artificial-intelligence-based-prescription-of-personalized-scalp-cosmetics-improved-the-scalp-condition-efficacy-results-from-100-participants
#4
JOURNAL ARTICLE
Bo Ri Kim, Min Jae Kim, Jieun Koo, Hwa-Jung Choi, Kyung Ho Paik, Soon Hyo Kwon, Hye-Ryung Choi, Chang Hun Huh, Jung Won Shin, Dong-Sun Park, Jung-Im Na
Background: Scalp-related symptoms such as dandruff and itching are common with diverse underlying etiologies. We previously proposed a novel classification and scoring system for scalp conditions, called the scalp photographic index (SPI); it grades five scalp features using trichoscopic images with good reliability. However, it requires trained evaluators. Aim: To develop artificial intelligence (AI) algorithms for assessment of scalp conditions and to assess the feasibility of AI-based recommendations on personalized scalp cosmetics...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38569598/a-systematic-review-investigating-the-proportion-of-clinical-images-shared-in-prospective-randomized-controlled-trials-involving-patients-with-atopic-dermatitis-and-systemic-pharmacotherapy
#5
REVIEW
Sam Polesie, Mikael Alsterholm
For individuals with atopic dermatitis (AD), interpreting scientific papers that present clinical outcomes including the Eczema Area and Severity Index (EASI) and Investigators Global Assessment may be difficult. When compared to tabulated data and graphs, images from before and after treatment are often far more meaningful to these patients that ultimately will be candidates for the treatment. This systematic review focused on determining the frequency of clinical image sharing in AD research. Conducted in accordance with PRISMA guidelines, the review concentrated on randomized controlled trials that investigated predefined and available systemic treatments for AD...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38568005/topical-clindamycin-for-acne-vulgaris-analysis-of-gastrointestinal-events
#6
REVIEW
Natalia M Pelet Del Toro, Andrew Strunk, Jashin J Wu, Linda Stein Gold, James Q Del Rosso, Robert T Brodell, George Han
Purpose: Topical clindamycin, a lincosamide antibiotic, is commonly combined with benzoyl peroxide or a retinoid for acne vulgaris (AV) treatment. While oral and topical clindamycin carry warnings/contraindications regarding gastrointestinal (GI) adverse events (AEs), real-world incidence of GI AEs with topical clindamycin is unknown. This review provides background information and an overview of safety data of topical clindamycin for treating AV. Materials and Methods: Available safety data from published literature, previously unpublished worldwide pharmacovigilance data, and two retrospective cohort studies were reviewed...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38565207/use-of-a-topical-janus-kinase-inhibitor-in-immune-checkpoint-inhibitor-induced-eczematous-reaction-a-case-report
#7
JOURNAL ARTICLE
Camille M Powers, Hannah Verma, Jeremy Orloff, Austin J Piontkowski, Amy Tiersten, Angela Lamb, Nicholas Gulati
In this report, we describe the case of a 28-year-old female with bilateral breast cancer in the setting of a BRCA1 mutation, who presented to dermatology with an eczematous reaction, ultimately diagnosed as a cutaneous immune-related adverse event (cirAE) secondary to an immune checkpoint inhibitor (ICI), pembrolizumab. Our case report highlights a novel therapeutic option for an eczematous cirAE: the topical JAK 1/2 inhibitor, ruxolitinib. CirAEs can occur in up to 55% of patients on ICIs, a class of medications seeing rapidly increasing use in cancer therapy, and prior research has demonstrated that ICI-induced dermatitis may involve different pathways than traditionally observed in their spontaneous counterparts...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38565205/successful-treatment-of-recalcitrant-generalized-pustular-psoriasis-of-pregnancy-with-spesolimab
#8
JOURNAL ARTICLE
Chenxin Yang, Yang Wang, Ruoyu Li, Ping Tu, Ruojun Wang
Generalized pustular psoriasis (GPP) in pregnancy can lead to severe complications for both mother and fetus. The treatment of this disease is challenging, especially in recalcitrant and severe cases. Until present, there are no evidence-based guidelines for the treatment of GPP in pregnancy. Spesolimab, a human monoclonal antibody against the IL-36 receptor, has recently attracted attention as a new therapy for GPP flare. This biologic provides rapid and sustained control of symptoms of GPP flare, although its use in pregnant women has not been reported to date...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38565198/managing-dry-skin-in-patients-with-comorbidities-or-with-advanced-age-unmet-needs-and-roles-for-products-containing-potential-emollient-plus-ingredients
#9
REVIEW
Matthias Augustin, Enzo Berardesca, Ulrike Blume-Peytavi, Peter Elsner, Davide Scafa, Leonard Christopher Schmeel, Ehrhardt Proksch
In dry skin (DS), skin-barrier function is easily disturbed and moisturizing factors in the stratum corneum are reduced. Despite being a common condition, DS is often overlooked in patients with advanced age or comorbid diseases. In September 2022, specialists in dermatology and skin care met to discuss unmet needs and management of patients with DS with existing medical conditions or DS induced by ongoing pharmacological treatments. There was consensus about the need to improve the current understanding and management of DS in patients with comorbidities, including type 2 diabetes, chronic kidney disease, radiodermatitis, and photodamaged skin...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38531388/a-case-of-generalized-eosinophilic-pustular-folliculitis-treatment-with-jak-inhibitor
#10
JOURNAL ARTICLE
Chunzhi Zheng, Yueqian Yu, Guizhi Zhou, Hong Liu
AIM: This case study aims to report the efficacy and safety of a Janus kinase (JAK) inhibitor in the treatment of generalized eosinophilic pustular folliculitis (EPF). METHODS: We present a case of a 16-year-old Chinese patient who had been suffering from EPF for two years and had shown no response to both topical and systemic glucocorticoids. The patient was subsequently treated with oral tofacitinib at a dosage of 5mg daily. RESULTS: Significant remission of eruption and pruritus was observed in the patient upon treatment with tofacitinib...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38531383/short-term-effectiveness-and-potential-factors-of-ustekinumab-based-on-real-world-data-in-chinese-psoriasis-patients
#11
JOURNAL ARTICLE
Xingyu Li, Xiaowen Xie, Jiashuai Li, Jingjin Hu, Kun Hu, Minjia Tan, Jing Yang, Sichun Deng, Yijie Liu, Mi Zhang, Yehong Kuang, Junchen Chen, Liqiu Liao, Wu Zhu
BACKGROUND: As one of the most effective biologic treatments for psoriasis, the short-term effectiveness of ustekinumab has yet to be studied extensively. OBJECTIVE: The purpose of this study was to evaluate the short-term effectiveness and potential factors within four weeks after the first-dose ustekinumab treatment based on real-world data. METHODS: The study enrolled 98 patients with moderate-to-severe psoriasis, given ustekinumab 45 mg at week 0, week 4, and then every 12 weeks...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38522861/successful-treatment-of-generalized-pustular-psoriasis-with-guselkumab
#12
JOURNAL ARTICLE
Martina Part
The purpose of the article: Generalized pustular psoriasis (GPP) is a rare auto-inflammatory disease. Patients with GPP may develop life-threatening complications, including sepsis, acute renal failure, neutrophilic cholangitis, high-output congestive heart failure, acute respiratory distress syndrome and death. The therapy of GPP is very limited and the course of the disease is unpredictable. Materials and methods: We report a 60-year-old woman presenting with widespread and confluent erythematous-desquamative plaques with numerous small pustules covering almost 70% of the body surface area...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38522860/real-world-insights-for-psoriasis-the-association-of-severity-of-skin-lesions-with-work-productivity-medical-consumption-costs-and-quality-of-life
#13
JOURNAL ARTICLE
Thom S Lysen, Edmée J G M Crombag, Loek Lennaerts, Amr Makady, Ralph H Bruin, Kelly Mulder, Elke M G J de Jong, Hanne van Ballegooijen
BACKGROUND: Psoriasis is a prevalent, chronic skin disease with a potential impact on work productivity, medical consumption costs, and quality of life. The influence of the extent of skin lesions on these outcomes is not well known. OBJECTIVE: We determined associations of self-reported skin lesions with self-reported work productivity, medical consumption costs, and health-related quality of life in respondents with psoriasis. METHODS: In this cross-sectional study, we included respondents with self-reported psoriasis in the Netherlands in an online questionnaire...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38513258/comparison-between-super-responders-and-non-super-responders-in-psoriasis-under-adalimumab-treatment-a-real-life-cohort-study-on-the-effectiveness-and-drug-survival-over-one-year
#14
JOURNAL ARTICLE
Yizhang Liu, Kun Hu, Lu Jian, Yongfang Duan, Mi Zhang, Yehong Kuang
BACKGROUND: Data on the characteristics and treatment outcomes of super-responders and non-super-responders in psoriasis under adalimumab treatment are limited. METHODS: A retrospective analysis from psoriatic patients treated with adalimumab was compared to characterize super-responders vs non-super-responders' groups, identify factors associated with super response, and assess treatment outcomes after switching. RESULTS: 15 out of 70 (21...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38508226/ucomb-real-life-data-treatment-strategies-for-chronic-urticaria-patients-with-comorbidities
#15
JOURNAL ARTICLE
Petra Staubach, Benedikt Bilo, Joachim W Fluhr, Karoline Krause, Kanokvalai Kulthanan, Andac Salman, Connie Katelaris, Jonathan A Bernstein, Marcus Maurer, Caroline Mann
BACKGROUND: There is a lack of real-life safety data on treatment options for chronic urticaria in the presence of comedication and comorbidities. METHODS: We present a single-center UCARE pilot study of 212 outpatients with chronic urticaria. Patients were divided into three groups according to different CU therapies according to international guidelines. RESULTS: Of 212 patients, 108 (mean age 48.9 years, 71.3% female) had 59 comorbidities, including cardiovascular, autoimmune and malignant diseases...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38493799/resolution-of-painful-trichodysplasia-spinulosa-with-topical-cidofovir-case-report
#16
JOURNAL ARTICLE
Kevin M Burningham, Ritu N Swali, Peter L Rady, Anisha B Patel, Stephen K Tyring
Purpose: Trichodysplasia spinulosa (TS) is a rare, disfiguring skin condition which presents with widespread asymptomatic or pruritic, skin-colored papules with white protruding keratin spiculations in immunocompromised individuals. Due to its rarity, there is little data to guide treatment decisions. The purpose of this article is to report a case of TS that completely resolved after treatment with topical cidofovir. Materials and methods: A 19-year-old immunosuppressed female presented with widespread painful, itchy bumps on the nose and face...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38479408/doxycycline-monotherapy-for-pyoderma-vegetans-a-case-report
#17
JOURNAL ARTICLE
Jihane Belcadi, Sara Oulad Ali, Fatima-Zahra Sassine, Mariame Meziane, Karima Senouci
Background: Pyoderma vegetans (PV) is a rare neutrophilic dermatosis of unknown etiology. Currently, there are no treatment guidelines for PV. Systemic steroids are often used as first-line therapy, but recurrence upon discontinuation or tapering is common. Materials and methods: We tested the efficacy of doxycycline at a dose of 200 mg/d to treat resistant PV. Results: After 4 weeks of treatment we noticed a significant improvement in the clinical appearance of PV. Conclusions: Our case demonstrates the potential utility of doxycycline as a systemic steroid-sparing agent in the treatment of PV...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38465887/mandated-step-therapy-for-dupilumab-delays-the-inevitable
#18
JOURNAL ARTICLE
Brian Florenzo, Catherine E Lyons, Aaron D Smith, Courtney Remington, R Hal Flowers, Bridget Bryer
No abstract text is available yet for this article.
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38465657/alopecia-areata-treatment-with-baricitinib-different-relapse-phenotypes
#19
JOURNAL ARTICLE
Federica Dall'Oglio, Maria Rita Nasca, Francesco Lacarrubba, Pasquale Vitale, Giuseppe Micali
No abstract text is available yet for this article.
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38417812/onychopapilloma-a-single-medical-center-experience-in-southern-taiwan
#20
JOURNAL ARTICLE
Po-Ta Lai, Yung-Wei Chang, Shang-Hung Lin
Background: Onychopapilloma is an uncommon benign tumor of the nail bed and the distal matrix. Objectives: We aimed to investigate the clinical and pathological features of onychopapilloma in Taiwan. Materials and methods: We conducted a retrospective analysis of 12 patients with histopathologically proven onychopapilloma in a medical center in southern Taiwan from 2017 to 2023. Results: This case series consisted of 5 men and 7 women aged 29 to 38, with a mean age of 41.25 years. The clinical features were as follows: distal subungual hyperkeratosis (100%), longitudinal erythronychia (50%), longitudinal leukonychia (50 %), distal onycholysis (41%), and distal nail plate fissuring (41%)...
December 2024: Journal of Dermatological Treatment
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